No evidence of bovine leukemia virus proviral DNA and antibodies in human specimens from Japan View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2022-05-18

AUTHORS

Meripet Polat Yamanaka, Susumu Saito, Yukiko Hara, Ryosuke Matsuura, Shin-nosuke Takeshima, Kazuyoshi Hosomichi, Yasunobu Matsumoto, Rika A. Furuta, Masami Takei, Yoko Aida

ABSTRACT

BackgroundThe potential risk and association of bovine leukemia virus (BLV) with human remains controversial as it has been reported to be both positive and negative in human breast cancer and blood samples. Therefore, establishing the presence of BLV in comprehensive human clinical samples in different geographical locations is essential.ResultIn this study, we examined the presence of BLV proviral DNA in human blood and breast cancer tissue specimens from Japan. PCR analysis of BLV provirus in 97 Japanese human blood samples and 23 breast cancer tissues showed negative result for all samples tested using long-fragment PCR and highly-sensitive short-fragment PCR amplification. No IgG and IgM antibodies were detected in any of the 97 human serum samples using BLV gp51 and p24 indirect ELISA test. Western blot analysis also showed negative result for IgG and IgM antibodies in all tested human serum samples.ConclusionOur results indicate that Japanese human specimens including 97 human blood, 23 breast cancer tissues, and 97 serum samples were negative for BLV. More... »

PAGES

7

References to SciGraph publications

  • 2017-10-16. Multiple oncogenic viruses are present in human breast tissues before development of virus associated breast cancer in INFECTIOUS AGENTS AND CANCER
  • 2017-11-02. Epidemiology and genetic diversity of bovine leukemia virus in VIROLOGY JOURNAL
  • 2016-11-04. Whole genome sequencing of 51 breast cancers reveals that tumors are devoid of bovine leukemia virus DNA in RETROVIROLOGY
  • 2016-07-14. Molecular evidence of viral DNA in non-small cell lung cancer and non-neoplastic lung in BRITISH JOURNAL OF CANCER
  • 1981-12. The zoonotic potential of bovine leukemia virus in VETERINARY RESEARCH COMMUNICATIONS
  • 2018-10-11. Development of a new recombinant p24 ELISA system for diagnosis of bovine leukemia virus in serum and milk in ARCHIVES OF VIROLOGY
  • 2016-10-10. Lack of association between bovine leukemia virus and breast cancer in Chinese patients in BREAST CANCER RESEARCH
  • 2019-11-29. Visualizing bovine leukemia virus (BLV)-infected cells and measuring BLV proviral loads in the milk of BLV seropositive dams in VETERINARY RESEARCH
  • 2019-04-02. Bovine leukemia virus discovered in human blood in BMC INFECTIOUS DISEASES
  • 2007-03-16. Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human in RETROVIROLOGY
  • 2019-02-27. Bovine leukemia virus DNA associated with breast cancer in women from South Brazil in SCIENTIFIC REPORTS
  • 2015-12-30. Identification and characterization of common B cell epitope in bovine leukemia virus via high-throughput peptide screening system in infected cattle in RETROVIROLOGY
  • 2019-11-27. Absence of bovine leukemia virus proviral DNA in Japanese human blood cell lines and human cancer cell lines in ARCHIVES OF VIROLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12977-022-00592-6

    DOI

    http://dx.doi.org/10.1186/s12977-022-00592-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1147970026

