A phase I dose escalation study of oxaliplatin plus oral S-1 and pelvic radiation in patients with locally advanced rectal ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-01-23

AUTHORS

Soichiro Ishihara, Satoshi Matsusaka, Keisaku Kondo, Hisanaga Horie, Keisuke Uehara, Masahiko Oguchi, Keiko Murofushi, Masashi Ueno, Nobuyuki Mizunuma, Taijyu Shinbo, Daiki Kato, Junji Okuda, Yojiro Hashiguchi, Masanori Nakazawa, Eiji Sunami, Kazushige Kawai, Hideomi Yamashita, Tohru Okada, Yuichi Ishikawa, Toshifusa Nakajima, Toshiaki Watanabe

ABSTRACT

BackgroundThe objective of this phase I study was to determine the maximum tolerated dose (MTD) and recommended dose (RD) of preoperative chemoradiotherapy (CRT) with S-1 plus oxaliplatin in patients with locally advanced rectal cancer.MethodsPatients received radiotherapy in a total dose of 50.4 Gy in 28 fractions. Concurrent chemotherapy consisted of a fixed oral dose of S-1 (80 mg/m2/day) on days 1–5, 8–12, 22–27, and 29–33, plus escalated doses of oxaliplatin as an intravenous infusion on days 1, 8, 22, and 29. Oxaliplatin was initially given in a dose of 40 mg/m2/week to three patients. The dose was then increased in a stepwise fashion to 50 mg/m2/week and the highest dose level of 60 mg/m2/week until the MTD was attained.ResultsThirteen patients were enrolled, and 12 received CRT. Dose-limiting toxicity (DLT) occurred in two of six patients (persistent grade 2 neutropenia, delaying oxaliplatin treatment by more than 3 days) at dose level 3; there were no grade 3 or 4 adverse events defined as DLT. The RD was 60 mg/m2/week of oxaliplatin on days 1, 8, 22, and 29. Twelve patients underwent histologically confirmed R0 resections, and two out of six patients (33%) given dose level 3 had pathological complete responses.ConclusionsThe RD for further studies is 80 mg/m2 of S-1 5 days per week plus 60 mg/m2 of oxaliplatin on days 1, 8, 22, and 29 and concurrent radiotherapy. Although our results are preliminary, this new regimen for neoadjuvant chemoradiotherapy is considered safe and active.Trial registrationThis trial was registered with Clinicaltrials.gov (identifier: NCT01227239). More... »

PAGES

24

Journal

TITLE

Radiation Oncology

ISSUE

1

VOLUME

10

Author Affiliations

  • Department of Surgical Oncology, University of Tokyo, 7-3-1, Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan
  • Department of Gastroenterology, Cancer Institute Hospital, 3-8-31, Ariake, 135-8550, Koto-ku, Tokyo, Japan
  • Department of General & Gastroenterological Surgery, Osaka Medical College, 2-7, Daigaku-cho, 569-8686, Takatsuki, Osaka, Japan
  • Department of Surgery, School of Medicine Jichi Medical University, 3311-1, Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan
  • Division of Surgical Oncology, Department of Surgery, Nagoya University, 65, Tsurumai-cho, Syowa-ku, 466-8550, Nagoya, Aichi, Japan
  • Department of Radiation Oncology, Cancer Institute Hospital, 3-8-31, Ariake, 135-8550, Koto-ku, Tokyo, Japan
  • Department of Gastroenterological Surgery, Cancer Institute Hospital, 3-8-31, Ariake, 135-8550, Koto-ku, Tokyo, Japan
  • Department of Radiology, Osaka Medical College, 2-7, Daigaku-cho, 569-8686, Takatsuki, Osaka, Japan
  • Department of Radiology, Teikyo University, 2-11-1, Kaga, 173-8605, Itabashi-ku, Tokyo, Japan
  • Department of Surgery, Teikyo University, 2-11-1, Kaga, 173-8605, Itabashi-ku, Tokyo, Japan
  • Department of Radiology, School of Medicine Jichi Medical University, 3311-1, Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan
  • Department of Radiology, University of Tokyo, 7-3-1, Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan
  • Department of Radiology, Nagoya University, 65, Tsurumai-cho, Syowa-ku, 466-8560, Nagoya, Aichi, Japan
  • Japanese Foundation for Cancer Research, 3-8-31, Ariake, 135-8550, Koto-ku, Tokyo, Japan
  • Japan Clinical Cancer Research Organization, 7F Ginza Wing Bldg. 1-14-5, Ginza, 104-0061, Chuo-ku, Tokyo, Japan
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13014-015-0333-8

    DOI

    http://dx.doi.org/10.1186/s13014-015-0333-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1022291989

