HIV-1 immune activation induces Siglec-1 expression and enhances viral trans-infection in blood and tissue myeloid cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Maria Pino, Itziar Erkizia, Susana Benet, Elina Erikson, Maria Teresa Fernández-Figueras, Dolores Guerrero, Judith Dalmau, Dan Ouchi, Antonio Rausell, Angela Ciuffi, Oliver T Keppler, Amalio Telenti, Hans-Georg Kräusslich, Javier Martinez-Picado, Nuria Izquierdo-Useros

ABSTRACT

BACKGROUND: Myeloid cells are key players in the recognition and response of the host against invading viruses. Paradoxically, upon HIV-1 infection, myeloid cells might also promote viral pathogenesis through trans-infection, a mechanism that promotes HIV-1 transmission to target cells via viral capture and storage. The receptor Siglec-1 (CD169) potently enhances HIV-1 trans-infection and is regulated by immune activating signals present throughout the course of HIV-1 infection, such as interferon α (IFNα). RESULTS: Here we show that IFNα-activated dendritic cells, monocytes and macrophages have an enhanced ability to capture and trans-infect HIV-1 via Siglec-1 recognition of viral membrane gangliosides. Monocytes from untreated HIV-1-infected individuals trans-infect HIV-1 via Siglec-1, but this capacity diminishes after effective antiretroviral treatment. Furthermore, Siglec-1 is expressed on myeloid cells residing in lymphoid tissues, where it can mediate viral trans-infection. CONCLUSIONS: Siglec-1 on myeloid cells could fuel novel CD4(+) T-cell infections and contribute to HIV-1 dissemination in vivo. More... »

PAGES

37

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12977-015-0160-x

DOI

http://dx.doi.org/10.1186/s12977-015-0160-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028162112

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25947229


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CD4-Positive T-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV-1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interferon-alpha", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myeloid Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sialic Acid Binding Ig-like Lectin 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Up-Regulation", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Autonomous University of Barcelona", 
          "id": "https://www.grid.ac/institutes/grid.7080.f", 
          "name": [
            "AIDS Research Institute IrsiCaixa, Institut d\u2019Investigaci\u00f3 en Ci\u00e8ncies de la Salut Germans Trias i Pujol IGTP, Universitat Aut\u00f2noma de Barcelona, Badalona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pino", 
        "givenName": "Maria", 
        "id": "sg:person.01243307517.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243307517.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Autonomous University of Barcelona", 
          "id": "https://www.grid.ac/institutes/grid.7080.f", 
          "name": [
            "AIDS Research Institute IrsiCaixa, Institut d\u2019Investigaci\u00f3 en Ci\u00e8ncies de la Salut Germans Trias i Pujol IGTP, Universitat Aut\u00f2noma de Barcelona, Badalona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Erkizia", 
        "givenName": "Itziar", 
        "id": "sg:person.01335511610.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335511610.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Autonomous University of Barcelona", 
          "id": "https://www.grid.ac/institutes/grid.7080.f", 
          "name": [
            "AIDS Research Institute IrsiCaixa, Institut d\u2019Investigaci\u00f3 en Ci\u00e8ncies de la Salut Germans Trias i Pujol IGTP, Universitat Aut\u00f2noma de Barcelona, Badalona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Benet", 
        "givenName": "Susana", 
        "id": "sg:person.01344054645.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344054645.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Heidelberg", 
          "id": "https://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "Institute of Medical Virology, National Reference Center for Retroviruses, University of Frankfurt, Frankfurt, Germany", 
            "Department of Infectious Diseases, Virology, Universit\u00e4tsklinikum Heidelberg, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Erikson", 
        "givenName": "Elina", 
        "id": "sg:person.0627161240.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627161240.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universitari Germans Trias i Pujol", 
          "id": "https://www.grid.ac/institutes/grid.411438.b", 
          "name": [
            "Pathology Department, University Hospital Germans Trias i Pujol (HUGTIP), Badalona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fern\u00e1ndez-Figueras", 
        "givenName": "Maria Teresa", 
        "id": "sg:person.0702455770.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702455770.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Otorhinolaryngology Department, HUGTIP, Badalona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guerrero", 
        "givenName": "Dolores", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Autonomous University of Barcelona", 
          "id": "https://www.grid.ac/institutes/grid.7080.f", 
          "name": [
            "AIDS Research Institute IrsiCaixa, Institut d\u2019Investigaci\u00f3 en Ci\u00e8ncies de la Salut Germans Trias i Pujol IGTP, Universitat Aut\u00f2noma de Barcelona, Badalona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dalmau", 
        "givenName": "Judith", 
        "id": "sg:person.01351063174.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351063174.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Autonomous University of Barcelona", 
          "id": "https://www.grid.ac/institutes/grid.7080.f", 
          "name": [
            "AIDS Research Institute IrsiCaixa, Institut d\u2019Investigaci\u00f3 en Ci\u00e8ncies de la Salut Germans Trias i Pujol IGTP, Universitat Aut\u00f2noma de Barcelona, Badalona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ouchi", 
        "givenName": "Dan", 
        "id": "sg:person.0612453460.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612453460.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Lausanne", 
          "id": "https://www.grid.ac/institutes/grid.9851.5", 
