Lung inflammation and lack of genotoxicity in the comet and micronucleus assays of industrial multiwalled carbon nanotubes Graphistrength© C100 after ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Daniela Pothmann, Sophie Simar, Detlef Schuler, Eva Dony, Stéphane Gaering, Jean-Loïc Le Net, Yoshi Okazaki, Jean Michel Chabagno, Cécile Bessibes, Julien Beausoleil, Fabrice Nesslany, Jean-François Régnier

ABSTRACT

BACKGROUND: Graphistrength (©) C100 multiwalled carbon nanotubes (MWCNT) provide superior electrical and mechanical properties for various applications. The evaluation of the intrinsic hazard properties of Graphistrength(©) C100 is an essential step for safe use. A general feature of multiwalled carbon nanotubes after inhalation or intratracheal exposures is the induction of an inflammatory reaction in the lungs sometimes associated with local genotoxic effects. METHODS: After investigating different parameters for the aerosol generation and performing a 5-day inhalation range finding study, male and female Wistar rats were exposed nose-only for 90 days to target concentrations of 0.05, 0.25 and 5.0 mg/m(3) air of Graphistrength (©) C100 and sacrificed 24 h and 90 days after the last exposure. Broncho-alveolar lavage fluid (BALF) was also collected and analyzed for inflammatory parameters. Twenty-four hours post-exposure, chromosomal aberrations in the bone marrow cells were evaluated by the micronucleus test and DNA damages in the lung, kidney and liver cells by both the standard and the human 8-oxoguanine DNA N-glycosylase 1 (hOGG1)-modified comet assay. All studies were performed according to the OECD test guidelines. RESULTS: An inflammatory lung reaction and the release of inflammatory factors in the BALF were observed in all rats exposed to 5.0 mg/m(3), associated with changes in the differential white blood cells counts. The slight changes in BALF parameters at 0.25 mg/m(3) recovered and signs of lung clearance of the MWCNT were observed. No pathological changes were observed on the pleura. Neither increase in the number of micronucleated polychromatic erythrocytes nor increase in percent DNA damage were observed at any concentration. CONCLUSIONS: Lung inflammation characteristic of an overload with insoluble particles was observed after a 90-day exposure to 5.0 mg/m(3) of Graphistrength (©) C100. Clear signs of clearance and recovery were observed at 0.25 mg/m(3). No genotoxicity was detected locally in lung and distally in bone marrow, liver and kidney. Therefore, Graphistrength (©) C100 appears of low concern in term of local and systemic genotoxicity and a No-Observed Adverse Effect Concentration (NOAEC) of 0.25 mg/m(3) (0.28 mg/m(3) as actual concentration) was established for the repeated-dose toxicity. More... »

PAGES

21

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12989-015-0096-2

DOI

http://dx.doi.org/10.1186/s12989-015-0096-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051593715

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26156627


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aerosols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bronchoalveolar Lavage Fluid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Comet Assay", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Damage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Glycosylases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dose-Response Relationship, Drug", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Inflammation Mediators", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Inhalation Exposure", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lung", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Micronuclei, Chromosome-Defective", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Micronucleus Tests", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nanotubes, Carbon", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "No-Observed-Adverse-Effect Level", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Particle Size", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pneumonia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Predictive Value of Tests", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Wistar", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Assessment", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Harlan Laboratories Ltd, Zelgliweg 1, 4452, Itingen, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pothmann", 
        "givenName": "Daniela", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pasteur Institute of Lille", 
          "id": "https://www.grid.ac/institutes/grid.8970.6", 
          "name": [
            "Laboratoire de Toxicologie G\u00e9n\u00e9tique, Institut Pasteur de Lille, 1 rue du Pr. Calmette, 59019, Lille, Cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Simar", 
        "givenName": "Sophie", 
        "id": "sg:person.0612402570.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612402570.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Harlan Laboratories Ltd, Zelgliweg 1, 4452, Itingen, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schuler", 
        "givenName": "Detlef", 
        "id": "sg:person.0616437751.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616437751.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Harlan Cytotest Cell Research GmbH, In den Leppsteinwiesen 19, 64380, Rossdorf, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dony", 
        "givenName": "Eva", 
        "id": "sg:person.01342774241.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342774241.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Harlan Laboratories Ltd, Zelgliweg 1, 4452, Itingen, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gaering", 
        "givenName": "St\u00e9phane", 
        "id": "sg:person.0664553151.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664553151.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Le Net Pathology Consulting, 18 rue Henry Dunant, 37400, Amboise, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Le Net", 
        "givenName": "Jean-Lo\u00efc", 
        "id": "sg:person.01160363537.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160363537.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "AnaPath GmbH, Buchsweg 56, 4625, Oberbuchsiten, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Okazaki", 
        "givenName": "Yoshi", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Arkema (France)", 
          "id": "https://www.grid.ac/institutes/grid.423748.e", 
          "name": [
            "Arkema France, Groupement de Recherches de Lacq (GRL), Laboratoires d\u2019analyse de surface et microscopie et de chimie analytique, 64170, Lacq, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chabagno", 
        "givenName": "Jean Michel", 
        "id": "sg:person.01001731741.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001731741.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Arkema (France)", 
          "id": "https://www.grid.ac/institutes/grid.423748.e", 
          "name": [
