Quantifying the effect of Vpu on the promotion of HIV-1 replication in the humanized mouse model View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-04-18

AUTHORS

Hiroki Ikeda, Shinji Nakaoka, Rob J. de Boer, Satoru Morita, Naoko Misawa, Yoshio Koyanagi, Kazuyuki Aihara, Kei Sato, Shingo Iwami

ABSTRACT

BackgroundTetherin is an intrinsic anti-viral factor impairing the release of nascent HIV-1 particles from infected cells. Vpu, an HIV-1 accessory protein, antagonizes the anti-viral action of tetherin. Although previous studies using in vitro cell culture systems have revealed the molecular mechanisms of the anti-viral action of tetherin and the antagonizing action of Vpu against tetherin, it still remains unclear how Vpu affects the kinetics of HIV-1 replication in vivo.ResultsTo quantitatively assess the role of Vpu in viral replication in vivo, we analyzed time courses of experimental data with viral load and target cell levels in the peripheral blood of humanized mice infected with wild-type and vpu-deficient HIV-1. Our recently developed mathematical model describes the acute phase of this infection reasonably, and allowed us to estimate several parameters characterizing HIV-1 infection in mice. Using a technique of Bayesian parameter estimation, we estimate distributions of the basic reproduction number of wild-type and vpu-deficient HIV-1. This reveals that Vpu markedly increases the rate of viral replication in vivo.ConclusionsCombining experiments with mathematical modeling, we provide an estimate for the contribution of Vpu to viral replication in humanized mice. More... »

PAGES

23

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12977-016-0252-2

DOI

http://dx.doi.org/10.1186/s12977-016-0252-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034852277

