Characteristics of influenza H13N8 subtype virus firstly isolated from Qinghai Lake Region, China View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-09-18

AUTHORS

Jie Dong, Hong Bo, Ye Zhang, Libo Dong, Shumei Zou, Weijuan Huang, Jia Liu, Dayan Wang, Yuelong Shu

ABSTRACT

BackgroundSince the highly pathogenic H5N1 influenza caused thousands of deaths of wild bird in this area in 2005, Qinghai Lake in China has become a hot spot for study of the influence of avian influenza to migratory wild birds. However, the ecology and evolution of low pathogenic avian influenza virus in this region are limited. This project-based avian influenza surveillance in Qinghai lake region was initiated in year 2012.MethodSamples of wild bird feces and lake surface water were collected in Qinghai Lake in year 2012.Virus isolation was conducted on embryonated chicken eggs. The influenza A virus was determined by rRT-PCR. Virus sequences were acquired by deep sequencing. The phylogenetic correlation and molecular characteristics of the viruses were analyzed. The virus growth and infection features, receptor binding preference were studied, and pathogenicity in vitro as well as.ResultsTwo H13N8 subtype influenza viruses were isolated. The viruses are phylogenetically belong to Eurasian lineage. Most of the genes are associated with gull origin influenza virus except PB1 gene, which is most probably derived from Anseriformes virus. The evidence of interspecies reassortment was presented. The two viruses have limited growth capacity on MDCK and A549 cells while grow well in embryonated eggs. The dual receptor binding features of the two viruses was shown up. The low pathogenic features were determined by trypsin dependence plaque formation assay.ConclusionsThe two H13N8 subtype influenza viruses are highly associated with gull origin. The interspecies reassortment of H13 subtype virus among Anseriforme sand Charadriiformes wild birds emphasizes the importance of strengthening avian influenza surveillance in this region. This study is helpful to understand the ecology, evolution and transmission pattern of H13 subtype influenza virus globally. More... »

PAGES

180

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12985-017-0842-1

DOI

http://dx.doi.org/10.1186/s12985-017-0842-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1091844964