            "Arkema France, Groupement de Recherches de Lacq (GRL), Laboratoires d\u2019analyse de surface et microscopie et de chimie analytique, 64170, Lacq, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bessibes", 
        "givenName": "C\u00e9cile", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Arkema (France)", 
          "id": "https://www.grid.ac/institutes/grid.423748.e", 
          "name": [
            "Arkema France, Groupement de Recherches de Lacq (GRL), Laboratoires d\u2019analyse de surface et microscopie et de chimie analytique, 64170, Lacq, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Beausoleil", 
        "givenName": "Julien", 
        "id": "sg:person.0617016542.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617016542.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e9 Lille 2 Droit et Sant\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.16780.38", 
          "name": [
            "Laboratoire de Toxicologie G\u00e9n\u00e9tique, Institut Pasteur de Lille, 1 rue du Pr. Calmette, 59019, Lille, Cedex, France", 
            "UDSL, EA 4483, D\u00e9partement Toxicologie-Sant\u00e9 Publique-Environnement, Facult\u00e9 de Pharmacie, 1 rue du Pr. Laguesse, 59019, Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nesslany", 
        "givenName": "Fabrice", 
        "id": "sg:person.01170135263.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170135263.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Arkema (France)", 
          "id": "https://www.grid.ac/institutes/grid.423748.e", 
          "name": [
            "Arkema France, D\u00e9partement Toxicologie et Environnement, 420 rue d\u2019 Estienne d\u2019 Orves, 92705, Colombes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "R\u00e9gnier", 
        "givenName": "Jean-Fran\u00e7ois", 
        "id": "sg:person.01040771212.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040771212.02"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s1470-2045(14)71109-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001331822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajpath.2011.02.040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004182430"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/pin.12093", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006183884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/08958370701496202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006709176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1222453", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007405937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/08958370902962291", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007645028"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2369-14-96", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008574359", 
          "https://doi.org/10.1186/1471-2369-14-96"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1743-8977-10-33", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010429460", 
          "https://doi.org/10.1186/1743-8977-10-33"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2131/jts.34.65", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011133183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0272-0590(90)90190-u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012025876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/08958370050029725", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012984644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1743-8977-9-46", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013777875", 
          "https://doi.org/10.1186/1743-8977-9-46"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12989-014-0061-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013973774", 
          "https://doi.org/10.1186/s12989-014-0061-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12989-014-0061-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013973774", 
          "https://doi.org/10.1186/s12989-014-0061-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/bgm243", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014113406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nano.2009.02.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014218183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00204-014-1356-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015708421", 
          "https://doi.org/10.1007/s00204-014-1356-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/toxsci/kfs161", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016772426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/b978-044452771-4/50007-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018024202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1110013108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018855731"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tiv.2013.06.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019165331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/mutage/gel019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020090552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/17435390.2012.674571", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022094423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.etp.2009.01.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022484171"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/toxsci/kft328", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024127161"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0027-5107(89)90035-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024490552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/9780470747803.ch17", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027038387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11051-010-0050-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029369624", 
          "https://doi.org/10.1007/s11051-010-0050-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/10715760601024122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029720953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1743-8977-11-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031007773", 
          "https://doi.org/10.1186/1743-8977-11-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1743-8977-11-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031007773", 
          "https://doi.org/10.1186/1743-8977-11-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/toxsci/kfp146", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031008275"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1743-8977-9-28", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031348540", 
          "https://doi.org/10.1186/1743-8977-9-28"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/08958378.2013.878006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034013970"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/17435390.2014.933903", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034200960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/15298668391405959", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037985620"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00204-011-0741-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038061282", 
