Efficacy of an inactivated bivalent vaccine against the prevalent strains of Newcastle disease and H9N2 avian influenza View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-03-16

AUTHORS

Jing Zhao, Huiming Yang, Hongjun Xu, Zengbin Ma, Guozhong Zhang

ABSTRACT

BackgroundNewcastle disease (ND) and avian influenza subtype H9N2 (H9N2 AI) are two of the most important diseases of poultry, causing severe economic losses in the global poultry industry. Vaccination is an effective way to prevent and control the spread of ND virus (NDV) and H9N2 AI virus (AIV), but the antigenic differences between the current circulating strains and the vaccine strains might account for recent ND and H9N2 AI outbreaks in vaccinated poultry flocks.MethodsWe developed an inactivated bivalent H9N2 and NDV vaccine based on the current prevalent strains of H9N2 AIV and NDV in China and evaluated its efficacy in chickens in this study.ResultsThe results indicated that the inactivated bivalent vaccine could induce a fast antibody response in vaccinated chickens. The hemagglutination inhibition (HI) titer in the sera increased rapidly, and the highest HI titer was observed at 4 weeks post-vaccination (wpv) with a mean titre of 8.6 log2 for NDV and 9.5 log2 for H9N2. Up until 15 wpv, HI titers were still detectable at a high level of over 6 log2. The immunized chickens showed no signs of disease after challenge at 3 wpv with the prevalent strains of NDV and H9N2 AIV isolated in 2012–2014. Moreover, viral shedding was completely inhibited in vaccinated chickens after challenge with H9N2 AIV and inhibited by at least 90% with NDV compared to the controls at 5dpc.ConclusionsOur findings suggest that the inactivated NDV and H9N2 vaccine induces a fast and strong antibody response in vaccinated chickens and is efficacious in poultry against NDVs and H9N2 AIVs. More... »

PAGES

56

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12985-017-0723-7

DOI

http://dx.doi.org/10.1186/s12985-017-0723-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084251625

