The invariant arginine within the chromatin-binding motif regulates both nucleolar localization and chromatin binding of Foamy virus Gag View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Joris Paris, Joëlle Tobaly-Tapiero, Marie-Lou Giron, Julien Burlaud-Gaillard, Florence Buseyne, Philippe Roingeard, Pascale Lesage, Alessia Zamborlini, Ali Saïb

ABSTRACT

BACKGROUND: Nuclear localization of Gag is a property shared by many retroviruses and retrotransposons. The importance of this stage for retroviral replication is still unknown, but studies on the Rous Sarcoma virus indicate that Gag might select the viral RNA genome for packaging in the nucleus. In the case of Foamy viruses, genome encapsidation is mediated by Gag C-terminal domain (CTD), which harbors three clusters of glycine and arginine residues named GR boxes (GRI-III). In this study we investigated how PFV Gag subnuclear distribution might be regulated. RESULTS: We show that the isolated GRI and GRIII boxes act as nucleolar localization signals. In contrast, both the entire Gag CTD and the isolated GRII box, which contains the chromatin-binding motif, target the nucleolus exclusively upon mutation of the evolutionary conserved arginine residue at position 540 (R540), which is a key determinant of FV Gag chromatin tethering. We also provide evidence that Gag localizes in the nucleolus during FV replication and uncovered that the viral protein interacts with and is methylated by Protein Arginine Methyltransferase 1 (PRMT1) in a manner that depends on the R540 residue. Finally, we show that PRMT1 depletion by RNA interference induces the concentration of Gag C-terminus in nucleoli. CONCLUSION: Altogether, our findings suggest that methylation by PRMT1 might finely tune the subnuclear distribution of Gag depending on the stage of the FV replication cycle. The role of this step for viral replication remains an open question. More... »

PAGES

48

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12977-018-0428-z

DOI

http://dx.doi.org/10.1186/s12977-018-0428-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105493194

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29996845


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Motifs", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Arginine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Nucleus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromatin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Evolution, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Products, gag", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nuclear Localization Signals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Binding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Interaction Domains and Motifs", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Processing, Post-Translational", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Transport", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein-Arginine N-Methyltransferases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Repressor Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retroviridae Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Spumavirus", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "CNRS UMR7212, H\u00f4pital St Louis, Inserm U944, Institut Universitaire d\u2019H\u00e9matologie, Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Paris", 
        "givenName": "Joris", 
        "id": "sg:person.0655704601.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655704601.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "CNRS UMR7212, H\u00f4pital St Louis, Inserm U944, Institut Universitaire d\u2019H\u00e9matologie, Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tobaly-Tapiero", 
        "givenName": "Jo\u00eblle", 
        "id": "sg:person.01304551103.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304551103.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "CNRS UMR7212, H\u00f4pital St Louis, Inserm U944, Institut Universitaire d\u2019H\u00e9matologie, Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Giron", 
        "givenName": "Marie-Lou", 
        "id": "sg:person.011561276004.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011561276004.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Universitaire de Tours", 
          "id": "https://www.grid.ac/institutes/grid.411167.4", 
          "name": [
            "Plateforme IBiSA de Microscopie Electronique, Universit\u00e9 Fran\u00e7ois Rabelais and CHRU de Tours, Tours, France", 
            "INSERM U1259, Universit\u00e9 Fran\u00e7ois Rabelais and CHRU de Tours, Tours, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Burlaud-Gaillard", 
        "givenName": "Julien", 
        "id": "sg:person.0657260064.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657260064.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "French National Centre for Scientific Research", 
          "id": "https://www.grid.ac/institutes/grid.4444.0", 
          "name": [
            "Institut Pasteur, Unit\u00e9 d\u2019Epid\u00e9miologie et Physiopathologie des Virus Oncog\u00e8nes, Paris, France", 
            "CNRS UMR3569, Insitut Pasteur, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Buseyne", 
        "givenName": "Florence", 
        "id": "sg:person.01113402464.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113402464.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Universitaire de Tours", 
          "id": "https://www.grid.ac/institutes/grid.411167.4", 
          "name": [
            "Plateforme IBiSA de Microscopie Electronique, Universit\u00e9 Fran\u00e7ois Rabelais and CHRU de Tours, Tours, France", 
            "INSERM U1259, Universit\u00e9 Fran\u00e7ois Rabelais and CHRU de Tours, Tours, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roingeard", 
        "givenName": "Philippe", 
