KRAS mutation in secondary malignant histiocytosis arising from low grade follicular lymphoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-10-15

AUTHORS

Sarah M. Choi, Aleodor A. Andea, Min Wang, Amir Behdad, Lina Shao, Yanming Zhang, Xinyan Lu, David Dittmann, Juan Castro, Yi-Hua Chen, Juehua Gao

ABSTRACT

BACKGROUND: Transformation of follicular lymphoma most typically occurs as diffuse large B-cell lymphoma, however other forms of transformation such as classic Hodgkin lymphoma and lymphoblastic transformation can occur. Secondary malignant histiocytosis also represents a rare form of transformation, which is thought to occur due to a process of transdifferentiation whereby the lymphoma cells exhibit lineage plasticity and lose all evidence of B-cell phenotype and instead acquire the phenotype of a histiocytic neoplasm. Little is known about the underlying genetic alterations that occur during this unusual process. Comparative genetic analysis of pre- and post-transformation/transdifferentiation would be one tool by which we could better understand how this phenomenon occurs. CASE PRESENTATION: Here we report the clinical, immunophenotypic and genetic features of a rare case of secondary malignant histiocytosis, Langerhans cell-type (Langerhans cell sarcoma) arising from a previous low grade follicular lymphoma. FISH analysis confirmed the presence of IgH/BCL2 rearrangement in both the low grade follicular lymphoma (FL) and transformed Langerhans cells sarcoma (LCS) samples, demonstrating a clonal relationship. Comparative whole exome sequencing was then performed, which identified a KRAS p.G13D mutation in the LCS that was not present in the FL. CONCLUSIONS: This report highlights genetic alterations, in particular an acquired somatic KRAS mutation, that may occur during transdifferentiation, with additional significance of KRAS mutation as a possible therapeutic target in cases which otherwise would have limited treatment options. More... »

PAGES

78

References to SciGraph publications

  • 2013-12-22. Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma in NATURE GENETICS
  • 2015-08-19. Langerhans cell sarcoma following marginal zone lymphoma: expanding the knowledge on mature B cell plasticity in VIRCHOWS ARCHIV
  • 2016-07-29. Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design in NATURE REVIEWS DRUG DISCOVERY
  • 2003-06. RAS oncogenes: the first 30 years in NATURE REVIEWS CANCER
  • 2013-08-11. Structure of the p300 catalytic core and implications for chromatin targeting and HAT regulation in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2012-06-13. Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer in NATURE
  • 2014-10-17. Drugging the undruggable RAS: Mission Possible? in NATURE REVIEWS DRUG DISCOVERY
  • 2012-02-03. Clonal relationship between langerhans cell histiocytosis and myeloid sarcoma in LEUKEMIA
  • 2007-04. Hyperactive Ras in developmental disorders and cancer in NATURE REVIEWS CANCER
  • 2011-06-10. Clonally related Histiocytic/dendritic cell sarcoma and chronic lymphocytic leukemia/small lymphocytic lymphoma: A study of 7 cases in MODERN PATHOLOGY
  • 2002-03. Acetyltransferase machinery conserved in p300/CBP-family proteins in ONCOGENE
  • 2017-07-06. New somatic BRAF splicing mutation in Langerhans cell histiocytosis in MOLECULAR CANCER
  • 2016-09-28. XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer in NATURE
  • 2015-02-18. Cross-laboratory validation of the OncoScanĀ® FFPE Assay, a multiplex tool for whole genome tumour profiling in BMC MEDICAL GENOMICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13000-018-0758-0

    DOI

    http://dx.doi.org/10.1186/s13000-018-0758-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1107642059