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25612635


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adenocarcinoma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antineoplastic Combined Chemotherapy Protocols", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chemoradiotherapy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drug Combinations", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Follow-Up Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Maximum Tolerated Dose", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Staging", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Organoplatinum Compounds", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Oxaliplatin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Oxonic Acid", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pelvis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prognosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Rectal Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Remission Induction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tegafur", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Young Adult", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Surgical Oncology, University of Tokyo, 7-3-1, Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Department of Surgical Oncology, University of Tokyo, 7-3-1, Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ishihara", 
            "givenName": "Soichiro", 
            "id": "sg:person.0605274525.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605274525.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Gastroenterology, Cancer Institute Hospital, 3-8-31, Ariake, 135-8550, Koto-ku, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.486756.e", 
              "name": [
                "Department of Gastroenterology, Cancer Institute Hospital, 3-8-31, Ariake, 135-8550, Koto-ku, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Matsusaka", 
            "givenName": "Satoshi", 
            "id": "sg:person.01125517543.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125517543.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of General & Gastroenterological Surgery, Osaka Medical College, 2-7, Daigaku-cho, 569-8686, Takatsuki, Osaka, Japan", 
              "id": "http://www.grid.ac/institutes/grid.444883.7", 
              "name": [
                "Department of General & Gastroenterological Surgery, Osaka Medical College, 2-7, Daigaku-cho, 569-8686, Takatsuki, Osaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kondo", 
            "givenName": "Keisaku", 
            "id": "sg:person.01101275130.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101275130.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgery, School of Medicine Jichi Medical University, 3311-1, Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410804.9", 
              "name": [
                "Department of Surgery, School of Medicine Jichi Medical University, 3311-1, Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Horie", 
            "givenName": "Hisanaga", 
            "id": "sg:person.0760333502.93", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760333502.93"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Surgical Oncology, Department of Surgery, Nagoya University, 65, Tsurumai-cho, Syowa-ku, 466-8550, Nagoya, Aichi, Japan", 
              "id": "http://www.grid.ac/institutes/grid.27476.30", 
              "name": [
                "Division of Surgical Oncology, Department of Surgery, Nagoya University, 65, Tsurumai-cho, Syowa-ku, 466-8550, Nagoya, Aichi, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Uehara", 
            "givenName": "Keisuke", 
            "id": "sg:person.01235507706.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235507706.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Radiation Oncology, Cancer Institute Hospital, 3-8-31, Ariake, 135-8550, Koto-ku, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.486756.e", 
              "name": [
                "Department of Radiation Oncology, Cancer Institute Hospital, 3-8-31, Ariake, 135-8550, Koto-ku, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Oguchi", 
            "givenName": "Masahiko", 
            "id": "sg:person.01331625450.94", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331625450.94"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Radiation Oncology, Cancer Institute Hospital, 3-8-31, Ariake, 135-8550, Koto-ku, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.486756.e", 
              "name": [
                "Department of Radiation Oncology, Cancer Institute Hospital, 3-8-31, Ariake, 135-8550, Koto-ku, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Murofushi", 
            "givenName": "Keiko", 
            "id": "sg:person.01136537205.85", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136537205.85"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Gastroenterological Surgery, Cancer Institute Hospital, 3-8-31, Ariake, 135-8550, Koto-ku, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.486756.e", 
              "name": [
                "Department of Gastroenterological Surgery, Cancer Institute Hospital, 3-8-31, Ariake, 135-8550, Koto-ku, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ueno", 
            "givenName": "Masashi", 
            "id": "sg:person.01332557730.68", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332557730.68"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Gastroenterology, Cancer Institute Hospital, 3-8-31, Ariake, 135-8550, Koto-ku, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.486756.e", 
              "name": [
                "Department of Gastroenterology, Cancer Institute Hospital, 3-8-31, Ariake, 135-8550, Koto-ku, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mizunuma", 
            "givenName": "Nobuyuki", 
            "id": "sg:person.01357134113.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357134113.91"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Radiology, Osaka Medical College, 2-7, Daigaku-cho, 569-8686, Takatsuki, Osaka, Japan", 
              "id": "http://www.grid.ac/institutes/grid.444883.7", 
              "name": [
                "Department of Radiology, Osaka Medical College, 2-7, Daigaku-cho, 569-8686, Takatsuki, Osaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shinbo", 
            "givenName": "Taijyu", 
            "id": "sg:person.016270210037.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016270210037.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Radiology, Teikyo University, 2-11-1, Kaga, 173-8605, Itabashi-ku, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.264706.1", 
              "name": [
                "Department of Radiology, Teikyo University, 2-11-1, Kaga, 173-8605, Itabashi-ku, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kato", 
            "givenName": "Daiki", 
            "id": "sg:person.01367214205.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367214205.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of General & Gastroenterological Surgery, Osaka Medical College, 2-7, Daigaku-cho, 569-8686, Takatsuki, Osaka, Japan", 
              "id": "http://www.grid.ac/institutes/grid.444883.7", 
              "name": [
                "Department of General & Gastroenterological Surgery, Osaka Medical College, 2-7, Daigaku-cho, 569-8686, Takatsuki, Osaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Okuda", 
            "givenName": "Junji", 
            "id": "sg:person.0765046530.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765046530.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgery, Teikyo University, 2-11-1, Kaga, 173-8605, Itabashi-ku, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.264706.1", 
              "name": [
                "Department of Surgery, Teikyo University, 2-11-1, Kaga, 173-8605, Itabashi-ku, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hashiguchi", 
            "givenName": "Yojiro", 
            "id": "sg:person.0667170237.99", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667170237.99"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Radiology, School of Medicine Jichi Medical University, 3311-1, Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410804.9", 
              "name": [
                "Department of Radiology, School of Medicine Jichi Medical University, 3311-1, Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nakazawa", 
            "givenName": "Masanori", 
