EZH2 overexpression in different immunophenotypes of breast carcinoma and association with clinicopathologic features View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Shuangping Guo, Xia Li, Joseph Rohr, Yingmei Wang, Shirong Ma, Peng Chen, Zhe Wang

ABSTRACT

BACKGROUND: Enhancer of zest homolog 2 (EZH2), a histone 3 methyltransferase, is associated with aggressive behavior of many tumors and is a promising target of molecular therapy. METHODS: To better elucidate the relevance of EZH2 in breast cancer subtypes, we evaluated EZH2 expression in 226 invasive breast carcinomas with four distinct immunophenotypes and in association with clinicopathological features. RESULTS: Of these cases, 138 (61.1 %) were defined as EZH2-overexpressing with a multiplicative score > 3. EZH2 expression was inversely related to the status of ER and PR (Chi-square, p < 0.001), and it was significantly associated with HER2 positivity, high proliferative index, and high histologic grade (Chi-square, p < 0.05). ER-positive breast carcinoma with low proliferative index (Ki67 < 14 %) showed the lowest expression and triple-negative breast carcinoma showed the highest overexpression of EZH2, 18.5 % (10/54) versus 90.9 % (50/55) (Chi-square, p < 0.001). Intriguingly, 88 % (44/50) cases of grade 3 triple-negative breast carcinoma showed uniformly strong EZH2 expression with a multiplicative score of 9. The percentage of EZH2 overexpression in ER-positive breast carcinoma with a high proliferative index or HER2-positive cases were 61.2 and 74 %, respectively. Furthermore, EZH2 expression was significantly elevated in high-grade DCIS compared to benign lesions (90 % versus 0, p < 0.001). However, there is no association between EZH2 expression and the status of histone 3 lysine 27 trimethylation or other clinicopathologic features. CONCLUSION: In summary, triple-negative breast carcinoma showed the highest overexpression of EZH2. EZH2 overexpression is associated aggressive pathologic features including high nuclear grade, high proliferative index, and positivity of HER2 of breast carcinoma. More... »

PAGES

41

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13000-016-0491-5

DOI

http://dx.doi.org/10.1186/s13000-016-0491-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012145202