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30322385


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "B-Lymphocytes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Histiocytic Sarcoma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunoglobulin Heavy Chains", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunophenotyping", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "In Situ Hybridization, Fluorescence", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Langerhans Cell Sarcoma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Langerhans Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lymphoma, Follicular", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Proto-Oncogene Proteins p21(ras)", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Current address: Department of Pathology, University of Michigan, 5242 Medical Science Building 1, 1301 Catherine Street, Ann Arbor, MI 48109 USA", 
              "id": "http://www.grid.ac/institutes/grid.214458.e", 
              "name": [
                "Department of Pathology, Northwestern University Feinberg School of Medicine, 251 E Huron Street, Chicago, IL 60611 USA", 
                "Current address: Department of Pathology, University of Michigan, 5242 Medical Science Building 1, 1301 Catherine Street, Ann Arbor, MI 48109 USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Choi", 
            "givenName": "Sarah M.", 
            "id": "sg:person.013451403343.84", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013451403343.84"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Current address: Department of Pathology, University of Michigan, 5242 Medical Science Building 1, 1301 Catherine Street, Ann Arbor, MI 48109 USA", 
              "id": "http://www.grid.ac/institutes/grid.214458.e", 
              "name": [
                "Current address: Department of Pathology, University of Michigan, 5242 Medical Science Building 1, 1301 Catherine Street, Ann Arbor, MI 48109 USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Andea", 
            "givenName": "Aleodor A.", 
            "id": "sg:person.01362607707.75", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362607707.75"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Current address: Department of Pathology, University of Michigan, 5242 Medical Science Building 1, 1301 Catherine Street, Ann Arbor, MI 48109 USA", 
              "id": "http://www.grid.ac/institutes/grid.214458.e", 
              "name": [
                "Current address: Department of Pathology, University of Michigan, 5242 Medical Science Building 1, 1301 Catherine Street, Ann Arbor, MI 48109 USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "Min", 
            "id": "sg:person.01015016144.71", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015016144.71"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, Northwestern University Feinberg School of Medicine, 251 E Huron Street, Chicago, IL 60611 USA", 
              "id": "http://www.grid.ac/institutes/grid.16753.36", 
              "name": [
                "Department of Pathology, Northwestern University Feinberg School of Medicine, 251 E Huron Street, Chicago, IL 60611 USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Behdad", 
            "givenName": "Amir", 
            "id": "sg:person.011240710367.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011240710367.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Current address: Department of Pathology, University of Michigan, 5242 Medical Science Building 1, 1301 Catherine Street, Ann Arbor, MI 48109 USA", 
              "id": "http://www.grid.ac/institutes/grid.214458.e", 
              "name": [
                "Current address: Department of Pathology, University of Michigan, 5242 Medical Science Building 1, 1301 Catherine Street, Ann Arbor, MI 48109 USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shao", 
            "givenName": "Lina", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Current address: Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065 USA", 
              "id": "http://www.grid.ac/institutes/grid.51462.34", 
              "name": [
                "Current address: Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065 USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhang", 
            "givenName": "Yanming", 
            "id": "sg:person.01034721243.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034721243.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, Northwestern University Feinberg School of Medicine, 251 E Huron Street, Chicago, IL 60611 USA", 
              "id": "http://www.grid.ac/institutes/grid.16753.36", 
              "name": [
                "Department of Pathology, Northwestern University Feinberg School of Medicine, 251 E Huron Street, Chicago, IL 60611 USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lu", 