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/35585539


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antibodies, Viral", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Blood", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Breast Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA, Viral", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunoglobulin G", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunoglobulin M", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Japan", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Leukemia Virus, Bovine", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Proviruses", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, 173-8610, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.260969.2", 
              "name": [
                "Laboratory of Global Infectious Diseases Control Science, Department of Global Agricultural Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, 113-8657, Tokyo, Japan", 
                "Viral Infectious Diseases Unit, RIKEN, 351-0198, Saitama, Japan", 
                "Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, 173-8610, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yamanaka", 
            "givenName": "Meripet Polat", 
            "id": "sg:person.011013753304.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011013753304.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, 173-8610, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.260969.2", 
              "name": [
                "Viral Infectious Diseases Unit, RIKEN, 351-0198, Saitama, Japan", 
                "Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, 173-8610, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Saito", 
            "givenName": "Susumu", 
            "id": "sg:person.0664252271.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664252271.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Department of Breast and Endocrine Surgery, Department of Surgery, Nihon University School of Medicine, 173-8610, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.260969.2", 
              "name": [
                "Division of Department of Breast and Endocrine Surgery, Department of Surgery, Nihon University School of Medicine, 173-8610, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hara", 
            "givenName": "Yukiko", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, 173-8610, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.260969.2", 
              "name": [
                "Laboratory of Global Infectious Diseases Control Science, Department of Global Agricultural Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, 113-8657, Tokyo, Japan", 
                "Viral Infectious Diseases Unit, RIKEN, 351-0198, Saitama, Japan", 
                "Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, 173-8610, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Matsuura", 
            "givenName": "Ryosuke", 
            "id": "sg:person.010251676203.82", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010251676203.82"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Food and Nutrition, Jumonji University, 352-8510, Saitama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.444497.e", 
              "name": [
                "Viral Infectious Diseases Unit, RIKEN, 351-0198, Saitama, Japan", 
                "Department of Food and Nutrition, Jumonji University, 352-8510, Saitama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Takeshima", 
            "givenName": "Shin-nosuke", 
            "id": "sg:person.0675312561.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675312561.57"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Bioinformatics and Genomics, Graduate School of Medical Sciences, Kanazawa University, 920-8640, Ishikawa, Japan", 
              "id": "http://www.grid.ac/institutes/grid.9707.9", 
              "name": [
                "Department of Bioinformatics and Genomics, Graduate School of Medical Sciences, Kanazawa University, 920-8640, Ishikawa, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hosomichi", 
            "givenName": "Kazuyoshi", 
            "id": "sg:person.01317242717.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317242717.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Laboratory of Global Animal Resource Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 113-8657, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Laboratory of Global Infectious Diseases Control Science, Department of Global Agricultural Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, 113-8657, Tokyo, Japan", 
                "Laboratory of Global Animal Resource Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 113-8657, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Matsumoto", 
            "givenName": "Yasunobu", 
            "id": "sg:person.015603446552.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015603446552.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Central Blood Institute, Blood Service Headquarters, Japanese Red Cross Society, 135-8521, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410775.0", 
              "name": [
                "Central Blood Institute, Blood Service Headquarters, Japanese Red Cross Society, 135-8521, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Furuta", 
            "givenName": "Rika A.", 
            "id": "sg:person.01017762237.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017762237.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, 173-8610, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.260969.2", 
              "name": [
                "Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, 173-8610, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Takei", 
            "givenName": "Masami", 
            "id": "sg:person.01307751612.93", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307751612.93"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, 173-8610, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.260969.2", 
              "name": [
                "Laboratory of Global Infectious Diseases Control Science, Department of Global Agricultural Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, 113-8657, Tokyo, Japan", 
                "Viral Infectious Diseases Unit, RIKEN, 351-0198, Saitama, Japan", 
                "Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, 173-8610, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Aida", 
            "givenName": "Yoko", 
