ALK rearrangement: a high-frequency alteration in ovarian metastasis from lung adenocarcinoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-08-28

AUTHORS

Rui Bi, Qianming Bai, Xiaoli Zhu, Xiaoyu Tu, Xu Cai, Wenhua Jiang, Xiaoli Xu, Shaoxian Tang, Huijuan Ge, Bin Chang, Yufan Cheng, Hualei Gan, Xiaoyan Zhou, Wentao Yang

ABSTRACT

BACKGROUND: Ovarian metastatic tumors from lung adenocarcinoma are rare, and a serial study of these tumors is lacking to date. Additionally, a better understanding of the clinicopathological and molecular characteristics of metastatic tumors is needed. METHODS: Seven cases of ovarian metastasis from lung adenocarcinoma from 2013 to 2017 at our institute were investigated. The results were combined with those found in literature review. A total of 16 cases were analyzed in the present study. We examined clinicopathological and immunohistochemical characteristics, further detected ALK rearrangement by FISH (fluorescence in situ hybridization), and assessed EGFR and KRAS mutations using Sanger sequencing or the amplification refractory mutation system (ARMS). RESULTS: The mean age of the patients was 44.6 years (range, 33-56 years). Eleven of sixteen patients developed ovarian tumors within a mean time of 18.5 months (range, 5-48 months) from the initial diagnosis of lung adenocarcinoma; 5 patients had lung tumors and ovarian masses simultaneously. Five tumors (5/16, 31%) occurred in the bilateral ovaries, and the others were unilateral ovarian tumors (11/16, 69%). All seven cases from our institute were positive for TTF-1 and Napsin A but negative for PAX8. In four cases, ALK (D5F3) was diffusely and strongly expressed, with ALK rearrangements (4/7, 57%). Overall, ALK rearrangement was found by FISH or immunohistochemistry in 11/16 (69%) cases. In two cases, EGFR mutations in exons 19 and 21, respectively, were found. One patient did not detected EGFR or ALK mutation in the metastatic tumor, but the primary lung adenocarcinoma did harbor an EGFR mutation. Two cases had no alterations in three genes above. Although the mean survival time of the patients with ALK rearrangement was longer than those without (mean survival time 25 m vs. 20 m), no statistical significance of the difference was found. CONCLUSIONS: As the largest case series of ovarian metastasis from lung adenocarcinoma, our findings indicate that ALK rearrangement is the most common molecular alteration. Although patients with ALK rearrangement appear to have a better prognosis than do those without ALK rearrangement, more cases with longer follow-up and multivariant analysis are needed to clarify this point. More... »

PAGES

96

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13000-019-0864-7

DOI

http://dx.doi.org/10.1186/s13000-019-0864-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1120633059

