Usefulness of pT1 substaging in papillary urothelial bladder carcinoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Carlo Patriarca, Rodolfo Hurle, Marco Moschini, Massimo Freschi, Piergiuseppe Colombo, Maurizio Colecchia, Lucia Ferrari, Giorgio Guazzoni, Andrea Conti, Giario Conti, Roberta Lucianò, Tiziana Magnani, Renzo Colombo

ABSTRACT

BACKGROUND: When treating bladder cancer patients, the most significant problems usually concern cases with high-grade non-muscle-invasive carcinoma, and a better understanding of which patients would benefit from early radical cystectomy is urgently needed. The uropathology community is seeking more user-friendly approaches to distinguishing between T1 cancers exhibiting different types of clinical behavior. METHODS: After a retrospective review, we selected a group of 314 patients who underwent transurethral resection of the bladder (TURB) and were diagnosed with high-grade urothelial carcinoma staged as T1. Three different substaging systems were applied: one was the anatomy-based T1 a/b; and two involved micrometric thresholds of either 0.5 mm of invasion (as proposed by van Rhijn et al.), or 1 mm of invasion (as proposed in the present study). Early reTUR (repeated transurethral resection) was performed in 250 patients, and the same substaging approaches were applied to cases of T1. RESULTS: It proved feasible to apply the 1 mm substaging system in 100 % of cases, the van Rhijn system in 100 %, and the anatomy-based method (T1 a/b) in 72.3 % of cases. At a mean follow-up of 46 months, the recurrence-free survival rate was significantly better (p < 0.001) in the group that underwent reTUR, while none of the three substaging systems reliably predicted recurrences. The 1 mm did seem promising, however, as a threshold for predicting progression, reaching statistical significance in the Kaplan Meier estimates (p < 0.04). CONCLUSION: Our study shows that micrometric substaging is feasible in this setting and should be extended to include any early reTUR to complete the substaging done after the first TURB. It can also provide helpful prognostic information. More... »

PAGES

6

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13000-016-0466-6

DOI

http://dx.doi.org/10.1186/s13000-016-0466-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046309137

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26791567


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Download the RDF metadata as:  json-ld nt turtle xml License info

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RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13000-016-0466-6'


 

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