          "https://doi.org/10.1007/s00204-011-0741-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nnano.2008.111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039268410", 
          "https://doi.org/10.1038/nnano.2008.111"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/17435390.2010.482751", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040788329"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/bgg144", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041020264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/0895-8378.1987.11463170", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041298983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2131/jts.33.105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041513197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/em.21881", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041850702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/15287390802476991", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043512006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tox.2010.04.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044243540"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1743-8977-10-23", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044394476", 
          "https://doi.org/10.1186/1743-8977-10-23"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/toxsci/kft089", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045860416"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/em.21922", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045975419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1743-8977-8-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048014863", 
          "https://doi.org/10.1186/1743-8977-8-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.2012.02318.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049043797"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/toxsci/kfp100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050782476"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/toxsci/kfp247", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053667774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/tx800100s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056299814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/tx800100s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056299814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/tx800101p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056299815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/tx800101p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056299815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0192623309353423", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063752828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0192623309353423", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063752828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077283345", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083169987", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-12", 
    "datePublishedReg": "2015-12-01", 
    "description": "BACKGROUND: Graphistrength (\u00a9) C100 multiwalled carbon nanotubes (MWCNT) provide superior electrical and mechanical properties for various applications. The evaluation of the intrinsic hazard properties of Graphistrength(\u00a9) C100 is an essential step for safe use. A general feature of multiwalled carbon nanotubes after inhalation or intratracheal exposures is the induction of an inflammatory reaction in the lungs sometimes associated with local genotoxic effects.\nMETHODS: After investigating different parameters for the aerosol generation and performing a 5-day inhalation range finding study, male and female Wistar rats were exposed nose-only for 90 days to target concentrations of 0.05, 0.25 and 5.0 mg/m(3) air of Graphistrength (\u00a9) C100 and sacrificed 24 h and 90 days after the last exposure. Broncho-alveolar lavage fluid (BALF) was also collected and analyzed for inflammatory parameters. Twenty-four hours post-exposure, chromosomal aberrations in the bone marrow cells were evaluated by the micronucleus test and DNA damages in the lung, kidney and liver cells by both the standard and the human 8-oxoguanine DNA N-glycosylase 1 (hOGG1)-modified comet assay. All studies were performed according to the OECD test guidelines.\nRESULTS: An inflammatory lung reaction and the release of inflammatory factors in the BALF were observed in all rats exposed to 5.0 mg/m(3), associated with changes in the differential white blood cells counts. The slight changes in BALF parameters at 0.25 mg/m(3) recovered and signs of lung clearance of the MWCNT were observed. No pathological changes were observed on the pleura. Neither increase in the number of micronucleated polychromatic erythrocytes nor increase in percent DNA damage were observed at any concentration.\nCONCLUSIONS: Lung inflammation characteristic of an overload with insoluble particles was observed after a 90-day exposure to 5.0 mg/m(3) of Graphistrength (\u00a9) C100. Clear signs of clearance and recovery were observed at 0.25 mg/m(3). No genotoxicity was detected locally in lung and distally in bone marrow, liver and kidney. Therefore, Graphistrength (\u00a9) C100 appears of low concern in term of local and systemic genotoxicity and a No-Observed Adverse Effect Concentration (NOAEC) of 0.25 mg/m(3) (0.28 mg/m(3) as actual concentration) was established for the repeated-dose toxicity.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12989-015-0096-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1034805", 
        "issn": [
          "1743-8977"
        ], 
        "name": "Particle and Fibre Toxicology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "12"
      }
    ], 
    "name": "Lung inflammation and lack of genotoxicity in the comet and micronucleus assays of industrial multiwalled carbon nanotubes Graphistrength\u00a9 C100 after a 90-day nose-only inhalation exposure of rats", 
    "pagination": "21", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "f5c45571c3cb573075e8c08ec580fd4f7b32e682ba63a7d148415904492c6652"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26156627"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101236354"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12989-015-0096-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1051593715"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12989-015-0096-2", 
      "https://app.dimensions.ai/details/publication/pub.1051593715"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:08", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000367_0000000367/records_88227_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2Fs12989-015-0096-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12989-015-0096-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12989-015-0096-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12989-015-0096-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12989-015-0096-2'


 

This table displays all metadata directly associated to this object as RDF triples.