            "id": "sg:person.01264264462.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264264462.02"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1186/s13567-019-0724-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1123022028", 
              "https://doi.org/10.1186/s13567-019-0724-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12879-019-3891-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1113179430", 
              "https://doi.org/10.1186/s12879-019-3891-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2016.213", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038278302", 
              "https://doi.org/10.1038/bjc.2016.213"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12977-016-0308-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046446439", 
              "https://doi.org/10.1186/s12977-016-0308-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1742-4690-4-18", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006295430", 
              "https://doi.org/10.1186/1742-4690-4-18"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13027-017-0165-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092240146", 
              "https://doi.org/10.1186/s13027-017-0165-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00705-018-4058-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107553076", 
              "https://doi.org/10.1007/s00705-018-4058-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12985-017-0876-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092508526", 
              "https://doi.org/10.1186/s12985-017-0876-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-019-39834-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1112393793", 
              "https://doi.org/10.1038/s41598-019-39834-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13058-016-0763-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049776099", 
              "https://doi.org/10.1186/s13058-016-0763-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02214976", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032043727", 
              "https://doi.org/10.1007/bf02214976"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00705-019-04474-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1122953616", 
              "https://doi.org/10.1007/s00705-019-04474-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12977-015-0233-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004163661", 
              "https://doi.org/10.1186/s12977-015-0233-x"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2022-05-18", 
        "datePublishedReg": "2022-05-18", 
        "description": "BackgroundThe potential risk and association of bovine leukemia virus (BLV) with human remains controversial as it has been reported to be both positive and negative in human breast cancer and blood samples. Therefore, establishing the presence of BLV in comprehensive human clinical samples in different geographical locations is essential.ResultIn this study, we examined the presence of BLV proviral DNA in human blood and breast cancer tissue specimens from Japan. PCR analysis of BLV provirus in 97 Japanese human blood\u00a0samples and 23 breast cancer tissues showed negative result for all samples tested using long-fragment PCR and highly-sensitive short-fragment PCR amplification. No IgG and IgM antibodies were detected in any of the 97 human serum samples using BLV gp51 and p24 indirect ELISA test. Western blot analysis also showed negative result for IgG and IgM antibodies in all tested human serum samples.ConclusionOur results indicate that Japanese human specimens including 97 human blood, 23 breast cancer tissues, and 97 serum samples  were negative for BLV.", 
        "genre": "article", 
        "id": "sg:pub.10.1186/s12977-022-00592-6", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.7545332", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.5903101", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1033800", 
            "issn": [
              "1742-4690"
            ], 
            "name": "Retrovirology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "19"
          }
        ], 
        "keywords": [
          "breast cancer tissues", 
          "bovine leukemia virus", 
          "cancer tissues", 
          "IgM antibodies", 
          "serum samples", 
          "proviral DNA", 
          "human blood", 
          "human specimens", 
          "human breast cancer", 
          "negative results", 
          "presence of BLV", 
          "indirect ELISA test", 
          "Western blot analysis", 
          "breast cancer", 
          "human clinical samples", 
          "blood samples", 
          "ConclusionOur results", 
          "BLV proviral DNA", 
          "ELISA test", 
          "long-fragment PCR", 
          "bovine leukemia virus proviral DNA", 
          "clinical samples", 
          "blood", 
          "antibodies", 
          "BLV gp51", 
          "leukemia virus", 
          "blot analysis", 
          "IgG", 
          "tissue", 
          "BLV provirus", 
          "potential risk", 
          "PCR analysis", 
          "human serum samples", 
          "cancer", 
          "PCR amplification", 
          "virus", 
          "risk", 
          "ResultIn", 
          "association", 
          "provirus", 
          "specimens", 
          "PCR", 
          "gp51", 
          "samples", 
          "presence", 
          "DNA", 
          "evidence", 
          "study", 
          "results", 
          "test", 
          "Japan", 
          "different geographical locations", 
          "analysis", 
          "amplification", 
          "geographical location", 
          "location"
        ], 
        "name": "No evidence of bovine leukemia virus proviral DNA and antibodies in human specimens from Japan", 
        "pagination": "7", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1147970026"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s12977-022-00592-6"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "35585539"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s12977-022-00592-6", 
          "https://app.dimensions.ai/details/publication/pub.1147970026"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-11-24T21:09", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_928.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1186/s12977-022-00592-6"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12977-022-00592-6'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12977-022-00592-6'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12977-022-00592-6'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12977-022-00592-6'