          "name": [
            "Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland", 
            "Swiss Institute of Bioinformatics (SIB) - Vital-IT, Lausanne, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rausell", 
        "givenName": "Antonio", 
        "id": "sg:person.01117240745.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117240745.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Lausanne", 
          "id": "https://www.grid.ac/institutes/grid.9851.5", 
          "name": [
            "Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ciuffi", 
        "givenName": "Angela", 
        "id": "sg:person.01221723017.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221723017.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Goethe University Frankfurt", 
          "id": "https://www.grid.ac/institutes/grid.7839.5", 
          "name": [
            "Institute of Medical Virology, National Reference Center for Retroviruses, University of Frankfurt, Frankfurt, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Keppler", 
        "givenName": "Oliver T", 
        "id": "sg:person.01266514445.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266514445.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "J. Craig Venter Institute", 
          "id": "https://www.grid.ac/institutes/grid.469946.0", 
          "name": [
            "Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland", 
            "Current address: The J. Craig Venter Institute, La Jolla, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Telenti", 
        "givenName": "Amalio", 
        "id": "sg:person.01162002733.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162002733.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Heidelberg", 
          "id": "https://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "Department of Infectious Diseases, Virology, Universit\u00e4tsklinikum Heidelberg, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kr\u00e4usslich", 
        "givenName": "Hans-Georg", 
        "id": "sg:person.0731120455.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731120455.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Vic", 
          "id": "https://www.grid.ac/institutes/grid.440820.a", 
          "name": [
            "AIDS Research Institute IrsiCaixa, Institut d\u2019Investigaci\u00f3 en Ci\u00e8ncies de la Salut Germans Trias i Pujol IGTP, Universitat Aut\u00f2noma de Barcelona, Badalona, Spain", 
            "Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats ICREA, Barcelona, Spain", 
            "University of Vic-Central University of Catalonia (UVic-UCC), Vic, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Martinez-Picado", 
        "givenName": "Javier", 
        "id": "sg:person.0641744032.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641744032.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Autonomous University of Barcelona", 
          "id": "https://www.grid.ac/institutes/grid.7080.f", 
          "name": [
            "AIDS Research Institute IrsiCaixa, Institut d\u2019Investigaci\u00f3 en Ci\u00e8ncies de la Salut Germans Trias i Pujol IGTP, Universitat Aut\u00f2noma de Barcelona, Badalona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Izquierdo-Useros", 
        "givenName": "Nuria", 
        "id": "sg:person.0726334110.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726334110.73"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nature10117", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000958136", 
          "https://doi.org/10.1038/nature10117"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.77.6.3777-3784.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001792445"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2012.10.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001824364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood.v97.1.288", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002405883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.virol.2006.10.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002603735"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.02321-07", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004375487"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.02572-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004788843"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1318249111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005652483"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci26032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005773148"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)80694-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005946082"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1101684108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005958361"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0001967", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008222293"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0506857102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009454563"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0506857102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009454563"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri3712", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011546421", 
          "https://doi.org/10.1038/nri3712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.79.16.10108-10125.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014523492"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1003530", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015322056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20041236", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016323983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1004156", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016568061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.01844-08", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019153840"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.1871", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019300068", 