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27113214


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enhancer of Zeste Homolog 2 Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ki-67 Antigen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Grading", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Invasiveness", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polycomb Repressive Complex 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Predictive Value of Tests", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptor, ErbB-2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Triple Negative Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Up-Regulation", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Fourth Military Medical University", 
          "id": "https://www.grid.ac/institutes/grid.233520.5", 
          "name": [
            "Department of Pathology, Xi Jing Hospital, the Fourth Military Medical University, 710032, Xi\u2019an, Shaan Xi Province, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guo", 
        "givenName": "Shuangping", 
        "id": "sg:person.01242362136.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242362136.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fourth Military Medical University", 
          "id": "https://www.grid.ac/institutes/grid.233520.5", 
          "name": [
            "Department of Pathology, Xi Jing Hospital, the Fourth Military Medical University, 710032, Xi\u2019an, Shaan Xi Province, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Xia", 
        "id": "sg:person.0630461205.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630461205.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Nebraska Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.266813.8", 
          "name": [
            "Department of Pathology and Microbiology, University of Nebraska Medical Center, 68105, Omaha, NE, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rohr", 
        "givenName": "Joseph", 
        "id": "sg:person.0637150121.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637150121.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fourth Military Medical University", 
          "id": "https://www.grid.ac/institutes/grid.233520.5", 
          "name": [
            "Department of Pathology, Xi Jing Hospital, the Fourth Military Medical University, 710032, Xi\u2019an, Shaan Xi Province, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Yingmei", 
        "id": "sg:person.01202060376.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202060376.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fourth Military Medical University", 
          "id": "https://www.grid.ac/institutes/grid.233520.5", 
          "name": [
            "Department of Pathology, Xi Jing Hospital, the Fourth Military Medical University, 710032, Xi\u2019an, Shaan Xi Province, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ma", 
        "givenName": "Shirong", 
        "id": "sg:person.01103252766.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103252766.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fourth Military Medical University", 
          "id": "https://www.grid.ac/institutes/grid.233520.5", 
          "name": [
            "Department of Pathology, Xi Jing Hospital, the Fourth Military Medical University, 710032, Xi\u2019an, Shaan Xi Province, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Peng", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fourth Military Medical University", 
          "id": "https://www.grid.ac/institutes/grid.233520.5", 
          "name": [
            "Department of Pathology, Xi Jing Hospital, the Fourth Military Medical University, 710032, Xi\u2019an, Shaan Xi Province, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Zhe", 
        "id": "sg:person.01067625121.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067625121.42"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1073/pnas.1308953111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000483367"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1933744100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006013665"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-05-1533", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006433730"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms6987", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007923439", 
          "https://doi.org/10.1038/ncomms6987"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-4300", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010802411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2217/epi.14.59", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010854839"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molonc.2012.06.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011420580"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2012.390", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011568592", 
          "https://doi.org/10.1038/onc.2012.390"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2009.25.6529", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016721540"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.humpath.2011.12.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017914229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-06-2384", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018316116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2008.433", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019798988", 
          "https://doi.org/10.1038/onc.2008.433"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-10-1199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022542303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-11-3546", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022967334"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5858/arpa.2013-0953-sa", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023063099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.00426-13", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026714846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/cdg542", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029576413"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2011.118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033534564", 
          "https://doi.org/10.1038/onc.2011.118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdu391", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035440462"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.22381", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036147682"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/epi.24532", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042356293"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/ott.s67673", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044115872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/00313020802563510", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045011485"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/00313020802563510", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045011485"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.01.5180", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046338079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-06-3045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048367977"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pat.0b013e3283534bcb", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060343612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pat.0b013e3283534bcb", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060343612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pat.0b013e3283534bcb", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060343612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/1871520615666150129211901", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069219098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cbt.27306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072293046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cbt.27306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072293046"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-12", 
    "datePublishedReg": "2016-12-01", 
    "description": "BACKGROUND: Enhancer of zest homolog 2 (EZH2), a histone 3 methyltransferase, is associated with aggressive behavior of many tumors and is a promising target of molecular therapy.\nMETHODS: To better elucidate the relevance of EZH2 in breast cancer subtypes, we evaluated EZH2 expression in 226 invasive breast carcinomas with four distinct immunophenotypes and in association with clinicopathological features.\nRESULTS: Of these cases, 138 (61.1\u00a0%) were defined as EZH2-overexpressing with a multiplicative score\u2009>\u20093. EZH2 expression was inversely related to the status of ER and PR (Chi-square, p\u2009<\u20090.001), and it was significantly associated with HER2 positivity, high proliferative index, and high histologic grade (Chi-square, p\u2009<\u20090.05). ER-positive breast carcinoma with low proliferative index (Ki67\u2009<\u200914\u00a0%) showed the lowest expression and triple-negative breast carcinoma showed the highest overexpression of EZH2, 18.5\u00a0% (10/54) versus 90.9\u00a0% (50/55) (Chi-square, p\u2009<\u20090.001). Intriguingly, 88\u00a0% (44/50) cases of grade 3 triple-negative breast carcinoma showed uniformly strong EZH2 expression with a multiplicative score of 9. The percentage of EZH2 overexpression in ER-positive breast carcinoma with a high proliferative index or HER2-positive cases were 61.2 and 74\u00a0%, respectively. Furthermore, EZH2 expression was significantly elevated in high-grade DCIS compared to benign lesions (90\u00a0% versus 0, p\u2009<\u20090.001). However, there is no association between EZH2 expression and the status of histone 3 lysine 27 trimethylation or other clinicopathologic features.\nCONCLUSION: In summary, triple-negative breast carcinoma showed the highest overexpression of EZH2. EZH2 overexpression is associated aggressive pathologic features including high nuclear grade, high proliferative index, and positivity of HER2 of breast carcinoma.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13000-016-0491-5", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1327435", 
        "issn": [
          "2364-4893", 
          "1746-1596"
        ], 
        "name": "Diagnostic Pathology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "11"
      }
    ], 
    "name": "EZH2 overexpression in different immunophenotypes of breast carcinoma and association with clinicopathologic features", 
    "pagination": "41", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "39dcfde2c02192883b8eb483d491df7a9a59de9f97fd96b641475b4ea422d08a"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27113214"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101251558"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13000-016-0491-5"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1012145202"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13000-016-0491-5", 
      "https://app.dimensions.ai/details/publication/pub.1012145202"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:51", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000347_0000000347/records_89789_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs13000-016-0491-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13000-016-0491-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13000-016-0491-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13000-016-0491-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13000-016-0491-5'


 

This table displays all metadata directly associated to this object as RDF triples.