425 TRIPLES      21 PREDICATES      106 URIs      43 LITERALS      31 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12989-015-0096-2 schema:about N05ecc12e8282489a828c2d3cfd084834
2 N113e68e90b46408e852985870b7ee1b0
3 N152122badd244ad496e0dd12d82ae839
4 N33a2446fd9ce4047a43c5cfa9a21b1df
5 N4de56d5560ee404fa8b75252d9d444a7
6 N4e9b10eddaa54faa813938a887dea04d
7 N51ca2a485f194a6692b1c6bbc7c15da5
8 N5aaf71706d524488bce947ffbc3e0126
9 N5addb3b8f5b444ccaac5bb19e59b6895
10 N5e4d6f3579e549d4975fee4741eac653
11 N787fc1b2fc07468c9e7711eb36d44b4d
12 N84913973208345988edd0a85498884a5
13 N854e836d8ab1474fbbdc6d74dc4846f1
14 N97903e6473fd4ee9be4584bc17025664
15 N9ee7a3de2c6d43df9176399308e9f19d
16 Na4756bdce89c48d4bfe251e1d9e1869a
17 Nab11b8e2a7e54303a678cb1731472b9a
18 Nb881ec7b94ce43aa9b94dca32378a879
19 Nbcb88df3f0c84e53bd68db4fdc76b303
20 Nbd15f372b96246838ff3c9bb17db5dda
21 Ndd39a2dbacbc4aaab8151fee21d35a6f
22 Neee443ee2a3c4b17ad25c6019582d5d0
23 anzsrc-for:11
24 anzsrc-for:1102
25 schema:author Nc10a4e4a133240d3b089265224b540fb
26 schema:citation sg:pub.10.1007/s00204-011-0741-y
27 sg:pub.10.1007/s00204-014-1356-x
28 sg:pub.10.1007/s11051-010-0050-z
29 sg:pub.10.1038/nnano.2008.111
30 sg:pub.10.1186/1471-2369-14-96
31 sg:pub.10.1186/1743-8977-10-23
32 sg:pub.10.1186/1743-8977-10-33
33 sg:pub.10.1186/1743-8977-11-3
34 sg:pub.10.1186/1743-8977-8-3
35 sg:pub.10.1186/1743-8977-9-28
36 sg:pub.10.1186/1743-8977-9-46
37 sg:pub.10.1186/s12989-014-0061-5
38 https://app.dimensions.ai/details/publication/pub.1077283345
39 https://app.dimensions.ai/details/publication/pub.1083169987
40 https://doi.org/10.1002/9780470747803.ch17
41 https://doi.org/10.1002/em.21881
42 https://doi.org/10.1002/em.21922
43 https://doi.org/10.1016/0027-5107(89)90035-3
44 https://doi.org/10.1016/0272-0590(90)90190-u
45 https://doi.org/10.1016/b978-044452771-4/50007-9
46 https://doi.org/10.1016/j.ajpath.2011.02.040
47 https://doi.org/10.1016/j.etp.2009.01.001
48 https://doi.org/10.1016/j.nano.2009.02.006
49 https://doi.org/10.1016/j.tiv.2013.06.009
50 https://doi.org/10.1016/j.tox.2010.04.001
51 https://doi.org/10.1016/s1470-2045(14)71109-x
52 https://doi.org/10.1021/tx800100s
53 https://doi.org/10.1021/tx800101p
54 https://doi.org/10.1073/pnas.1110013108
55 https://doi.org/10.1080/0895-8378.1987.11463170
56 https://doi.org/10.1080/08958370050029725
57 https://doi.org/10.1080/08958370701496202
58 https://doi.org/10.1080/08958370902962291
59 https://doi.org/10.1080/10715760601024122
60 https://doi.org/10.1080/15287390802476991
61 https://doi.org/10.1080/15298668391405959
62 https://doi.org/10.1093/carcin/bgg144
63 https://doi.org/10.1093/carcin/bgm243
64 https://doi.org/10.1093/mutage/gel019
65 https://doi.org/10.1093/toxsci/kfp100
66 https://doi.org/10.1093/toxsci/kfp146
67 https://doi.org/10.1093/toxsci/kfp247
68 https://doi.org/10.1093/toxsci/kfs161
69 https://doi.org/10.1093/toxsci/kft089
70 https://doi.org/10.1093/toxsci/kft328
71 https://doi.org/10.1111/j.1349-7006.2012.02318.x
72 https://doi.org/10.1111/pin.12093
73 https://doi.org/10.1126/science.1222453
74 https://doi.org/10.1177/0192623309353423
75 https://doi.org/10.2131/jts.33.105
76 https://doi.org/10.2131/jts.34.65
77 https://doi.org/10.3109/08958378.2013.878006
78 https://doi.org/10.3109/17435390.2010.482751
79 https://doi.org/10.3109/17435390.2012.674571
80 https://doi.org/10.3109/17435390.2014.933903
81 schema:datePublished 2015-12
82 schema:datePublishedReg 2015-12-01
83 schema:description BACKGROUND: Graphistrength (©) C100 multiwalled carbon nanotubes (MWCNT) provide superior electrical and mechanical properties for various applications. The evaluation of the intrinsic hazard properties of Graphistrength(©) C100 is an essential step for safe use. A general feature of multiwalled carbon nanotubes after inhalation or intratracheal exposures is the induction of an inflammatory reaction in the lungs sometimes associated with local genotoxic effects. METHODS: After investigating different parameters for the aerosol generation and performing a 5-day inhalation range finding study, male and female Wistar rats were exposed nose-only for 90 days to target concentrations of 0.05, 0.25 and 5.0 mg/m(3) air of Graphistrength (©) C100 and sacrificed 24 h and 90 days after the last exposure. Broncho-alveolar lavage fluid (BALF) was also collected and analyzed for inflammatory parameters. Twenty-four hours post-exposure, chromosomal aberrations in the bone marrow cells were evaluated by the micronucleus test and DNA damages in the lung, kidney and liver cells by both the standard and the human 8-oxoguanine DNA N-glycosylase 1 (hOGG1)-modified comet assay. All studies were performed according to the OECD test guidelines. RESULTS: An inflammatory lung reaction and the release of inflammatory factors in the BALF were observed in all rats exposed to 5.0 mg/m(3), associated with changes in the differential white blood cells counts. The slight changes in BALF parameters at 0.25 mg/m(3) recovered and signs of lung clearance of the MWCNT were observed. No pathological changes were observed on the pleura. Neither increase in the number of micronucleated polychromatic erythrocytes nor increase in percent DNA damage were observed at any concentration. CONCLUSIONS: Lung inflammation characteristic of an overload with insoluble particles was observed after a 90-day exposure to 5.0 mg/m(3) of Graphistrength (©) C100. Clear signs of clearance and recovery were observed at 0.25 mg/m(3). No genotoxicity was detected locally in lung and distally in bone marrow, liver and kidney. Therefore, Graphistrength (©) C100 appears of low concern in term of local and systemic genotoxicity and a No-Observed Adverse Effect Concentration (NOAEC) of 0.25 mg/m(3) (0.28 mg/m(3) as actual concentration) was established for the repeated-dose toxicity.