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31455365


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenocarcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anaplastic Lymphoma Kinase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Rearrangement", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lung Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Metastasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ovarian Neoplasms", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong An Road, Shanghai, 200032 China", 
          "id": "http://www.grid.ac/institutes/grid.11841.3d", 
          "name": [
            "Department of Pathology, Fudan University Shanghai Cancer Center, Fudan University, 270 Dong An Road, Shanghai, 200032 China", 
            "Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong An Road, Shanghai, 200032 China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bi", 
        "givenName": "Rui", 
        "id": "sg:person.01103220634.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103220634.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong An Road, Shanghai, 200032 China", 
          "id": "http://www.grid.ac/institutes/grid.11841.3d", 
          "name": [
            "Department of Pathology, Fudan University Shanghai Cancer Center, Fudan University, 270 Dong An Road, Shanghai, 200032 China", 
            "Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong An Road, Shanghai, 200032 China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bai", 
        "givenName": "Qianming", 
        "id": "sg:person.01257353151.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257353151.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong An Road, Shanghai, 200032 China", 
          "id": "http://www.grid.ac/institutes/grid.11841.3d", 
          "name": [
            "Department of Pathology, Fudan University Shanghai Cancer Center, Fudan University, 270 Dong An Road, Shanghai, 200032 China", 
            "Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong An Road, Shanghai, 200032 China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhu", 
        "givenName": "Xiaoli", 
        "id": "sg:person.01311726114.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311726114.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong An Road, Shanghai, 200032 China", 
          "id": "http://www.grid.ac/institutes/grid.11841.3d", 
          "name": [
            "Department of Pathology, Fudan University Shanghai Cancer Center, Fudan University, 270 Dong An Road, Shanghai, 200032 China", 
            "Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong An Road, Shanghai, 200032 China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tu", 
        "givenName": "Xiaoyu", 
        "id": "sg:person.0731707551.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731707551.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong An Road, Shanghai, 200032 China", 
          "id": "http://www.grid.ac/institutes/grid.11841.3d", 
          "name": [
            "Department of Pathology, Fudan University Shanghai Cancer Center, Fudan University, 270 Dong An Road, Shanghai, 200032 China", 
            "Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong An Road, Shanghai, 200032 China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cai", 
        "givenName": "Xu", 
        "id": "sg:person.015240736727.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015240736727.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong An Road, Shanghai, 200032 China", 
          "id": "http://www.grid.ac/institutes/grid.11841.3d", 
          "name": [
            "Department of Pathology, Fudan University Shanghai Cancer Center, Fudan University, 270 Dong An Road, Shanghai, 200032 China", 
            "Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong An Road, Shanghai, 200032 China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jiang", 
        "givenName": "Wenhua", 
        "id": "sg:person.013421532703.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013421532703.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong An Road, Shanghai, 200032 China", 
          "id": "http://www.grid.ac/institutes/grid.11841.3d", 
          "name": [
            "Department of Pathology, Fudan University Shanghai Cancer Center, Fudan University, 270 Dong An Road, Shanghai, 200032 China", 
            "Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong An Road, Shanghai, 200032 China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xu", 
        "givenName": "Xiaoli", 
        "id": "sg:person.0652222332.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652222332.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong An Road, Shanghai, 200032 China", 
          "id": "http://www.grid.ac/institutes/grid.11841.3d", 
          "name": [
            "Department of Pathology, Fudan University Shanghai Cancer Center, Fudan University, 270 Dong An Road, Shanghai, 200032 China", 
            "Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong An Road, Shanghai, 200032 China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tang", 