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28302119


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0605", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Microbiology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Microbiology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Viral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chickens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "China", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Influenza A Virus, H9N2 Subtype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Influenza in Birds", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Newcastle Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Newcastle disease virus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vaccines, Combined", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vaccines, Inactivated", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Viral Vaccines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Virus Shedding", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Key Laboratory of Animal Epidemiology and Zoonoses;, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, No.2 Yuanmingyuan West Road, Haidian District, 100193, Beijing, People\u2019s Republic of China", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Key Laboratory of Animal Epidemiology and Zoonoses;, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, No.2 Yuanmingyuan West Road, Haidian District, 100193, Beijing, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhao", 
        "givenName": "Jing", 
        "id": "sg:person.01212547171.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212547171.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Key Laboratory of Animal Epidemiology and Zoonoses;, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, No.2 Yuanmingyuan West Road, Haidian District, 100193, Beijing, People\u2019s Republic of China", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Key Laboratory of Animal Epidemiology and Zoonoses;, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, No.2 Yuanmingyuan West Road, Haidian District, 100193, Beijing, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Huiming", 
        "id": "sg:person.012410714447.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012410714447.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chengdu Tecbond Biological Products Co., Ltd, 610100, Sichuan, People\u2019s Republic of China", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Chengdu Tecbond Biological Products Co., Ltd, 610100, Sichuan, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xu", 
        "givenName": "Hongjun", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Key Laboratory of Animal Epidemiology and Zoonoses;, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, No.2 Yuanmingyuan West Road, Haidian District, 100193, Beijing, People\u2019s Republic of China", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Key Laboratory of Animal Epidemiology and Zoonoses;, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, No.2 Yuanmingyuan West Road, Haidian District, 100193, Beijing, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ma", 
        "givenName": "Zengbin", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Key Laboratory of Animal Epidemiology and Zoonoses;, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, No.2 Yuanmingyuan West Road, Haidian District, 100193, Beijing, People\u2019s Republic of China", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Key Laboratory of Animal Epidemiology and Zoonoses;, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, No.2 Yuanmingyuan West Road, Haidian District, 100193, Beijing, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Guozhong", 
        "id": "sg:person.01166756567.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166756567.26"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/s12917-015-0537-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031614046", 
          "https://doi.org/10.1186/s12917-015-0537-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11262-009-0370-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048341921", 
          "https://doi.org/10.1007/s11262-009-0370-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s13337-015-0299-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006022244", 
          "https://doi.org/10.1007/s13337-015-0299-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00705-009-0540-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048245135", 
          "https://doi.org/10.1007/s00705-009-0540-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11250-013-0475-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034585976", 
          "https://doi.org/10.1007/s11250-013-0475-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11250-014-0677-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032317534", 
          "https://doi.org/10.1007/s11250-014-0677-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10529-015-1799-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029611220", 
          "https://doi.org/10.1007/s10529-015-1799-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11262-012-0738-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004281431", 
          "https://doi.org/10.1007/s11262-012-0738-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00705-003-0014-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075306424", 
          "https://doi.org/10.1007/s00705-003-0014-z"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-03-16", 
    "datePublishedReg": "2017-03-16", 
    "description": "BackgroundNewcastle disease (ND) and avian influenza subtype H9N2 (H9N2 AI) are two of the most important diseases of poultry, causing severe economic losses in the global poultry industry. Vaccination is an effective way to prevent and control the spread of ND virus (NDV) and H9N2 AI virus (AIV), but the antigenic differences between the current circulating strains and the vaccine strains might account for recent ND and H9N2 AI outbreaks in vaccinated poultry flocks.MethodsWe developed an inactivated bivalent H9N2 and NDV vaccine based on the current prevalent strains of H9N2 AIV and NDV in China and evaluated its efficacy in chickens in this study.ResultsThe results indicated that the inactivated bivalent vaccine could induce a fast antibody response in vaccinated chickens. The hemagglutination inhibition (HI) titer in the sera increased rapidly, and the highest HI titer was observed at 4\u00a0weeks post-vaccination (wpv) with a mean titre of 8.6 log2 for NDV and 9.5 log2 for H9N2. Up until 15 wpv, HI titers were still detectable at a high level of over 6 log2. The immunized chickens showed no signs of disease after challenge at 3 wpv with the prevalent strains of NDV and H9N2 AIV isolated in 2012\u20132014. Moreover, viral shedding was completely inhibited in vaccinated chickens after challenge with H9N2 AIV and inhibited by at least 90% with NDV compared to the controls at 5dpc.ConclusionsOur findings suggest that the inactivated NDV and H9N2 vaccine induces a fast and strong antibody response in vaccinated chickens and is efficacious in poultry against NDVs and H9N2 AIVs.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s12985-017-0723-7", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1034449", 
        "issn": [
          "1743-422X"
        ], 
        "name": "Virology Journal", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "14"
      }
    ], 
    "keywords": [
      "inactivated bivalent vaccine", 
      "AI viruses", 
      "ND virus", 
      "bivalent vaccine", 
      "global poultry industry", 
      "severe economic losses", 
      "avian influenza subtypes", 
      "vaccinated poultry flocks", 
      "HI titers", 
      "prevalent strains", 
      "higher HI titers", 
      "AI outbreaks", 
      "H9N2 vaccine", 
      "poultry industry", 
      "poultry flocks", 
      "Newcastle disease", 
      "important disease", 
      "NDV vaccine", 
      "avian influenza", 
      "economic losses", 
      "immunized chickens", 
      "vaccine strain", 
      "faster antibody response", 
      "signs of disease", 
      "hemagglutination inhibition titers", 
      "chickens", 
      "poultry", 
      "influenza subtypes", 
      "viral shedding", 
      "strong antibody response", 
      "antigenic differences", 
      "inhibition titers", 
      "vaccine", 
      "ResultsThe results", 
      "H9N2", 
      "WPV", 
      "flocks", 
      "antibody response", 
      "virus", 
      "strains", 
      "outbreak", 
      "high levels", 
      "log2", 
      "shedding", 
      "vaccination", 
      "ConclusionsOur findings", 
      "influenza", 
      "spread", 
      "mean titres", 
      "bivalents", 
      "effective way", 
      "titers", 
      "disease", 
      "industry", 
      "response", 
      "China", 
      "loss", 
      "titres", 
      "control", 
      "challenges", 
      "efficacy", 
      "levels", 
      "differences", 
      "subtypes", 
      "MethodsWe", 
      "serum", 
      "weeks", 
      "study", 
      "signs", 
      "results", 
      "findings", 
      "way", 
      "Nd"
    ], 
    "name": "Efficacy of an inactivated bivalent vaccine against the prevalent strains of Newcastle disease and H9N2 avian influenza", 
    "pagination": "56", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1084251625"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12985-017-0723-7"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28302119"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12985-017-0723-7", 
      "https://app.dimensions.ai/details/publication/pub.1084251625"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:35", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_723.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s12985-017-0723-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12985-017-0723-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12985-017-0723-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12985-017-0723-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12985-017-0723-7'


 

This table displays all metadata directly associated to this object as RDF triples.