        "id": "sg:person.01266523455.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266523455.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "CNRS UMR7212, H\u00f4pital St Louis, Inserm U944, Institut Universitaire d\u2019H\u00e9matologie, Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lesage", 
        "givenName": "Pascale", 
        "id": "sg:person.0665161073.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665161073.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "CNRS UMR7212, H\u00f4pital St Louis, Inserm U944, Institut Universitaire d\u2019H\u00e9matologie, Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, Paris, France", 
            "CNRS UMR7212, H\u00f4pital St Louis, Inserm U944, Institut Universitaire d\u2019H\u00e9matologie, Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, Laboratoire PVM, Conservatoire National des Arts et M\u00e9tiers (Cnam), Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zamborlini", 
        "givenName": "Alessia", 
        "id": "sg:person.01357764427.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357764427.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "CNRS UMR7212, H\u00f4pital St Louis, Inserm U944, Institut Universitaire d\u2019H\u00e9matologie, Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sa\u00efb", 
        "givenName": "Ali", 
        "id": "sg:person.0606145657.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606145657.22"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1128/jvi.01888-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002103154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m111.289496", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003315952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1742-4690-8-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003506364", 
          "https://doi.org/10.1186/1742-4690-8-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fmicb.2015.00553", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006957152"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2008.12.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008557307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/embor.2009.14", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012557841"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4614-0514-6_14", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017747426", 
          "https://doi.org/10.1007/978-1-4614-0514-6_14"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.00101-09", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020109859"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep36610", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021057104", 
          "https://doi.org/10.1038/srep36610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.78.17.9423-9430.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021182127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1221736110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021269842"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.75.9.4367-4375.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021765902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0684.2006.00171.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021927725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.virol.2012.09.035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022962377"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.00613", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023668517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/v5041023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024712054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.02049-07", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025001893"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1005981", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027422560"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.emboj.7601389", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029557839"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.01731-10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031624107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.00812-08", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031723860"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tcb.2006.11.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032501621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e32803277ae", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035687030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e32803277ae", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035687030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e32803277ae", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035687030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1003376", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035877943"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkv428", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036132471"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0854.2008.00792.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036228405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12977-014-0087-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039101412", 
          "https://doi.org/10.1186/s12977-014-0087-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12977-014-0087-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039101412", 
          "https://doi.org/10.1186/s12977-014-0087-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m502458200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039518445"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.93.9.4137", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041068035"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.19.8.5768", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041735261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.00663-11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041855279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1742-4690-3-93", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042207378", 