        "givenName": "Shaoxian", 
        "id": "sg:person.01047646601.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047646601.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong An Road, Shanghai, 200032 China", 
          "id": "http://www.grid.ac/institutes/grid.11841.3d", 
          "name": [
            "Department of Pathology, Fudan University Shanghai Cancer Center, Fudan University, 270 Dong An Road, Shanghai, 200032 China", 
            "Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong An Road, Shanghai, 200032 China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ge", 
        "givenName": "Huijuan", 
        "id": "sg:person.01257307704.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257307704.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong An Road, Shanghai, 200032 China", 
          "id": "http://www.grid.ac/institutes/grid.11841.3d", 
          "name": [
            "Department of Pathology, Fudan University Shanghai Cancer Center, Fudan University, 270 Dong An Road, Shanghai, 200032 China", 
            "Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong An Road, Shanghai, 200032 China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chang", 
        "givenName": "Bin", 
        "id": "sg:person.0736217102.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736217102.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong An Road, Shanghai, 200032 China", 
          "id": "http://www.grid.ac/institutes/grid.11841.3d", 
          "name": [
            "Department of Pathology, Fudan University Shanghai Cancer Center, Fudan University, 270 Dong An Road, Shanghai, 200032 China", 
            "Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong An Road, Shanghai, 200032 China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cheng", 
        "givenName": "Yufan", 
        "id": "sg:person.01151334034.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151334034.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong An Road, Shanghai, 200032 China", 
          "id": "http://www.grid.ac/institutes/grid.11841.3d", 
          "name": [
            "Department of Pathology, Fudan University Shanghai Cancer Center, Fudan University, 270 Dong An Road, Shanghai, 200032 China", 
            "Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong An Road, Shanghai, 200032 China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gan", 
        "givenName": "Hualei", 
        "id": "sg:person.01241037701.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241037701.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong An Road, Shanghai, 200032 China", 
          "id": "http://www.grid.ac/institutes/grid.11841.3d", 
          "name": [
            "Department of Pathology, Fudan University Shanghai Cancer Center, Fudan University, 270 Dong An Road, Shanghai, 200032 China", 
            "Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong An Road, Shanghai, 200032 China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhou", 
        "givenName": "Xiaoyan", 
        "id": "sg:person.01010610662.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010610662.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong An Road, Shanghai, 200032 China", 
          "id": "http://www.grid.ac/institutes/grid.11841.3d", 
          "name": [
            "Department of Pathology, Fudan University Shanghai Cancer Center, Fudan University, 270 Dong An Road, Shanghai, 200032 China", 
            "Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong An Road, Shanghai, 200032 China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Wentao", 
        "id": "sg:person.01333675634.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333675634.21"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nature05945", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017221313", 
          "https://doi.org/10.1038/nature05945"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-009-0808-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001051684", 
          "https://doi.org/10.1245/s10434-009-0808-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12885-016-2169-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014280580", 
          "https://doi.org/10.1186/s12885-016-2169-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2009.2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041377919", 
          "https://doi.org/10.1038/modpathol.2009.2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1476-4598-9-188", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013449323", 
          "https://doi.org/10.1186/1476-4598-9-188"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-08-28", 
    "datePublishedReg": "2019-08-28", 