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28923071


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Microbiology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals, Wild", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "China", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dogs", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Feces", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Viral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genome, Viral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Influenza A virus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Influenza in Birds", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lakes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Madin Darby Canine Kidney Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phylogeny", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Viral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Virus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Turkeys", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Viral Plaque Assay", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Water Microbiology", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, 155 Changbai Road, Changping District, 102206, Beijing, China", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, 155 Changbai Road, Changping District, 102206, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dong", 
        "givenName": "Jie", 
        "id": "sg:person.0714411274.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714411274.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, 155 Changbai Road, Changping District, 102206, Beijing, China", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, 155 Changbai Road, Changping District, 102206, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bo", 
        "givenName": "Hong", 
        "id": "sg:person.01346633534.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346633534.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, 155 Changbai Road, Changping District, 102206, Beijing, China", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, 155 Changbai Road, Changping District, 102206, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Ye", 
        "id": "sg:person.01024076710.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024076710.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, 155 Changbai Road, Changping District, 102206, Beijing, China", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, 155 Changbai Road, Changping District, 102206, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dong", 
        "givenName": "Libo", 
        "id": "sg:person.0607456462.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607456462.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, 155 Changbai Road, Changping District, 102206, Beijing, China", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, 155 Changbai Road, Changping District, 102206, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zou", 
        "givenName": "Shumei", 
        "id": "sg:person.01207035134.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207035134.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, 155 Changbai Road, Changping District, 102206, Beijing, China", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, 155 Changbai Road, Changping District, 102206, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huang", 
        "givenName": "Weijuan", 
        "id": "sg:person.01136032533.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136032533.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, 155 Changbai Road, Changping District, 102206, Beijing, China", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, 155 Changbai Road, Changping District, 102206, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Jia", 
        "id": "sg:person.016407442103.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016407442103.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, 155 Changbai Road, Changping District, 102206, Beijing, China", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, 155 Changbai Road, Changping District, 102206, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Dayan", 
        "id": "sg:person.01032364301.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032364301.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, 155 Changbai Road, Changping District, 102206, Beijing, China", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, 155 Changbai Road, Changping District, 102206, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shu", 
        "givenName": "Yuelong", 
        "id": "sg:person.016041231657.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016041231657.83"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/1743-422x-10-112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051063312", 
          "https://doi.org/10.1186/1743-422x-10-112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1743-422x-10-179", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026022396", 
          "https://doi.org/10.1186/1743-422x-10-179"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1743-422x-3-63", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000911842", 
          "https://doi.org/10.1186/1743-422x-3-63"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature12379", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028464892", 