          "https://doi.org/10.1038/nm.1871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jneuroim.2004.08.039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019413951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002030-200309050-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021801254"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002030-200309050-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021801254"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri1960", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022250802", 
          "https://doi.org/10.1038/nri1960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri1960", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022250802", 
          "https://doi.org/10.1038/nri1960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0024559", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026215822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1511", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026493537", 
          "https://doi.org/10.1038/nm1511"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1511", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026493537", 
          "https://doi.org/10.1038/nm1511"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pbio.1001448", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030123233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1003291", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033303918"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2008-07-170803", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035415574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2008-07-170803", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035415574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10195", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037288305", 
          "https://doi.org/10.1038/nature10195"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002030-200203290-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040635539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002030-200203290-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040635539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pbio.1001315", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042405056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2249.2000.01144.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048580916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1201104109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049367877"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0000257", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051834086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qai.0b013e3181664b60", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052514666"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qai.0b013e3181664b60", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052514666"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btu638", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053282140"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/bts635", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053365587"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/aid.1991.7.375", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059223266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1084238", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062448091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1352913", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062477283"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.274.5289.985", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062554761"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082893158", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-12", 
    "datePublishedReg": "2015-12-01", 
    "description": "BACKGROUND: Myeloid cells are key players in the recognition and response of the host against invading viruses. Paradoxically, upon HIV-1 infection, myeloid cells might also promote viral pathogenesis through trans-infection, a mechanism that promotes HIV-1 transmission to target cells via viral capture and storage. The receptor Siglec-1 (CD169) potently enhances HIV-1 trans-infection and is regulated by immune activating signals present throughout the course of HIV-1 infection, such as interferon \u03b1 (IFN\u03b1).\nRESULTS: Here we show that IFN\u03b1-activated dendritic cells, monocytes and macrophages have an enhanced ability to capture and trans-infect HIV-1 via Siglec-1 recognition of viral membrane gangliosides. Monocytes from untreated HIV-1-infected individuals trans-infect HIV-1 via Siglec-1, but this capacity diminishes after effective antiretroviral treatment. Furthermore, Siglec-1 is expressed on myeloid cells residing in lymphoid tissues, where it can mediate viral trans-infection.\nCONCLUSIONS: Siglec-1 on myeloid cells could fuel novel CD4(+) T-cell infections and contribute to HIV-1 dissemination in vivo.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12977-015-0160-x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1033800", 
        "issn": [
          "1742-4690"
        ], 
        "name": "Retrovirology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "12"
      }
    ], 
    "name": "HIV-1 immune activation induces Siglec-1 expression and enhances viral trans-infection in blood and tissue myeloid cells", 
    "pagination": "37", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "86289a8498f4f01673a27fccc205b106a2988f2798d05489ae59f8333f506066"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25947229"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101216893"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12977-015-0160-x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1028162112"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12977-015-0160-x", 
      "https://app.dimensions.ai/details/publication/pub.1028162112"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:09", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000367_0000000367/records_88236_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2Fs12977-015-0160-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12977-015-0160-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12977-015-0160-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12977-015-0160-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12977-015-0160-x'


 

This table displays all metadata directly associated to this object as RDF triples.

