Ontology type: schema:ScholarlyArticle Open Access: True
2015-01-23
AUTHORSSoichiro Ishihara, Satoshi Matsusaka, Keisaku Kondo, Hisanaga Horie, Keisuke Uehara, Masahiko Oguchi, Keiko Murofushi, Masashi Ueno, Nobuyuki Mizunuma, Taijyu Shinbo, Daiki Kato, Junji Okuda, Yojiro Hashiguchi, Masanori Nakazawa, Eiji Sunami, Kazushige Kawai, Hideomi Yamashita, Tohru Okada, Yuichi Ishikawa, Toshifusa Nakajima, Toshiaki Watanabe
ABSTRACTBackgroundThe objective of this phase I study was to determine the maximum tolerated dose (MTD) and recommended dose (RD) of preoperative chemoradiotherapy (CRT) with S-1 plus oxaliplatin in patients with locally advanced rectal cancer.MethodsPatients received radiotherapy in a total dose of 50.4 Gy in 28 fractions. Concurrent chemotherapy consisted of a fixed oral dose of S-1 (80 mg/m2/day) on days 1–5, 8–12, 22–27, and 29–33, plus escalated doses of oxaliplatin as an intravenous infusion on days 1, 8, 22, and 29. Oxaliplatin was initially given in a dose of 40 mg/m2/week to three patients. The dose was then increased in a stepwise fashion to 50 mg/m2/week and the highest dose level of 60 mg/m2/week until the MTD was attained.ResultsThirteen patients were enrolled, and 12 received CRT. Dose-limiting toxicity (DLT) occurred in two of six patients (persistent grade 2 neutropenia, delaying oxaliplatin treatment by more than 3 days) at dose level 3; there were no grade 3 or 4 adverse events defined as DLT. The RD was 60 mg/m2/week of oxaliplatin on days 1, 8, 22, and 29. Twelve patients underwent histologically confirmed R0 resections, and two out of six patients (33%) given dose level 3 had pathological complete responses.ConclusionsThe RD for further studies is 80 mg/m2 of S-1 5 days per week plus 60 mg/m2 of oxaliplatin on days 1, 8, 22, and 29 and concurrent radiotherapy. Although our results are preliminary, this new regimen for neoadjuvant chemoradiotherapy is considered safe and active.Trial registrationThis trial was registered with Clinicaltrials.gov (identifier: NCT01227239). More... »
PAGES24
http://scigraph.springernature.com/pub.10.1186/s13014-015-0333-8
DOIhttp://dx.doi.org/10.1186/s13014-015-0333-8
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/25612635
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"description": "BackgroundThe objective of this phase I study was to determine the maximum tolerated dose (MTD) and recommended dose (RD) of preoperative chemoradiotherapy (CRT) with S-1 plus oxaliplatin in patients with locally advanced rectal cancer.MethodsPatients received radiotherapy in a total dose of 50.4\u00a0Gy in 28 fractions. Concurrent chemotherapy consisted of a fixed oral dose of S-1 (80\u00a0mg/m2/day) on days 1\u20135, 8\u201312, 22\u201327, and 29\u201333, plus escalated doses of oxaliplatin as an intravenous infusion on days 1, 8, 22, and 29. Oxaliplatin was initially given in a dose of 40\u00a0mg/m2/week to three patients. The dose was then increased in a stepwise fashion to 50\u00a0mg/m2/week and the highest dose level of 60\u00a0mg/m2/week until the MTD was attained.ResultsThirteen patients were enrolled, and 12 received CRT. Dose-limiting toxicity (DLT) occurred in two of six patients (persistent grade 2 neutropenia, delaying oxaliplatin treatment by more than 3\u00a0days) at dose level 3; there were no grade 3 or 4 adverse events defined as DLT. The RD was 60\u00a0mg/m2/week of oxaliplatin on days 1, 8, 22, and 29. Twelve patients underwent histologically confirmed R0 resections, and two out of six patients (33%) given dose level 3 had pathological complete responses.ConclusionsThe RD for further studies is 80\u00a0mg/m2 of S-1 5\u00a0days per week plus 60\u00a0mg/m2 of oxaliplatin on days 1, 8, 22, and 29 and concurrent radiotherapy. Although our results are preliminary, this new regimen for neoadjuvant chemoradiotherapy is considered safe and active.Trial registrationThis trial was registered with Clinicaltrials.gov (identifier: NCT01227239).",
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]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13014-015-0333-8'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13014-015-0333-8'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13014-015-0333-8'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13014-015-0333-8'
This table displays all metadata directly associated to this object as RDF triples.
394 TRIPLES
21 PREDICATES
108 URIs
98 LITERALS
29 BLANK NODES