     

    This table displays all metadata directly associated to this object as RDF triples.

    296 TRIPLES      21 PREDICATES      105 URIs      84 LITERALS      18 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s12977-022-00592-6 schema:about N343671b0a0f242c990227b76fc31d44e
    2 N34a6bc9be1ec4730a2548e0626d6751e
    3 N40ddfddb18a0414b92942149778443d2
    4 N4839c94fe50040fba0792af0a2534f3c
    5 N74e2b24030f243eabd26c90e0228401b
    6 Na7c26c5c90b742f897d310faa64b56bd
    7 Nc34456300bc04716ba938ebfecdff50e
    8 Ne155633d626042f38f32febeb336a18c
    9 Ne567e2243b8d4edab6cb651afda4eb38
    10 Neb061d4427bc4422a676cf92c509d115
    11 Nf05cc3ef79e64db78e0214757899f104
    12 anzsrc-for:11
    13 anzsrc-for:1112
    14 schema:author N289274eb23164bb88ee3a684ba424f13
    15 schema:citation sg:pub.10.1007/bf02214976
    16 sg:pub.10.1007/s00705-018-4058-5
    17 sg:pub.10.1007/s00705-019-04474-9
    18 sg:pub.10.1038/bjc.2016.213
    19 sg:pub.10.1038/s41598-019-39834-7
    20 sg:pub.10.1186/1742-4690-4-18
    21 sg:pub.10.1186/s12879-019-3891-9
    22 sg:pub.10.1186/s12977-015-0233-x
    23 sg:pub.10.1186/s12977-016-0308-3
    24 sg:pub.10.1186/s12985-017-0876-4
    25 sg:pub.10.1186/s13027-017-0165-2
    26 sg:pub.10.1186/s13058-016-0763-8
    27 sg:pub.10.1186/s13567-019-0724-1
    28 schema:datePublished 2022-05-18
    29 schema:datePublishedReg 2022-05-18
    30 schema:description BackgroundThe potential risk and association of bovine leukemia virus (BLV) with human remains controversial as it has been reported to be both positive and negative in human breast cancer and blood samples. Therefore, establishing the presence of BLV in comprehensive human clinical samples in different geographical locations is essential.ResultIn this study, we examined the presence of BLV proviral DNA in human blood and breast cancer tissue specimens from Japan. PCR analysis of BLV provirus in 97 Japanese human blood samples and 23 breast cancer tissues showed negative result for all samples tested using long-fragment PCR and highly-sensitive short-fragment PCR amplification. No IgG and IgM antibodies were detected in any of the 97 human serum samples using BLV gp51 and p24 indirect ELISA test. Western blot analysis also showed negative result for IgG and IgM antibodies in all tested human serum samples.ConclusionOur results indicate that Japanese human specimens including 97 human blood, 23 breast cancer tissues, and 97 serum samples were negative for BLV.
    31 schema:genre article
    32 schema:isAccessibleForFree true
    33 schema:isPartOf Nb8a2ce87d0f940f9bc037225ce62c357
    34 Nbf95ba334f4043cb85d8b11f69f87ddf
    35 sg:journal.1033800
    36 schema:keywords BLV gp51
    37 BLV proviral DNA
    38 BLV provirus
    39 ConclusionOur results
    40 DNA
    41 ELISA test
    42 IgG
    43 IgM antibodies
    44 Japan
    45 PCR
    46 PCR amplification
    47 PCR analysis
    48 ResultIn
    49 Western blot analysis
    50 amplification
    51 analysis
    52 antibodies
    53 association
    54 blood
    55 blood samples
    56 blot analysis
    57 bovine leukemia virus
    58 bovine leukemia virus proviral DNA
    59 breast cancer
    60 breast cancer tissues
    61 cancer
    62 cancer tissues
    63 clinical samples
    64 different geographical locations
    65 evidence
    66 geographical location
    67 gp51
    68 human blood
    69 human breast cancer
    70 human clinical samples
    71 human serum samples
    72 human specimens
    73 indirect ELISA test
    74 leukemia virus
    75 location
    76 long-fragment PCR
    77 negative results
    78 potential risk
    79 presence
    80 presence of BLV
    81 proviral DNA
    82 provirus
    83 results
    84 risk
    85 samples
    86 serum samples
    87 specimens
    88 study
    89 test
    90 tissue
    91 virus
    92 schema:name No evidence of bovine leukemia virus proviral DNA and antibodies in human specimens from Japan
    93 schema:pagination 7
    94 schema:productId N0cc74bc809e64eb9894133cfd7e9615e
    95 N928060e38e724def9381a05463cfaa8f