          "https://doi.org/10.1186/1742-4690-3-93"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-55701-9_8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042850626", 
          "https://doi.org/10.1007/978-3-642-55701-9_8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-55701-9_8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042850626", 
          "https://doi.org/10.1007/978-3-642-55701-9_8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1005860", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043078834"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.virusres.2012.09.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043680354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/v5112767", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043784678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1002790", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044031531"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1000304107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044273739"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.062652199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045345858"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkl722", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047353313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.0030074", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047743190"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gku316", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049119825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/viro.1995.0016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050222725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbamcr.2015.11.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051253754"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.75.15.6857-6864.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051483452"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/vir.0.022186-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060398590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/vir.0.022186-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060398590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.271.5255.1579", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062552465"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1586/eri.09.39", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068079965"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cc.3.8.1075", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072298030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082427090", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082619972", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082855519", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082943951", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083020197", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083031197", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083031257", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083152666", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1621159114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085464468"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "BACKGROUND: Nuclear localization of Gag is a property shared by many retroviruses and retrotransposons. The importance of this stage for retroviral replication is still unknown, but studies on the Rous Sarcoma virus indicate that Gag might select the viral RNA genome for packaging in the nucleus. In the case of Foamy viruses, genome encapsidation is mediated by Gag C-terminal domain (CTD), which harbors three clusters of glycine and arginine residues named GR boxes (GRI-III). In this study we investigated how PFV Gag subnuclear distribution might be regulated.\nRESULTS: We show that the isolated GRI and GRIII boxes act as nucleolar localization signals. In contrast, both the entire Gag CTD and the isolated GRII box, which contains the chromatin-binding motif, target the nucleolus exclusively upon mutation of the evolutionary conserved arginine residue at position 540 (R540), which is a key determinant of FV Gag chromatin tethering. We also provide evidence that Gag localizes in the nucleolus during FV replication and uncovered that the viral protein interacts with and is methylated by Protein Arginine Methyltransferase 1 (PRMT1) in a manner that depends on the R540 residue. Finally, we show that PRMT1 depletion by RNA interference induces the concentration of Gag C-terminus in nucleoli.\nCONCLUSION: Altogether, our findings suggest that methylation by PRMT1 might finely tune the subnuclear distribution of Gag depending on the stage of the FV replication cycle. The role of this step for viral replication remains an open question.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12977-018-0428-z", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.4523515", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4731080", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1033800", 
        "issn": [
          "1742-4690"
        ], 
        "name": "Retrovirology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "15"
      }
    ], 
    "name": "The invariant arginine within the chromatin-binding motif regulates both nucleolar localization and chromatin binding of Foamy virus Gag", 
    "pagination": "48", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e4910285bc2d8fc97017bd517012210241038372d40ec4ffb12e49c3b60e9e05"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29996845"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101216893"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12977-018-0428-z"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1105493194"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12977-018-0428-z", 