            "givenName": "Xinyan", 
            "id": "sg:person.014527601717.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014527601717.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Diagnostic Molecular Biology Laboratory, Northwestern Memorial Hospital, 251 E Huron Street, Chicago, IL 60611 USA", 
              "id": "http://www.grid.ac/institutes/grid.416565.5", 
              "name": [
                "Diagnostic Molecular Biology Laboratory, Northwestern Memorial Hospital, 251 E Huron Street, Chicago, IL 60611 USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dittmann", 
            "givenName": "David", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Diagnostic Molecular Biology Laboratory, Northwestern Memorial Hospital, 251 E Huron Street, Chicago, IL 60611 USA", 
              "id": "http://www.grid.ac/institutes/grid.416565.5", 
              "name": [
                "Diagnostic Molecular Biology Laboratory, Northwestern Memorial Hospital, 251 E Huron Street, Chicago, IL 60611 USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Castro", 
            "givenName": "Juan", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, Northwestern University Feinberg School of Medicine, 251 E Huron Street, Chicago, IL 60611 USA", 
              "id": "http://www.grid.ac/institutes/grid.16753.36", 
              "name": [
                "Department of Pathology, Northwestern University Feinberg School of Medicine, 251 E Huron Street, Chicago, IL 60611 USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chen", 
            "givenName": "Yi-Hua", 
            "id": "sg:person.01107320342.90", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107320342.90"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, Northwestern University Feinberg School of Medicine, 251 E Huron Street, Chicago, IL 60611 USA", 
              "id": "http://www.grid.ac/institutes/grid.16753.36", 
              "name": [
                "Department of Pathology, Northwestern University Feinberg School of Medicine, 251 E Huron Street, Chicago, IL 60611 USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gao", 
            "givenName": "Juehua", 
            "id": "sg:person.0656643342.59", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656643342.59"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1186/s12920-015-0079-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003287317", 
              "https://doi.org/10.1186/s12920-015-0079-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11156", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024120060", 
              "https://doi.org/10.1038/nature11156"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040267703", 
              "https://doi.org/10.1038/nrc2109"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1097", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044819609", 
              "https://doi.org/10.1038/nrc1097"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd.2016.139", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031321400", 
              "https://doi.org/10.1038/nrd.2016.139"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.2011.102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002616806", 
              "https://doi.org/10.1038/modpathol.2011.102"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12943-017-0690-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090388823", 
              "https://doi.org/10.1186/s12943-017-0690-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00428-015-1814-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047814759", 
              "https://doi.org/10.1007/s00428-015-1814-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2012.27", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002801350", 
              "https://doi.org/10.1038/leu.2012.27"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature19771", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026301171", 
              "https://doi.org/10.1038/nature19771"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.2642", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000594152", 
              "https://doi.org/10.1038/nsmb.2642"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1205283", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032979124", 
              "https://doi.org/10.1038/sj.onc.1205283"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2856", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015438319", 
              "https://doi.org/10.1038/ng.2856"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd4389", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017651463", 
              "https://doi.org/10.1038/nrd4389"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-10-15", 
        "datePublishedReg": "2018-10-15", 