84 schema:genre research_article
85 schema:inLanguage en
86 schema:isAccessibleForFree true
87 schema:isPartOf N1115922738904ad69d0b2ac17d85a20a
88 N831e5646c384435ab899426e0165ba89
89 sg:journal.1034805
90 schema:name Lung inflammation and lack of genotoxicity in the comet and micronucleus assays of industrial multiwalled carbon nanotubes Graphistrength© C100 after a 90-day nose-only inhalation exposure of rats
91 schema:pagination 21
92 schema:productId N0e91622d75424572b5d238d41ef4b12f
93 N981cf22ba10f4ff5a9bdc66e8a630a4a
94 N9bc163c06278458896d5ca230645fbc0
95 Nad48286ab267447283cceb8d2ceacd22
96 Nc7d57e44c69248a38cd3635abf50f962
97 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051593715
98 https://doi.org/10.1186/s12989-015-0096-2
99 schema:sdDatePublished 2019-04-11T13:08
100 schema:sdLicense https://scigraph.springernature.com/explorer/license/
101 schema:sdPublisher Ne95ab401e4bc48078667d5766f3c517d
102 schema:url http://link.springer.com/10.1186%2Fs12989-015-0096-2
103 sgo:license sg:explorer/license/
104 sgo:sdDataset articles
105 rdf:type schema:ScholarlyArticle
106 N05ecc12e8282489a828c2d3cfd084834 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Animals
108 rdf:type schema:DefinedTerm
109 N0e91622d75424572b5d238d41ef4b12f schema:name readcube_id
110 schema:value f5c45571c3cb573075e8c08ec580fd4f7b32e682ba63a7d148415904492c6652
111 rdf:type schema:PropertyValue
112 N10724a43f44740148bf80d5e6f0d973f rdf:first sg:person.01342774241.99
113 rdf:rest N681d766fec8942c7a277686ae51f91c7
114 N1115922738904ad69d0b2ac17d85a20a schema:volumeNumber 12
115 rdf:type schema:PublicationVolume
116 N113e68e90b46408e852985870b7ee1b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Micronuclei, Chromosome-Defective
118 rdf:type schema:DefinedTerm
119 N1217b7befa954cc68705c0ba03a2cf76 schema:name Le Net Pathology Consulting, 18 rue Henry Dunant, 37400, Amboise, France
120 rdf:type schema:Organization
121 N1427ed7d55374d5eb1cab89d76d3e60e rdf:first sg:person.0612402570.84
122 rdf:rest N9800c70c1844476ab6bad38a32647617
123 N152122badd244ad496e0dd12d82ae839 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Nanotubes, Carbon
125 rdf:type schema:DefinedTerm
126 N1d03dd47c17c4da98c265a5908700b14 schema:affiliation Nde1882168bf24a6d99808ea29ac269ba
127 schema:familyName Okazaki
128 schema:givenName Yoshi
129 rdf:type schema:Person
130 N33a2446fd9ce4047a43c5cfa9a21b1df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Comet Assay
132 rdf:type schema:DefinedTerm
133 N42225dc1d42a4180a27204106fbeec6b schema:name Harlan Laboratories Ltd, Zelgliweg 1, 4452, Itingen, Switzerland
134 rdf:type schema:Organization
135 N4a50898c3d1f4a53b1d6e155a539c4f8 schema:affiliation Ncde6e2d833684849872393245fef0a3c
136 schema:familyName Pothmann
137 schema:givenName Daniela
138 rdf:type schema:Person
139 N4de56d5560ee404fa8b75252d9d444a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Male
141 rdf:type schema:DefinedTerm
142 N4e9b10eddaa54faa813938a887dea04d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name DNA Glycosylases
144 rdf:type schema:DefinedTerm
145 N51ca2a485f194a6692b1c6bbc7c15da5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Inflammation Mediators
147 rdf:type schema:DefinedTerm
148 N5aaf71706d524488bce947ffbc3e0126 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Bronchoalveolar Lavage Fluid
150 rdf:type schema:DefinedTerm
151 N5addb3b8f5b444ccaac5bb19e59b6895 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Female
153 rdf:type schema:DefinedTerm
154 N5c3dbd32c2ed414e8282eb917d1cdc98 schema:name Harlan Cytotest Cell Research GmbH, In den Leppsteinwiesen 19, 64380, Rossdorf, Germany
155 rdf:type schema:Organization
156 N5e4d6f3579e549d4975fee4741eac653 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Pneumonia
158 rdf:type schema:DefinedTerm
159 N65bbf58ebbc14a7a89b73655c59ec8ff rdf:first sg:person.01170135263.88
160 rdf:rest Ndfb57e96da574e5abd1ed9cacdb0a556
161 N681d766fec8942c7a277686ae51f91c7 rdf:first sg:person.0664553151.60
162 rdf:rest Nefef254e1c144fe9a7674f04dc227dea
163 N787fc1b2fc07468c9e7711eb36d44b4d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Dose-Response Relationship, Drug
165 rdf:type schema:DefinedTerm
166 N831e5646c384435ab899426e0165ba89 schema:issueNumber 1
167 rdf:type schema:PublicationIssue
168 N83d0d152d1cf49be905a60f3d7e5c3cf schema:name Harlan Laboratories Ltd, Zelgliweg 1, 4452, Itingen, Switzerland
169 rdf:type schema:Organization
170 N84913973208345988edd0a85498884a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Inhalation Exposure
172 rdf:type schema:DefinedTerm
173 N854e836d8ab1474fbbdc6d74dc4846f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Rats, Wistar
175 rdf:type schema:DefinedTerm
176 N97903e6473fd4ee9be4584bc17025664 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Particle Size
178 rdf:type schema:DefinedTerm
179 N9800c70c1844476ab6bad38a32647617 rdf:first sg:person.0616437751.64