285 TRIPLES      21 PREDICATES      78 URIs      42 LITERALS      30 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13000-016-0491-5 schema:about N02d7e5580bd04d768396329b8eff0f63
2 N10ae7dbbd1eb4ca2a466876692a2cdd7
3 N10ebd49eac84422283ebe5390eaab1ba
4 N1df9ea402b59467891283e53d165f972
5 N237c33de50e44804a941360153897e05
6 N3239630593f64dccbbd8eb6e85c4b94a
7 N3fcd84ebfa8041369d9f39c97fb08b29
8 N454265a8817b4b9b91ece78f42ff3749
9 N4da34310894b4867a1409c16e6367728
10 N5012a706c4be4c6690377e6bb1b1000d
11 N538ca3a60b814b99a0c5480b7c37f1d5
12 N5b933c858ee6433b95340c6d2d65f164
13 N609418b4fe9142e5ba4fa1ae93dc1169
14 N6849a4e3522e4035b023a74b2113ad6b
15 N6cdc47c0d61c41f29aac0ac91b5635c5
16 Nbf86b5f915a04e65bd8770283beb08bc
17 Ndaa8c580260b4936a03e0d36157e1c28
18 Nde154cf3bf9a45bbb3e9a3e98c87ca6d
19 Ne6a7c97723ef4bc39b6a2ffd4c9b2c72
20 Needdfc64e804494bbdddf6d86127eeff
21 Nf92cc9e4792642618dfafc89fcf0c0f3
22 anzsrc-for:11
23 anzsrc-for:1112
24 schema:author Nfe6bb4d44b8145db9d08168ce56e1b1e
25 schema:citation sg:pub.10.1038/ncomms6987
26 sg:pub.10.1038/onc.2008.433
27 sg:pub.10.1038/onc.2011.118
28 sg:pub.10.1038/onc.2012.390
29 https://doi.org/10.1002/cncr.22381
30 https://doi.org/10.1016/j.humpath.2011.12.004
31 https://doi.org/10.1016/j.molonc.2012.06.002
32 https://doi.org/10.1073/pnas.1308953111
33 https://doi.org/10.1073/pnas.1933744100
34 https://doi.org/10.1080/00313020802563510
35 https://doi.org/10.1093/annonc/mdu391
36 https://doi.org/10.1093/emboj/cdg542
37 https://doi.org/10.1097/pat.0b013e3283534bcb
38 https://doi.org/10.1128/mcb.00426-13
39 https://doi.org/10.1158/0008-5472.can-05-4300
40 https://doi.org/10.1158/0008-5472.can-06-2384
41 https://doi.org/10.1158/0008-5472.can-10-1199
42 https://doi.org/10.1158/0008-5472.can-11-3546
43 https://doi.org/10.1158/1078-0432.ccr-05-1533
44 https://doi.org/10.1158/1078-0432.ccr-06-3045
45 https://doi.org/10.1200/jco.2005.01.5180
46 https://doi.org/10.1200/jco.2009.25.6529
47 https://doi.org/10.2147/ott.s67673
48 https://doi.org/10.2174/1871520615666150129211901
49 https://doi.org/10.2217/epi.14.59
50 https://doi.org/10.4161/cbt.27306
51 https://doi.org/10.4161/epi.24532
52 https://doi.org/10.5858/arpa.2013-0953-sa
53 schema:datePublished 2016-12
54 schema:datePublishedReg 2016-12-01
55 schema:description BACKGROUND: Enhancer of zest homolog 2 (EZH2), a histone 3 methyltransferase, is associated with aggressive behavior of many tumors and is a promising target of molecular therapy. METHODS: To better elucidate the relevance of EZH2 in breast cancer subtypes, we evaluated EZH2 expression in 226 invasive breast carcinomas with four distinct immunophenotypes and in association with clinicopathological features. RESULTS: Of these cases, 138 (61.1 %) were defined as EZH2-overexpressing with a multiplicative score > 3. EZH2 expression was inversely related to the status of ER and PR (Chi-square, p < 0.001), and it was significantly associated with HER2 positivity, high proliferative index, and high histologic grade (Chi-square, p < 0.05). ER-positive breast carcinoma with low proliferative index (Ki67 < 14 %) showed the lowest expression and triple-negative breast carcinoma showed the highest overexpression of EZH2, 18.5 % (10/54) versus 90.9 % (50/55) (Chi-square, p < 0.001). Intriguingly, 88 % (44/50) cases of grade 3 triple-negative breast carcinoma showed uniformly strong EZH2 expression with a multiplicative score of 9. The percentage of EZH2 overexpression in ER-positive breast carcinoma with a high proliferative index or HER2-positive cases were 61.2 and 74 %, respectively. Furthermore, EZH2 expression was significantly elevated in high-grade DCIS compared to benign lesions (90 % versus 0, p < 0.001). However, there is no association between EZH2 expression and the status of histone 3 lysine 27 trimethylation or other clinicopathologic features. CONCLUSION: In summary, triple-negative breast carcinoma showed the highest overexpression of EZH2. EZH2 overexpression is associated aggressive pathologic features including high nuclear grade, high proliferative index, and positivity of HER2 of breast carcinoma.