      "https://app.dimensions.ai/details/publication/pub.1105493194"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T15:15", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000604.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs12977-018-0428-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12977-018-0428-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12977-018-0428-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12977-018-0428-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12977-018-0428-z'


 

This table displays all metadata directly associated to this object as RDF triples.

386 TRIPLES      21 PREDICATES      104 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12977-018-0428-z schema:about N053e2908cf5f447fbbcca24a85319146
2 N0b7e6b0b8bf04c4782d0c5d0ffc5097b
3 N3ada4f7036ff4fdd9f45decd57d6cf40
4 N531948ee917a4e9eb22413dd7dc67e26
5 N6454fcd903e343de9c2be57adea81516
6 N6b363e7ddf7c4043b22982406293b363
7 N7f280d6fcd4e4e81a011471c75e543b8
8 N9019b1aa51f94396900a344c04ee840c
9 Na7a8f10d243349dc97853bfa96e68299
10 Naf3a40a2d7bd449297a6e1702a2443e4
11 Nd759364b750c4d38b00b71cd01f27381
12 Nd9716e09931748e28172f13999f86783
13 Ndb02e7962fd1476da3bc1936c723ff8e
14 Nde41a72df2d34057ae8891202adb7091
15 Ne540d224adfb4d9ca4481cea353d01d0
16 Ne6244a831d3b4436a69a32786b5c752c
17 Nf78963ce2bbe4ed38f4bcfbbd5c4ebc6
18 anzsrc-for:06
19 anzsrc-for:0604
20 schema:author N72dddfe5048047ea9e2c2c79a277e932
21 schema:citation sg:pub.10.1007/978-1-4614-0514-6_14
22 sg:pub.10.1007/978-3-642-55701-9_8
23 sg:pub.10.1038/srep36610
24 sg:pub.10.1186/1742-4690-3-93
25 sg:pub.10.1186/1742-4690-8-6
26 sg:pub.10.1186/s12977-014-0087-7
27 https://app.dimensions.ai/details/publication/pub.1082427090
28 https://app.dimensions.ai/details/publication/pub.1082619972
29 https://app.dimensions.ai/details/publication/pub.1082855519
30 https://app.dimensions.ai/details/publication/pub.1082943951
31 https://app.dimensions.ai/details/publication/pub.1083020197
32 https://app.dimensions.ai/details/publication/pub.1083031197
33 https://app.dimensions.ai/details/publication/pub.1083031257
34 https://app.dimensions.ai/details/publication/pub.1083152666
35 https://doi.org/10.1006/viro.1995.0016
36 https://doi.org/10.1016/j.bbamcr.2015.11.019
37 https://doi.org/10.1016/j.molcel.2008.12.013
38 https://doi.org/10.1016/j.tcb.2006.11.010
39 https://doi.org/10.1016/j.virol.2012.09.035
40 https://doi.org/10.1016/j.virusres.2012.09.011
41 https://doi.org/10.1038/embor.2009.14
42 https://doi.org/10.1038/sj.emboj.7601389
43 https://doi.org/10.1073/pnas.062652199
44 https://doi.org/10.1073/pnas.1000304107
45 https://doi.org/10.1073/pnas.1221736110
46 https://doi.org/10.1073/pnas.1621159114
47 https://doi.org/10.1073/pnas.93.9.4137
48 https://doi.org/10.1074/jbc.m111.289496
49 https://doi.org/10.1074/jbc.m502458200
50 https://doi.org/10.1093/nar/gkl722
51 https://doi.org/10.1093/nar/gku316
52 https://doi.org/10.1093/nar/gkv428
53 https://doi.org/10.1097/qad.0b013e32803277ae
54 https://doi.org/10.1099/vir.0.022186-0
55 https://doi.org/10.1111/j.1600-0684.2006.00171.x
56 https://doi.org/10.1111/j.1600-0854.2008.00792.x
57 https://doi.org/10.1126/science.271.5255.1579
58 https://doi.org/10.1128/jvi.00101-09
59 https://doi.org/10.1128/jvi.00663-11
60 https://doi.org/10.1128/jvi.00812-08
61 https://doi.org/10.1128/jvi.01731-10
62 https://doi.org/10.1128/jvi.01888-06
63 https://doi.org/10.1128/jvi.02049-07
64 https://doi.org/10.1128/jvi.75.15.6857-6864.2001
65 https://doi.org/10.1128/jvi.75.9.4367-4375.2001
66 https://doi.org/10.1128/jvi.78.17.9423-9430.2004
67 https://doi.org/10.1128/mcb.19.8.5768
68 https://doi.org/10.1242/jcs.00613
69 https://doi.org/10.1371/journal.ppat.0030074
70 https://doi.org/10.1371/journal.ppat.1002790
71 https://doi.org/10.1371/journal.ppat.1003376
72 https://doi.org/10.1371/journal.ppat.1005860
73 https://doi.org/10.1371/journal.ppat.1005981
74 https://doi.org/10.1586/eri.09.39
75 https://doi.org/10.3389/fmicb.2015.00553
76 https://doi.org/10.3390/v5041023
77 https://doi.org/10.3390/v5112767
78 https://doi.org/10.4161/cc.3.8.1075
79 schema:datePublished 2018-12
80 schema:datePublishedReg 2018-12-01
81 schema:description BACKGROUND: Nuclear localization of Gag is a property shared by many retroviruses and retrotransposons. The importance of this stage for retroviral replication is still unknown, but studies on the Rous Sarcoma virus indicate that Gag might select the viral RNA genome for packaging in the nucleus. In the case of Foamy viruses, genome encapsidation is mediated by Gag C-terminal domain (CTD), which harbors three clusters of glycine and arginine residues named GR boxes (GRI-III). In this study we investigated how PFV Gag subnuclear distribution might be regulated. RESULTS: We show that the isolated GRI and GRIII boxes act as nucleolar localization signals. In contrast, both the entire Gag CTD and the isolated GRII box, which contains the chromatin-binding motif, target the nucleolus exclusively upon mutation of the evolutionary conserved arginine residue at position 540 (R540), which is a key determinant of FV Gag chromatin tethering. We also provide evidence that Gag localizes in the nucleolus during FV replication and uncovered that the viral protein interacts with and is methylated by Protein Arginine Methyltransferase 1 (PRMT1) in a manner that depends on the R540 residue. Finally, we show that PRMT1 depletion by RNA interference induces the concentration of Gag C-terminus in nucleoli. CONCLUSION: Altogether, our findings suggest that methylation by PRMT1 might finely tune the subnuclear distribution of Gag depending on the stage of the FV replication cycle. The role of this step for viral replication remains an open question.