        "description": "BACKGROUND: Transformation of follicular lymphoma most typically occurs as diffuse large B-cell lymphoma, however other forms of transformation such as classic Hodgkin lymphoma and lymphoblastic transformation can occur. Secondary malignant histiocytosis also represents a rare form of transformation, which is thought to occur due to a process of transdifferentiation whereby the lymphoma cells exhibit lineage plasticity and lose all evidence of B-cell phenotype and instead acquire the phenotype of a histiocytic neoplasm. Little is known about the underlying genetic alterations that occur during this unusual process. Comparative genetic analysis of pre- and post-transformation/transdifferentiation would be one tool by which we could better understand how this phenomenon occurs.\nCASE PRESENTATION: Here we report the clinical, immunophenotypic and genetic features of a rare case of secondary malignant histiocytosis, Langerhans cell-type (Langerhans cell sarcoma) arising from a previous low grade follicular lymphoma. FISH analysis confirmed the presence of IgH/BCL2 rearrangement in both the low grade follicular lymphoma (FL) and transformed Langerhans cells sarcoma (LCS) samples, demonstrating a clonal relationship. Comparative whole exome sequencing was then performed, which identified a KRAS p.G13D mutation in the LCS that was not present in the FL.\nCONCLUSIONS: This report highlights genetic alterations, in particular an acquired somatic KRAS mutation, that may occur during transdifferentiation, with additional significance of KRAS mutation as a possible therapeutic target in cases which otherwise would have limited treatment options.", 
        "genre": "article", 
        "id": "sg:pub.10.1186/s13000-018-0758-0", 
        "inLanguage": "en", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1327435", 
            "issn": [
              "2364-4893", 
              "1746-1596"
            ], 
            "name": "Diagnostic Pathology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "13"
          }
        ], 
        "keywords": [
          "comparative whole exome sequencing", 
          "comparative genetic analysis", 
          "genetic alterations", 
          "process of transdifferentiation", 
          "genetic analysis", 
          "lineage plasticity", 
          "whole-exome sequencing", 
          "somatic KRAS mutations", 
          "FISH analysis", 
          "mutations", 
          "exome sequencing", 
          "cell phenotype", 
          "transdifferentiation", 
          "possible therapeutic target", 
          "unusual process", 
          "IGH/BCL2 rearrangement", 
          "therapeutic target", 
          "genetic features", 
          "phenotype", 
          "lymphoma cells", 
          "sarcoma samples", 
          "KRAS mutations", 
          "sequencing", 
          "alterations", 
          "plasticity", 
          "clonal relationship", 
          "rearrangement", 
          "cells", 
          "KRAS p.", 
          "follicular lymphoma", 
          "target", 
          "additional significance", 
          "low-grade follicular lymphoma", 
          "cell lymphoma", 
          "p.", 
          "analysis", 
          "Langerhans", 
          "transformation", 
          "form", 
          "process", 
          "malignant histiocytosis", 
          "presence", 
          "evidence", 
          "BCL2 rearrangement", 
          "lymphoma", 
          "significance", 
          "rare form", 
          "classic Hodgkin lymphoma", 
          "histiocytic neoplasms", 
          "tool", 
          "relationship", 
          "lymphoblastic transformation", 
          "Hodgkin's lymphoma", 
          "treatment options", 
          "rare case", 
          "features", 
          "histiocytosis", 
          "form of transformation", 
          "report", 
          "samples", 
          "phenomenon", 
          "diffuse", 
          "neoplasms", 
          "pre", 
          "cases", 
          "options", 
          "LCS", 
          "secondary malignant histiocytosis", 
          "previous low grade follicular lymphoma", 
          "grade follicular lymphoma", 
          "Langerhans cells sarcoma (LCS) samples", 
          "cells sarcoma (LCS) samples"
        ], 
        "name": "KRAS mutation in secondary malignant histiocytosis arising from low grade follicular lymphoma", 
        "pagination": "78", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1107642059"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s13000-018-0758-0"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30322385"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s13000-018-0758-0", 
          "https://app.dimensions.ai/details/publication/pub.1107642059"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2021-12-01T19:40", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_771.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1186/s13000-018-0758-0"
      }
    ]
     