          "https://doi.org/10.1038/nature12379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1743-422x-9-133", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010740442", 
          "https://doi.org/10.1186/1743-422x-9-133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1743-422x-8-21", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014394427", 
          "https://doi.org/10.1186/1743-422x-8-21"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-09-18", 
    "datePublishedReg": "2017-09-18", 
    "description": "BackgroundSince the highly pathogenic H5N1 influenza caused thousands of deaths of wild bird in this area in 2005, Qinghai Lake in China has become a hot spot for study of the influence of avian influenza to migratory wild birds. However, the ecology and evolution of low pathogenic avian influenza virus in this region are limited. This project-based avian influenza surveillance in Qinghai lake region was initiated in year 2012.MethodSamples of wild bird feces and lake surface water were collected in Qinghai Lake in year 2012.Virus isolation was conducted on embryonated chicken eggs. The influenza A virus was determined by rRT-PCR. Virus sequences were acquired by deep sequencing. The phylogenetic correlation and molecular characteristics of the viruses were analyzed. The virus growth and infection features, receptor binding preference were studied, and pathogenicity in vitro as well as.ResultsTwo H13N8 subtype influenza viruses were isolated. The viruses are phylogenetically belong to Eurasian lineage. Most of the genes are associated with gull origin influenza virus except PB1 gene, which is most probably derived from Anseriformes virus. The evidence of interspecies reassortment was presented. The two viruses have limited growth capacity on MDCK and A549 cells while grow well in embryonated eggs. The dual receptor binding features of the two viruses was shown up. The low pathogenic features were determined by trypsin dependence plaque formation assay.ConclusionsThe two H13N8 subtype influenza viruses are highly associated with gull origin. The interspecies reassortment of H13 subtype virus among Anseriforme sand Charadriiformes wild birds emphasizes the importance of strengthening avian influenza surveillance in this region. This study is helpful to understand the ecology, evolution and transmission pattern of H13 subtype influenza virus globally.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s12985-017-0842-1", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1034449", 
        "issn": [
          "1743-422X"
        ], 
        "name": "Virology Journal", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "14"
      }
    ], 
    "keywords": [
      "wild birds", 
      "interspecies reassortment", 
      "Qinghai Lake region", 
      "avian influenza surveillance", 
      "wild bird feces", 
      "migratory wild birds", 
      "subtype influenza viruses", 
      "phylogenetic correlation", 
      "deep sequencing", 
      "Eurasian lineage", 
      "bird feces", 
      "low pathogenic avian influenza viruses", 
      "Qinghai Lake", 
      "binding preferences", 
      "Lakes region", 
      "PB1 gene", 
      "influenza virus", 
      "receptor binding preferences", 
      "pathogenic avian influenza viruses", 
      "birds", 
      "avian influenza viruses", 
      "growth capacity", 
      "virus sequences", 
      "pathogenic H5N1 influenza", 
      "subtype viruses", 
      "influenza surveillance", 
      "virus growth", 
      "ecology", 
      "genes", 
      "A549 cells", 
      "binding features", 
      "reassortment", 
      "molecular characteristics", 
      "eggs", 
      "pathogenic features", 
      "lakes", 
      "thousands of deaths", 
      "lake surface water", 
      "virus", 
      "lineages", 
      "H5N1 influenza", 
      "plaque formation", 
      "avian influenza", 
      "rRT-PCR", 
      "sequencing", 
      "infection features", 
      "influenza", 
      "transmission patterns", 
      "pathogenicity", 
      "evolution", 
      "MDCK", 
      "region", 
      "sequence", 
      "hot spots", 
      "chicken eggs", 
      "cells", 
      "surveillance", 
      "isolation", 
      "growth", 
      "surface water", 
      "thousands", 
      "death", 
      "origin", 
      "patterns", 
      "feces", 
      "spots", 
      "study", 
      "formation", 
      "evidence", 
      "importance", 
      "features", 
      "China", 
      "preferences", 
      "water", 
      "correlation", 
      "capacity", 
      "characteristics", 
      "area", 
      "sand", 
      "influence"
    ], 
    "name": "Characteristics of influenza H13N8 subtype virus firstly isolated from Qinghai Lake Region, China", 
    "pagination": "180", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1091844964"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12985-017-0842-1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28923071"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12985-017-0842-1", 
      "https://app.dimensions.ai/details/publication/pub.1091844964"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:36", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_733.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s12985-017-0842-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12985-017-0842-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12985-017-0842-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12985-017-0842-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12985-017-0842-1'