56 schema:genre research_article
57 schema:inLanguage en
58 schema:isAccessibleForFree true
59 schema:isPartOf N0da9777cf3a14290afc739c3ac42b109
60 Ncb4e848bcb874ef7a4f14bd8ab88520a
61 sg:journal.1327435
62 schema:name EZH2 overexpression in different immunophenotypes of breast carcinoma and association with clinicopathologic features
63 schema:pagination 41
64 schema:productId N059b5191510c4ae7aae09b989c3edc56
65 N2ccf6233f77a4171a9cc3500386b1d7e
66 N86c592bd50494d328cb6a8e7ebd20379
67 Nf0fa582fd7044d75ace9f71276e453eb
68 Nf52b12ea89964ab39bd0c3b082ed0400
69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012145202
70 https://doi.org/10.1186/s13000-016-0491-5
71 schema:sdDatePublished 2019-04-11T09:51
72 schema:sdLicense https://scigraph.springernature.com/explorer/license/
73 schema:sdPublisher Ndd57aa9d14a44bf0b75bd39cfeaf4430
74 schema:url https://link.springer.com/10.1186%2Fs13000-016-0491-5
75 sgo:license sg:explorer/license/
76 sgo:sdDataset articles
77 rdf:type schema:ScholarlyArticle
78 N00344d03b3ef4f888d382784a8b37bdc rdf:first Nd1491c0856e44c69b919c7f29af393e7
79 rdf:rest Nb899075e57fe4864b804f8695e7dddb0
80 N02d7e5580bd04d768396329b8eff0f63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Enhancer of Zeste Homolog 2 Protein
82 rdf:type schema:DefinedTerm
83 N059b5191510c4ae7aae09b989c3edc56 schema:name pubmed_id
84 schema:value 27113214
85 rdf:type schema:PropertyValue
86 N0da9777cf3a14290afc739c3ac42b109 schema:issueNumber 1
87 rdf:type schema:PublicationIssue
88 N10ae7dbbd1eb4ca2a466876692a2cdd7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Cell Proliferation
90 rdf:type schema:DefinedTerm
91 N10ebd49eac84422283ebe5390eaab1ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Neoplasm Grading
93 rdf:type schema:DefinedTerm
94 N1df9ea402b59467891283e53d165f972 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Triple Negative Breast Neoplasms
96 rdf:type schema:DefinedTerm
97 N237c33de50e44804a941360153897e05 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Humans
99 rdf:type schema:DefinedTerm
100 N2ccf6233f77a4171a9cc3500386b1d7e schema:name readcube_id
101 schema:value 39dcfde2c02192883b8eb483d491df7a9a59de9f97fd96b641475b4ea422d08a
102 rdf:type schema:PropertyValue
103 N3239630593f64dccbbd8eb6e85c4b94a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Aged
105 rdf:type schema:DefinedTerm
106 N3fcd84ebfa8041369d9f39c97fb08b29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Immunohistochemistry
108 rdf:type schema:DefinedTerm
109 N454265a8817b4b9b91ece78f42ff3749 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Predictive Value of Tests
111 rdf:type schema:DefinedTerm
112 N47757881e8f94788be2f9d8154255df3 rdf:first sg:person.0630461205.19
113 rdf:rest Nf8f3cf61d9b142e489aec728e9da82dc
114 N4da34310894b4867a1409c16e6367728 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Polycomb Repressive Complex 2
116 rdf:type schema:DefinedTerm
117 N5012a706c4be4c6690377e6bb1b1000d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Phenotype
119 rdf:type schema:DefinedTerm
120 N538ca3a60b814b99a0c5480b7c37f1d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Receptor, ErbB-2
122 rdf:type schema:DefinedTerm
123 N5b933c858ee6433b95340c6d2d65f164 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Aged, 80 and over
125 rdf:type schema:DefinedTerm
126 N609418b4fe9142e5ba4fa1ae93dc1169 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Middle Aged
128 rdf:type schema:DefinedTerm
129 N6849a4e3522e4035b023a74b2113ad6b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Female
131 rdf:type schema:DefinedTerm
132 N6cdc47c0d61c41f29aac0ac91b5635c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Breast Neoplasms
134 rdf:type schema:DefinedTerm
135 N86c592bd50494d328cb6a8e7ebd20379 schema:name dimensions_id
136 schema:value pub.1012145202
137 rdf:type schema:PropertyValue
138 Na89753f0bfa041b99f101b1f93c60e85 rdf:first sg:person.01202060376.90
139 rdf:rest Nd415b6ec3641464ba194aa7c057a651b
140 Nb899075e57fe4864b804f8695e7dddb0 rdf:first sg:person.01067625121.42
141 rdf:rest rdf:nil