    96 Nbc9f044e5f544c2ea4cf01c7ec009c80
    97 schema:sameAs https://app.dimensions.ai/details/publication/pub.1147970026
    98 https://doi.org/10.1186/s12977-022-00592-6
    99 schema:sdDatePublished 2022-11-24T21:09
    100 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    101 schema:sdPublisher N3f5ec1bb69954659ac752b04e7f067b1
    102 schema:url https://doi.org/10.1186/s12977-022-00592-6
    103 sgo:license sg:explorer/license/
    104 sgo:sdDataset articles
    105 rdf:type schema:ScholarlyArticle
    106 N0cc74bc809e64eb9894133cfd7e9615e schema:name pubmed_id
    107 schema:value 35585539
    108 rdf:type schema:PropertyValue
    109 N289274eb23164bb88ee3a684ba424f13 rdf:first sg:person.011013753304.23
    110 rdf:rest N63b45c23f15b47d8a49e5477ddaad293
    111 N343671b0a0f242c990227b76fc31d44e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    112 schema:name DNA, Viral
    113 rdf:type schema:DefinedTerm
    114 N34a6bc9be1ec4730a2548e0626d6751e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    115 schema:name Proviruses
    116 rdf:type schema:DefinedTerm
    117 N3f5ec1bb69954659ac752b04e7f067b1 schema:name Springer Nature - SN SciGraph project
    118 rdf:type schema:Organization
    119 N40ddfddb18a0414b92942149778443d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    120 schema:name Japan
    121 rdf:type schema:DefinedTerm
    122 N4839c94fe50040fba0792af0a2534f3c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    123 schema:name Blood
    124 rdf:type schema:DefinedTerm
    125 N63b45c23f15b47d8a49e5477ddaad293 rdf:first sg:person.0664252271.20
    126 rdf:rest Nc1b142806dae42489546728b9d71c94b
    127 N6400428a549a49fa95bb4f66ecd7b719 rdf:first sg:person.015603446552.33
    128 rdf:rest Nfafe616fed6f44ceb11573fba6919176
    129 N74e2b24030f243eabd26c90e0228401b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    130 schema:name Immunoglobulin M
    131 rdf:type schema:DefinedTerm
    132 N928060e38e724def9381a05463cfaa8f schema:name dimensions_id
    133 schema:value pub.1147970026
    134 rdf:type schema:PropertyValue
    135 N9d60ed2e0c1247d6b09ef2340422817f rdf:first sg:person.0675312561.57
    136 rdf:rest Nd785ba8b10e44d8ba793f7f47655a359
    137 Na7c26c5c90b742f897d310faa64b56bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Breast Neoplasms
    139 rdf:type schema:DefinedTerm
    140 Nb8a2ce87d0f940f9bc037225ce62c357 schema:volumeNumber 19
    141 rdf:type schema:PublicationVolume
    142 Nbc9f044e5f544c2ea4cf01c7ec009c80 schema:name doi
    143 schema:value 10.1186/s12977-022-00592-6
    144 rdf:type schema:PropertyValue
    145 Nbf95ba334f4043cb85d8b11f69f87ddf schema:issueNumber 1
    146 rdf:type schema:PublicationIssue
    147 Nc1b142806dae42489546728b9d71c94b rdf:first Nce776c25d1f145f78ccfcbf2fe064a0e
    148 rdf:rest Ndf5f106bd461493587490e947872e690
    149 Nc34456300bc04716ba938ebfecdff50e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Humans
    151 rdf:type schema:DefinedTerm
    152 Nce776c25d1f145f78ccfcbf2fe064a0e schema:affiliation grid-institutes:grid.260969.2
    153 schema:familyName Hara
    154 schema:givenName Yukiko
    155 rdf:type schema:Person
    156 Nced971b44b174f878e4066b48d62078d rdf:first sg:person.01264264462.02
    157 rdf:rest rdf:nil
    158 Nd785ba8b10e44d8ba793f7f47655a359 rdf:first sg:person.01317242717.32
    159 rdf:rest N6400428a549a49fa95bb4f66ecd7b719
    160 Ndaeac2319d68417bb2ffcd16d4de99ec rdf:first sg:person.01307751612.93
    161 rdf:rest Nced971b44b174f878e4066b48d62078d
    162 Ndf5f106bd461493587490e947872e690 rdf:first sg:person.010251676203.82
    163 rdf:rest N9d60ed2e0c1247d6b09ef2340422817f
    164 Ne155633d626042f38f32febeb336a18c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    165 schema:name Female
    166 rdf:type schema:DefinedTerm
    167 Ne567e2243b8d4edab6cb651afda4eb38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    168 schema:name Antibodies, Viral
    169 rdf:type schema:DefinedTerm
    170 Neb061d4427bc4422a676cf92c509d115 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    171 schema:name Immunoglobulin G