    "description": "BACKGROUND: Ovarian metastatic tumors from lung adenocarcinoma are rare, and a serial study of these tumors is lacking to date. Additionally, a better understanding of the clinicopathological and molecular characteristics of metastatic tumors is needed.\nMETHODS: Seven cases of ovarian metastasis from lung adenocarcinoma from 2013 to 2017 at our institute were investigated. The results were combined with those found in literature review. A total of 16 cases were analyzed in the present study. We examined clinicopathological and immunohistochemical characteristics, further detected ALK rearrangement by FISH (fluorescence in situ hybridization), and assessed EGFR and KRAS mutations using Sanger sequencing or the amplification refractory mutation system (ARMS).\nRESULTS: The mean age of the patients was 44.6\u2009years (range, 33-56\u2009years). Eleven of sixteen patients developed ovarian tumors within a mean time of 18.5\u2009months (range, 5-48\u2009months) from the initial diagnosis of lung adenocarcinoma; 5 patients had lung tumors and ovarian masses simultaneously. Five tumors (5/16, 31%) occurred in the bilateral ovaries, and the others were unilateral ovarian tumors (11/16, 69%). All seven cases from our institute were positive for TTF-1 and Napsin A but negative for PAX8. In four cases, ALK (D5F3) was diffusely and strongly expressed, with ALK rearrangements (4/7, 57%). Overall, ALK rearrangement was found by FISH or immunohistochemistry in 11/16 (69%) cases. In two cases, EGFR mutations in exons 19 and 21, respectively, were found. One patient did not detected EGFR or ALK mutation in the metastatic tumor, but the primary lung adenocarcinoma did harbor an EGFR mutation. Two cases had no alterations in three genes above. Although the mean survival time of the patients with ALK rearrangement was longer than those without (mean survival time 25\u2009m vs. 20\u2009m), no statistical significance of the difference was found.\nCONCLUSIONS: As the largest case series of ovarian metastasis from lung adenocarcinoma, our findings indicate that ALK rearrangement is the most common molecular alteration. Although patients with ALK rearrangement appear to have a better prognosis than do those without ALK rearrangement, more cases with longer follow-up and multivariant analysis are needed to clarify this point.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s13000-019-0864-7", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1327435", 
        "issn": [
          "2364-4893", 
          "1746-1596"
        ], 
        "name": "Diagnostic Pathology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "14"
      }
    ], 
    "keywords": [
      "ALK rearrangement", 
      "lung adenocarcinoma", 
      "ovarian metastasis", 
      "metastatic tumors", 
      "amplification refractory mutation system", 
      "ovarian tumors", 
      "EGFR mutations", 
      "ovarian metastatic tumors", 
      "primary lung adenocarcinoma", 
      "large case series", 
      "unilateral ovarian tumor", 
      "mean survival time", 
      "common molecular alterations", 
      "better prognosis", 
      "initial diagnosis", 
      "case series", 
      "mean age", 
      "ovarian masses", 
      "bilateral ovaries", 
      "immunohistochemical characteristics", 
      "ALK mutations", 
      "KRAS mutations", 
      "lung tumors", 
      "napsin A", 
      "survival time", 
      "high-frequency alterations", 
      "serial studies", 
      "adenocarcinoma", 
      "refractory mutation system", 
      "patients", 
      "molecular alterations", 
      "tumors", 
      "TTF-1", 
      "multivariant analysis", 
      "more cases", 
      "metastasis", 
      "mean time", 
      "exon 19", 
      "statistical significance", 
      "Sanger sequencing", 
      "EGFR", 
      "present study", 
      "mutation system", 
      "molecular characteristics", 
      "alterations", 
      "literature review", 
      "mutations", 
      "prognosis", 
      "cases", 
      "immunohistochemistry", 
      "diagnosis", 
      "ALK", 
      "months", 
      "age", 
      "PAX8", 
      "ovaries", 
      "total", 
      "study", 
      "Institute", 
      "better understanding", 
      "review", 
      "years", 
      "findings", 
      "differences", 
      "significance", 
      "rearrangement", 
      "sequencing", 
      "genes", 
      "time", 
      "date", 
      "characteristics", 
      "fish", 
      "mass", 
      "analysis", 
      "series", 
      "results", 
      "understanding", 
      "point", 
      "system", 
      "detected ALK rearrangement"
    ], 
    "name": "ALK rearrangement: a high-frequency alteration in ovarian metastasis from lung adenocarcinoma", 
    "pagination": "96", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1120633059"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13000-019-0864-7"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "31455365"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13000-019-0864-7", 
      "https://app.dimensions.ai/details/publication/pub.1120633059"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:52", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_820.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s13000-019-0864-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13000-019-0864-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13000-019-0864-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13000-019-0864-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13000-019-0864-7'


