Quantitative assessment of cerebellar ataxia, through automated limb functional tests View Full Text


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Article Info

DATE

2019-02-27

AUTHORS

Ragil Krishna, Pubudu N. Pathirana, Malcolm Horne, Laura Power, David J. Szmulewicz

ABSTRACT

BACKGROUND: Cerebellar damage can often result in disabilities affecting the peripheral regions of the body. These include poor and inaccurate coordination, tremors and irregular movements that often manifest as disorders associated with balance, gait and speech. The severity assessment of Cerebellar ataxia (CA) is determined by expert opinion and is likely to be subjective in nature. This paper investigates automated versions of three commonly used tests: Finger to Nose test (FNT), test for upper limb Dysdiadochokinesia Test (DDK) and Heel to Shin Test (HST), in evaluating disability due to CA. METHODS: Limb movements associated with these tests are measured using Inertial Measurement Units (IMU) to capture the disability. Kinematic parameters such as acceleration, velocity and angle are considered in both time and frequency domain in three orthogonal axes to obtain relevant disability related information. The collective dominance in the data distributions of the underlying features were observed though the Principal Component Analysis (PCA). The dominant features were combined to substantiate the correlation with the expert clinical assessments through Linear Discriminant Analysis. Here, the Pearson correlation is used to examine the relationship between the objective assessments and the expert clinical scores while the performance was also verified by means of cross validation. RESULTS: The experimental results show that acceleration is a major feature in DDK and HST, whereas rotation is the main feature responsible for classification in FNT. Combining the features enhanced the correlations in each domain. The subject data was classified based on the severity information based on expert clinical scores. CONCLUSION: For the predominantly translational movement in the upper limb FNT, the rotation captures disability and for the DDK test with predominantly rotational movements, the linear acceleration captures the disability but cannot be extended to the lower limb HST. The orthogonal direction manifestation of ataxia attributed to sensory measurements was determined for each test. TRIAL REGISTRATION: Human Research and Ethics Committee, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia (HREC Reference Number: 11/994H/16). More... »

PAGES

31

References to SciGraph publications

  • 2014-11-27. Rehabilitation exercise assessment using inertial sensors: a cross-sectional analytical study in JOURNAL OF NEUROENGINEERING AND REHABILITATION
  • 2011. Dysdiadochokinesia in ENCYCLOPEDIA OF CLINICAL NEUROPSYCHOLOGY
  • 2011. Finger to Nose Test in ENCYCLOPEDIA OF CLINICAL NEUROPSYCHOLOGY
  • 2004-04-08. A clinical and genetic study in a large cohort of patients with spinocerebellar ataxia type 6 in JOURNAL OF HUMAN GENETICS
  • 2017-02-10. The added value of kinematic evaluation of the timed finger-to-nose test in persons post-stroke in JOURNAL OF NEUROENGINEERING AND REHABILITATION
  • 2017-01-23. Does the Finger-to-Nose Test measure upper limb coordination in chronic stroke? in JOURNAL OF NEUROENGINEERING AND REHABILITATION
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    URI

    http://scigraph.springernature.com/pub.10.1186/s12984-019-0490-3

    DOI

    http://dx.doi.org/10.1186/s12984-019-0490-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112436934

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30813963


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