253 TRIPLES      21 PREDICATES      121 URIs      102 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12985-017-0723-7 schema:about N0a3700768aa1469688908d752afd5aca
2 N178a34217ff746829d0bd1e8ba6ec517
3 N2da83507feb540ada77b2351ba3b480d
4 N38c3818842594ab2a5fc1b6ff9f12f98
5 N3b276ae9faa447a3867d7f51eca2bcc4
6 N8bf324e8e5774938b8305a1c6553cfa1
7 N9e3797537ec44db1baffd2259c276c28
8 Na29fa25f640d42689f129e41530c5cd2
9 Nd4dd23e5fba14a648d93147459c638e4
10 Ne2e16b643a4d4b76ad94c3b775090dd1
11 Ne7ecb41f933445879a56e44a6458ab34
12 Nf335d1f094af4af3a9b08802101c464b
13 anzsrc-for:06
14 anzsrc-for:0605
15 anzsrc-for:11
16 anzsrc-for:1108
17 schema:author N459d7ad579d843878e49544ab29c5731
18 schema:citation sg:pub.10.1007/s00705-003-0014-z
19 sg:pub.10.1007/s00705-009-0540-4
20 sg:pub.10.1007/s10529-015-1799-z
21 sg:pub.10.1007/s11250-013-0475-3
22 sg:pub.10.1007/s11250-014-0677-3
23 sg:pub.10.1007/s11262-009-0370-1
24 sg:pub.10.1007/s11262-012-0738-5
25 sg:pub.10.1007/s13337-015-0299-z
26 sg:pub.10.1186/s12917-015-0537-z
27 schema:datePublished 2017-03-16
28 schema:datePublishedReg 2017-03-16
29 schema:description BackgroundNewcastle disease (ND) and avian influenza subtype H9N2 (H9N2 AI) are two of the most important diseases of poultry, causing severe economic losses in the global poultry industry. Vaccination is an effective way to prevent and control the spread of ND virus (NDV) and H9N2 AI virus (AIV), but the antigenic differences between the current circulating strains and the vaccine strains might account for recent ND and H9N2 AI outbreaks in vaccinated poultry flocks.MethodsWe developed an inactivated bivalent H9N2 and NDV vaccine based on the current prevalent strains of H9N2 AIV and NDV in China and evaluated its efficacy in chickens in this study.ResultsThe results indicated that the inactivated bivalent vaccine could induce a fast antibody response in vaccinated chickens. The hemagglutination inhibition (HI) titer in the sera increased rapidly, and the highest HI titer was observed at 4 weeks post-vaccination (wpv) with a mean titre of 8.6 log2 for NDV and 9.5 log2 for H9N2. Up until 15 wpv, HI titers were still detectable at a high level of over 6 log2. The immunized chickens showed no signs of disease after challenge at 3 wpv with the prevalent strains of NDV and H9N2 AIV isolated in 2012–2014. Moreover, viral shedding was completely inhibited in vaccinated chickens after challenge with H9N2 AIV and inhibited by at least 90% with NDV compared to the controls at 5dpc.ConclusionsOur findings suggest that the inactivated NDV and H9N2 vaccine induces a fast and strong antibody response in vaccinated chickens and is efficacious in poultry against NDVs and H9N2 AIVs.
30 schema:genre article
31 schema:isAccessibleForFree true
32 schema:isPartOf N229e3905cd084b2fad06fb508a3d24ff
33 N361d3c2e231e4b28ad0ae01bb3ed68c6
34 sg:journal.1034449
35 schema:keywords AI outbreaks
36 AI viruses
37 China
38 ConclusionsOur findings
39 H9N2
40 H9N2 vaccine
41 HI titers
42 MethodsWe
43 ND virus
44 NDV vaccine
45 Nd
46 Newcastle disease
47 ResultsThe results
48 WPV
49 antibody response
50 antigenic differences
51 avian influenza
52 avian influenza subtypes
53 bivalent vaccine
54 bivalents
55 challenges
56 chickens
57 control
58 differences
59 disease
60 economic losses
61 effective way
62 efficacy
63 faster antibody response
64 findings
65 flocks
66 global poultry industry
67 hemagglutination inhibition titers
68 high levels
69 higher HI titers
70 immunized chickens
71 important disease
72 inactivated bivalent vaccine
73 industry
74 influenza
75 influenza subtypes
76 inhibition titers
77 levels
78 log2
79 loss
80 mean titres
81 outbreak
82 poultry
83 poultry flocks
84 poultry industry
85 prevalent strains
86 response
87 results
88 serum
89 severe economic losses
90 shedding
91 signs
92 signs of disease
93 spread
94 strains
95 strong antibody response