 

This table displays all metadata directly associated to this object as RDF triples.

294 TRIPLES      22 PREDICATES      121 URIs      108 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13000-019-0864-7 schema:about N2d3694e93a384d389b74a4bc7f01c5e9
2 N71c21089b49a4f11a2ad6e3a8cae6ece
3 N784e4ae1c1be42fe8b31aeacefb76f8a
4 Na37959bbb0db43a7a5b90229dfbe2f5d
5 Nab15f81f5ab14544a52b9cacb005c8e0
6 Nba7d4fbb80234748abccf84337ee8bcf
7 Nc6563d6d314447be95daa0db8bbcfbe9
8 Nd5549556efdc45df933f9eabad3f6f56
9 Nedb5fde81e3c44749ed5d6e6df05caea
10 Nfe7b0d34d5e6483c9a6957e54fc02913
11 anzsrc-for:11
12 anzsrc-for:1112
13 schema:author N03682f2eccfc43d48f6f3a2a3077a81a
14 schema:citation sg:pub.10.1038/modpathol.2009.2
15 sg:pub.10.1038/nature05945
16 sg:pub.10.1186/1476-4598-9-188
17 sg:pub.10.1186/s12885-016-2169-5
18 sg:pub.10.1245/s10434-009-0808-7
19 schema:datePublished 2019-08-28
20 schema:datePublishedReg 2019-08-28
21 schema:description BACKGROUND: Ovarian metastatic tumors from lung adenocarcinoma are rare, and a serial study of these tumors is lacking to date. Additionally, a better understanding of the clinicopathological and molecular characteristics of metastatic tumors is needed. METHODS: Seven cases of ovarian metastasis from lung adenocarcinoma from 2013 to 2017 at our institute were investigated. The results were combined with those found in literature review. A total of 16 cases were analyzed in the present study. We examined clinicopathological and immunohistochemical characteristics, further detected ALK rearrangement by FISH (fluorescence in situ hybridization), and assessed EGFR and KRAS mutations using Sanger sequencing or the amplification refractory mutation system (ARMS). RESULTS: The mean age of the patients was 44.6 years (range, 33-56 years). Eleven of sixteen patients developed ovarian tumors within a mean time of 18.5 months (range, 5-48 months) from the initial diagnosis of lung adenocarcinoma; 5 patients had lung tumors and ovarian masses simultaneously. Five tumors (5/16, 31%) occurred in the bilateral ovaries, and the others were unilateral ovarian tumors (11/16, 69%). All seven cases from our institute were positive for TTF-1 and Napsin A but negative for PAX8. In four cases, ALK (D5F3) was diffusely and strongly expressed, with ALK rearrangements (4/7, 57%). Overall, ALK rearrangement was found by FISH or immunohistochemistry in 11/16 (69%) cases. In two cases, EGFR mutations in exons 19 and 21, respectively, were found. One patient did not detected EGFR or ALK mutation in the metastatic tumor, but the primary lung adenocarcinoma did harbor an EGFR mutation. Two cases had no alterations in three genes above. Although the mean survival time of the patients with ALK rearrangement was longer than those without (mean survival time 25 m vs. 20 m), no statistical significance of the difference was found. CONCLUSIONS: As the largest case series of ovarian metastasis from lung adenocarcinoma, our findings indicate that ALK rearrangement is the most common molecular alteration. Although patients with ALK rearrangement appear to have a better prognosis than do those without ALK rearrangement, more cases with longer follow-up and multivariant analysis are needed to clarify this point.
22 schema:genre article
23 schema:inLanguage en
24 schema:isAccessibleForFree true
25 schema:isPartOf N26db74cc38ce4049b2e7ca1367872831
26 N60df5e23d9e54807b6b8c323b129a640
27 sg:journal.1327435
28 schema:keywords ALK
29 ALK mutations
30 ALK rearrangement
31 EGFR
32 EGFR mutations
33 Institute
34 KRAS mutations
35 PAX8
36 Sanger sequencing
37 TTF-1
38 adenocarcinoma
39 age
40 alterations
41 amplification refractory mutation system
42 analysis
43 better prognosis
44 better understanding
45 bilateral ovaries
46 case series
47 cases
48 characteristics
49 common molecular alterations
50 date
51 detected ALK rearrangement
52 diagnosis
53 differences
54 exon 19
55 findings
56 fish
57 genes
58 high-frequency alterations
59 immunohistochemical characteristics
60 immunohistochemistry
61 initial diagnosis
62 large case series
63 literature review
64 lung adenocarcinoma
65 lung tumors
66 mass
67 mean age
68 mean survival time
69 mean time
70 metastasis
71 metastatic tumors
72 molecular alterations
73 molecular characteristics
74 months
75 more cases
76 multivariant analysis
77 mutation system
78 mutations
79 napsin A
80 ovarian masses
81 ovarian metastasis
82 ovarian metastatic tumors
83 ovarian tumors
84 ovaries
85 patients
86 point
87 present study
88 primary lung adenocarcinoma
89 prognosis
90 rearrangement
91 refractory mutation system
92 results
93 review
94 sequencing
95 serial studies
96 series
97 significance
98 statistical significance