82 schema:genre research_article
83 schema:inLanguage en
84 schema:isAccessibleForFree true
85 schema:isPartOf N449acb8821ab497cbd669ff168f65d93
86 Ncd174402e3ed4291b1a43badd358cb21
87 sg:journal.1033800
88 schema:name The invariant arginine within the chromatin-binding motif regulates both nucleolar localization and chromatin binding of Foamy virus Gag
89 schema:pagination 48
90 schema:productId N338b0773598d4b59abd2d1e7bbc6acd5
91 N94d6e7e1d6db4583b45ec7d453fae545
92 Nb283e416ed64437f8f8474fab4d21a9c
93 Ndf87238b61f74223aca91a0bd1286985
94 Nfe67cd2f57bc4dc18daaffb3013db007
95 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105493194
96 https://doi.org/10.1186/s12977-018-0428-z
97 schema:sdDatePublished 2019-04-10T15:15
98 schema:sdLicense https://scigraph.springernature.com/explorer/license/
99 schema:sdPublisher N76d690e6920a4a858e3d362c5931bec8
100 schema:url https://link.springer.com/10.1186%2Fs12977-018-0428-z
101 sgo:license sg:explorer/license/
102 sgo:sdDataset articles
103 rdf:type schema:ScholarlyArticle
104 N053e2908cf5f447fbbcca24a85319146 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Protein Binding
106 rdf:type schema:DefinedTerm
107 N0b7e6b0b8bf04c4782d0c5d0ffc5097b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Protein-Arginine N-Methyltransferases
109 rdf:type schema:DefinedTerm
110 N0f105c0af20849f798162e22fb455549 rdf:first sg:person.01113402464.88
111 rdf:rest Nef04ef355c4647d0864959cdb3b21a8f
112 N1c73dfd5a3d44c6dad94e9b7343c6f8e schema:name CNRS UMR7212, Hôpital St Louis, Inserm U944, Institut Universitaire d’Hématologie, Université Paris Diderot, Sorbonne Paris Cité, Paris, France
113 rdf:type schema:Organization
114 N2e144665e5c641d3860792b3404bae2e rdf:first sg:person.0606145657.22
115 rdf:rest rdf:nil
116 N338b0773598d4b59abd2d1e7bbc6acd5 schema:name nlm_unique_id
117 schema:value 101216893
118 rdf:type schema:PropertyValue
119 N3a782e57c0464cf581b0997f4da39cb2 rdf:first sg:person.01357764427.15
120 rdf:rest N2e144665e5c641d3860792b3404bae2e
121 N3ada4f7036ff4fdd9f45decd57d6cf40 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Chromatin
123 rdf:type schema:DefinedTerm
124 N449acb8821ab497cbd669ff168f65d93 schema:issueNumber 1
125 rdf:type schema:PublicationIssue
126 N531948ee917a4e9eb22413dd7dc67e26 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Spumavirus
128 rdf:type schema:DefinedTerm
129 N5dc99e0b32904afbbf58dd76a7c68b39 schema:name CNRS UMR7212, Hôpital St Louis, Inserm U944, Institut Universitaire d’Hématologie, Université Paris Diderot, Sorbonne Paris Cité, Paris, France
130 rdf:type schema:Organization
131 N6454fcd903e343de9c2be57adea81516 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Evolution, Molecular
133 rdf:type schema:DefinedTerm
134 N6b363e7ddf7c4043b22982406293b363 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Gene Products, gag
136 rdf:type schema:DefinedTerm
137 N72dddfe5048047ea9e2c2c79a277e932 rdf:first sg:person.0655704601.60
138 rdf:rest Nfe21d5c0bab04d68929fbecb768e5b91
139 N76d690e6920a4a858e3d362c5931bec8 schema:name Springer Nature - SN SciGraph project
140 rdf:type schema:Organization
141 N7f280d6fcd4e4e81a011471c75e543b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Arginine
143 rdf:type schema:DefinedTerm
144 N81df26d805ce4234878c0d82df3ef213 schema:name CNRS UMR7212, Hôpital St Louis, Inserm U944, Institut Universitaire d’Hématologie, Université Paris Diderot, Sorbonne Paris Cité, Paris, France
145 rdf:type schema:Organization
146 N89505333034e4570bdaef30490d9765b schema:name CNRS UMR7212, Hôpital St Louis, Inserm U944, Institut Universitaire d’Hématologie, Université Paris Diderot, Sorbonne Paris Cité, Laboratoire PVM, Conservatoire National des Arts et Métiers (Cnam), Paris, France
147 CNRS UMR7212, Hôpital St Louis, Inserm U944, Institut Universitaire d’Hématologie, Université Paris Diderot, Sorbonne Paris Cité, Paris, France
148 rdf:type schema:Organization
149 N9019b1aa51f94396900a344c04ee840c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Protein Transport
151 rdf:type schema:DefinedTerm
152 N94d6e7e1d6db4583b45ec7d453fae545 schema:name pubmed_id
153 schema:value 29996845
154 rdf:type schema:PropertyValue
155 Na6dd45a89f4b4de2bfa4961d65500c0f schema:name CNRS UMR7212, Hôpital St Louis, Inserm U944, Institut Universitaire d’Hématologie, Université Paris Diderot, Sorbonne Paris Cité, Paris, France
156 rdf:type schema:Organization
157 Na7a8f10d243349dc97853bfa96e68299 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Cell Nucleus
159 rdf:type schema:DefinedTerm
