Osteopontin enhances multi-walled carbon nanotube-triggered lung fibrosis by promoting TGF-β1 activation and myofibroblast differentiation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Jie Dong, Qiang Ma

ABSTRACT

BACKGROUND: Carbon nanotubes (CNTs) have been used in a variety of applications because of their unique properties and functions. However, many CNTs have been shown to induce lung fibrosis in experimental animals with some at a potency greater than that of silica, raising concern over possible toxic effects of CNT exposure in humans. Research into the mechanisms by which CNTs induce pulmonary fibrosis is warranted in order to facilitate the understanding, monitoring, and treatment of CNT-induced lung lesions that might occur in exposed populations. The current study focuses on investigating the role of osteopontin (OPN) in the development of lung fibrosis upon exposure to multi-walled carbon nanotubes (MWCNTs). METHODS: C57BL/6J (WT) and Opn knockout (KO) mice were exposed to MWCNTs by pharyngeal aspiration to examine the acute and chronic effects of MWCNT exposure. The role of OPN and its mode of action in lung fibrosis development were analyzed at the cellular and molecular levels in vivo and in vitro. RESULTS: OPN was highly and persistently induced in both the acute and chronic phases of the response to MWCNT exposure in mouse lungs. Comparison between WT and Opn KO mice revealed that OPN critically regulated MWCNT-induced lung fibrosis as indicated by reduced fibrotic focus formation and myofibroblast accumulation in Opn KO lungs. At the molecular level, OPN promotes the expression and activation of TGF-β1, stimulates the differentiation of myofibroblasts from fibroblasts, and increases the production of fibrous matrix proteins in lungs and cultured lung cells exposed to MWCNTs. CONCLUSION: OPN is highly induced in CNT-exposed lungs and plays critical roles in TGF-β1 signaling activation and myofibroblast differentiation to promote fibrosis development from MWCNT exposure. This study reveals an OPN-dependent mechanism to promote MWCNT-induced lung fibrosis. The findings raise the possibility of using OPN as a biomarker to monitor CNT exposure and as a drug target to halt fibrosis development. More... »

PAGES

18

References to SciGraph publications

  • 2012-10. Targeting the TGFβ signalling pathway in disease in NATURE REVIEWS DRUG DISCOVERY
  • 2016-09. In vivo activation of a T helper 2-driven innate immune response in lung fibrosis induced by multi-walled carbon nanotubes in ARCHIVES OF TOXICOLOGY
  • 2015-03. Evaluation of Fibrogenic Potential of Industrial Multi-Walled Carbon Nanotubes in Acute Aspiration Experiment in BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
  • 2016-06. TGF-β: the master regulator of fibrosis in NATURE REVIEWS NEPHROLOGY
  • 2002-05. Myofibroblasts and mechano-regulation of connective tissue remodelling in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2010-12. Asbestos, carbon nanotubes and the pleural mesothelium: a review of the hypothesis regarding the role of long fibre retention in the parietal pleura, inflammation and mesothelioma in PARTICLE AND FIBRE TOXICOLOGY
  • 2015-09. Osteopontin mediates an MZF1–TGF-β1-dependent transformation of mesenchymal stem cells into cancer-associated fibroblasts in breast cancer in ONCOGENE
  • 2012-06. Osteopontin in Systemic Sclerosis and Its Role in Dermal Fibrosis in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2011-12. Pulmonary fibrotic response to aspiration of multi-walled carbon nanotubes in PARTICLE AND FIBRE TOXICOLOGY
  • 2015-04. Pathologic and molecular profiling of rapid-onset fibrosis and inflammation induced by multi-walled carbon nanotubes in ARCHIVES OF TOXICOLOGY
  • 2013-12. Distribution and fibrotic response following inhalation exposure to multi-walled carbon nanotubes in PARTICLE AND FIBRE TOXICOLOGY
  • 2016-12. Myofibroblasts and lung fibrosis induced by carbon nanotube exposure in PARTICLE AND FIBRE TOXICOLOGY
  • 2013-12. Matrix regulation of idiopathic pulmonary fibrosis: the role of enzymes in FIBROGENESIS & TISSUE REPAIR
  • 2016-02. Common and distinct mechanisms of induced pulmonary fibrosis by particulate and soluble chemical fibrogenic agents in ARCHIVES OF TOXICOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12989-017-0198-0

    DOI

    http://dx.doi.org/10.1186/s12989-017-0198-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1085930507

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28595626


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