361 TRIPLES      21 PREDICATES      81 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12977-015-0160-x schema:about N213c59599172478190ebeead85f012fc
2 N35a5faf2db4a4794b7e432a78519664c
3 N4f31cd943de142b7a479038749a144ac
4 N5a9c9da8d1d4418aa007fa24356db1a1
5 N5cb9962295214d129cd57308fce8755c
6 N8bdc6413968c49e6a742895fc2354919
7 N8bf08f6cea8a4e4182f91ccbb1b2b81b
8 N9c275b478c074bf8b2ef781d2d680047
9 Na81833a8e9b24da39ef8c70f91f12813
10 Nd763a6c902d441deb4d05326a9985c50
11 anzsrc-for:11
12 anzsrc-for:1107
13 schema:author N5e75d52d28d049d9a8009f92f2261509
14 schema:citation sg:pub.10.1038/nature10117
15 sg:pub.10.1038/nature10195
16 sg:pub.10.1038/nm.1871
17 sg:pub.10.1038/nm1511
18 sg:pub.10.1038/nri1960
19 sg:pub.10.1038/nri3712
20 https://app.dimensions.ai/details/publication/pub.1082893158
21 https://doi.org/10.1016/j.immuni.2012.10.018
22 https://doi.org/10.1016/j.jneuroim.2004.08.039
23 https://doi.org/10.1016/j.virol.2006.10.005
24 https://doi.org/10.1016/s0092-8674(00)80694-7
25 https://doi.org/10.1046/j.1365-2249.2000.01144.x
26 https://doi.org/10.1073/pnas.0506857102
27 https://doi.org/10.1073/pnas.1101684108
28 https://doi.org/10.1073/pnas.1201104109
29 https://doi.org/10.1073/pnas.1318249111
30 https://doi.org/10.1084/jem.20041236
31 https://doi.org/10.1089/aid.1991.7.375
32 https://doi.org/10.1093/bioinformatics/bts635
33 https://doi.org/10.1093/bioinformatics/btu638
34 https://doi.org/10.1097/00002030-200203290-00003
35 https://doi.org/10.1097/00002030-200309050-00006
36 https://doi.org/10.1097/qai.0b013e3181664b60
37 https://doi.org/10.1126/science.1084238
38 https://doi.org/10.1126/science.1352913
39 https://doi.org/10.1126/science.274.5289.985
40 https://doi.org/10.1128/jvi.01844-08
41 https://doi.org/10.1128/jvi.02321-07
42 https://doi.org/10.1128/jvi.02572-06
43 https://doi.org/10.1128/jvi.77.6.3777-3784.2003
44 https://doi.org/10.1128/jvi.79.16.10108-10125.2005
45 https://doi.org/10.1172/jci26032
46 https://doi.org/10.1182/blood-2008-07-170803
47 https://doi.org/10.1182/blood.v97.1.288
48 https://doi.org/10.1371/journal.pbio.1001315
49 https://doi.org/10.1371/journal.pbio.1001448
50 https://doi.org/10.1371/journal.pone.0000257
51 https://doi.org/10.1371/journal.pone.0001967
52 https://doi.org/10.1371/journal.pone.0024559
53 https://doi.org/10.1371/journal.ppat.1003291
54 https://doi.org/10.1371/journal.ppat.1003530
55 https://doi.org/10.1371/journal.ppat.1004156
56 schema:datePublished 2015-12
57 schema:datePublishedReg 2015-12-01
58 schema:description BACKGROUND: Myeloid cells are key players in the recognition and response of the host against invading viruses. Paradoxically, upon HIV-1 infection, myeloid cells might also promote viral pathogenesis through trans-infection, a mechanism that promotes HIV-1 transmission to target cells via viral capture and storage. The receptor Siglec-1 (CD169) potently enhances HIV-1 trans-infection and is regulated by immune activating signals present throughout the course of HIV-1 infection, such as interferon α (IFNα). RESULTS: Here we show that IFNα-activated dendritic cells, monocytes and macrophages have an enhanced ability to capture and trans-infect HIV-1 via Siglec-1 recognition of viral membrane gangliosides. Monocytes from untreated HIV-1-infected individuals trans-infect HIV-1 via Siglec-1, but this capacity diminishes after effective antiretroviral treatment. Furthermore, Siglec-1 is expressed on myeloid cells residing in lymphoid tissues, where it can mediate viral trans-infection. CONCLUSIONS: Siglec-1 on myeloid cells could fuel novel CD4(+) T-cell infections and contribute to HIV-1 dissemination in vivo.
