Obstacles and opportunities in Chinese pharmaceutical innovation View Full Text


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Article Info

DATE

2017-12

AUTHORS

Jingyun Ni, Junrui Zhao, Carolina Oi Lam Ung, Yuanjia Hu, Hao Hu, Yitao Wang

ABSTRACT

BACKGROUND: Global healthcare innovation networks nowadays have expanded beyond developed countries with many developing countries joining the force and becoming important players. China, in particular, has seen a significant increase in the number of innovative firms and research organizations stepping up to the global network in recent years. Nevertheless, the intense Research and Development input has not brought about the expectable output. While China is ascending at a great speed to a leading position worldwide in terms of Research and Development investment, scientific publications and patents, the innovation capabilities in the pharmaceutical sector remain weak. DISCUSSION: This study discusses the challenges and opportunities for pharmaceutical innovation in China. One hand, academic, industrial, institutional and financial constraints were found to be the major and inevitable barriers hindering the development of drug innovation. On the other hand, unique advantages had been observed which included growing pharmaceutical market, Research and Development funding, distinctive source, and international cooperation. The most important thing for China's pharmaceutical sector to leap forward is to break though innovation barriers and integrate own advantages into global value-chain of healthcare product development. More... »

PAGES

21

References to SciGraph publications

  • 2010-03. Deconstructing the Drug Development Process: The New Face of Innovation in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2014-12. The Dutch health care performance report: seven years of health care performance assessment in the Netherlands in HEALTH RESEARCH POLICY AND SYSTEMS
  • 2012-10. Innovative drugs and vaccines in China, India and Brazil in NATURE BIOTECHNOLOGY
  • 2010-01-14. Publish or perish in China in NATURE
  • 2013-12. How to create innovation by building the translation bridge from basic research into medicinal drugs: an industrial perspective in HUMAN GENOMICS
  • 2013-12. Softwares and methods for estimating genetic ancestry in human populations in HUMAN GENOMICS
  • 2014-03-05. China: At a crossroads in NATURE
  • 2011-05. Innovative drug R&D in China in NATURE REVIEWS DRUG DISCOVERY
  • 2014-09-23. Chinese science gets mass transformation in NATURE
  • 2014-09. Market watch: A framework for biomedical innovation in emerging markets in NATURE REVIEWS DRUG DISCOVERY
  • 2010-06. Evolving R&D for emerging markets in NATURE REVIEWS DRUG DISCOVERY
  • 2010-05. Can Open‐Source Drug R&D Repower Pharmaceutical Innovation? in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2012-12. Emergence of biopharmaceutical innovators in China, India, Brazil, and South Africa as global competitors and collaborators in HEALTH RESEARCH POLICY AND SYSTEMS
  • 2014-12. Contract Research Organizations (CROs) in China: integrating Chinese research and development capabilities for global drug innovation in GLOBALIZATION AND HEALTH
  • 2008-11. Enforcing pharmaceutical and biotech patent rights in China in NATURE BIOTECHNOLOGY
  • 2012-12. Clinical practice guidelines within the Southern African development community: a descriptive study of the quality of guideline development and concordance with best evidence for five priority diseases in HEALTH RESEARCH POLICY AND SYSTEMS
  • 2008-01. Chinese health biotech and the billion-patient market in NATURE BIOTECHNOLOGY
  • 2014-12. Public funding and private investment for R&D: a survey in China’s pharmaceutical industry in HEALTH RESEARCH POLICY AND SYSTEMS
  • 2016-12. Analyzing the Chinese landscape in anti-diabetic drug research: leading knowledge production institutions and thematic communities in CHINESE MEDICINE
  • 2012-03. Diagnosing the decline in pharmaceutical R&D efficiency in NATURE REVIEWS DRUG DISCOVERY
  • 2010-11. Location of pharmaceutical innovation: 2000–2009 in NATURE REVIEWS DRUG DISCOVERY
  • 2014-12. Value innovation: an important aspect of global surgical care in GLOBALIZATION AND HEALTH
  • 2013-03. Life sciences venture capital in emerging markets in NATURE BIOTECHNOLOGY
  • 2010-09. Global health or global wealth? in NATURE BIOTECHNOLOGY
  • Identifiers

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    http://scigraph.springernature.com/pub.10.1186/s12992-017-0244-6

    DOI

    http://dx.doi.org/10.1186/s12992-017-0244-6

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28340579


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    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12992-017-0244-6'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12992-017-0244-6'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12992-017-0244-6'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12992-017-0244-6'


     

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