Effects of maternal inhalation of carbon black nanoparticles on reproductive and fertility parameters in a four-generation study of male mice View Full Text


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Article Info

DATE

2019-03-18

AUTHORS

Astrid Skovmand, Alexander C. Ø. Jensen, Clotilde Maurice, Francesco Marchetti, Anna J. Lauvås, Ismo K. Koponen, Keld A. Jensen, Sandra Goericke-Pesch, Ulla Vogel, Karin S. Hougaard

ABSTRACT

BackgroundPrevious findings indicate that in utero exposure to nanoparticles may affect the reproductive system in male offspring. Effects such as decreased sperm counts and testicular structural changes in F1 males have been reported following maternal airway exposure to carbon black during gestation. In addition, a previous study in our laboratory suggested that the effects of in utero exposure of nanoparticles may span further than the first generation, as sperm content per gram of testis was significantly lowered in F2 males. In the present study we assessed male fertility parameters following in utero inhalation exposure to carbon black in four generations of mice.ResultsFilter measurements demonstrated that the time-mated females were exposed to a mean total suspended particle mass concentration of 4.79 ± 1.86 or 33.87 ± 14.77 mg/m3 for the low and high exposure, respectively. The control exposure was below the detection limit (LOD 0.08 mg/m3). Exposure did not affect gestation and litter parameters in any generation. No significant changes were observed in body and reproductive organ weights, epididymal sperm parameters, daily sperm production, plasma testosterone or fertility.ConclusionIn utero exposure to carbon black nanoparticles, at occupationally relevant exposure levels, via maternal whole body inhalation did not affect male-specific reproductive, fertility and litter parameters in four generations of mice. More... »

PAGES

13

References to SciGraph publications

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    33 schema:description BackgroundPrevious findings indicate that in utero exposure to nanoparticles may affect the reproductive system in male offspring. Effects such as decreased sperm counts and testicular structural changes in F1 males have been reported following maternal airway exposure to carbon black during gestation. In addition, a previous study in our laboratory suggested that the effects of in utero exposure of nanoparticles may span further than the first generation, as sperm content per gram of testis was significantly lowered in F2 males. In the present study we assessed male fertility parameters following in utero inhalation exposure to carbon black in four generations of mice.ResultsFilter measurements demonstrated that the time-mated females were exposed to a mean total suspended particle mass concentration of 4.79 ± 1.86 or 33.87 ± 14.77 mg/m3 for the low and high exposure, respectively. The control exposure was below the detection limit (LOD 0.08 mg/m3). Exposure did not affect gestation and litter parameters in any generation. No significant changes were observed in body and reproductive organ weights, epididymal sperm parameters, daily sperm production, plasma testosterone or fertility.ConclusionIn utero exposure to carbon black nanoparticles, at occupationally relevant exposure levels, via maternal whole body inhalation did not affect male-specific reproductive, fertility and litter parameters in four generations of mice.
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    43 F2 males
    44 ResultsFilter measurements
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    46 airway exposure
    47 black nanoparticles
    48 body
    49 body inhalation
    50 carbon
    51 carbon black nanoparticles
    52 changes
    53 concentration
    54 content
    55 control exposure
    56 count
    57 daily sperm production
    58 detection limit
    59 effect
    60 epididymal sperm parameters
    61 exposure
    62 exposure levels
    63 females
    64 fertility
    65 fertility parameters
    66 findings
    67 first generation
    68 four-generation study
    69 generation
    70 generation of mice
    71 gestation
    72 high exposure
    73 inhalation
    74 inhalation exposure
    75 laboratory
    76 levels
    77 limit
    78 litter parameters
    79 m3
    80 male fertility parameters
    81 male mice
    82 male offspring
    83 male-specific reproductive
    84 males
    85 mass concentration
    86 maternal airway exposure
    87 maternal inhalation
    88 maternal whole body inhalation
    89 mean total
    90 measurements
    91 mice
    92 nanoparticles
    93 offspring
    94 organ weights
    95 parameters
    96 particle mass concentration
    97 present study
    98 previous studies
    99 production
    100 reproductive
    101 reproductive organ weights
    102 reproductive system
    103 significant changes
    104 sperm content
    105 sperm count
    106 sperm parameters
    107 sperm production
    108 structural changes
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