 

This table displays all metadata directly associated to this object as RDF triples.

300 TRIPLES      21 PREDICATES      131 URIs      117 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12985-017-0842-1 schema:about N0aab2a2dbb244179abb1383513272804
2 N1300630c5e8242ec88fae88f2384332b
3 N190f5998c6ab4c1d9e8108f066012125
4 N2346e3ed59984a34be9b270f788713c7
5 N309b6fdd81124ff2ad69879707b24109
6 N3cddb7473cd5443ea43aa1abcb93d87b
7 N418918780736480bbeada97c3846b653
8 N4551eeba80f54352b8a2de4cb5739688
9 N4a3ad2f59de84578bb285cf35b137418
10 N607920a381674c4b8f9fd4804cd46b5e
11 N6206e6c7fe894bcf84298585fde2d712
12 N627300a97fc241fa88359dc8f9dde34d
13 N65009f24cad84b7bbfd821170349c0d6
14 N6fa5b1aece5c494eb2f1cb3a2bcb6f1d
15 N72cd96a10a624772a3e9f9d178a46610
16 N9fe0fe02b2fd4ef6a32f117cbcc29555
17 Na82101d3b9314a0f9e529c60b0462fcd
18 Ncda154d94ad24bc58bffbbae7d0eef29
19 Neddb2d4d09a94e75965774b55b9242d7
20 Nfaacaa7bf8244a50a29444cc1c3bf6c3
21 anzsrc-for:11
22 anzsrc-for:1108
23 schema:author N5c60c50d3fdd4465938446ec9d965c5c
24 schema:citation sg:pub.10.1038/nature12379
25 sg:pub.10.1186/1743-422x-10-112
26 sg:pub.10.1186/1743-422x-10-179
27 sg:pub.10.1186/1743-422x-3-63
28 sg:pub.10.1186/1743-422x-8-21
29 sg:pub.10.1186/1743-422x-9-133
30 schema:datePublished 2017-09-18
31 schema:datePublishedReg 2017-09-18
32 schema:description BackgroundSince the highly pathogenic H5N1 influenza caused thousands of deaths of wild bird in this area in 2005, Qinghai Lake in China has become a hot spot for study of the influence of avian influenza to migratory wild birds. However, the ecology and evolution of low pathogenic avian influenza virus in this region are limited. This project-based avian influenza surveillance in Qinghai lake region was initiated in year 2012.MethodSamples of wild bird feces and lake surface water were collected in Qinghai Lake in year 2012.Virus isolation was conducted on embryonated chicken eggs. The influenza A virus was determined by rRT-PCR. Virus sequences were acquired by deep sequencing. The phylogenetic correlation and molecular characteristics of the viruses were analyzed. The virus growth and infection features, receptor binding preference were studied, and pathogenicity in vitro as well as.ResultsTwo H13N8 subtype influenza viruses were isolated. The viruses are phylogenetically belong to Eurasian lineage. Most of the genes are associated with gull origin influenza virus except PB1 gene, which is most probably derived from Anseriformes virus. The evidence of interspecies reassortment was presented. The two viruses have limited growth capacity on MDCK and A549 cells while grow well in embryonated eggs. The dual receptor binding features of the two viruses was shown up. The low pathogenic features were determined by trypsin dependence plaque formation assay.ConclusionsThe two H13N8 subtype influenza viruses are highly associated with gull origin. The interspecies reassortment of H13 subtype virus among Anseriforme sand Charadriiformes wild birds emphasizes the importance of strengthening avian influenza surveillance in this region. This study is helpful to understand the ecology, evolution and transmission pattern of H13 subtype influenza virus globally.
33 schema:genre article
34 schema:isAccessibleForFree true
35 schema:isPartOf N7c99c5d23fc54da6a7531cf2218a3010
36 N8c43923f3aab456ba637cec5dcab7c26
37 sg:journal.1034449
38 schema:keywords A549 cells
39 China
40 Eurasian lineage
41 H5N1 influenza
42 Lakes region
43 MDCK
44 PB1 gene
45 Qinghai Lake
46 Qinghai Lake region
47 area
48 avian influenza
49 avian influenza surveillance
50 avian influenza viruses
51 binding features
52 binding preferences
53 bird feces
54 birds
55 capacity
56 cells
57 characteristics
58 chicken eggs
59 correlation
60 death
61 deep sequencing
62 ecology
63 eggs
64 evidence
65 evolution
66 features
67 feces
68 formation
69 genes
70 growth
71 growth capacity
72 hot spots
73 importance
74 infection features
75 influence
76 influenza
77 influenza surveillance
78 influenza virus
79 interspecies reassortment
80 isolation
81 lake surface water
82 lakes
83 lineages
84 low pathogenic avian influenza viruses
85 migratory wild birds
86 molecular characteristics
87 origin
88 pathogenic H5N1 influenza
89 pathogenic avian influenza viruses
90 pathogenic features
91 pathogenicity
92 patterns
93 phylogenetic correlation
94 plaque formation
95 preferences
96 rRT-PCR
97 reassortment
98 receptor binding preferences
99 region
100 sand
101 sequence
102 sequencing
103 spots
104 study
105 subtype influenza viruses
106 subtype viruses
