Elevated levels of inflammatory plasma biomarkers are associated with risk of HIV infection View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-03-17

AUTHORS

Samantha McInally, Kristin Wall, Tianwei Yu, Rabindra Tirouvanziam, William Kilembe, Jill Gilmour, Susan A. Allen, Eric Hunter

ABSTRACT

BackgroundTo determine if individuals, from HIV-1 serodiscordant couple cohorts from Rwanda and Zambia, who become HIV-positive have a distinct inflammatory biomarker profile compared to individuals who remain HIV-negative, we compared levels of biomarkers in plasma of HIV-negative individuals who either seroconverted (pre-infection) and became HIV-positive or remained HIV-negative (uninfected).ResultsWe observed that individuals in the combined cohort, as well as those in the individual country cohorts, who later became HIV-1 infected had significantly higher baseline levels of multiple inflammatory cytokines/chemokines compared to individuals who remained HIV-negative. Genital inflammation/ulceration or schistosome infections were not associated with this elevated profile. Defined levels of ITAC and IL-7 were significant predictors of later HIV acquisition in ROC predictive analyses, whereas the classical Th1 and Th2 inflammatory cytokines such as IL-12 and interferon-γ or IL-4, IL-5 and Il-13 were not.ConclusionsOverall, the data show a significant association between increased plasma biomarkers linked to inflammation and immune activation and HIV acquisition and suggests that pre-existing conditions that increase systemic biomarkers represent a factor for increased risk of HIV infection. More... »

PAGES

8

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12977-021-00552-6

DOI

http://dx.doi.org/10.1186/s12977-021-00552-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1136471870

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/33731158


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