    Download the RDF metadata as:Ā  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13000-018-0758-0'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13000-018-0758-0'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13000-018-0758-0'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13000-018-0758-0'


     

    This table displays all metadata directly associated to this object as RDF triples.

    307 TRIPLES      22 PREDICATES      122 URIs      100 LITERALS      17 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s13000-018-0758-0 schema:about N2381e6f96bbd420193a6b561a26a73f8
    2 N2713b798ca36499b9c32eeef2364b7c8
    3 N2b8b8079930c4614a2dac94958099a2e
    4 N3785b982a54746f0a71da671ff859a3d
    5 N5ffe64073af544e994356e477ef4db9a
    6 N99838832f5e848ebbf138939a97ccbbb
    7 Nbe10d64826a5499098df4e1264bbfd1b
    8 Nc96a3c70ac7442ad9b45112d701eb589
    9 Ne866fce40b4e4e72934bf6ad85219d1d
    10 Nf4d0a776b66e47ffb382cc7b12d96a81
    11 anzsrc-for:11
    12 anzsrc-for:1112
    13 schema:author Nfe975701508f4cd19698cc35c0151fbe
    14 schema:citation sg:pub.10.1007/s00428-015-1814-8
    15 sg:pub.10.1038/leu.2012.27
    16 sg:pub.10.1038/modpathol.2011.102
    17 sg:pub.10.1038/nature11156
    18 sg:pub.10.1038/nature19771
    19 sg:pub.10.1038/ng.2856
    20 sg:pub.10.1038/nrc1097
    21 sg:pub.10.1038/nrc2109
    22 sg:pub.10.1038/nrd.2016.139
    23 sg:pub.10.1038/nrd4389
    24 sg:pub.10.1038/nsmb.2642
    25 sg:pub.10.1038/sj.onc.1205283
    26 sg:pub.10.1186/s12920-015-0079-z
    27 sg:pub.10.1186/s12943-017-0690-z
    28 schema:datePublished 2018-10-15
    29 schema:datePublishedReg 2018-10-15
    30 schema:description BACKGROUND: Transformation of follicular lymphoma most typically occurs as diffuse large B-cell lymphoma, however other forms of transformation such as classic Hodgkin lymphoma and lymphoblastic transformation can occur. Secondary malignant histiocytosis also represents a rare form of transformation, which is thought to occur due to a process of transdifferentiation whereby the lymphoma cells exhibit lineage plasticity and lose all evidence of B-cell phenotype and instead acquire the phenotype of a histiocytic neoplasm. Little is known about the underlying genetic alterations that occur during this unusual process. Comparative genetic analysis of pre- and post-transformation/transdifferentiation would be one tool by which we could better understand how this phenomenon occurs. CASE PRESENTATION: Here we report the clinical, immunophenotypic and genetic features of a rare case of secondary malignant histiocytosis, Langerhans cell-type (Langerhans cell sarcoma) arising from a previous low grade follicular lymphoma. FISH analysis confirmed the presence of IgH/BCL2 rearrangement in both the low grade follicular lymphoma (FL) and transformed Langerhans cells sarcoma (LCS) samples, demonstrating a clonal relationship. Comparative whole exome sequencing was then performed, which identified a KRAS p.G13D mutation in the LCS that was not present in the FL. CONCLUSIONS: This report highlights genetic alterations, in particular an acquired somatic KRAS mutation, that may occur during transdifferentiation, with additional significance of KRAS mutation as a possible therapeutic target in cases which otherwise would have limited treatment options.
    31 schema:genre article
    32 schema:inLanguage en
    33 schema:isAccessibleForFree true
    34 schema:isPartOf N68469d96578f43208feb79e92346c3a7
    35 N9624a260d5c24cc5b5d35dc794689045
    36 sg:journal.1327435
    37 schema:keywords BCL2 rearrangement
    38 FISH analysis
    39 Hodgkin's lymphoma
    40 IGH/BCL2 rearrangement
    41 KRAS mutations
    42 KRAS p.
    43 LCS
    44 Langerhans
    45 Langerhans cells sarcoma (LCS) samples
    46 additional significance
    47 alterations
    48 analysis
    49 cases
    50 cell lymphoma
    51 cell phenotype
    52 cells
    53 cells sarcoma (LCS) samples
    54 classic Hodgkin lymphoma
    55 clonal relationship
    56 comparative genetic analysis
    57 comparative whole exome sequencing
    58 diffuse
    59 evidence
    60 exome sequencing
    61 features
    62 follicular lymphoma
    63 form
    64 form of transformation