96 study
97 subtypes
98 titers
99 titres
100 vaccinated poultry flocks
101 vaccination
102 vaccine
103 vaccine strain
104 viral shedding
105 virus
106 way
107 weeks
108 schema:name Efficacy of an inactivated bivalent vaccine against the prevalent strains of Newcastle disease and H9N2 avian influenza
109 schema:pagination 56
110 schema:productId N632bcbf8c2a649d0879d09961dbad14c
111 N8fe1b03522eb4f0db3d3e6df205af474
112 Nd91ce2814b22467c8c0e9debef43fe22
113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084251625
114 https://doi.org/10.1186/s12985-017-0723-7
115 schema:sdDatePublished 2022-12-01T06:35
116 schema:sdLicense https://scigraph.springernature.com/explorer/license/
117 schema:sdPublisher Ndd5ae8241a054ceea5d886effa5867d8
118 schema:url https://doi.org/10.1186/s12985-017-0723-7
119 sgo:license sg:explorer/license/
120 sgo:sdDataset articles
121 rdf:type schema:ScholarlyArticle
122 N0a3700768aa1469688908d752afd5aca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Vaccines, Combined
124 rdf:type schema:DefinedTerm
125 N178a34217ff746829d0bd1e8ba6ec517 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name China
127 rdf:type schema:DefinedTerm
128 N1a112e3202e840128cb5113ecb9bc7d5 rdf:first sg:person.01166756567.26
129 rdf:rest rdf:nil
130 N229e3905cd084b2fad06fb508a3d24ff schema:volumeNumber 14
131 rdf:type schema:PublicationVolume
132 N2da83507feb540ada77b2351ba3b480d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Virus Shedding
134 rdf:type schema:DefinedTerm
135 N361d3c2e231e4b28ad0ae01bb3ed68c6 schema:issueNumber 1
136 rdf:type schema:PublicationIssue
137 N38c3818842594ab2a5fc1b6ff9f12f98 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Newcastle Disease
139 rdf:type schema:DefinedTerm
140 N3b276ae9faa447a3867d7f51eca2bcc4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Newcastle disease virus
142 rdf:type schema:DefinedTerm
143 N459d7ad579d843878e49544ab29c5731 rdf:first sg:person.01212547171.35
144 rdf:rest N4ff09ffb54ef4580a11e8229a48a10c0
145 N4ff09ffb54ef4580a11e8229a48a10c0 rdf:first sg:person.012410714447.34
146 rdf:rest Nbb2911d54a8b46c0a3af32cec326db44
147 N5eccf27632e342e4ba8fcb103941c6ff schema:affiliation grid-institutes:None
148 schema:familyName Ma
149 schema:givenName Zengbin
150 rdf:type schema:Person
151 N632bcbf8c2a649d0879d09961dbad14c schema:name pubmed_id
152 schema:value 28302119
153 rdf:type schema:PropertyValue
154 N8bf324e8e5774938b8305a1c6553cfa1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Vaccines, Inactivated
156 rdf:type schema:DefinedTerm
157 N8fe1b03522eb4f0db3d3e6df205af474 schema:name dimensions_id
158 schema:value pub.1084251625
159 rdf:type schema:PropertyValue
160 N9e3797537ec44db1baffd2259c276c28 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Animals
162 rdf:type schema:DefinedTerm
163 Na29fa25f640d42689f129e41530c5cd2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Influenza A Virus, H9N2 Subtype
165 rdf:type schema:DefinedTerm
166 Nbb2911d54a8b46c0a3af32cec326db44 rdf:first Ne27916de81544820989635acf156e8dd
167 rdf:rest Nd949f3ba3f3b479e996d13068bbeece4
168 Nd4dd23e5fba14a648d93147459c638e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Viral Vaccines
170 rdf:type schema:DefinedTerm
171 Nd91ce2814b22467c8c0e9debef43fe22 schema:name doi
172 schema:value 10.1186/s12985-017-0723-7
173 rdf:type schema:PropertyValue
174 Nd949f3ba3f3b479e996d13068bbeece4 rdf:first N5eccf27632e342e4ba8fcb103941c6ff
175 rdf:rest N1a112e3202e840128cb5113ecb9bc7d5
176 Ndd5ae8241a054ceea5d886effa5867d8 schema:name Springer Nature - SN SciGraph project
177 rdf:type schema:Organization
178 Ne27916de81544820989635acf156e8dd schema:affiliation grid-institutes:None
179 schema:familyName Xu
180 schema:givenName Hongjun
181 rdf:type schema:Person
182 Ne2e16b643a4d4b76ad94c3b775090dd1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Chickens
184 rdf:type schema:DefinedTerm