180 rdf:rest N10724a43f44740148bf80d5e6f0d973f
181 N981cf22ba10f4ff5a9bdc66e8a630a4a schema:name nlm_unique_id
182 schema:value 101236354
183 rdf:type schema:PropertyValue
184 N9bc163c06278458896d5ca230645fbc0 schema:name pubmed_id
185 schema:value 26156627
186 rdf:type schema:PropertyValue
187 N9ebc8f557b654df9921b6be7f1c7e51a rdf:first sg:person.01001731741.29
188 rdf:rest Nb45aa738161e49a3a3747df8a05cd9a9
189 N9ee7a3de2c6d43df9176399308e9f19d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Time Factors
191 rdf:type schema:DefinedTerm
192 Na4756bdce89c48d4bfe251e1d9e1869a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Risk Assessment
194 rdf:type schema:DefinedTerm
195 Nab11b8e2a7e54303a678cb1731472b9a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Aerosols
197 rdf:type schema:DefinedTerm
198 Nad48286ab267447283cceb8d2ceacd22 schema:name dimensions_id
199 schema:value pub.1051593715
200 rdf:type schema:PropertyValue
201 Nae6c0d0425604255b5be0693d7ab7823 schema:affiliation https://www.grid.ac/institutes/grid.423748.e
202 schema:familyName Bessibes
203 schema:givenName Cécile
204 rdf:type schema:Person
205 Nb45aa738161e49a3a3747df8a05cd9a9 rdf:first Nae6c0d0425604255b5be0693d7ab7823
206 rdf:rest Nfcd2d206334444caa5bcf249affb3746
207 Nb881ec7b94ce43aa9b94dca32378a879 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
208 schema:name Predictive Value of Tests
209 rdf:type schema:DefinedTerm
210 Nb91d1fee7ed04d8f85605f3782ddd470 rdf:first N1d03dd47c17c4da98c265a5908700b14
211 rdf:rest N9ebc8f557b654df9921b6be7f1c7e51a
212 Nbcb88df3f0c84e53bd68db4fdc76b303 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
213 schema:name DNA Damage
214 rdf:type schema:DefinedTerm
215 Nbd15f372b96246838ff3c9bb17db5dda schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
216 schema:name Micronucleus Tests
217 rdf:type schema:DefinedTerm
218 Nc10a4e4a133240d3b089265224b540fb rdf:first N4a50898c3d1f4a53b1d6e155a539c4f8
219 rdf:rest N1427ed7d55374d5eb1cab89d76d3e60e
220 Nc7d57e44c69248a38cd3635abf50f962 schema:name doi
221 schema:value 10.1186/s12989-015-0096-2
222 rdf:type schema:PropertyValue
223 Ncde6e2d833684849872393245fef0a3c schema:name Harlan Laboratories Ltd, Zelgliweg 1, 4452, Itingen, Switzerland
224 rdf:type schema:Organization
225 Ndd39a2dbacbc4aaab8151fee21d35a6f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
226 schema:name No-Observed-Adverse-Effect Level
227 rdf:type schema:DefinedTerm
228 Nde1882168bf24a6d99808ea29ac269ba schema:name AnaPath GmbH, Buchsweg 56, 4625, Oberbuchsiten, Switzerland
229 rdf:type schema:Organization
230 Ndfb57e96da574e5abd1ed9cacdb0a556 rdf:first sg:person.01040771212.02
231 rdf:rest rdf:nil
232 Ne95ab401e4bc48078667d5766f3c517d schema:name Springer Nature - SN SciGraph project
233 rdf:type schema:Organization
234 Neee443ee2a3c4b17ad25c6019582d5d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
235 schema:name Lung
236 rdf:type schema:DefinedTerm
237 Nefef254e1c144fe9a7674f04dc227dea rdf:first sg:person.01160363537.45
238 rdf:rest Nb91d1fee7ed04d8f85605f3782ddd470
239 Nfcd2d206334444caa5bcf249affb3746 rdf:first sg:person.0617016542.41
240 rdf:rest N65bbf58ebbc14a7a89b73655c59ec8ff
241 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
242 schema:name Medical and Health Sciences
243 rdf:type schema:DefinedTerm
244 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
245 schema:name Cardiorespiratory Medicine and Haematology
246 rdf:type schema:DefinedTerm
247 sg:journal.1034805 schema:issn 1743-8977
248 schema:name Particle and Fibre Toxicology
249 rdf:type schema:Periodical
250 sg:person.01001731741.29 schema:affiliation https://www.grid.ac/institutes/grid.423748.e
251 schema:familyName Chabagno
252 schema:givenName Jean Michel
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001731741.29
254 rdf:type schema:Person
255 sg:person.01040771212.02 schema:affiliation https://www.grid.ac/institutes/grid.423748.e
256 schema:familyName Régnier
257 schema:givenName Jean-François
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040771212.02
259 rdf:type schema:Person
260 sg:person.01160363537.45 schema:affiliation N1217b7befa954cc68705c0ba03a2cf76
261 schema:familyName Le Net
262 schema:givenName Jean-Loïc
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160363537.45
264 rdf:type schema:Person
265 sg:person.01170135263.88 schema:affiliation https://www.grid.ac/institutes/grid.16780.38
266 schema:familyName Nesslany
267 schema:givenName Fabrice
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170135263.88
269 rdf:type schema:Person
270 sg:person.01342774241.99 schema:affiliation N5c3dbd32c2ed414e8282eb917d1cdc98
271 schema:familyName Dony
272 schema:givenName Eva
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342774241.99
274 rdf:type schema:Person
275 sg:person.0612402570.84 schema:affiliation https://www.grid.ac/institutes/grid.8970.6
276 schema:familyName Simar