160 Naf3a40a2d7bd449297a6e1702a2443e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Repressor Proteins
162 rdf:type schema:DefinedTerm
163 Nb283e416ed64437f8f8474fab4d21a9c schema:name doi
164 schema:value 10.1186/s12977-018-0428-z
165 rdf:type schema:PropertyValue
166 Ncd174402e3ed4291b1a43badd358cb21 schema:volumeNumber 15
167 rdf:type schema:PublicationVolume
168 Nd5834f11f6304382a50a74867e7a4775 rdf:first sg:person.0657260064.22
169 rdf:rest N0f105c0af20849f798162e22fb455549
170 Nd759364b750c4d38b00b71cd01f27381 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Humans
172 rdf:type schema:DefinedTerm
173 Nd9716e09931748e28172f13999f86783 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Protein Processing, Post-Translational
175 rdf:type schema:DefinedTerm
176 Ndb02e7962fd1476da3bc1936c723ff8e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Nuclear Localization Signals
178 rdf:type schema:DefinedTerm
179 Nde41a72df2d34057ae8891202adb7091 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Amino Acid Motifs
181 rdf:type schema:DefinedTerm
182 Ndf87238b61f74223aca91a0bd1286985 schema:name readcube_id
183 schema:value e4910285bc2d8fc97017bd517012210241038372d40ec4ffb12e49c3b60e9e05
184 rdf:type schema:PropertyValue
185 Ne540d224adfb4d9ca4481cea353d01d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Retroviridae Infections
187 rdf:type schema:DefinedTerm
188 Ne6244a831d3b4436a69a32786b5c752c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Protein Interaction Domains and Motifs
190 rdf:type schema:DefinedTerm
191 Nec138aaddb1540359a962547e6dbc098 rdf:first sg:person.011561276004.50
192 rdf:rest Nd5834f11f6304382a50a74867e7a4775
193 Nef04ef355c4647d0864959cdb3b21a8f rdf:first sg:person.01266523455.09
194 rdf:rest Nf5391d66c25e4ae39b3c5f0ac05f9cf8
195 Nf299d8b279b34af19d3872ff6a4ef2b2 schema:name CNRS UMR7212, Hôpital St Louis, Inserm U944, Institut Universitaire d’Hématologie, Université Paris Diderot, Sorbonne Paris Cité, Paris, France
196 rdf:type schema:Organization
197 Nf5391d66c25e4ae39b3c5f0ac05f9cf8 rdf:first sg:person.0665161073.52
198 rdf:rest N3a782e57c0464cf581b0997f4da39cb2
199 Nf78963ce2bbe4ed38f4bcfbbd5c4ebc6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Amino Acid Sequence
201 rdf:type schema:DefinedTerm
202 Nfe21d5c0bab04d68929fbecb768e5b91 rdf:first sg:person.01304551103.65
203 rdf:rest Nec138aaddb1540359a962547e6dbc098
204 Nfe67cd2f57bc4dc18daaffb3013db007 schema:name dimensions_id
205 schema:value pub.1105493194
206 rdf:type schema:PropertyValue
207 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
208 schema:name Biological Sciences
209 rdf:type schema:DefinedTerm
210 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
211 schema:name Genetics
212 rdf:type schema:DefinedTerm
213 sg:grant.4523515 http://pending.schema.org/fundedItem sg:pub.10.1186/s12977-018-0428-z
214 rdf:type schema:MonetaryGrant
215 sg:grant.4731080 http://pending.schema.org/fundedItem sg:pub.10.1186/s12977-018-0428-z
216 rdf:type schema:MonetaryGrant
217 sg:journal.1033800 schema:issn 1742-4690
218 schema:name Retrovirology
219 rdf:type schema:Periodical
220 sg:person.01113402464.88 schema:affiliation https://www.grid.ac/institutes/grid.4444.0
221 schema:familyName Buseyne
222 schema:givenName Florence
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113402464.88
224 rdf:type schema:Person
225 sg:person.011561276004.50 schema:affiliation Nf299d8b279b34af19d3872ff6a4ef2b2
226 schema:familyName Giron
227 schema:givenName Marie-Lou
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011561276004.50
229 rdf:type schema:Person
230 sg:person.01266523455.09 schema:affiliation https://www.grid.ac/institutes/grid.411167.4
231 schema:familyName Roingeard
232 schema:givenName Philippe
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266523455.09
234 rdf:type schema:Person
235 sg:person.01304551103.65 schema:affiliation N5dc99e0b32904afbbf58dd76a7c68b39
236 schema:familyName Tobaly-Tapiero
237 schema:givenName Joëlle
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304551103.65
239 rdf:type schema:Person
240 sg:person.01357764427.15 schema:affiliation N89505333034e4570bdaef30490d9765b
241 schema:familyName Zamborlini
242 schema:givenName Alessia
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357764427.15
244 rdf:type schema:Person
245 sg:person.0606145657.22 schema:affiliation Na6dd45a89f4b4de2bfa4961d65500c0f
246 schema:familyName Saïb
247 schema:givenName Ali
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606145657.22
249 rdf:type schema:Person