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27086687


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Microbiology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV-1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Human Immunodeficiency Virus Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, SCID", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Theoretical", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Viral Regulatory and Accessory Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Virus Replication", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Biology, Faculty of Sciences, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, 812-8581, Fukuoka, Fukuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.177174.3", 
          "name": [
            "Department of Biology, Faculty of Sciences, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, 812-8581, Fukuoka, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ikeda", 
        "givenName": "Hiroki", 
        "id": "sg:person.0732120026.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732120026.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Graduate School of Medicine, University of Tokyo, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Graduate School of Medicine, University of Tokyo, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakaoka", 
        "givenName": "Shinji", 
        "id": "sg:person.01255366502.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255366502.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Theoretical Biology, Utrecht University, Utrecht, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.5477.1", 
          "name": [
            "Theoretical Biology, Utrecht University, Utrecht, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Boer", 
        "givenName": "Rob J.", 
        "id": "sg:person.0774503452.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774503452.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Mathematical and Systems Engineering, Shizuoka University, Shizuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.263536.7", 
          "name": [
            "Department of Mathematical and Systems Engineering, Shizuoka University, Shizuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morita", 
        "givenName": "Satoru", 
        "id": "sg:person.01076202570.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076202570.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory of Viral Pathogenesis, Institute for Virus Research, Kyoto University, 53 Shogoinkawara-cho, Sakyo-ku, 606-8507, Kyoto, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Laboratory of Viral Pathogenesis, Institute for Virus Research, Kyoto University, 53 Shogoinkawara-cho, Sakyo-ku, 606-8507, Kyoto, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Misawa", 
        "givenName": "Naoko", 
        "id": "sg:person.0734604661.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734604661.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory of Viral Pathogenesis, Institute for Virus Research, Kyoto University, 53 Shogoinkawara-cho, Sakyo-ku, 606-8507, Kyoto, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Laboratory of Viral Pathogenesis, Institute for Virus Research, Kyoto University, 53 Shogoinkawara-cho, Sakyo-ku, 606-8507, Kyoto, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Koyanagi", 
        "givenName": "Yoshio", 
        "id": "sg:person.01233375061.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233375061.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Graduate School of Information Science and Technology, The University of Tokyo, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Institute of Industrial Science, The University of Tokyo, Tokyo, Japan", 
            "Graduate School of Information Science and Technology, The University of Tokyo, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aihara", 
        "givenName": "Kazuyuki", 
        "id": "sg:person.01323523402.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323523402.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "CREST, JST, Saitama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.419082.6", 
          "name": [
            "Laboratory of Viral Pathogenesis, Institute for Virus Research, Kyoto University, 53 Shogoinkawara-cho, Sakyo-ku, 606-8507, Kyoto, Kyoto, Japan", 
            "CREST, JST, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sato", 
        "givenName": "Kei", 
        "id": "sg:person.0710074174.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710074174.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "PRESTO, JST, Saitama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.419082.6", 
          "name": [
            "Department of Biology, Faculty of Sciences, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, 812-8581, Fukuoka, Fukuoka, Japan", 
            "CREST, JST, Saitama, Japan", 
            "PRESTO, JST, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iwami", 
        "givenName": "Shingo", 
        "id": "sg:person.01051033261.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051033261.50"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nature16933", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007201638", 
          "https://doi.org/10.1038/nature16933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature06553", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050660540", 
          "https://doi.org/10.1038/nature06553"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri700", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003731496", 
          "https://doi.org/10.1038/nri700"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1742-4682-11-22", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027609943", 
          "https://doi.org/10.1186/1742-4682-11-22"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep12256", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046426190", 
          "https://doi.org/10.1038/srep12256"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-04-18", 
    "datePublishedReg": "2016-04-18", 
    "description": "BackgroundTetherin is an intrinsic anti-viral factor impairing the release of nascent HIV-1 particles from infected cells. Vpu, an HIV-1 accessory protein, antagonizes the anti-viral action of tetherin. Although previous studies using in vitro cell culture systems have revealed the molecular mechanisms of the anti-viral action of tetherin and the antagonizing action of Vpu against tetherin, it still remains unclear how Vpu affects the kinetics of HIV-1 replication in vivo.ResultsTo quantitatively assess the role of Vpu in viral replication in vivo, we analyzed time courses of experimental data with viral load and target cell levels in the peripheral blood of humanized mice infected with wild-type and vpu-deficient HIV-1. Our recently developed mathematical model describes the acute phase of this infection reasonably, and allowed us to estimate several parameters characterizing HIV-1 infection in mice. Using a technique of Bayesian parameter estimation, we estimate distributions of the basic reproduction number of wild-type and vpu-deficient HIV-1. This reveals that Vpu markedly increases the rate of viral replication in vivo.ConclusionsCombining experiments with mathematical modeling, we provide an estimate for the contribution of Vpu to viral replication in humanized mice.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s12977-016-0252-2", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5864367", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6135475", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5871545", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5881554", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6536661", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6081990", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6085506", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.9341583", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6134570", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1033800", 
        "issn": [
          "1742-4690"
        ], 
        "name": "Retrovirology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "13"
      }
    ], 
    "keywords": [
      "vpu-deficient HIV-1", 
      "HIV-1 replication", 
      "anti-viral action", 
      "viral replication", 
      "humanized mice", 
      "HIV-1", 
      "nascent HIV-1 particles", 
      "HIV-1 infection", 
      "humanized mouse model", 
      "effect of Vpu", 
      "role of Vpu", 
      "anti-viral factors", 
      "HIV-1 particles", 
      "HIV-1 accessory protein", 
      "viral load", 
      "acute phase", 
      "peripheral blood", 
      "mouse model", 
      "infected cells", 
      "mice", 
      "cell culture system", 
      "Vpu", 
      "time course", 
      "tetherin", 
      "infection", 
      "basic reproduction number", 
      "vivo", 
      "molecular mechanisms", 
      "cell level", 
      "reproduction number", 
      "culture system", 
      "previous studies", 
      "replication", 
      "blood", 
      "accessory proteins", 
      "action", 
      "cells", 
      "release", 
      "course", 
      "factors", 
      "levels", 
      "protein", 
      "study", 
      "ResultsTo", 
      "role", 
      "promotion", 
      "rate", 
      "effect", 
      "mechanism", 
      "data", 
      "number", 
      "model", 
      "technique", 
      "estimates", 
      "phase", 
      "load", 
      "parameters", 
      "system", 
      "contribution", 
      "distribution", 
      "kinetics", 
      "experiments", 
      "mathematical modeling", 
      "estimation", 
      "mathematical model", 
      "particles", 
      "modeling", 
      "Bayesian parameter estimation", 
      "parameter estimation", 
      "experimental data"
    ], 
    "name": "Quantifying the effect of Vpu on the promotion of HIV-1 replication in the humanized mouse model", 
    "pagination": "23", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1034852277"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12977-016-0252-2"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27086687"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12977-016-0252-2", 
      "https://app.dimensions.ai/details/publication/pub.1034852277"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T16:00", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_706.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s12977-016-0252-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12977-016-0252-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12977-016-0252-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12977-016-0252-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12977-016-0252-2'