            "id": "sg:person.0712226545.85", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712226545.85"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgical Oncology, University of Tokyo, 7-3-1, Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Department of Surgical Oncology, University of Tokyo, 7-3-1, Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sunami", 
            "givenName": "Eiji", 
            "id": "sg:person.01326706310.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326706310.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgical Oncology, University of Tokyo, 7-3-1, Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Department of Surgical Oncology, University of Tokyo, 7-3-1, Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kawai", 
            "givenName": "Kazushige", 
            "id": "sg:person.0757126657.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757126657.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Radiology, University of Tokyo, 7-3-1, Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Department of Radiology, University of Tokyo, 7-3-1, Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yamashita", 
            "givenName": "Hideomi", 
            "id": "sg:person.01177762172.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177762172.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Radiology, Nagoya University, 65, Tsurumai-cho, Syowa-ku, 466-8560, Nagoya, Aichi, Japan", 
              "id": "http://www.grid.ac/institutes/grid.27476.30", 
              "name": [
                "Department of Radiology, Nagoya University, 65, Tsurumai-cho, Syowa-ku, 466-8560, Nagoya, Aichi, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Okada", 
            "givenName": "Tohru", 
            "id": "sg:person.01051047351.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051047351.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Japanese Foundation for Cancer Research, 3-8-31, Ariake, 135-8550, Koto-ku, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410807.a", 
              "name": [
                "Japanese Foundation for Cancer Research, 3-8-31, Ariake, 135-8550, Koto-ku, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ishikawa", 
            "givenName": "Yuichi", 
            "id": "sg:person.01052642300.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052642300.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Japan Clinical Cancer Research Organization, 7F Ginza Wing Bldg. 1-14-5, Ginza, 104-0061, Chuo-ku, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.490252.8", 
              "name": [
                "Japan Clinical Cancer Research Organization, 7F Ginza Wing Bldg. 1-14-5, Ginza, 104-0061, Chuo-ku, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nakajima", 
            "givenName": "Toshifusa", 
            "id": "sg:person.014752533172.89", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014752533172.89"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgical Oncology, University of Tokyo, 7-3-1, Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Department of Surgical Oncology, University of Tokyo, 7-3-1, Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Watanabe", 
            "givenName": "Toshiaki", 
            "id": "sg:person.01333100753.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333100753.35"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/bjc.2011.17", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044516624", 
              "https://doi.org/10.1038/bjc.2011.17"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6604271", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032321775", 
              "https://doi.org/10.1038/sj.bjc.6604271"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2015-01-23", 
        "datePublishedReg": "2015-01-23", 
        "description": "BackgroundThe objective of this phase I study was to determine the maximum tolerated dose (MTD) and recommended dose (RD) of preoperative chemoradiotherapy (CRT) with S-1 plus oxaliplatin in patients with locally advanced rectal cancer.MethodsPatients received radiotherapy in a total dose of 50.4\u00a0Gy in 28 fractions. Concurrent chemotherapy consisted of a fixed oral dose of S-1 (80\u00a0mg/m2/day) on days 1\u20135, 8\u201312, 22\u201327, and 29\u201333, plus escalated doses of oxaliplatin as an intravenous infusion on days 1, 8, 22, and 29. Oxaliplatin was initially given in a dose of 40\u00a0mg/m2/week to three patients. The dose was then increased in a stepwise fashion to 50\u00a0mg/m2/week and the highest dose level of 60\u00a0mg/m2/week until the MTD was attained.ResultsThirteen patients were enrolled, and 12 received CRT. Dose-limiting toxicity (DLT) occurred in two of six patients (persistent grade 2 neutropenia, delaying oxaliplatin treatment by more than 3\u00a0days) at dose level 3; there were no grade 3 or 4 adverse events defined as DLT. The RD was 60\u00a0mg/m2/week of oxaliplatin on days 1, 8, 22, and 29. Twelve patients underwent histologically confirmed R0 resections, and two out of six patients (33%) given dose level 3 had pathological complete responses.ConclusionsThe RD for further studies is 80\u00a0mg/m2 of S-1 5\u00a0days per week plus 60\u00a0mg/m2 of oxaliplatin on days 1, 8, 22, and 29 and concurrent radiotherapy. Although our results are preliminary, this new regimen for neoadjuvant chemoradiotherapy is considered safe and active.Trial registrationThis trial was registered with Clinicaltrials.gov (identifier: NCT01227239).", 
        "genre": "article", 
        "id": "sg:pub.10.1186/s13014-015-0333-8", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.6115392", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6083352", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1036451", 
            "issn": [
              "1748-717X"
            ], 
            "name": "Radiation Oncology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "10"
          }
        ], 
        "keywords": [
          "dose level 3", 
          "advanced rectal cancer", 
          "day 1", 
          "rectal cancer", 
          "phase I", 
          "doses of oxaliplatin", 
          "pathological complete response", 
          "highest dose level", 
          "concurrent chemotherapy", 
          "concurrent radiotherapy", 
          "oral S", 
          "pelvic radiation", 
          "preoperative chemoradiotherapy", 
          "R0 resection", 
          "neoadjuvant chemoradiotherapy", 
          "ResultsThirteen patients", 
          "adverse events", 
          "escalation study", 
          "complete response", 
          "oral dose", 
          "new regimen", 
          "intravenous infusion", 
          "grade 3", 
          "BackgroundThe objective", 
          "chemoradiotherapy", 
          "patients", 
          "dose levels", 
          "total dose", 
          "oxaliplatin", 
          "dose", 
          "weeks", 
          "level 3", 
          "Further studies", 
          "radiotherapy", 
          "cancer", 
          "trials", 
          "stepwise fashion", 
          "MethodsPatients", 
          "resection", 
          "regimen", 
          "chemotherapy", 
          "infusion", 
          "MTD", 
          "doses", 
          "study", 
          "toxicity", 
          "days", 
          "m2", 
          "DLT", 
          "RD", 
          "response", 
          "levels", 
          "events", 
          "objective", 
          "fashion", 
          "fraction", 
          "results", 
          "radiation", 
          "maximum"
        ], 
        "name": "A phase I dose escalation study of oxaliplatin plus oral S-1 and pelvic radiation in patients with locally advanced rectal cancer (SHOGUN trial)", 
        "pagination": "24", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1022291989"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s13014-015-0333-8"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "25612635"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s13014-015-0333-8", 
          "https://app.dimensions.ai/details/publication/pub.1022291989"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-08-04T17:03", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_658.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1186/s13014-015-0333-8"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13014-015-0333-8'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13014-015-0333-8'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13014-015-0333-8'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13014-015-0333-8'