250 sg:person.0655704601.60 schema:affiliation N81df26d805ce4234878c0d82df3ef213
251 schema:familyName Paris
252 schema:givenName Joris
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655704601.60
254 rdf:type schema:Person
255 sg:person.0657260064.22 schema:affiliation https://www.grid.ac/institutes/grid.411167.4
256 schema:familyName Burlaud-Gaillard
257 schema:givenName Julien
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657260064.22
259 rdf:type schema:Person
260 sg:person.0665161073.52 schema:affiliation N1c73dfd5a3d44c6dad94e9b7343c6f8e
261 schema:familyName Lesage
262 schema:givenName Pascale
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665161073.52
264 rdf:type schema:Person
265 sg:pub.10.1007/978-1-4614-0514-6_14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017747426
266 https://doi.org/10.1007/978-1-4614-0514-6_14
267 rdf:type schema:CreativeWork
268 sg:pub.10.1007/978-3-642-55701-9_8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042850626
269 https://doi.org/10.1007/978-3-642-55701-9_8
270 rdf:type schema:CreativeWork
271 sg:pub.10.1038/srep36610 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021057104
272 https://doi.org/10.1038/srep36610
273 rdf:type schema:CreativeWork
274 sg:pub.10.1186/1742-4690-3-93 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042207378
275 https://doi.org/10.1186/1742-4690-3-93
276 rdf:type schema:CreativeWork
277 sg:pub.10.1186/1742-4690-8-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003506364
278 https://doi.org/10.1186/1742-4690-8-6
279 rdf:type schema:CreativeWork
280 sg:pub.10.1186/s12977-014-0087-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039101412
281 https://doi.org/10.1186/s12977-014-0087-7
282 rdf:type schema:CreativeWork
283 https://app.dimensions.ai/details/publication/pub.1082427090 schema:CreativeWork
284 https://app.dimensions.ai/details/publication/pub.1082619972 schema:CreativeWork
285 https://app.dimensions.ai/details/publication/pub.1082855519 schema:CreativeWork
286 https://app.dimensions.ai/details/publication/pub.1082943951 schema:CreativeWork
287 https://app.dimensions.ai/details/publication/pub.1083020197 schema:CreativeWork
288 https://app.dimensions.ai/details/publication/pub.1083031197 schema:CreativeWork
289 https://app.dimensions.ai/details/publication/pub.1083031257 schema:CreativeWork
290 https://app.dimensions.ai/details/publication/pub.1083152666 schema:CreativeWork
291 https://doi.org/10.1006/viro.1995.0016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050222725
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/j.bbamcr.2015.11.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051253754
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/j.molcel.2008.12.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008557307
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1016/j.tcb.2006.11.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032501621
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1016/j.virol.2012.09.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022962377
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1016/j.virusres.2012.09.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043680354
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1038/embor.2009.14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012557841
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1038/sj.emboj.7601389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029557839
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1073/pnas.062652199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045345858
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1073/pnas.1000304107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044273739
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1073/pnas.1221736110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021269842
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1073/pnas.1621159114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085464468
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1073/pnas.93.9.4137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041068035
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1074/jbc.m111.289496 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003315952
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1074/jbc.m502458200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039518445
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1093/nar/gkl722 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047353313