185 Ne7ecb41f933445879a56e44a6458ab34 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Antibodies, Viral
187 rdf:type schema:DefinedTerm
188 Nf335d1f094af4af3a9b08802101c464b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Influenza in Birds
190 rdf:type schema:DefinedTerm
191 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
192 schema:name Biological Sciences
193 rdf:type schema:DefinedTerm
194 anzsrc-for:0605 schema:inDefinedTermSet anzsrc-for:
195 schema:name Microbiology
196 rdf:type schema:DefinedTerm
197 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
198 schema:name Medical and Health Sciences
199 rdf:type schema:DefinedTerm
200 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
201 schema:name Medical Microbiology
202 rdf:type schema:DefinedTerm
203 sg:journal.1034449 schema:issn 1743-422X
204 schema:name Virology Journal
205 schema:publisher Springer Nature
206 rdf:type schema:Periodical
207 sg:person.01166756567.26 schema:affiliation grid-institutes:None
208 schema:familyName Zhang
209 schema:givenName Guozhong
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166756567.26
211 rdf:type schema:Person
212 sg:person.01212547171.35 schema:affiliation grid-institutes:None
213 schema:familyName Zhao
214 schema:givenName Jing
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212547171.35
216 rdf:type schema:Person
217 sg:person.012410714447.34 schema:affiliation grid-institutes:None
218 schema:familyName Yang
219 schema:givenName Huiming
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012410714447.34
221 rdf:type schema:Person
222 sg:pub.10.1007/s00705-003-0014-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1075306424
223 https://doi.org/10.1007/s00705-003-0014-z
224 rdf:type schema:CreativeWork
225 sg:pub.10.1007/s00705-009-0540-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048245135
226 https://doi.org/10.1007/s00705-009-0540-4
227 rdf:type schema:CreativeWork
228 sg:pub.10.1007/s10529-015-1799-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1029611220
229 https://doi.org/10.1007/s10529-015-1799-z
230 rdf:type schema:CreativeWork
231 sg:pub.10.1007/s11250-013-0475-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034585976
232 https://doi.org/10.1007/s11250-013-0475-3
233 rdf:type schema:CreativeWork
234 sg:pub.10.1007/s11250-014-0677-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032317534
235 https://doi.org/10.1007/s11250-014-0677-3
236 rdf:type schema:CreativeWork
237 sg:pub.10.1007/s11262-009-0370-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048341921
238 https://doi.org/10.1007/s11262-009-0370-1
239 rdf:type schema:CreativeWork
240 sg:pub.10.1007/s11262-012-0738-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004281431
241 https://doi.org/10.1007/s11262-012-0738-5
242 rdf:type schema:CreativeWork
243 sg:pub.10.1007/s13337-015-0299-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1006022244
244 https://doi.org/10.1007/s13337-015-0299-z
245 rdf:type schema:CreativeWork
246 sg:pub.10.1186/s12917-015-0537-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1031614046
247 https://doi.org/10.1186/s12917-015-0537-z
248 rdf:type schema:CreativeWork
249 grid-institutes:None schema:alternateName Chengdu Tecbond Biological Products Co., Ltd, 610100, Sichuan, People’s Republic of China
250 Key Laboratory of Animal Epidemiology and Zoonoses;, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, No.2 Yuanmingyuan West Road, Haidian District, 100193, Beijing, People’s Republic of China
251 schema:name Chengdu Tecbond Biological Products Co., Ltd, 610100, Sichuan, People’s Republic of China
252 Key Laboratory of Animal Epidemiology and Zoonoses;, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, No.2 Yuanmingyuan West Road, Haidian District, 100193, Beijing, People’s Republic of China
253 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...