     

    This table displays all metadata directly associated to this object as RDF triples.

    394 TRIPLES      21 PREDICATES      108 URIs      98 LITERALS      29 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s13014-015-0333-8 schema:about N1d9ecb0551314990939fc828933aa6ff
    2 N24c87b8fed0a4ced8c14e4eece77b09f
    3 N3e159579132f457f8581ab62829b32ec
    4 N46394e9a0794441f8c3d63ef70b7ce38
    5 N4b898935a2cb4f24b84ae05e7f376f93
    6 N5cf1edfa05ce4c949540469e1b8c7985
    7 N7479d4b82c114fd5afad0c2908e2f9a7
    8 N76419fb90b094651bb4eb4f4e49a5bfc
    9 N7aa202fd6335474ebb4337b9fb490543
    10 N80790ffb2cf04fd1868bc913784282ac
    11 N8b7c671338aa4c78bdb6ff9460635693
    12 N9b74abb7346641d7b0261da478e878b0
    13 N9d772a2a6c9b4304b8e2eee37de761fc
    14 Na2eaf1d44eea4249a3b112d3fbfd1c37
    15 Nb91892eab8014b9e9e32660111c40d32
    16 Nbbd63accd4b641b9bc4633eef99167c6
    17 Ncba076f62f3c4a41ada8ff9ae396dd27
    18 Nccd24d1335bd42bfacb62534c4c26ff5
    19 Ne0433a033e12442db8984846e508d2d0
    20 Ne9420394e8854d68a99a917fdbdf15e0
    21 Ned0ed32e929f4a72828b585ecf25722b
    22 Nee7c779ab4e84b7e824590ca081169c8
    23 anzsrc-for:11
    24 anzsrc-for:1112
    25 schema:author N5b94ffb2acb341d1be4056ed251774cb
    26 schema:citation sg:pub.10.1038/bjc.2011.17
    27 sg:pub.10.1038/sj.bjc.6604271
    28 schema:datePublished 2015-01-23
    29 schema:datePublishedReg 2015-01-23
    30 schema:description BackgroundThe objective of this phase I study was to determine the maximum tolerated dose (MTD) and recommended dose (RD) of preoperative chemoradiotherapy (CRT) with S-1 plus oxaliplatin in patients with locally advanced rectal cancer.MethodsPatients received radiotherapy in a total dose of 50.4 Gy in 28 fractions. Concurrent chemotherapy consisted of a fixed oral dose of S-1 (80 mg/m2/day) on days 1–5, 8–12, 22–27, and 29–33, plus escalated doses of oxaliplatin as an intravenous infusion on days 1, 8, 22, and 29. Oxaliplatin was initially given in a dose of 40 mg/m2/week to three patients. The dose was then increased in a stepwise fashion to 50 mg/m2/week and the highest dose level of 60 mg/m2/week until the MTD was attained.ResultsThirteen patients were enrolled, and 12 received CRT. Dose-limiting toxicity (DLT) occurred in two of six patients (persistent grade 2 neutropenia, delaying oxaliplatin treatment by more than 3 days) at dose level 3; there were no grade 3 or 4 adverse events defined as DLT. The RD was 60 mg/m2/week of oxaliplatin on days 1, 8, 22, and 29. Twelve patients underwent histologically confirmed R0 resections, and two out of six patients (33%) given dose level 3 had pathological complete responses.ConclusionsThe RD for further studies is 80 mg/m2 of S-1 5 days per week plus 60 mg/m2 of oxaliplatin on days 1, 8, 22, and 29 and concurrent radiotherapy. Although our results are preliminary, this new regimen for neoadjuvant chemoradiotherapy is considered safe and active.Trial registrationThis trial was registered with Clinicaltrials.gov (identifier: NCT01227239).
    31 schema:genre article
    32 schema:isAccessibleForFree true
    33 schema:isPartOf N2ca8051e2b594028a0910aa6391e5e63
    34 N43a55a4302264e0a8a8508929062ed99
    35 sg:journal.1036451
    36 schema:keywords BackgroundThe objective
    37 DLT
    38 Further studies
    39 MTD
    40 MethodsPatients
    41 R0 resection
    42 RD
    43 ResultsThirteen patients
    44 advanced rectal cancer
    45 adverse events
    46 cancer
    47 chemoradiotherapy
    48 chemotherapy
    49 complete response
    50 concurrent chemotherapy
    51 concurrent radiotherapy
    52 day 1
    53 days
    54 dose
    55 dose level 3
    56 dose levels
    57 doses
    58 doses of oxaliplatin
    59 escalation study
    60 events
    61 fashion
    62 fraction
    63 grade 3
    64 highest dose level
    65 infusion
    66 intravenous infusion
    67 level 3
    68 levels
    69 m2
    70 maximum
    71 neoadjuvant chemoradiotherapy
    72 new regimen
    73 objective
    74 oral S
    75 oral dose
    76 oxaliplatin
    77 pathological complete response
    78 patients
    79 pelvic radiation
    80 phase I
    81 preoperative chemoradiotherapy
    82 radiation
    83 radiotherapy
    84 rectal cancer
    85 regimen
    86 resection
    87 response
    88 results
    89 stepwise fashion
    90 study
    91 total dose
    92 toxicity
    93 trials
    94 weeks
    95 schema:name A phase I dose escalation study of oxaliplatin plus oral S-1 and pelvic radiation in patients with locally advanced rectal cancer (SHOGUN trial)