107 surface water
108 surveillance
109 thousands
110 thousands of deaths
111 transmission patterns
112 virus
113 virus growth
114 virus sequences
115 water
116 wild bird feces
117 wild birds
118 schema:name Characteristics of influenza H13N8 subtype virus firstly isolated from Qinghai Lake Region, China
119 schema:pagination 180
120 schema:productId N80fa11897ce842b690f7659ede943247
121 Nb3c13f2b6f7b43bca3cb21b6f0dc098d
122 Nbd790b00f79b4b58a02323ff9aa572d4
123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091844964
124 https://doi.org/10.1186/s12985-017-0842-1
125 schema:sdDatePublished 2022-12-01T06:36
126 schema:sdLicense https://scigraph.springernature.com/explorer/license/
127 schema:sdPublisher N23cf3a5021974ce284bff56653d972c7
128 schema:url https://doi.org/10.1186/s12985-017-0842-1
129 sgo:license sg:explorer/license/
130 sgo:sdDataset articles
131 rdf:type schema:ScholarlyArticle
132 N09c9542cdd734c68b1f89952de610146 rdf:first sg:person.016407442103.77
133 rdf:rest N605a1f859dd14af1afee24d329e28144
134 N0aab2a2dbb244179abb1383513272804 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Influenza in Birds
136 rdf:type schema:DefinedTerm
137 N1300630c5e8242ec88fae88f2384332b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Feces
139 rdf:type schema:DefinedTerm
140 N190f5998c6ab4c1d9e8108f066012125 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Dogs
142 rdf:type schema:DefinedTerm
143 N1ff31ac609474875ab6d7275c5d6ee97 rdf:first sg:person.01207035134.82
144 rdf:rest N8bf66fa20ee14786b9d8b4027964b2c9
145 N2346e3ed59984a34be9b270f788713c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Turkeys
147 rdf:type schema:DefinedTerm
148 N23cf3a5021974ce284bff56653d972c7 schema:name Springer Nature - SN SciGraph project
149 rdf:type schema:Organization
150 N309b6fdd81124ff2ad69879707b24109 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Mutation
152 rdf:type schema:DefinedTerm
153 N3cddb7473cd5443ea43aa1abcb93d87b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Phylogeny
155 rdf:type schema:DefinedTerm
156 N418918780736480bbeada97c3846b653 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Humans
158 rdf:type schema:DefinedTerm
159 N4551eeba80f54352b8a2de4cb5739688 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Madin Darby Canine Kidney Cells
161 rdf:type schema:DefinedTerm
162 N4a3ad2f59de84578bb285cf35b137418 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Viral Plaque Assay
164 rdf:type schema:DefinedTerm
165 N5c60c50d3fdd4465938446ec9d965c5c rdf:first sg:person.0714411274.44
166 rdf:rest Nafe8b059f6034fe8b83511e9f981b2f6
167 N605a1f859dd14af1afee24d329e28144 rdf:first sg:person.01032364301.95
168 rdf:rest Nd8c0ea170a1a4563b9c4c6e53178aa09
169 N607920a381674c4b8f9fd4804cd46b5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Influenza A virus
171 rdf:type schema:DefinedTerm
172 N6206e6c7fe894bcf84298585fde2d712 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name RNA, Viral
174 rdf:type schema:DefinedTerm
175 N627300a97fc241fa88359dc8f9dde34d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Genes, Viral
177 rdf:type schema:DefinedTerm
178 N65009f24cad84b7bbfd821170349c0d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Animals
180 rdf:type schema:DefinedTerm
181 N6fa5b1aece5c494eb2f1cb3a2bcb6f1d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Cell Line
183 rdf:type schema:DefinedTerm
184 N72cd96a10a624772a3e9f9d178a46610 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name China
186 rdf:type schema:DefinedTerm
187 N7c99c5d23fc54da6a7531cf2218a3010 schema:issueNumber 1
188 rdf:type schema:PublicationIssue
189 N80fa11897ce842b690f7659ede943247 schema:name pubmed_id
190 schema:value 28923071
191 rdf:type schema:PropertyValue
192 N8bf66fa20ee14786b9d8b4027964b2c9 rdf:first sg:person.01136032533.11
193 rdf:rest N09c9542cdd734c68b1f89952de610146
194 N8c43923f3aab456ba637cec5dcab7c26 schema:volumeNumber 14
195 rdf:type schema:PublicationVolume
196 N9fe0fe02b2fd4ef6a32f117cbcc29555 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Genome, Viral
198 rdf:type schema:DefinedTerm
199 Na82101d3b9314a0f9e529c60b0462fcd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Water Microbiology
201 rdf:type schema:DefinedTerm
202 Nafe8b059f6034fe8b83511e9f981b2f6 rdf:first sg:person.01346633534.18
203 rdf:rest Nd8d7a4896716458393fd2762ecf0cade
204 Nb3c13f2b6f7b43bca3cb21b6f0dc098d schema:name dimensions_id
205 schema:value pub.1091844964
206 rdf:type schema:PropertyValue
207 Nbd790b00f79b4b58a02323ff9aa572d4 schema:name doi
208 schema:value 10.1186/s12985-017-0842-1
