Bacillus coagulans GBI-30, 6086 improves amino acid absorption from milk protein View Full Text


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Article Info

DATE

2020-10-23

AUTHORS

Richard A. Stecker, Jessica M. Moon, Travis J. Russo, Kayla M. Ratliff, Petey W. Mumford, Ralf Jäger, Martin Purpura, Chad M. Kerksick

ABSTRACT

BackgroundProbiotic Bacillus coagulans GBI-30, 6086 (BC30) has been shown to increase protein digestion in an in vitro model of the stomach and small intestine. Once active in the small intestine after germination, BC30 aids the digestion of carbohydrates and proteins. The extent to which BC30 administration may impact protein digestion and amino acid appearance in humans after protein ingestion is currently unknown. This study examined the impact of adding BC30 to a 25-g dose of milk protein concentrate on post-prandial changes in blood amino acids concentrations.Methods14 males and 16 females (n = 30, 26.4 ± 6.5 years; 172.3 ± 10.8 cm; 78.2 ± 14.8 kg; 22.6 ± 7.2% fat) completed two supplementation protocols that each spanned two weeks separated by a washout period that lasted three weeks. Participants were instructed to track their dietary intake and ingest a daily 25-g dose of milk protein concentrate with (MPCBC30) or without (MPC) the addition of BC30. Body composition and demographics were assessed upon arrival to the laboratory. Upon ingestion of their final assigned supplemental dose, blood samples were taken at 0 (baseline), 30, 60, 90, 120, 180, and 240 min post-consumption and analyzed for amino acid concentrations.ResultsArginine (p = 0.03) and Isoleucine (p = 0.05) revealed greater area-under-the curve (AUC) in MPCBC30 group compared to MPC. In addition, Arginine (p = 0.02), Serine (p = 0.01), Ornithine (p = 0.02), Methionine (p = 0.04), Glutamic Acid (p = 0.01), Phenylalanine (p = 0.05), Isoleucine (p = 0.04), Tyrosine (p = 0.02), Essential Amino Acids (p = 0.02), and Total Amino Acids (p < 0.01) all revealed significantly greater concentration maximum (CMax) in MPCBC30 compared to MPC. Finally, time to reach CMax (TMax) was significantly faster for Glutamine (p < 0.01), Citrulline (p < 0.01), Threonine (p = 0.04), Alanine (p = 0.02) in MPCBC30 when compared to MPC. Greater mean differences between groups for AUC and CMax in women when compared to the mean differences in men were found for several amino acids.ConclusionIn concert with previous in vitro evidence of improved protein digestion and amino acid appearance, these results reveal that adding BC30 to protein sources such as milk protein concentrate can improve AUC, CMax, and faster TMax. Follow-up research should examine differences between gender and explore how aging can impact these outcomes. Retrospectively registered on June 11, 2020 at ClinicalTrials.gov as NCT04427020. More... »

PAGES

93

References to SciGraph publications

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  • 2009-11-18. A prospective, randomized, double-blind, placebo-controlled parallel-group dual site trial to evaluate the effects of a Bacillus coagulans-based product on functional intestinal gas symptoms in BMC GASTROENTEROLOGY
  • 2014-06-10. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
  • 2017-12-01. Probiotic Bacillus coagulans GBI-30, 6086 Improves Protein Absorption and Utilization in PROBIOTICS AND ANTIMICROBIAL PROTEINS
  • 2019-01-15. International Society of Sports Nutrition Position Stand: Probiotics in JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION
  • 2020-05-01. Probiotic Administration Increases Amino Acid Absorption from Plant Protein: a Placebo-Controlled, Randomized, Double-Blind, Multicenter, Crossover Study in PROBIOTICS AND ANTIMICROBIAL PROTEINS
  • 2017-01-03. International Society of Sports Nutrition Position Stand: protein and exercise in JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION
  • 2011-10-05. Skeletal muscle protein metabolism in the elderly: Interventions to counteract the 'anabolic resistance' of ageing in NUTRITION & METABOLISM
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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/33110439


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