 

This table displays all metadata directly associated to this object as RDF triples.

282 TRIPLES      21 PREDICATES      109 URIs      96 LITERALS      16 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12977-016-0252-2 schema:about N0c69c56c37b8430d9f015f07912f3a67
2 N3c7fe87bd33f45b58d6d98f1253007da
3 N4d35f7cca0474425b3f8c3b49a4dcad0
4 N7ab2cf7a456e4943a643f746a5ae06e6
5 N96e86b86b88b4115896f1a936de2702f
6 Nb84bbc9f0e3649b3a9c96fad76fb1669
7 Ndc45969f21e14e7a99b73bb5f021f2a4
8 Neeff344c4675467f9f71ee78fd3fdd3b
9 Nfb95fff2f13c4bf7baf844740c743b31
10 anzsrc-for:11
11 anzsrc-for:1108
12 schema:author N9f9d8e95358b49eb933a8910eae16192
13 schema:citation sg:pub.10.1038/nature06553
14 sg:pub.10.1038/nature16933
15 sg:pub.10.1038/nri700
16 sg:pub.10.1038/srep12256
17 sg:pub.10.1186/1742-4682-11-22
18 schema:datePublished 2016-04-18
19 schema:datePublishedReg 2016-04-18
20 schema:description BackgroundTetherin is an intrinsic anti-viral factor impairing the release of nascent HIV-1 particles from infected cells. Vpu, an HIV-1 accessory protein, antagonizes the anti-viral action of tetherin. Although previous studies using in vitro cell culture systems have revealed the molecular mechanisms of the anti-viral action of tetherin and the antagonizing action of Vpu against tetherin, it still remains unclear how Vpu affects the kinetics of HIV-1 replication in vivo.ResultsTo quantitatively assess the role of Vpu in viral replication in vivo, we analyzed time courses of experimental data with viral load and target cell levels in the peripheral blood of humanized mice infected with wild-type and vpu-deficient HIV-1. Our recently developed mathematical model describes the acute phase of this infection reasonably, and allowed us to estimate several parameters characterizing HIV-1 infection in mice. Using a technique of Bayesian parameter estimation, we estimate distributions of the basic reproduction number of wild-type and vpu-deficient HIV-1. This reveals that Vpu markedly increases the rate of viral replication in vivo.ConclusionsCombining experiments with mathematical modeling, we provide an estimate for the contribution of Vpu to viral replication in humanized mice.
21 schema:genre article
22 schema:isAccessibleForFree true
23 schema:isPartOf N80061c2a0a304a52b62dc3160253be15
24 Nc34761d8d44d410e9609ac63237a5646
25 sg:journal.1033800
26 schema:keywords Bayesian parameter estimation
27 HIV-1
28 HIV-1 accessory protein
29 HIV-1 infection
30 HIV-1 particles
31 HIV-1 replication
32 ResultsTo
33 Vpu
34 accessory proteins
35 action
36 acute phase
37 anti-viral action
38 anti-viral factors
39 basic reproduction number
40 blood
41 cell culture system
42 cell level
43 cells
44 contribution
45 course
46 culture system
47 data
48 distribution
49 effect
50 effect of Vpu
51 estimates
52 estimation
53 experimental data
54 experiments
55 factors
56 humanized mice
57 humanized mouse model
58 infected cells
59 infection
60 kinetics
61 levels
62 load
63 mathematical model
64 mathematical modeling
65 mechanism
66 mice
67 model
68 modeling
69 molecular mechanisms
70 mouse model
71 nascent HIV-1 particles
72 number
73 parameter estimation
74 parameters
75 particles
76 peripheral blood
77 phase
78 previous studies
79 promotion
80 protein
81 rate
82 release
83 replication
84 reproduction number
85 role
86 role of Vpu
87 study
88 system
89 technique
90 tetherin
91 time course
92 viral load
93 viral replication
94 vivo
95 vpu-deficient HIV-1