59 schema:genre research_article
60 schema:inLanguage en
61 schema:isAccessibleForFree true
62 schema:isPartOf Naae39e1804174c9e99171bc5e94d30ba
63 Ne08b5c2b26cc45a79826a05f507c7379
64 sg:journal.1033800
65 schema:name HIV-1 immune activation induces Siglec-1 expression and enhances viral trans-infection in blood and tissue myeloid cells
66 schema:pagination 37
67 schema:productId N38c7b5f485524175867c0001a8f013a8
68 N3a4dc092262148b6a851f48e1a12c8d0
69 N897ca70ee40b49aea29a461b1270817c
70 Na07588820f294275a22be9e410cecd4e
71 Nb6974d2f7dc4408f82a552b2f132b472
72 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028162112
73 https://doi.org/10.1186/s12977-015-0160-x
74 schema:sdDatePublished 2019-04-11T13:09
75 schema:sdLicense https://scigraph.springernature.com/explorer/license/
76 schema:sdPublisher Nf89e02d5d33741a396f1efa6b6510027
77 schema:url http://link.springer.com/10.1186%2Fs12977-015-0160-x
78 sgo:license sg:explorer/license/
79 sgo:sdDataset articles
80 rdf:type schema:ScholarlyArticle
81 N1ee467fcaee642bf8eb9ffe54138d76b rdf:first sg:person.01266514445.93
82 rdf:rest N528cb031954f4df492740e7c42c31069
83 N213c59599172478190ebeead85f012fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name HIV-1
85 rdf:type schema:DefinedTerm
86 N2bee9dd37e3748b9a66c67a589289c22 rdf:first sg:person.01344054645.26
87 rdf:rest N704312402e734fe38f314815bd6e33ab
88 N32d8a1c282174d2783f26dc009b54acb rdf:first sg:person.01117240745.14
89 rdf:rest N708f1f37717a48509a6a56f8a3a4ef9b
90 N35a5faf2db4a4794b7e432a78519664c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Myeloid Cells
92 rdf:type schema:DefinedTerm
93 N38c7b5f485524175867c0001a8f013a8 schema:name nlm_unique_id
94 schema:value 101216893
95 rdf:type schema:PropertyValue
96 N3a4dc092262148b6a851f48e1a12c8d0 schema:name doi
97 schema:value 10.1186/s12977-015-0160-x
98 rdf:type schema:PropertyValue
99 N4164cfb78d834a07b122300eac3caa64 rdf:first sg:person.01335511610.30
100 rdf:rest N2bee9dd37e3748b9a66c67a589289c22
101 N46390b7a2ca9478ab3794e543a009717 rdf:first sg:person.01351063174.34
102 rdf:rest N747f17dfd47e44728f6b407facf6e7c7
103 N4f31cd943de142b7a479038749a144ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name CD4-Positive T-Lymphocytes
105 rdf:type schema:DefinedTerm
106 N528cb031954f4df492740e7c42c31069 rdf:first sg:person.01162002733.02
107 rdf:rest N57a039d51c7b4186b1d5a7491da1d96a
108 N57a039d51c7b4186b1d5a7491da1d96a rdf:first sg:person.0731120455.54
109 rdf:rest Na20a9b386d024f909211a62f0bdefd1d
110 N5a9c9da8d1d4418aa007fa24356db1a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Humans
112 rdf:type schema:DefinedTerm
113 N5cb9962295214d129cd57308fce8755c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Male
115 rdf:type schema:DefinedTerm
116 N5e75d52d28d049d9a8009f92f2261509 rdf:first sg:person.01243307517.11
117 rdf:rest N4164cfb78d834a07b122300eac3caa64
118 N704312402e734fe38f314815bd6e33ab rdf:first sg:person.0627161240.36
119 rdf:rest N8f492a4a7a3e4809a1a3d32a8c6e54e7
120 N708f1f37717a48509a6a56f8a3a4ef9b rdf:first sg:person.01221723017.37
121 rdf:rest N1ee467fcaee642bf8eb9ffe54138d76b
122 N747f17dfd47e44728f6b407facf6e7c7 rdf:first sg:person.0612453460.36
123 rdf:rest N32d8a1c282174d2783f26dc009b54acb
124 N897ca70ee40b49aea29a461b1270817c schema:name pubmed_id
125 schema:value 25947229