    96 schema:pagination 24
    97 schema:productId N31df2a9f4bed40d2b4d319a732a25d6c
    98 N33a659d98bc24026a22118a3a43a04cb
    99 N34979a52a074444b830ccb71502dc4bd
    100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022291989
    101 https://doi.org/10.1186/s13014-015-0333-8
    102 schema:sdDatePublished 2022-08-04T17:03
    103 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    104 schema:sdPublisher Nb6bb43e2d98b4715b2b8a58cff0d345c
    105 schema:url https://doi.org/10.1186/s13014-015-0333-8
    106 sgo:license sg:explorer/license/
    107 sgo:sdDataset articles
    108 rdf:type schema:ScholarlyArticle
    109 N058974eaa99d4689a01d551a2fc73a8f rdf:first sg:person.01331625450.94
    110 rdf:rest N53f53fd4621e42b081f96cc4a1431065
    111 N0848d03f134647fbae655067be312b4f rdf:first sg:person.016270210037.08
    112 rdf:rest Ne48e9ae99c734f0a88c5167321ecbf7c
    113 N1d9ecb0551314990939fc828933aa6ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    114 schema:name Follow-Up Studies
    115 rdf:type schema:DefinedTerm
    116 N1f36cf9202024a9087c5fc61c171d90d rdf:first sg:person.01177762172.31
    117 rdf:rest N5f8a150b2dd6453e9220bcdd092b0a8d
    118 N24c87b8fed0a4ced8c14e4eece77b09f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name Pelvis
    120 rdf:type schema:DefinedTerm
    121 N2a4e06b1e17f444398df88b493e00fb1 rdf:first sg:person.0667170237.99
    122 rdf:rest N8f5734675e734c6b9b99f6e6eaf646b6
    123 N2ca8051e2b594028a0910aa6391e5e63 schema:issueNumber 1
    124 rdf:type schema:PublicationIssue
    125 N31df2a9f4bed40d2b4d319a732a25d6c schema:name doi
    126 schema:value 10.1186/s13014-015-0333-8
    127 rdf:type schema:PropertyValue
    128 N32cd7f417a6042b4848734fbb95888f4 rdf:first sg:person.01101275130.22
    129 rdf:rest Nb28ce892a56742ed8bf16b3762cfb3cf
    130 N33a659d98bc24026a22118a3a43a04cb schema:name pubmed_id
    131 schema:value 25612635
    132 rdf:type schema:PropertyValue
    133 N34979a52a074444b830ccb71502dc4bd schema:name dimensions_id
    134 schema:value pub.1022291989
    135 rdf:type schema:PropertyValue
    136 N3d9e495ca36d4c9798702e8d68fe5fae rdf:first sg:person.01326706310.35
    137 rdf:rest Ndd659b0557324aeb8905bee40d1c50d0
    138 N3e159579132f457f8581ab62829b32ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Female
    140 rdf:type schema:DefinedTerm
    141 N43a55a4302264e0a8a8508929062ed99 schema:volumeNumber 10
    142 rdf:type schema:PublicationVolume
    143 N46394e9a0794441f8c3d63ef70b7ce38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Male
    145 rdf:type schema:DefinedTerm
    146 N4b898935a2cb4f24b84ae05e7f376f93 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Oxonic Acid
    148 rdf:type schema:DefinedTerm
    149 N53f53fd4621e42b081f96cc4a1431065 rdf:first sg:person.01136537205.85
    150 rdf:rest N8f388573e3714a5ba30615fb6fed9064
    151 N55fd4064c9e4438bb930dc0ede94f17e rdf:first sg:person.01357134113.91
    152 rdf:rest N0848d03f134647fbae655067be312b4f
    153 N5b94ffb2acb341d1be4056ed251774cb rdf:first sg:person.0605274525.19
    154 rdf:rest Nbb1f3aa9cac34c75af5e289b1c3007c0
    155 N5cf1edfa05ce4c949540469e1b8c7985 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    156 schema:name Oxaliplatin
    157 rdf:type schema:DefinedTerm
    158 N5f8a150b2dd6453e9220bcdd092b0a8d rdf:first sg:person.01051047351.32
    159 rdf:rest Ne57c9b0e45394123a54a404dee79496f
    160 N7479d4b82c114fd5afad0c2908e2f9a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Tegafur
    162 rdf:type schema:DefinedTerm
    163 N76419fb90b094651bb4eb4f4e49a5bfc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Prognosis
    165 rdf:type schema:DefinedTerm
    166 N7aa202fd6335474ebb4337b9fb490543 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Drug Combinations
    168 rdf:type schema:DefinedTerm
    169 N80790ffb2cf04fd1868bc913784282ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Humans
    171 rdf:type schema:DefinedTerm
    172 N8b7c671338aa4c78bdb6ff9460635693 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Neoplasm Staging
    174 rdf:type schema:DefinedTerm
    175 N8e86d34517164d95a7885cc0db52d6b5 rdf:first sg:person.014752533172.89
    176 rdf:rest Nf6b968742dc54013977b0f2cb4be1e6e
    177 N8f388573e3714a5ba30615fb6fed9064 rdf:first sg:person.01332557730.68
    178 rdf:rest N55fd4064c9e4438bb930dc0ede94f17e
    179 N8f5734675e734c6b9b99f6e6eaf646b6 rdf:first sg:person.0712226545.85
    180 rdf:rest N3d9e495ca36d4c9798702e8d68fe5fae