99 study
100 survival time
101 system
102 time
103 total
104 tumors
105 understanding
106 unilateral ovarian tumor
107 years
108 schema:name ALK rearrangement: a high-frequency alteration in ovarian metastasis from lung adenocarcinoma
109 schema:pagination 96
110 schema:productId N35f0b4ec6dda44cb8646715a09df4521
111 Nb9f2a041c7af4fd8b835df07d7620dd3
112 Ndf96216ad20045c19cf98278063b4821
113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1120633059
114 https://doi.org/10.1186/s13000-019-0864-7
115 schema:sdDatePublished 2022-01-01T18:52
116 schema:sdLicense https://scigraph.springernature.com/explorer/license/
117 schema:sdPublisher N9e533d336fa94343825c85ebcb87672c
118 schema:url https://doi.org/10.1186/s13000-019-0864-7
119 sgo:license sg:explorer/license/
120 sgo:sdDataset articles
121 rdf:type schema:ScholarlyArticle
122 N03682f2eccfc43d48f6f3a2a3077a81a rdf:first sg:person.01103220634.32
123 rdf:rest Nabbec39ebf2e40b3a99778e5b24ea0c1
124 N06854e4f73b947498e4c619e5871089f rdf:first sg:person.01241037701.75
125 rdf:rest N673f3b20317c411fa85c752443094cd8
126 N12e0d34c7d15458ba5180d968615d6df rdf:first sg:person.0652222332.79
127 rdf:rest Ne1ddc26f8ae744df830bf0fbe61ab60d
128 N14a92fcfe9d840399d0d605ce9e5b916 rdf:first sg:person.01151334034.28
129 rdf:rest N06854e4f73b947498e4c619e5871089f
130 N1ef19c06ca184672a0787456333fda3d rdf:first sg:person.015240736727.27
131 rdf:rest N7e16d65c044049dfbabc88e9e71cc0d9
132 N26db74cc38ce4049b2e7ca1367872831 schema:issueNumber 1
133 rdf:type schema:PublicationIssue
134 N2d3694e93a384d389b74a4bc7f01c5e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Neoplasm Metastasis
136 rdf:type schema:DefinedTerm
137 N31feb8dbe46d4ea5b1cf3c17f9d231b0 rdf:first sg:person.01333675634.21
138 rdf:rest rdf:nil
139 N35f0b4ec6dda44cb8646715a09df4521 schema:name doi
140 schema:value 10.1186/s13000-019-0864-7
141 rdf:type schema:PropertyValue
142 N4b5f72b6d7c241b4903ecbb81234c8eb rdf:first sg:person.01257307704.75
143 rdf:rest N8153578fc2994a7c9dffd6d38d87cd81
144 N60df5e23d9e54807b6b8c323b129a640 schema:volumeNumber 14
145 rdf:type schema:PublicationVolume
146 N673f3b20317c411fa85c752443094cd8 rdf:first sg:person.01010610662.09
147 rdf:rest N31feb8dbe46d4ea5b1cf3c17f9d231b0
148 N71c21089b49a4f11a2ad6e3a8cae6ece schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Female
150 rdf:type schema:DefinedTerm
151 N784e4ae1c1be42fe8b31aeacefb76f8a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Adenocarcinoma
153 rdf:type schema:DefinedTerm
154 N7e16d65c044049dfbabc88e9e71cc0d9 rdf:first sg:person.013421532703.33
155 rdf:rest N12e0d34c7d15458ba5180d968615d6df
156 N8153578fc2994a7c9dffd6d38d87cd81 rdf:first sg:person.0736217102.75
157 rdf:rest N14a92fcfe9d840399d0d605ce9e5b916
158 N91660402d61249ceb744449c904c37a8 rdf:first sg:person.0731707551.36
159 rdf:rest N1ef19c06ca184672a0787456333fda3d
160 N9e533d336fa94343825c85ebcb87672c schema:name Springer Nature - SN SciGraph project
161 rdf:type schema:Organization
162 Na37959bbb0db43a7a5b90229dfbe2f5d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Gene Rearrangement
164 rdf:type schema:DefinedTerm
165 Nab15f81f5ab14544a52b9cacb005c8e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Anaplastic Lymphoma Kinase
167 rdf:type schema:DefinedTerm
168 Nabbec39ebf2e40b3a99778e5b24ea0c1 rdf:first sg:person.01257353151.80
169 rdf:rest Ne55c8e4e8d044af2ba9a1f27f6a4d15d
170 Nb9f2a041c7af4fd8b835df07d7620dd3 schema:name dimensions_id
171 schema:value pub.1120633059
172 rdf:type schema:PropertyValue
173 Nba7d4fbb80234748abccf84337ee8bcf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Ovarian Neoplasms
175 rdf:type schema:DefinedTerm
176 Nc6563d6d314447be95daa0db8bbcfbe9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Middle Aged
178 rdf:type schema:DefinedTerm
179 Nd5549556efdc45df933f9eabad3f6f56 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Lung Neoplasms
181 rdf:type schema:DefinedTerm
182 Ndf96216ad20045c19cf98278063b4821 schema:name pubmed_id
183 schema:value 31455365
184 rdf:type schema:PropertyValue
185 Ne1ddc26f8ae744df830bf0fbe61ab60d rdf:first sg:person.01047646601.98
186 rdf:rest N4b5f72b6d7c241b4903ecbb81234c8eb
187 Ne55c8e4e8d044af2ba9a1f27f6a4d15d rdf:first sg:person.01311726114.78
188 rdf:rest N91660402d61249ceb744449c904c37a8
189 Nedb5fde81e3c44749ed5d6e6df05caea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Humans
191 rdf:type schema:DefinedTerm
192 Nfe7b0d34d5e6483c9a6957e54fc02913 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Adult
194 rdf:type schema:DefinedTerm
195 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
196 schema:name Medical and Health Sciences
197 rdf:type schema:DefinedTerm
198 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