209 rdf:type schema:PropertyValue
210 Nc77b7b940f3549f7b4895dce23362e2b rdf:first sg:person.0607456462.34
211 rdf:rest N1ff31ac609474875ab6d7275c5d6ee97
212 Ncda154d94ad24bc58bffbbae7d0eef29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
213 schema:name Receptors, Virus
214 rdf:type schema:DefinedTerm
215 Nd8c0ea170a1a4563b9c4c6e53178aa09 rdf:first sg:person.016041231657.83
216 rdf:rest rdf:nil
217 Nd8d7a4896716458393fd2762ecf0cade rdf:first sg:person.01024076710.14
218 rdf:rest Nc77b7b940f3549f7b4895dce23362e2b
219 Neddb2d4d09a94e75965774b55b9242d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
220 schema:name Animals, Wild
221 rdf:type schema:DefinedTerm
222 Nfaacaa7bf8244a50a29444cc1c3bf6c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
223 schema:name Lakes
224 rdf:type schema:DefinedTerm
225 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
226 schema:name Medical and Health Sciences
227 rdf:type schema:DefinedTerm
228 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
229 schema:name Medical Microbiology
230 rdf:type schema:DefinedTerm
231 sg:journal.1034449 schema:issn 1743-422X
232 schema:name Virology Journal
233 schema:publisher Springer Nature
234 rdf:type schema:Periodical
235 sg:person.01024076710.14 schema:affiliation grid-institutes:None
236 schema:familyName Zhang
237 schema:givenName Ye
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024076710.14
239 rdf:type schema:Person
240 sg:person.01032364301.95 schema:affiliation grid-institutes:None
241 schema:familyName Wang
242 schema:givenName Dayan
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032364301.95
244 rdf:type schema:Person
245 sg:person.01136032533.11 schema:affiliation grid-institutes:None
246 schema:familyName Huang
247 schema:givenName Weijuan
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136032533.11
249 rdf:type schema:Person
250 sg:person.01207035134.82 schema:affiliation grid-institutes:None
251 schema:familyName Zou
252 schema:givenName Shumei
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207035134.82
254 rdf:type schema:Person
255 sg:person.01346633534.18 schema:affiliation grid-institutes:None
256 schema:familyName Bo
257 schema:givenName Hong
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346633534.18
259 rdf:type schema:Person
260 sg:person.016041231657.83 schema:affiliation grid-institutes:None
261 schema:familyName Shu
262 schema:givenName Yuelong
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016041231657.83
264 rdf:type schema:Person
265 sg:person.016407442103.77 schema:affiliation grid-institutes:None
266 schema:familyName Liu
267 schema:givenName Jia
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016407442103.77
269 rdf:type schema:Person
270 sg:person.0607456462.34 schema:affiliation grid-institutes:None
271 schema:familyName Dong
272 schema:givenName Libo
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607456462.34
274 rdf:type schema:Person
275 sg:person.0714411274.44 schema:affiliation grid-institutes:None
276 schema:familyName Dong
277 schema:givenName Jie
278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714411274.44
279 rdf:type schema:Person
280 sg:pub.10.1038/nature12379 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028464892
281 https://doi.org/10.1038/nature12379
282 rdf:type schema:CreativeWork
283 sg:pub.10.1186/1743-422x-10-112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051063312
284 https://doi.org/10.1186/1743-422x-10-112
285 rdf:type schema:CreativeWork
286 sg:pub.10.1186/1743-422x-10-179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026022396
287 https://doi.org/10.1186/1743-422x-10-179
288 rdf:type schema:CreativeWork
289 sg:pub.10.1186/1743-422x-3-63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000911842
290 https://doi.org/10.1186/1743-422x-3-63
291 rdf:type schema:CreativeWork
292 sg:pub.10.1186/1743-422x-8-21 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014394427
293 https://doi.org/10.1186/1743-422x-8-21
294 rdf:type schema:CreativeWork
295 sg:pub.10.1186/1743-422x-9-133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010740442
296 https://doi.org/10.1186/1743-422x-9-133
297 rdf:type schema:CreativeWork
298 grid-institutes:None schema:alternateName National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, 155 Changbai Road, Changping District, 102206, Beijing, China
299 schema:name National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, 155 Changbai Road, Changping District, 102206, Beijing, China
300 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...