126 rdf:type schema:PropertyValue
127 N8bdc6413968c49e6a742895fc2354919 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Sialic Acid Binding Ig-like Lectin 1
129 rdf:type schema:DefinedTerm
130 N8bf08f6cea8a4e4182f91ccbb1b2b81b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Adult
132 rdf:type schema:DefinedTerm
133 N8f492a4a7a3e4809a1a3d32a8c6e54e7 rdf:first sg:person.0702455770.13
134 rdf:rest Nad201d59a7dd469ba10e6a80c2d36c8c
135 N9aaa6460f08249a08fd00243a837cdf9 schema:name Otorhinolaryngology Department, HUGTIP, Badalona, Spain
136 rdf:type schema:Organization
137 N9bc14d401a7240f7be4aad3e422f20a0 schema:affiliation N9aaa6460f08249a08fd00243a837cdf9
138 schema:familyName Guerrero
139 schema:givenName Dolores
140 rdf:type schema:Person
141 N9c275b478c074bf8b2ef781d2d680047 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Interferon-alpha
143 rdf:type schema:DefinedTerm
144 Na07588820f294275a22be9e410cecd4e schema:name dimensions_id
145 schema:value pub.1028162112
146 rdf:type schema:PropertyValue
147 Na20a9b386d024f909211a62f0bdefd1d rdf:first sg:person.0641744032.98
148 rdf:rest Nad4fb51b623f48ee8e0e40bdf20a47ab
149 Na81833a8e9b24da39ef8c70f91f12813 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Up-Regulation
151 rdf:type schema:DefinedTerm
152 Naae39e1804174c9e99171bc5e94d30ba schema:issueNumber 1
153 rdf:type schema:PublicationIssue
154 Nad201d59a7dd469ba10e6a80c2d36c8c rdf:first N9bc14d401a7240f7be4aad3e422f20a0
155 rdf:rest N46390b7a2ca9478ab3794e543a009717
156 Nad4fb51b623f48ee8e0e40bdf20a47ab rdf:first sg:person.0726334110.73
157 rdf:rest rdf:nil
158 Nb6974d2f7dc4408f82a552b2f132b472 schema:name readcube_id
159 schema:value 86289a8498f4f01673a27fccc205b106a2988f2798d05489ae59f8333f506066
160 rdf:type schema:PropertyValue
161 Nd763a6c902d441deb4d05326a9985c50 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Cells, Cultured
163 rdf:type schema:DefinedTerm
164 Ne08b5c2b26cc45a79826a05f507c7379 schema:volumeNumber 12
165 rdf:type schema:PublicationVolume
166 Nf89e02d5d33741a396f1efa6b6510027 schema:name Springer Nature - SN SciGraph project
167 rdf:type schema:Organization
168 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
169 schema:name Medical and Health Sciences
170 rdf:type schema:DefinedTerm
171 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
172 schema:name Immunology
173 rdf:type schema:DefinedTerm
174 sg:journal.1033800 schema:issn 1742-4690
175 schema:name Retrovirology
176 rdf:type schema:Periodical
177 sg:person.01117240745.14 schema:affiliation https://www.grid.ac/institutes/grid.9851.5
178 schema:familyName Rausell
179 schema:givenName Antonio
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117240745.14
181 rdf:type schema:Person
182 sg:person.01162002733.02 schema:affiliation https://www.grid.ac/institutes/grid.469946.0
183 schema:familyName Telenti
184 schema:givenName Amalio
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162002733.02
186 rdf:type schema:Person
187 sg:person.01221723017.37 schema:affiliation https://www.grid.ac/institutes/grid.9851.5
188 schema:familyName Ciuffi
189 schema:givenName Angela
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221723017.37
191 rdf:type schema:Person
192 sg:person.01243307517.11 schema:affiliation https://www.grid.ac/institutes/grid.7080.f
193 schema:familyName Pino