199 schema:name Oncology and Carcinogenesis
200 rdf:type schema:DefinedTerm
201 sg:journal.1327435 schema:issn 1746-1596
202 2364-4893
203 schema:name Diagnostic Pathology
204 schema:publisher Springer Nature
205 rdf:type schema:Periodical
206 sg:person.01010610662.09 schema:affiliation grid-institutes:grid.11841.3d
207 schema:familyName Zhou
208 schema:givenName Xiaoyan
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010610662.09
210 rdf:type schema:Person
211 sg:person.01047646601.98 schema:affiliation grid-institutes:grid.11841.3d
212 schema:familyName Tang
213 schema:givenName Shaoxian
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047646601.98
215 rdf:type schema:Person
216 sg:person.01103220634.32 schema:affiliation grid-institutes:grid.11841.3d
217 schema:familyName Bi
218 schema:givenName Rui
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103220634.32
220 rdf:type schema:Person
221 sg:person.01151334034.28 schema:affiliation grid-institutes:grid.11841.3d
222 schema:familyName Cheng
223 schema:givenName Yufan
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151334034.28
225 rdf:type schema:Person
226 sg:person.01241037701.75 schema:affiliation grid-institutes:grid.11841.3d
227 schema:familyName Gan
228 schema:givenName Hualei
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241037701.75
230 rdf:type schema:Person
231 sg:person.01257307704.75 schema:affiliation grid-institutes:grid.11841.3d
232 schema:familyName Ge
233 schema:givenName Huijuan
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257307704.75
235 rdf:type schema:Person
236 sg:person.01257353151.80 schema:affiliation grid-institutes:grid.11841.3d
237 schema:familyName Bai
238 schema:givenName Qianming
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257353151.80
240 rdf:type schema:Person
241 sg:person.01311726114.78 schema:affiliation grid-institutes:grid.11841.3d
242 schema:familyName Zhu
243 schema:givenName Xiaoli
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311726114.78
245 rdf:type schema:Person
246 sg:person.01333675634.21 schema:affiliation grid-institutes:grid.11841.3d
247 schema:familyName Yang
248 schema:givenName Wentao
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333675634.21
250 rdf:type schema:Person
251 sg:person.013421532703.33 schema:affiliation grid-institutes:grid.11841.3d
252 schema:familyName Jiang
253 schema:givenName Wenhua
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013421532703.33
255 rdf:type schema:Person
256 sg:person.015240736727.27 schema:affiliation grid-institutes:grid.11841.3d
257 schema:familyName Cai
258 schema:givenName Xu
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015240736727.27
260 rdf:type schema:Person
261 sg:person.0652222332.79 schema:affiliation grid-institutes:grid.11841.3d
262 schema:familyName Xu
263 schema:givenName Xiaoli
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652222332.79
265 rdf:type schema:Person
266 sg:person.0731707551.36 schema:affiliation grid-institutes:grid.11841.3d
267 schema:familyName Tu
268 schema:givenName Xiaoyu
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731707551.36
270 rdf:type schema:Person
271 sg:person.0736217102.75 schema:affiliation grid-institutes:grid.11841.3d
272 schema:familyName Chang
273 schema:givenName Bin
274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736217102.75
275 rdf:type schema:Person
276 sg:pub.10.1038/modpathol.2009.2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041377919
277 https://doi.org/10.1038/modpathol.2009.2
278 rdf:type schema:CreativeWork
279 sg:pub.10.1038/nature05945 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017221313
280 https://doi.org/10.1038/nature05945
281 rdf:type schema:CreativeWork
282 sg:pub.10.1186/1476-4598-9-188 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013449323
283 https://doi.org/10.1186/1476-4598-9-188
284 rdf:type schema:CreativeWork
285 sg:pub.10.1186/s12885-016-2169-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014280580
286 https://doi.org/10.1186/s12885-016-2169-5
287 rdf:type schema:CreativeWork
288 sg:pub.10.1245/s10434-009-0808-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001051684
289 https://doi.org/10.1245/s10434-009-0808-7
290 rdf:type schema:CreativeWork
291 grid-institutes:grid.11841.3d schema:alternateName Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong An Road, Shanghai, 200032 China
292 schema:name Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong An Road, Shanghai, 200032 China
293 Department of Pathology, Fudan University Shanghai Cancer Center, Fudan University, 270 Dong An Road, Shanghai, 200032 China
294 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...