142 Nbf86b5f915a04e65bd8770283beb08bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Carcinoma
144 rdf:type schema:DefinedTerm
145 Ncb4e848bcb874ef7a4f14bd8ab88520a schema:volumeNumber 11
146 rdf:type schema:PublicationVolume
147 Nd1491c0856e44c69b919c7f29af393e7 schema:affiliation https://www.grid.ac/institutes/grid.233520.5
148 schema:familyName Chen
149 schema:givenName Peng
150 rdf:type schema:Person
151 Nd415b6ec3641464ba194aa7c057a651b rdf:first sg:person.01103252766.82
152 rdf:rest N00344d03b3ef4f888d382784a8b37bdc
153 Ndaa8c580260b4936a03e0d36157e1c28 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Neoplasm Invasiveness
155 rdf:type schema:DefinedTerm
156 Ndd57aa9d14a44bf0b75bd39cfeaf4430 schema:name Springer Nature - SN SciGraph project
157 rdf:type schema:Organization
158 Nde154cf3bf9a45bbb3e9a3e98c87ca6d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Biomarkers, Tumor
160 rdf:type schema:DefinedTerm
161 Ne6a7c97723ef4bc39b6a2ffd4c9b2c72 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Up-Regulation
163 rdf:type schema:DefinedTerm
164 Needdfc64e804494bbdddf6d86127eeff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Adult
166 rdf:type schema:DefinedTerm
167 Nf0fa582fd7044d75ace9f71276e453eb schema:name nlm_unique_id
168 schema:value 101251558
169 rdf:type schema:PropertyValue
170 Nf52b12ea89964ab39bd0c3b082ed0400 schema:name doi
171 schema:value 10.1186/s13000-016-0491-5
172 rdf:type schema:PropertyValue
173 Nf8f3cf61d9b142e489aec728e9da82dc rdf:first sg:person.0637150121.38
174 rdf:rest Na89753f0bfa041b99f101b1f93c60e85
175 Nf92cc9e4792642618dfafc89fcf0c0f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Ki-67 Antigen
177 rdf:type schema:DefinedTerm
178 Nfe6bb4d44b8145db9d08168ce56e1b1e rdf:first sg:person.01242362136.78
179 rdf:rest N47757881e8f94788be2f9d8154255df3
180 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
181 schema:name Medical and Health Sciences
182 rdf:type schema:DefinedTerm
183 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
184 schema:name Oncology and Carcinogenesis
185 rdf:type schema:DefinedTerm
186 sg:journal.1327435 schema:issn 1746-1596
187 2364-4893
188 schema:name Diagnostic Pathology
189 rdf:type schema:Periodical
190 sg:person.01067625121.42 schema:affiliation https://www.grid.ac/institutes/grid.233520.5
191 schema:familyName Wang
192 schema:givenName Zhe
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067625121.42
194 rdf:type schema:Person
195 sg:person.01103252766.82 schema:affiliation https://www.grid.ac/institutes/grid.233520.5
196 schema:familyName Ma
197 schema:givenName Shirong
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103252766.82
199 rdf:type schema:Person
200 sg:person.01202060376.90 schema:affiliation https://www.grid.ac/institutes/grid.233520.5
201 schema:familyName Wang
202 schema:givenName Yingmei
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202060376.90
204 rdf:type schema:Person
205 sg:person.01242362136.78 schema:affiliation https://www.grid.ac/institutes/grid.233520.5
206 schema:familyName Guo
207 schema:givenName Shuangping
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242362136.78
209 rdf:type schema:Person
210 sg:person.0630461205.19 schema:affiliation https://www.grid.ac/institutes/grid.233520.5
211 schema:familyName Li
212 schema:givenName Xia
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630461205.19
214 rdf:type schema:Person
215 sg:person.0637150121.38 schema:affiliation https://www.grid.ac/institutes/grid.266813.8
216 schema:familyName Rohr
217 schema:givenName Joseph
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637150121.38
219 rdf:type schema:Person
220 sg:pub.10.1038/ncomms6987 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007923439
221 https://doi.org/10.1038/ncomms6987
222 rdf:type schema:CreativeWork
223 sg:pub.10.1038/onc.2008.433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019798988
224 https://doi.org/10.1038/onc.2008.433
225 rdf:type schema:CreativeWork
226 sg:pub.10.1038/onc.2011.118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033534564
227 https://doi.org/10.1038/onc.2011.118