    172 rdf:type schema:DefinedTerm
    173 Nf05cc3ef79e64db78e0214757899f104 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    174 schema:name Leukemia Virus, Bovine
    175 rdf:type schema:DefinedTerm
    176 Nfafe616fed6f44ceb11573fba6919176 rdf:first sg:person.01017762237.22
    177 rdf:rest Ndaeac2319d68417bb2ffcd16d4de99ec
    178 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    179 schema:name Medical and Health Sciences
    180 rdf:type schema:DefinedTerm
    181 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    182 schema:name Oncology and Carcinogenesis
    183 rdf:type schema:DefinedTerm
    184 sg:grant.5903101 http://pending.schema.org/fundedItem sg:pub.10.1186/s12977-022-00592-6
    185 rdf:type schema:MonetaryGrant
    186 sg:grant.7545332 http://pending.schema.org/fundedItem sg:pub.10.1186/s12977-022-00592-6
    187 rdf:type schema:MonetaryGrant
    188 sg:journal.1033800 schema:issn 1742-4690
    189 schema:name Retrovirology
    190 schema:publisher Springer Nature
    191 rdf:type schema:Periodical
    192 sg:person.01017762237.22 schema:affiliation grid-institutes:grid.410775.0
    193 schema:familyName Furuta
    194 schema:givenName Rika A.
    195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017762237.22
    196 rdf:type schema:Person
    197 sg:person.010251676203.82 schema:affiliation grid-institutes:grid.260969.2
    198 schema:familyName Matsuura
    199 schema:givenName Ryosuke
    200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010251676203.82
    201 rdf:type schema:Person
    202 sg:person.011013753304.23 schema:affiliation grid-institutes:grid.260969.2
    203 schema:familyName Yamanaka
    204 schema:givenName Meripet Polat
    205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011013753304.23
    206 rdf:type schema:Person
    207 sg:person.01264264462.02 schema:affiliation grid-institutes:grid.260969.2
    208 schema:familyName Aida
    209 schema:givenName Yoko
    210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264264462.02
    211 rdf:type schema:Person
    212 sg:person.01307751612.93 schema:affiliation grid-institutes:grid.260969.2
    213 schema:familyName Takei
    214 schema:givenName Masami
    215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307751612.93
    216 rdf:type schema:Person
    217 sg:person.01317242717.32 schema:affiliation grid-institutes:grid.9707.9
    218 schema:familyName Hosomichi
    219 schema:givenName Kazuyoshi
    220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317242717.32
    221 rdf:type schema:Person
    222 sg:person.015603446552.33 schema:affiliation grid-institutes:grid.26999.3d
    223 schema:familyName Matsumoto
    224 schema:givenName Yasunobu
    225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015603446552.33
    226 rdf:type schema:Person
    227 sg:person.0664252271.20 schema:affiliation grid-institutes:grid.260969.2
    228 schema:familyName Saito
    229 schema:givenName Susumu
    230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664252271.20
    231 rdf:type schema:Person
    232 sg:person.0675312561.57 schema:affiliation grid-institutes:grid.444497.e
    233 schema:familyName Takeshima
    234 schema:givenName Shin-nosuke
    235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675312561.57
    236 rdf:type schema:Person
    237 sg:pub.10.1007/bf02214976 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032043727
    238 https://doi.org/10.1007/bf02214976
    239 rdf:type schema:CreativeWork
    240 sg:pub.10.1007/s00705-018-4058-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107553076
    241 https://doi.org/10.1007/s00705-018-4058-5
    242 rdf:type schema:CreativeWork
    243 sg:pub.10.1007/s00705-019-04474-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1122953616
    244 https://doi.org/10.1007/s00705-019-04474-9
    245 rdf:type schema:CreativeWork
    246 sg:pub.10.1038/bjc.2016.213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038278302
    247 https://doi.org/10.1038/bjc.2016.213
    248 rdf:type schema:CreativeWork