96 schema:name Quantifying the effect of Vpu on the promotion of HIV-1 replication in the humanized mouse model
97 schema:pagination 23
98 schema:productId N060bebd7e11240e7a61e67f644c7ad64
99 N19b8f4fde93a4697890093ccf50555e5
100 Nd823aaefdeae46b79807c7e767e1bc76
101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034852277
102 https://doi.org/10.1186/s12977-016-0252-2
103 schema:sdDatePublished 2022-09-02T16:00
104 schema:sdLicense https://scigraph.springernature.com/explorer/license/
105 schema:sdPublisher N5b51d509ec8344fda628b35576a0346b
106 schema:url https://doi.org/10.1186/s12977-016-0252-2
107 sgo:license sg:explorer/license/
108 sgo:sdDataset articles
109 rdf:type schema:ScholarlyArticle
110 N060bebd7e11240e7a61e67f644c7ad64 schema:name doi
111 schema:value 10.1186/s12977-016-0252-2
112 rdf:type schema:PropertyValue
113 N0c69c56c37b8430d9f015f07912f3a67 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name HIV-1
115 rdf:type schema:DefinedTerm
116 N0c9f9e9e13974c8a9d717e796442586f rdf:first sg:person.01233375061.92
117 rdf:rest N857afadb48414549b30b4283a8dee1c1
118 N11c424a04bc64a879fe06f0717059396 rdf:first sg:person.0734604661.00
119 rdf:rest N0c9f9e9e13974c8a9d717e796442586f
120 N19b8f4fde93a4697890093ccf50555e5 schema:name dimensions_id
121 schema:value pub.1034852277
122 rdf:type schema:PropertyValue
123 N389f0a668e4046ecb18c8c734cd3c4e6 rdf:first sg:person.01051033261.50
124 rdf:rest rdf:nil
125 N3c7fe87bd33f45b58d6d98f1253007da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Humans
127 rdf:type schema:DefinedTerm
128 N46668ea65157416d90ac019adef4583e rdf:first sg:person.01076202570.34
129 rdf:rest N11c424a04bc64a879fe06f0717059396
130 N4d35f7cca0474425b3f8c3b49a4dcad0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Viral Regulatory and Accessory Proteins
132 rdf:type schema:DefinedTerm
133 N4ff5f68ad2384ce5943800bf2fedb635 rdf:first sg:person.01255366502.55
134 rdf:rest Nb32d4df17af846c2aa220d9b144fb49b
135 N5b51d509ec8344fda628b35576a0346b schema:name Springer Nature - SN SciGraph project
136 rdf:type schema:Organization
137 N5b67d6a5074c4c7a894bbdc719cfea2f rdf:first sg:person.0710074174.33
138 rdf:rest N389f0a668e4046ecb18c8c734cd3c4e6
139 N7ab2cf7a456e4943a643f746a5ae06e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Models, Theoretical
141 rdf:type schema:DefinedTerm
142 N80061c2a0a304a52b62dc3160253be15 schema:volumeNumber 13
143 rdf:type schema:PublicationVolume
144 N857afadb48414549b30b4283a8dee1c1 rdf:first sg:person.01323523402.06
145 rdf:rest N5b67d6a5074c4c7a894bbdc719cfea2f
146 N96e86b86b88b4115896f1a936de2702f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Human Immunodeficiency Virus Proteins
148 rdf:type schema:DefinedTerm
149 N9f9d8e95358b49eb933a8910eae16192 rdf:first sg:person.0732120026.62
150 rdf:rest N4ff5f68ad2384ce5943800bf2fedb635
151 Nb32d4df17af846c2aa220d9b144fb49b rdf:first sg:person.0774503452.97
152 rdf:rest N46668ea65157416d90ac019adef4583e
153 Nb84bbc9f0e3649b3a9c96fad76fb1669 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Mice, SCID
155 rdf:type schema:DefinedTerm
156 Nc34761d8d44d410e9609ac63237a5646 schema:issueNumber 1
157 rdf:type schema:PublicationIssue
158 Nd823aaefdeae46b79807c7e767e1bc76 schema:name pubmed_id
159 schema:value 27086687
160 rdf:type schema:PropertyValue
161 Ndc45969f21e14e7a99b73bb5f021f2a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Mice
163 rdf:type schema:DefinedTerm