    65 genetic alterations
    66 genetic analysis
    67 genetic features
    68 grade follicular lymphoma
    69 histiocytic neoplasms
    70 histiocytosis
    71 lineage plasticity
    72 low-grade follicular lymphoma
    73 lymphoblastic transformation
    74 lymphoma
    75 lymphoma cells
    76 malignant histiocytosis
    77 mutations
    78 neoplasms
    79 options
    80 p.
    81 phenomenon
    82 phenotype
    83 plasticity
    84 possible therapeutic target
    85 pre
    86 presence
    87 previous low grade follicular lymphoma
    88 process
    89 process of transdifferentiation
    90 rare case
    91 rare form
    92 rearrangement
    93 relationship
    94 report
    95 samples
    96 sarcoma samples
    97 secondary malignant histiocytosis
    98 sequencing
    99 significance
    100 somatic KRAS mutations
    101 target
    102 therapeutic target
    103 tool
    104 transdifferentiation
    105 transformation
    106 treatment options
    107 unusual process
    108 whole-exome sequencing
    109 schema:name KRAS mutation in secondary malignant histiocytosis arising from low grade follicular lymphoma
    110 schema:pagination 78
    111 schema:productId N0f54edb77c2447b49de9cb1f63d4d946
    112 N487ecb6c9f1a4fb28c3ac4f8667d97ee
    113 Nebeb6bb45dee47e1b098b5f02aad53ca
    114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107642059
    115 https://doi.org/10.1186/s13000-018-0758-0
    116 schema:sdDatePublished 2021-12-01T19:40
    117 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    118 schema:sdPublisher Nabb6ba581c8a414ea42fdb4a75c2f2f1
    119 schema:url https://doi.org/10.1186/s13000-018-0758-0
    120 sgo:license sg:explorer/license/
    121 sgo:sdDataset articles
    122 rdf:type schema:ScholarlyArticle
    123 N0f54edb77c2447b49de9cb1f63d4d946 schema:name doi
    124 schema:value 10.1186/s13000-018-0758-0
    125 rdf:type schema:PropertyValue
    126 N2381e6f96bbd420193a6b561a26a73f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    127 schema:name In Situ Hybridization, Fluorescence
    128 rdf:type schema:DefinedTerm
    129 N2713b798ca36499b9c32eeef2364b7c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    130 schema:name Immunoglobulin Heavy Chains
    131 rdf:type schema:DefinedTerm
    132 N2b8b8079930c4614a2dac94958099a2e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Humans
    134 rdf:type schema:DefinedTerm
    135 N3785b982a54746f0a71da671ff859a3d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    136 schema:name B-Lymphocytes
    137 rdf:type schema:DefinedTerm
    138 N487ecb6c9f1a4fb28c3ac4f8667d97ee schema:name pubmed_id
    139 schema:value 30322385
    140 rdf:type schema:PropertyValue
    141 N50d7ff9068f948d488364d457079db67 schema:affiliation grid-institutes:grid.214458.e
    142 schema:familyName Shao
    143 schema:givenName Lina
    144 rdf:type schema:Person
    145 N5680f10bd3744059817168a1df808fe6 rdf:first sg:person.011240710367.37
    146 rdf:rest Na45552a2d32a4b9f98fc7d73b3baf2d7
    147 N5ffe64073af544e994356e477ef4db9a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    148 schema:name Lymphoma, Follicular
    149 rdf:type schema:DefinedTerm
    150 N68469d96578f43208feb79e92346c3a7 schema:issueNumber 1
    151 rdf:type schema:PublicationIssue
    152 N78cad6e4182b4474af8d602f75a73848 rdf:first N7f19072bea294df7adaab6af72181356
    153 rdf:rest Ne313694ce1b14623965d4872baf770ac
    154 N7f19072bea294df7adaab6af72181356 schema:affiliation grid-institutes:grid.416565.5
    155 schema:familyName Castro
    156 schema:givenName Juan
    157 rdf:type schema:Person
    158 N9300c4fdee3b44049052d3a5d91c6420 rdf:first sg:person.0656643342.59
    159 rdf:rest rdf:nil
    160 N9624a260d5c24cc5b5d35dc794689045 schema:volumeNumber 13
    161 rdf:type schema:PublicationVolume
    162 N99838832f5e848ebbf138939a97ccbbb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Histiocytic Sarcoma
    164 rdf:type schema:DefinedTerm
    165 Na45552a2d32a4b9f98fc7d73b3baf2d7 rdf:first N50d7ff9068f948d488364d457079db67
    166 rdf:rest Nd69d5cd6fb0f41969ac8f3871d982d15
    167 Nabb6ba581c8a414ea42fdb4a75c2f2f1 schema:name Springer Nature - SN SciGraph project