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1093/nar/gku316 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049119825
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1093/nar/gkv428 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036132471
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1097/qad.0b013e32803277ae schema:sameAs https://app.dimensions.ai/details/publication/pub.1035687030
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1099/vir.0.022186-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060398590
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1111/j.1600-0684.2006.00171.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021927725
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1111/j.1600-0854.2008.00792.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036228405
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1126/science.271.5255.1579 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062552465
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1128/jvi.00101-09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020109859
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1128/jvi.00663-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041855279
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1128/jvi.00812-08 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031723860
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1128/jvi.01731-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031624107
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1128/jvi.01888-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002103154
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1128/jvi.02049-07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025001893
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1128/jvi.75.15.6857-6864.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051483452
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1128/jvi.75.9.4367-4375.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021765902
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1128/jvi.78.17.9423-9430.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021182127
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1128/mcb.19.8.5768 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041735261
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1242/jcs.00613 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023668517
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1371/journal.ppat.0030074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047743190
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1371/journal.ppat.1002790 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044031531
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1371/journal.ppat.1003376 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035877943
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1371/journal.ppat.1005860 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043078834
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1371/journal.ppat.1005981 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027422560
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1586/eri.09.39 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068079965
370 rdf:type schema:CreativeWork
371 https://doi.org/10.3389/fmicb.2015.00553 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006957152
372 rdf:type schema:CreativeWork
373 https://doi.org/10.3390/v5041023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024712054
374 rdf:type schema:CreativeWork
375 https://doi.org/10.3390/v5112767 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043784678
376 rdf:type schema:CreativeWork
377 https://doi.org/10.4161/cc.3.8.1075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072298030
378 rdf:type schema:CreativeWork
379 https://www.grid.ac/institutes/grid.411167.4 schema:alternateName Centre Hospitalier Universitaire de Tours
380 schema:name INSERM U1259, Université François Rabelais and CHRU de Tours, Tours, France
381 Plateforme IBiSA de Microscopie Electronique, Université François Rabelais and CHRU de Tours, Tours, France
382 rdf:type schema:Organization
383 https://www.grid.ac/institutes/grid.4444.0 schema:alternateName French National Centre for Scientific Research
384 schema:name CNRS UMR3569, Insitut Pasteur, Paris, France
385 Institut Pasteur, Unité d’Epidémiologie et Physiopathologie des Virus Oncogènes, Paris, France
386 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...