164 Neeff344c4675467f9f71ee78fd3fdd3b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Virus Replication
166 rdf:type schema:DefinedTerm
167 Nfb95fff2f13c4bf7baf844740c743b31 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Animals
169 rdf:type schema:DefinedTerm
170 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
171 schema:name Medical and Health Sciences
172 rdf:type schema:DefinedTerm
173 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
174 schema:name Medical Microbiology
175 rdf:type schema:DefinedTerm
176 sg:grant.5864367 http://pending.schema.org/fundedItem sg:pub.10.1186/s12977-016-0252-2
177 rdf:type schema:MonetaryGrant
178 sg:grant.5871545 http://pending.schema.org/fundedItem sg:pub.10.1186/s12977-016-0252-2
179 rdf:type schema:MonetaryGrant
180 sg:grant.5881554 http://pending.schema.org/fundedItem sg:pub.10.1186/s12977-016-0252-2
181 rdf:type schema:MonetaryGrant
182 sg:grant.6081990 http://pending.schema.org/fundedItem sg:pub.10.1186/s12977-016-0252-2
183 rdf:type schema:MonetaryGrant
184 sg:grant.6085506 http://pending.schema.org/fundedItem sg:pub.10.1186/s12977-016-0252-2
185 rdf:type schema:MonetaryGrant
186 sg:grant.6134570 http://pending.schema.org/fundedItem sg:pub.10.1186/s12977-016-0252-2
187 rdf:type schema:MonetaryGrant
188 sg:grant.6135475 http://pending.schema.org/fundedItem sg:pub.10.1186/s12977-016-0252-2
189 rdf:type schema:MonetaryGrant
190 sg:grant.6536661 http://pending.schema.org/fundedItem sg:pub.10.1186/s12977-016-0252-2
191 rdf:type schema:MonetaryGrant
192 sg:grant.9341583 http://pending.schema.org/fundedItem sg:pub.10.1186/s12977-016-0252-2
193 rdf:type schema:MonetaryGrant
194 sg:journal.1033800 schema:issn 1742-4690
195 schema:name Retrovirology
196 schema:publisher Springer Nature
197 rdf:type schema:Periodical
198 sg:person.01051033261.50 schema:affiliation grid-institutes:grid.419082.6
199 schema:familyName Iwami
200 schema:givenName Shingo
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051033261.50
202 rdf:type schema:Person
203 sg:person.01076202570.34 schema:affiliation grid-institutes:grid.263536.7
204 schema:familyName Morita
205 schema:givenName Satoru
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076202570.34
207 rdf:type schema:Person
208 sg:person.01233375061.92 schema:affiliation grid-institutes:grid.258799.8
209 schema:familyName Koyanagi
210 schema:givenName Yoshio
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233375061.92
212 rdf:type schema:Person
213 sg:person.01255366502.55 schema:affiliation grid-institutes:grid.26999.3d
214 schema:familyName Nakaoka
215 schema:givenName Shinji
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255366502.55
217 rdf:type schema:Person
218 sg:person.01323523402.06 schema:affiliation grid-institutes:grid.26999.3d
219 schema:familyName Aihara
220 schema:givenName Kazuyuki
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323523402.06
222 rdf:type schema:Person
223 sg:person.0710074174.33 schema:affiliation grid-institutes:grid.419082.6
224 schema:familyName Sato
225 schema:givenName Kei
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710074174.33
227 rdf:type schema:Person
228 sg:person.0732120026.62 schema:affiliation grid-institutes:grid.177174.3
229 schema:familyName Ikeda
230 schema:givenName Hiroki
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732120026.62
232 rdf:type schema:Person
233 sg:person.0734604661.00 schema:affiliation grid-institutes:grid.258799.8
234 schema:familyName Misawa