228 rdf:type schema:CreativeWork
229 sg:pub.10.1038/onc.2012.390 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011568592
230 https://doi.org/10.1038/onc.2012.390
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1002/cncr.22381 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036147682
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/j.humpath.2011.12.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017914229
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/j.molonc.2012.06.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011420580
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1073/pnas.1308953111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000483367
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1073/pnas.1933744100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006013665
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1080/00313020802563510 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045011485
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1093/annonc/mdu391 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035440462
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1093/emboj/cdg542 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029576413
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1097/pat.0b013e3283534bcb schema:sameAs https://app.dimensions.ai/details/publication/pub.1060343612
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1128/mcb.00426-13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026714846
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1158/0008-5472.can-05-4300 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010802411
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1158/0008-5472.can-06-2384 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018316116
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1158/0008-5472.can-10-1199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022542303
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1158/0008-5472.can-11-3546 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022967334
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1158/1078-0432.ccr-05-1533 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006433730
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1158/1078-0432.ccr-06-3045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048367977
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1200/jco.2005.01.5180 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046338079
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1200/jco.2009.25.6529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016721540
267 rdf:type schema:CreativeWork
268 https://doi.org/10.2147/ott.s67673 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044115872
269 rdf:type schema:CreativeWork
270 https://doi.org/10.2174/1871520615666150129211901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069219098
271 rdf:type schema:CreativeWork
272 https://doi.org/10.2217/epi.14.59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010854839
273 rdf:type schema:CreativeWork
274 https://doi.org/10.4161/cbt.27306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072293046
275 rdf:type schema:CreativeWork
276 https://doi.org/10.4161/epi.24532 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042356293
277 rdf:type schema:CreativeWork
278 https://doi.org/10.5858/arpa.2013-0953-sa schema:sameAs https://app.dimensions.ai/details/publication/pub.1023063099
279 rdf:type schema:CreativeWork
280 https://www.grid.ac/institutes/grid.233520.5 schema:alternateName Fourth Military Medical University
281 schema:name Department of Pathology, Xi Jing Hospital, the Fourth Military Medical University, 710032, Xi’an, Shaan Xi Province, China
282 rdf:type schema:Organization
283 https://www.grid.ac/institutes/grid.266813.8 schema:alternateName University of Nebraska Medical Center
284 schema:name Department of Pathology and Microbiology, University of Nebraska Medical Center, 68105, Omaha, NE, USA
285 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...