    181 N9b74abb7346641d7b0261da478e878b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    182 schema:name Remission Induction
    183 rdf:type schema:DefinedTerm
    184 N9d772a2a6c9b4304b8e2eee37de761fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    185 schema:name Aged
    186 rdf:type schema:DefinedTerm
    187 Na2eaf1d44eea4249a3b112d3fbfd1c37 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    188 schema:name Rectal Neoplasms
    189 rdf:type schema:DefinedTerm
    190 Nb28ce892a56742ed8bf16b3762cfb3cf rdf:first sg:person.0760333502.93
    191 rdf:rest Nfdf36cc789e54811a3a8aa6fb886a8ec
    192 Nb6bb43e2d98b4715b2b8a58cff0d345c schema:name Springer Nature - SN SciGraph project
    193 rdf:type schema:Organization
    194 Nb91892eab8014b9e9e32660111c40d32 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    195 schema:name Antineoplastic Combined Chemotherapy Protocols
    196 rdf:type schema:DefinedTerm
    197 Nbb1f3aa9cac34c75af5e289b1c3007c0 rdf:first sg:person.01125517543.23
    198 rdf:rest N32cd7f417a6042b4848734fbb95888f4
    199 Nbbd63accd4b641b9bc4633eef99167c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    200 schema:name Chemoradiotherapy
    201 rdf:type schema:DefinedTerm
    202 Nc686459d7c3c4c71b0e699f9305cbb63 rdf:first sg:person.0765046530.39
    203 rdf:rest N2a4e06b1e17f444398df88b493e00fb1
    204 Ncba076f62f3c4a41ada8ff9ae396dd27 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    205 schema:name Maximum Tolerated Dose
    206 rdf:type schema:DefinedTerm
    207 Nccd24d1335bd42bfacb62534c4c26ff5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    208 schema:name Organoplatinum Compounds
    209 rdf:type schema:DefinedTerm
    210 Ndd659b0557324aeb8905bee40d1c50d0 rdf:first sg:person.0757126657.29
    211 rdf:rest N1f36cf9202024a9087c5fc61c171d90d
    212 Ne0433a033e12442db8984846e508d2d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    213 schema:name Adult
    214 rdf:type schema:DefinedTerm
    215 Ne48e9ae99c734f0a88c5167321ecbf7c rdf:first sg:person.01367214205.39
    216 rdf:rest Nc686459d7c3c4c71b0e699f9305cbb63
    217 Ne57c9b0e45394123a54a404dee79496f rdf:first sg:person.01052642300.03
    218 rdf:rest N8e86d34517164d95a7885cc0db52d6b5
    219 Ne9420394e8854d68a99a917fdbdf15e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    220 schema:name Middle Aged
    221 rdf:type schema:DefinedTerm
    222 Ned0ed32e929f4a72828b585ecf25722b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    223 schema:name Young Adult
    224 rdf:type schema:DefinedTerm
    225 Nee7c779ab4e84b7e824590ca081169c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    226 schema:name Adenocarcinoma
    227 rdf:type schema:DefinedTerm
    228 Nf6b968742dc54013977b0f2cb4be1e6e rdf:first sg:person.01333100753.35
    229 rdf:rest rdf:nil
    230 Nfdf36cc789e54811a3a8aa6fb886a8ec rdf:first sg:person.01235507706.37
    231 rdf:rest N058974eaa99d4689a01d551a2fc73a8f
    232 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    233 schema:name Medical and Health Sciences
    234 rdf:type schema:DefinedTerm
    235 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    236 schema:name Oncology and Carcinogenesis
    237 rdf:type schema:DefinedTerm
    238 sg:grant.6083352 http://pending.schema.org/fundedItem sg:pub.10.1186/s13014-015-0333-8
    239 rdf:type schema:MonetaryGrant
    240 sg:grant.6115392 http://pending.schema.org/fundedItem sg:pub.10.1186/s13014-015-0333-8
    241 rdf:type schema:MonetaryGrant
    242 sg:journal.1036451 schema:issn 1748-717X
    243 schema:name Radiation Oncology
    244 schema:publisher Springer Nature
    245 rdf:type schema:Periodical
    246 sg:person.01051047351.32 schema:affiliation grid-institutes:grid.27476.30
    247 schema:familyName Okada
    248 schema:givenName Tohru
    249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051047351.32
    250 rdf:type schema:Person
    251 sg:person.01052642300.03 schema:affiliation grid-institutes:grid.410807.a
    252 schema:familyName Ishikawa
    253 schema:givenName Yuichi
    254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052642300.03
    255 rdf:type schema:Person
    256 sg:person.01101275130.22 schema:affiliation grid-institutes:grid.444883.7
    257 schema:familyName Kondo
    258 schema:givenName Keisaku
    259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101275130.22
    260 rdf:type schema:Person
    261 sg:person.01125517543.23 schema:affiliation grid-institutes:grid.486756.e
    262 schema:familyName Matsusaka
    263 schema:givenName Satoshi
    264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125517543.23
