No evidence of bovine leukemia virus proviral DNA and antibodies in human specimens from Japan View Full Text


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DATE

2022-05-18

AUTHORS

Meripet Polat Yamanaka, Susumu Saito, Yukiko Hara, Ryosuke Matsuura, Shin-nosuke Takeshima, Kazuyoshi Hosomichi, Yasunobu Matsumoto, Rika A. Furuta, Masami Takei, Yoko Aida

ABSTRACT

BackgroundThe potential risk and association of bovine leukemia virus (BLV) with human remains controversial as it has been reported to be both positive and negative in human breast cancer and blood samples. Therefore, establishing the presence of BLV in comprehensive human clinical samples in different geographical locations is essential.ResultIn this study, we examined the presence of BLV proviral DNA in human blood and breast cancer tissue specimens from Japan. PCR analysis of BLV provirus in 97 Japanese human blood samples and 23 breast cancer tissues showed negative result for all samples tested using long-fragment PCR and highly-sensitive short-fragment PCR amplification. No IgG and IgM antibodies were detected in any of the 97 human serum samples using BLV gp51 and p24 indirect ELISA test. Western blot analysis also showed negative result for IgG and IgM antibodies in all tested human serum samples.ConclusionOur results indicate that Japanese human specimens including 97 human blood, 23 breast cancer tissues, and 97 serum samples were negative for BLV. More... »

PAGES

7

References to SciGraph publications

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  • 2019-11-27. Absence of bovine leukemia virus proviral DNA in Japanese human blood cell lines and human cancer cell lines in ARCHIVES OF VIROLOGY
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    http://scigraph.springernature.com/pub.10.1186/s12977-022-00592-6

    DOI

    http://dx.doi.org/10.1186/s12977-022-00592-6

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/35585539


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    30 schema:description BackgroundThe potential risk and association of bovine leukemia virus (BLV) with human remains controversial as it has been reported to be both positive and negative in human breast cancer and blood samples. Therefore, establishing the presence of BLV in comprehensive human clinical samples in different geographical locations is essential.ResultIn this study, we examined the presence of BLV proviral DNA in human blood and breast cancer tissue specimens from Japan. PCR analysis of BLV provirus in 97 Japanese human blood samples and 23 breast cancer tissues showed negative result for all samples tested using long-fragment PCR and highly-sensitive short-fragment PCR amplification. No IgG and IgM antibodies were detected in any of the 97 human serum samples using BLV gp51 and p24 indirect ELISA test. Western blot analysis also showed negative result for IgG and IgM antibodies in all tested human serum samples.ConclusionOur results indicate that Japanese human specimens including 97 human blood, 23 breast cancer tissues, and 97 serum samples were negative for BLV.
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    38 BLV provirus
    39 ConclusionOur results
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    47 PCR analysis
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    51 analysis
    52 antibodies
    53 association
    54 blood
    55 blood samples
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    57 bovine leukemia virus
    58 bovine leukemia virus proviral DNA
    59 breast cancer
    60 breast cancer tissues
    61 cancer
    62 cancer tissues
    63 clinical samples
    64 different geographical locations
    65 evidence
    66 geographical location
    67 gp51
    68 human blood
    69 human breast cancer
    70 human clinical samples
    71 human serum samples
    72 human specimens
    73 indirect ELISA test
    74 leukemia virus
    75 location
    76 long-fragment PCR
    77 negative results
    78 potential risk
    79 presence
    80 presence of BLV
    81 proviral DNA
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    83 results
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