Targeting IAP proteins in combination with radiotherapy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Simone Fulda

ABSTRACT

The efficacy of radiotherapy critically depends on the activation of intrinsic cell death programs in cancer cells. This implies that evasion of cell death, a hallmark of human cancers, can contribute to radioresistance. Therefore, novel strategies to reactivate cell death programs in cancer cells are required in order to overcome resistance to radiotherapy. Since Inhibitor of Apoptosis (IAP) proteins are expressed at high levels in multiple cancers and block cell death induction at a central point, therapeutic targeting of IAP proteins represents a promising approach to potentiate the efficacy of radiotherapy. The current review discusses the concept of targeting IAP proteins in combination with radiotherapy. More... »

PAGES

105

References to SciGraph publications

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  • 2008-12. Smac/DIABLO enhances the therapeutic potential of chemotherapeutic drugs and irradiation, and sensitizes TRAIL-resistant breast cancer cells in MOLECULAR CANCER
  • 2006-08. Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy in ONCOGENE
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  • 2004-09. XIAP and survivin as therapeutic targets for radiation sensitization in preclinical models of lung cancer in ONCOGENE
  • 2012-02. Targeting IAP proteins for therapeutic intervention in cancer in NATURE REVIEWS DRUG DISCOVERY
  • 2014-02. Regulated necrosis: the expanding network of non-apoptotic cell death pathways in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2012-05. Smac-mimetic compound SM-164 induces radiosensitization in breast cancer cells through activation of caspases and induction of apoptosis in BREAST CANCER RESEARCH AND TREATMENT
  • 2013-11. Identification of DR5 as a critical, NF-κB-regulated mediator of Smac-induced apoptosis in CELL DEATH & DISEASE
  • 2008-03. Apoptosis: controlled demolition at the cellular level in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13014-015-0399-3

    DOI

    http://dx.doi.org/10.1186/s13014-015-0399-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1039333630

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25927408


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