    265 rdf:type schema:Person
    266 sg:person.01136537205.85 schema:affiliation grid-institutes:grid.486756.e
    267 schema:familyName Murofushi
    268 schema:givenName Keiko
    269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136537205.85
    270 rdf:type schema:Person
    271 sg:person.01177762172.31 schema:affiliation grid-institutes:grid.26999.3d
    272 schema:familyName Yamashita
    273 schema:givenName Hideomi
    274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177762172.31
    275 rdf:type schema:Person
    276 sg:person.01235507706.37 schema:affiliation grid-institutes:grid.27476.30
    277 schema:familyName Uehara
    278 schema:givenName Keisuke
    279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235507706.37
    280 rdf:type schema:Person
    281 sg:person.01326706310.35 schema:affiliation grid-institutes:grid.26999.3d
    282 schema:familyName Sunami
    283 schema:givenName Eiji
    284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326706310.35
    285 rdf:type schema:Person
    286 sg:person.01331625450.94 schema:affiliation grid-institutes:grid.486756.e
    287 schema:familyName Oguchi
    288 schema:givenName Masahiko
    289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331625450.94
    290 rdf:type schema:Person
    291 sg:person.01332557730.68 schema:affiliation grid-institutes:grid.486756.e
    292 schema:familyName Ueno
    293 schema:givenName Masashi
    294 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332557730.68
    295 rdf:type schema:Person
    296 sg:person.01333100753.35 schema:affiliation grid-institutes:grid.26999.3d
    297 schema:familyName Watanabe
    298 schema:givenName Toshiaki
    299 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333100753.35
    300 rdf:type schema:Person
    301 sg:person.01357134113.91 schema:affiliation grid-institutes:grid.486756.e
    302 schema:familyName Mizunuma
    303 schema:givenName Nobuyuki
    304 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357134113.91
    305 rdf:type schema:Person
    306 sg:person.01367214205.39 schema:affiliation grid-institutes:grid.264706.1
    307 schema:familyName Kato
    308 schema:givenName Daiki
    309 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367214205.39
    310 rdf:type schema:Person
    311 sg:person.014752533172.89 schema:affiliation grid-institutes:grid.490252.8
    312 schema:familyName Nakajima
    313 schema:givenName Toshifusa
    314 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014752533172.89
    315 rdf:type schema:Person
    316 sg:person.016270210037.08 schema:affiliation grid-institutes:grid.444883.7
    317 schema:familyName Shinbo
    318 schema:givenName Taijyu
    319 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016270210037.08
    320 rdf:type schema:Person
    321 sg:person.0605274525.19 schema:affiliation grid-institutes:grid.26999.3d
    322 schema:familyName Ishihara
    323 schema:givenName Soichiro
    324 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605274525.19
    325 rdf:type schema:Person
    326 sg:person.0667170237.99 schema:affiliation grid-institutes:grid.264706.1
    327 schema:familyName Hashiguchi
    328 schema:givenName Yojiro
    329 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667170237.99
    330 rdf:type schema:Person
    331 sg:person.0712226545.85 schema:affiliation grid-institutes:grid.410804.9
    332 schema:familyName Nakazawa
    333 schema:givenName Masanori
    334 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712226545.85
    335 rdf:type schema:Person
    336 sg:person.0757126657.29 schema:affiliation grid-institutes:grid.26999.3d
    337 schema:familyName Kawai
    338 schema:givenName Kazushige
    339 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757126657.29
    340 rdf:type schema:Person
    341 sg:person.0760333502.93 schema:affiliation grid-institutes:grid.410804.9
    342 schema:familyName Horie
    343 schema:givenName Hisanaga
    344 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760333502.93
    345 rdf:type schema:Person
    346 sg:person.0765046530.39 schema:affiliation grid-institutes:grid.444883.7
    347 schema:familyName Okuda
    348 schema:givenName Junji
    349 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765046530.39
    350 rdf:type schema:Person
    351 sg:pub.10.1038/bjc.2011.17 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044516624
    352 https://doi.org/10.1038/bjc.2011.17
    353 rdf:type schema:CreativeWork