    168 rdf:type schema:Organization
    169 Nbe10d64826a5499098df4e1264bbfd1b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Langerhans Cell Sarcoma
    171 rdf:type schema:DefinedTerm
    172 Nc0d548916a844247b986efe155b26a1a schema:affiliation grid-institutes:grid.416565.5
    173 schema:familyName Dittmann
    174 schema:givenName David
    175 rdf:type schema:Person
    176 Nc96a3c70ac7442ad9b45112d701eb589 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    177 schema:name Proto-Oncogene Proteins p21(ras)
    178 rdf:type schema:DefinedTerm
    179 Ncf599d273a09423d9a49181274b2457c rdf:first Nc0d548916a844247b986efe155b26a1a
    180 rdf:rest N78cad6e4182b4474af8d602f75a73848
    181 Nd69d5cd6fb0f41969ac8f3871d982d15 rdf:first sg:person.01034721243.45
    182 rdf:rest Ne446c903bb26407c9faea5d737a4b3b6
    183 Ne313694ce1b14623965d4872baf770ac rdf:first sg:person.01107320342.90
    184 rdf:rest N9300c4fdee3b44049052d3a5d91c6420
    185 Ne446c903bb26407c9faea5d737a4b3b6 rdf:first sg:person.014527601717.15
    186 rdf:rest Ncf599d273a09423d9a49181274b2457c
    187 Ne65cabf24b7a4ff9a7dd6f770a2985c9 rdf:first sg:person.01362607707.75
    188 rdf:rest Nfd2feb7c15834032952b209952ad9204
    189 Ne866fce40b4e4e72934bf6ad85219d1d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    190 schema:name Langerhans Cells
    191 rdf:type schema:DefinedTerm
    192 Nebeb6bb45dee47e1b098b5f02aad53ca schema:name dimensions_id
    193 schema:value pub.1107642059
    194 rdf:type schema:PropertyValue
    195 Nf4d0a776b66e47ffb382cc7b12d96a81 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    196 schema:name Immunophenotyping
    197 rdf:type schema:DefinedTerm
    198 Nfd2feb7c15834032952b209952ad9204 rdf:first sg:person.01015016144.71
    199 rdf:rest N5680f10bd3744059817168a1df808fe6
    200 Nfe975701508f4cd19698cc35c0151fbe rdf:first sg:person.013451403343.84
    201 rdf:rest Ne65cabf24b7a4ff9a7dd6f770a2985c9
    202 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    203 schema:name Medical and Health Sciences
    204 rdf:type schema:DefinedTerm
    205 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    206 schema:name Oncology and Carcinogenesis
    207 rdf:type schema:DefinedTerm
    208 sg:journal.1327435 schema:issn 1746-1596
    209 2364-4893
    210 schema:name Diagnostic Pathology
    211 schema:publisher Springer Nature
    212 rdf:type schema:Periodical
    213 sg:person.01015016144.71 schema:affiliation grid-institutes:grid.214458.e
    214 schema:familyName Wang
    215 schema:givenName Min
    216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015016144.71
    217 rdf:type schema:Person
    218 sg:person.01034721243.45 schema:affiliation grid-institutes:grid.51462.34
    219 schema:familyName Zhang
    220 schema:givenName Yanming
    221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034721243.45
    222 rdf:type schema:Person
    223 sg:person.01107320342.90 schema:affiliation grid-institutes:grid.16753.36
    224 schema:familyName Chen
    225 schema:givenName Yi-Hua
    226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107320342.90
    227 rdf:type schema:Person
    228 sg:person.011240710367.37 schema:affiliation grid-institutes:grid.16753.36
    229 schema:familyName Behdad
    230 schema:givenName Amir
    231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011240710367.37
    232 rdf:type schema:Person
    233 sg:person.013451403343.84 schema:affiliation grid-institutes:grid.214458.e
    234 schema:familyName Choi
    235 schema:givenName Sarah M.
    236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013451403343.84
    237 rdf:type schema:Person
    238 sg:person.01362607707.75 schema:affiliation grid-institutes:grid.214458.e
    239 schema:familyName Andea
    240 schema:givenName Aleodor A.
    241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362607707.75
    242 rdf:type schema:Person
    243 sg:person.014527601717.15 schema:affiliation grid-institutes:grid.16753.36
    244 schema:familyName Lu
    245 schema:givenName Xinyan
    246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014527601717.15
    247 rdf:type schema:Person
    248 sg:person.0656643342.59 schema:affiliation grid-institutes:grid.16753.36