235 schema:givenName Naoko
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734604661.00
237 rdf:type schema:Person
238 sg:person.0774503452.97 schema:affiliation grid-institutes:grid.5477.1
239 schema:familyName de Boer
240 schema:givenName Rob J.
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774503452.97
242 rdf:type schema:Person
243 sg:pub.10.1038/nature06553 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050660540
244 https://doi.org/10.1038/nature06553
245 rdf:type schema:CreativeWork
246 sg:pub.10.1038/nature16933 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007201638
247 https://doi.org/10.1038/nature16933
248 rdf:type schema:CreativeWork
249 sg:pub.10.1038/nri700 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003731496
250 https://doi.org/10.1038/nri700
251 rdf:type schema:CreativeWork
252 sg:pub.10.1038/srep12256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046426190
253 https://doi.org/10.1038/srep12256
254 rdf:type schema:CreativeWork
255 sg:pub.10.1186/1742-4682-11-22 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027609943
256 https://doi.org/10.1186/1742-4682-11-22
257 rdf:type schema:CreativeWork
258 grid-institutes:grid.177174.3 schema:alternateName Department of Biology, Faculty of Sciences, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, 812-8581, Fukuoka, Fukuoka, Japan
259 schema:name Department of Biology, Faculty of Sciences, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, 812-8581, Fukuoka, Fukuoka, Japan
260 rdf:type schema:Organization
261 grid-institutes:grid.258799.8 schema:alternateName Laboratory of Viral Pathogenesis, Institute for Virus Research, Kyoto University, 53 Shogoinkawara-cho, Sakyo-ku, 606-8507, Kyoto, Kyoto, Japan
262 schema:name Laboratory of Viral Pathogenesis, Institute for Virus Research, Kyoto University, 53 Shogoinkawara-cho, Sakyo-ku, 606-8507, Kyoto, Kyoto, Japan
263 rdf:type schema:Organization
264 grid-institutes:grid.263536.7 schema:alternateName Department of Mathematical and Systems Engineering, Shizuoka University, Shizuoka, Japan
265 schema:name Department of Mathematical and Systems Engineering, Shizuoka University, Shizuoka, Japan
266 rdf:type schema:Organization
267 grid-institutes:grid.26999.3d schema:alternateName Graduate School of Information Science and Technology, The University of Tokyo, Tokyo, Japan
268 Graduate School of Medicine, University of Tokyo, Tokyo, Japan
269 schema:name Graduate School of Information Science and Technology, The University of Tokyo, Tokyo, Japan
270 Graduate School of Medicine, University of Tokyo, Tokyo, Japan
271 Institute of Industrial Science, The University of Tokyo, Tokyo, Japan
272 rdf:type schema:Organization
273 grid-institutes:grid.419082.6 schema:alternateName CREST, JST, Saitama, Japan
274 PRESTO, JST, Saitama, Japan
275 schema:name CREST, JST, Saitama, Japan
276 Department of Biology, Faculty of Sciences, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, 812-8581, Fukuoka, Fukuoka, Japan
277 Laboratory of Viral Pathogenesis, Institute for Virus Research, Kyoto University, 53 Shogoinkawara-cho, Sakyo-ku, 606-8507, Kyoto, Kyoto, Japan
278 PRESTO, JST, Saitama, Japan
279 rdf:type schema:Organization
280 grid-institutes:grid.5477.1 schema:alternateName Theoretical Biology, Utrecht University, Utrecht, The Netherlands
281 schema:name Theoretical Biology, Utrecht University, Utrecht, The Netherlands
282 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...