    354 sg:pub.10.1038/sj.bjc.6604271 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032321775
    355 https://doi.org/10.1038/sj.bjc.6604271
    356 rdf:type schema:CreativeWork
    357 grid-institutes:grid.264706.1 schema:alternateName Department of Radiology, Teikyo University, 2-11-1, Kaga, 173-8605, Itabashi-ku, Tokyo, Japan
    358 Department of Surgery, Teikyo University, 2-11-1, Kaga, 173-8605, Itabashi-ku, Tokyo, Japan
    359 schema:name Department of Radiology, Teikyo University, 2-11-1, Kaga, 173-8605, Itabashi-ku, Tokyo, Japan
    360 Department of Surgery, Teikyo University, 2-11-1, Kaga, 173-8605, Itabashi-ku, Tokyo, Japan
    361 rdf:type schema:Organization
    362 grid-institutes:grid.26999.3d schema:alternateName Department of Radiology, University of Tokyo, 7-3-1, Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan
    363 Department of Surgical Oncology, University of Tokyo, 7-3-1, Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan
    364 schema:name Department of Radiology, University of Tokyo, 7-3-1, Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan
    365 Department of Surgical Oncology, University of Tokyo, 7-3-1, Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan
    366 rdf:type schema:Organization
    367 grid-institutes:grid.27476.30 schema:alternateName Department of Radiology, Nagoya University, 65, Tsurumai-cho, Syowa-ku, 466-8560, Nagoya, Aichi, Japan
    368 Division of Surgical Oncology, Department of Surgery, Nagoya University, 65, Tsurumai-cho, Syowa-ku, 466-8550, Nagoya, Aichi, Japan
    369 schema:name Department of Radiology, Nagoya University, 65, Tsurumai-cho, Syowa-ku, 466-8560, Nagoya, Aichi, Japan
    370 Division of Surgical Oncology, Department of Surgery, Nagoya University, 65, Tsurumai-cho, Syowa-ku, 466-8550, Nagoya, Aichi, Japan
    371 rdf:type schema:Organization
    372 grid-institutes:grid.410804.9 schema:alternateName Department of Radiology, School of Medicine Jichi Medical University, 3311-1, Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan
    373 Department of Surgery, School of Medicine Jichi Medical University, 3311-1, Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan
    374 schema:name Department of Radiology, School of Medicine Jichi Medical University, 3311-1, Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan
    375 Department of Surgery, School of Medicine Jichi Medical University, 3311-1, Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan
    376 rdf:type schema:Organization
    377 grid-institutes:grid.410807.a schema:alternateName Japanese Foundation for Cancer Research, 3-8-31, Ariake, 135-8550, Koto-ku, Tokyo, Japan
    378 schema:name Japanese Foundation for Cancer Research, 3-8-31, Ariake, 135-8550, Koto-ku, Tokyo, Japan
    379 rdf:type schema:Organization
    380 grid-institutes:grid.444883.7 schema:alternateName Department of General & Gastroenterological Surgery, Osaka Medical College, 2-7, Daigaku-cho, 569-8686, Takatsuki, Osaka, Japan
    381 Department of Radiology, Osaka Medical College, 2-7, Daigaku-cho, 569-8686, Takatsuki, Osaka, Japan
    382 schema:name Department of General & Gastroenterological Surgery, Osaka Medical College, 2-7, Daigaku-cho, 569-8686, Takatsuki, Osaka, Japan
    383 Department of Radiology, Osaka Medical College, 2-7, Daigaku-cho, 569-8686, Takatsuki, Osaka, Japan
    384 rdf:type schema:Organization
    385 grid-institutes:grid.486756.e schema:alternateName Department of Gastroenterological Surgery, Cancer Institute Hospital, 3-8-31, Ariake, 135-8550, Koto-ku, Tokyo, Japan
    386 Department of Gastroenterology, Cancer Institute Hospital, 3-8-31, Ariake, 135-8550, Koto-ku, Tokyo, Japan
    387 Department of Radiation Oncology, Cancer Institute Hospital, 3-8-31, Ariake, 135-8550, Koto-ku, Tokyo, Japan
    388 schema:name Department of Gastroenterological Surgery, Cancer Institute Hospital, 3-8-31, Ariake, 135-8550, Koto-ku, Tokyo, Japan
    389 Department of Gastroenterology, Cancer Institute Hospital, 3-8-31, Ariake, 135-8550, Koto-ku, Tokyo, Japan
    390 Department of Radiation Oncology, Cancer Institute Hospital, 3-8-31, Ariake, 135-8550, Koto-ku, Tokyo, Japan
    391 rdf:type schema:Organization
    392 grid-institutes:grid.490252.8 schema:alternateName Japan Clinical Cancer Research Organization, 7F Ginza Wing Bldg. 1-14-5, Ginza, 104-0061, Chuo-ku, Tokyo, Japan
    393 schema:name Japan Clinical Cancer Research Organization, 7F Ginza Wing Bldg. 1-14-5, Ginza, 104-0061, Chuo-ku, Tokyo, Japan
    394 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...