    249 sg:pub.10.1038/s41598-019-39834-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112393793
    250 https://doi.org/10.1038/s41598-019-39834-7
    251 rdf:type schema:CreativeWork
    252 sg:pub.10.1186/1742-4690-4-18 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006295430
    253 https://doi.org/10.1186/1742-4690-4-18
    254 rdf:type schema:CreativeWork
    255 sg:pub.10.1186/s12879-019-3891-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113179430
    256 https://doi.org/10.1186/s12879-019-3891-9
    257 rdf:type schema:CreativeWork
    258 sg:pub.10.1186/s12977-015-0233-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004163661
    259 https://doi.org/10.1186/s12977-015-0233-x
    260 rdf:type schema:CreativeWork
    261 sg:pub.10.1186/s12977-016-0308-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046446439
    262 https://doi.org/10.1186/s12977-016-0308-3
    263 rdf:type schema:CreativeWork
    264 sg:pub.10.1186/s12985-017-0876-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092508526
    265 https://doi.org/10.1186/s12985-017-0876-4
    266 rdf:type schema:CreativeWork
    267 sg:pub.10.1186/s13027-017-0165-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092240146
    268 https://doi.org/10.1186/s13027-017-0165-2
    269 rdf:type schema:CreativeWork
    270 sg:pub.10.1186/s13058-016-0763-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049776099
    271 https://doi.org/10.1186/s13058-016-0763-8
    272 rdf:type schema:CreativeWork
    273 sg:pub.10.1186/s13567-019-0724-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1123022028
    274 https://doi.org/10.1186/s13567-019-0724-1
    275 rdf:type schema:CreativeWork
    276 grid-institutes:grid.260969.2 schema:alternateName Division of Department of Breast and Endocrine Surgery, Department of Surgery, Nihon University School of Medicine, 173-8610, Tokyo, Japan
    277 Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, 173-8610, Tokyo, Japan
    278 schema:name Division of Department of Breast and Endocrine Surgery, Department of Surgery, Nihon University School of Medicine, 173-8610, Tokyo, Japan
    279 Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, 173-8610, Tokyo, Japan
    280 Laboratory of Global Infectious Diseases Control Science, Department of Global Agricultural Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, 113-8657, Tokyo, Japan
    281 Viral Infectious Diseases Unit, RIKEN, 351-0198, Saitama, Japan
    282 rdf:type schema:Organization
    283 grid-institutes:grid.26999.3d schema:alternateName Laboratory of Global Animal Resource Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 113-8657, Tokyo, Japan
    284 schema:name Laboratory of Global Animal Resource Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 113-8657, Tokyo, Japan
    285 Laboratory of Global Infectious Diseases Control Science, Department of Global Agricultural Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, 113-8657, Tokyo, Japan
    286 rdf:type schema:Organization
    287 grid-institutes:grid.410775.0 schema:alternateName Central Blood Institute, Blood Service Headquarters, Japanese Red Cross Society, 135-8521, Tokyo, Japan
    288 schema:name Central Blood Institute, Blood Service Headquarters, Japanese Red Cross Society, 135-8521, Tokyo, Japan
    289 rdf:type schema:Organization
    290 grid-institutes:grid.444497.e schema:alternateName Department of Food and Nutrition, Jumonji University, 352-8510, Saitama, Japan
    291 schema:name Department of Food and Nutrition, Jumonji University, 352-8510, Saitama, Japan
    292 Viral Infectious Diseases Unit, RIKEN, 351-0198, Saitama, Japan
    293 rdf:type schema:Organization
    294 grid-institutes:grid.9707.9 schema:alternateName Department of Bioinformatics and Genomics, Graduate School of Medical Sciences, Kanazawa University, 920-8640, Ishikawa, Japan
    295 schema:name Department of Bioinformatics and Genomics, Graduate School of Medical Sciences, Kanazawa University, 920-8640, Ishikawa, Japan
    296 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...