    249 schema:familyName Gao
    250 schema:givenName Juehua
    251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656643342.59
    252 rdf:type schema:Person
    253 sg:pub.10.1007/s00428-015-1814-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047814759
    254 https://doi.org/10.1007/s00428-015-1814-8
    255 rdf:type schema:CreativeWork
    256 sg:pub.10.1038/leu.2012.27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002801350
    257 https://doi.org/10.1038/leu.2012.27
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1038/modpathol.2011.102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002616806
    260 https://doi.org/10.1038/modpathol.2011.102
    261 rdf:type schema:CreativeWork
    262 sg:pub.10.1038/nature11156 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024120060
    263 https://doi.org/10.1038/nature11156
    264 rdf:type schema:CreativeWork
    265 sg:pub.10.1038/nature19771 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026301171
    266 https://doi.org/10.1038/nature19771
    267 rdf:type schema:CreativeWork
    268 sg:pub.10.1038/ng.2856 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015438319
    269 https://doi.org/10.1038/ng.2856
    270 rdf:type schema:CreativeWork
    271 sg:pub.10.1038/nrc1097 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044819609
    272 https://doi.org/10.1038/nrc1097
    273 rdf:type schema:CreativeWork
    274 sg:pub.10.1038/nrc2109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040267703
    275 https://doi.org/10.1038/nrc2109
    276 rdf:type schema:CreativeWork
    277 sg:pub.10.1038/nrd.2016.139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031321400
    278 https://doi.org/10.1038/nrd.2016.139
    279 rdf:type schema:CreativeWork
    280 sg:pub.10.1038/nrd4389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017651463
    281 https://doi.org/10.1038/nrd4389
    282 rdf:type schema:CreativeWork
    283 sg:pub.10.1038/nsmb.2642 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000594152
    284 https://doi.org/10.1038/nsmb.2642
    285 rdf:type schema:CreativeWork
    286 sg:pub.10.1038/sj.onc.1205283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032979124
    287 https://doi.org/10.1038/sj.onc.1205283
    288 rdf:type schema:CreativeWork
    289 sg:pub.10.1186/s12920-015-0079-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1003287317
    290 https://doi.org/10.1186/s12920-015-0079-z
    291 rdf:type schema:CreativeWork
    292 sg:pub.10.1186/s12943-017-0690-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1090388823
    293 https://doi.org/10.1186/s12943-017-0690-z
    294 rdf:type schema:CreativeWork
    295 grid-institutes:grid.16753.36 schema:alternateName Department of Pathology, Northwestern University Feinberg School of Medicine, 251 E Huron Street, Chicago, IL 60611 USA
    296 schema:name Department of Pathology, Northwestern University Feinberg School of Medicine, 251 E Huron Street, Chicago, IL 60611 USA
    297 rdf:type schema:Organization
    298 grid-institutes:grid.214458.e schema:alternateName Current address: Department of Pathology, University of Michigan, 5242 Medical Science Building 1, 1301 Catherine Street, Ann Arbor, MI 48109 USA
    299 schema:name Current address: Department of Pathology, University of Michigan, 5242 Medical Science Building 1, 1301 Catherine Street, Ann Arbor, MI 48109 USA
    300 Department of Pathology, Northwestern University Feinberg School of Medicine, 251 E Huron Street, Chicago, IL 60611 USA
    301 rdf:type schema:Organization
    302 grid-institutes:grid.416565.5 schema:alternateName Diagnostic Molecular Biology Laboratory, Northwestern Memorial Hospital, 251 E Huron Street, Chicago, IL 60611 USA
    303 schema:name Diagnostic Molecular Biology Laboratory, Northwestern Memorial Hospital, 251 E Huron Street, Chicago, IL 60611 USA
    304 rdf:type schema:Organization
    305 grid-institutes:grid.51462.34 schema:alternateName Current address: Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065 USA
    306 schema:name Current address: Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065 USA
    307 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...