277 schema:givenName Sophie
278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612402570.84
279 rdf:type schema:Person
280 sg:person.0616437751.64 schema:affiliation N42225dc1d42a4180a27204106fbeec6b
281 schema:familyName Schuler
282 schema:givenName Detlef
283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616437751.64
284 rdf:type schema:Person
285 sg:person.0617016542.41 schema:affiliation https://www.grid.ac/institutes/grid.423748.e
286 schema:familyName Beausoleil
287 schema:givenName Julien
288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617016542.41
289 rdf:type schema:Person
290 sg:person.0664553151.60 schema:affiliation N83d0d152d1cf49be905a60f3d7e5c3cf
291 schema:familyName Gaering
292 schema:givenName Stéphane
293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664553151.60
294 rdf:type schema:Person
295 sg:pub.10.1007/s00204-011-0741-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1038061282
296 https://doi.org/10.1007/s00204-011-0741-y
297 rdf:type schema:CreativeWork
298 sg:pub.10.1007/s00204-014-1356-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015708421
299 https://doi.org/10.1007/s00204-014-1356-x
300 rdf:type schema:CreativeWork
301 sg:pub.10.1007/s11051-010-0050-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1029369624
302 https://doi.org/10.1007/s11051-010-0050-z
303 rdf:type schema:CreativeWork
304 sg:pub.10.1038/nnano.2008.111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039268410
305 https://doi.org/10.1038/nnano.2008.111
306 rdf:type schema:CreativeWork
307 sg:pub.10.1186/1471-2369-14-96 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008574359
308 https://doi.org/10.1186/1471-2369-14-96
309 rdf:type schema:CreativeWork
310 sg:pub.10.1186/1743-8977-10-23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044394476
311 https://doi.org/10.1186/1743-8977-10-23
312 rdf:type schema:CreativeWork
313 sg:pub.10.1186/1743-8977-10-33 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010429460
314 https://doi.org/10.1186/1743-8977-10-33
315 rdf:type schema:CreativeWork
316 sg:pub.10.1186/1743-8977-11-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031007773
317 https://doi.org/10.1186/1743-8977-11-3
318 rdf:type schema:CreativeWork
319 sg:pub.10.1186/1743-8977-8-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048014863
320 https://doi.org/10.1186/1743-8977-8-3
321 rdf:type schema:CreativeWork
322 sg:pub.10.1186/1743-8977-9-28 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031348540
323 https://doi.org/10.1186/1743-8977-9-28
324 rdf:type schema:CreativeWork
325 sg:pub.10.1186/1743-8977-9-46 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013777875
326 https://doi.org/10.1186/1743-8977-9-46
327 rdf:type schema:CreativeWork
328 sg:pub.10.1186/s12989-014-0061-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013973774
329 https://doi.org/10.1186/s12989-014-0061-5
330 rdf:type schema:CreativeWork
331 https://app.dimensions.ai/details/publication/pub.1077283345 schema:CreativeWork
332 https://app.dimensions.ai/details/publication/pub.1083169987 schema:CreativeWork
333 https://doi.org/10.1002/9780470747803.ch17 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027038387
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1002/em.21881 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041850702
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1002/em.21922 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045975419
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1016/0027-5107(89)90035-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024490552
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1016/0272-0590(90)90190-u schema:sameAs https://app.dimensions.ai/details/publication/pub.1012025876
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1016/b978-044452771-4/50007-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018024202
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1016/j.ajpath.2011.02.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004182430
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1016/j.etp.2009.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022484171
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1016/j.nano.2009.02.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014218183
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1016/j.tiv.2013.06.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019165331
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1016/j.tox.2010.04.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044243540
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1016/s1470-2045(14)71109-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001331822
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1021/tx800100s schema:sameAs https://app.dimensions.ai/details/publication/pub.1056299814
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1021/tx800101p schema:sameAs https://app.dimensions.ai/details/publication/pub.1056299815
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1073/pnas.1110013108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018855731
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1080/0895-8378.1987.11463170 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041298983
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1080/08958370050029725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012984644
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1080/08958370701496202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006709176
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1080/08958370902962291 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007645028
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1080/10715760601024122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029720953
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1080/15287390802476991 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043512006
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1080/15298668391405959 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037985620
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1093/carcin/bgg144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041020264
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1093/carcin/bgm243 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014113406
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1093/mutage/gel019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020090552
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1093/toxsci/kfp100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050782476
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1093/toxsci/kfp146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031008275
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1093/toxsci/kfp247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053667774
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1093/toxsci/kfs161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016772426
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1093/toxsci/kft089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045860416
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1093/toxsci/kft328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024127161
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1111/j.1349-7006.2012.02318.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049043797
396 rdf:type schema:CreativeWork
397 https://doi.org/10.1111/pin.12093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006183884
398 rdf:type schema:CreativeWork
399 https://doi.org/10.1126/science.1222453 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007405937
400 rdf:type schema:CreativeWork
401 https://doi.org/10.1177/0192623309353423 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063752828
402 rdf:type schema:CreativeWork
403 https://doi.org/10.2131/jts.33.105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041513197
404 rdf:type schema:CreativeWork
405 https://doi.org/10.2131/jts.34.65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011133183
406 rdf:type schema:CreativeWork
407 https://doi.org/10.3109/08958378.2013.878006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034013970
408 rdf:type schema:CreativeWork
409 https://doi.org/10.3109/17435390.2010.482751 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040788329
410 rdf:type schema:CreativeWork
411 https://doi.org/10.3109/17435390.2012.674571 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022094423
412 rdf:type schema:CreativeWork
413 https://doi.org/10.3109/17435390.2014.933903 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034200960
414 rdf:type schema:CreativeWork
415 https://www.grid.ac/institutes/grid.16780.38 schema:alternateName Université Lille 2 Droit et Santé
416 schema:name Laboratoire de Toxicologie Génétique, Institut Pasteur de Lille, 1 rue du Pr. Calmette, 59019, Lille, Cedex, France
417 UDSL, EA 4483, Département Toxicologie-Santé Publique-Environnement, Faculté de Pharmacie, 1 rue du Pr. Laguesse, 59019, Lille, France
418 rdf:type schema:Organization
419 https://www.grid.ac/institutes/grid.423748.e schema:alternateName Arkema (France)
420 schema:name Arkema France, Département Toxicologie et Environnement, 420 rue d’ Estienne d’ Orves, 92705, Colombes, France
421 Arkema France, Groupement de Recherches de Lacq (GRL), Laboratoires d’analyse de surface et microscopie et de chimie analytique, 64170, Lacq, France
422 rdf:type schema:Organization
423 https://www.grid.ac/institutes/grid.8970.6 schema:alternateName Pasteur Institute of Lille
424 schema:name Laboratoire de Toxicologie Génétique, Institut Pasteur de Lille, 1 rue du Pr. Calmette, 59019, Lille, Cedex, France
425 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...