194 schema:givenName Maria
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243307517.11
196 rdf:type schema:Person
197 sg:person.01266514445.93 schema:affiliation https://www.grid.ac/institutes/grid.7839.5
198 schema:familyName Keppler
199 schema:givenName Oliver T
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266514445.93
201 rdf:type schema:Person
202 sg:person.01335511610.30 schema:affiliation https://www.grid.ac/institutes/grid.7080.f
203 schema:familyName Erkizia
204 schema:givenName Itziar
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335511610.30
206 rdf:type schema:Person
207 sg:person.01344054645.26 schema:affiliation https://www.grid.ac/institutes/grid.7080.f
208 schema:familyName Benet
209 schema:givenName Susana
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344054645.26
211 rdf:type schema:Person
212 sg:person.01351063174.34 schema:affiliation https://www.grid.ac/institutes/grid.7080.f
213 schema:familyName Dalmau
214 schema:givenName Judith
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351063174.34
216 rdf:type schema:Person
217 sg:person.0612453460.36 schema:affiliation https://www.grid.ac/institutes/grid.7080.f
218 schema:familyName Ouchi
219 schema:givenName Dan
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612453460.36
221 rdf:type schema:Person
222 sg:person.0627161240.36 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
223 schema:familyName Erikson
224 schema:givenName Elina
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627161240.36
226 rdf:type schema:Person
227 sg:person.0641744032.98 schema:affiliation https://www.grid.ac/institutes/grid.440820.a
228 schema:familyName Martinez-Picado
229 schema:givenName Javier
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641744032.98
231 rdf:type schema:Person
232 sg:person.0702455770.13 schema:affiliation https://www.grid.ac/institutes/grid.411438.b
233 schema:familyName Fernández-Figueras
234 schema:givenName Maria Teresa
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702455770.13
236 rdf:type schema:Person
237 sg:person.0726334110.73 schema:affiliation https://www.grid.ac/institutes/grid.7080.f
238 schema:familyName Izquierdo-Useros
239 schema:givenName Nuria
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726334110.73
241 rdf:type schema:Person
242 sg:person.0731120455.54 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
243 schema:familyName Kräusslich
244 schema:givenName Hans-Georg
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731120455.54
246 rdf:type schema:Person
247 sg:pub.10.1038/nature10117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000958136
248 https://doi.org/10.1038/nature10117
249 rdf:type schema:CreativeWork
250 sg:pub.10.1038/nature10195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037288305
251 https://doi.org/10.1038/nature10195
252 rdf:type schema:CreativeWork
253 sg:pub.10.1038/nm.1871 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019300068
254 https://doi.org/10.1038/nm.1871
255 rdf:type schema:CreativeWork
256 sg:pub.10.1038/nm1511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026493537
257 https://doi.org/10.1038/nm1511
258 rdf:type schema:CreativeWork
259 sg:pub.10.1038/nri1960 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022250802
260 https://doi.org/10.1038/nri1960
261 rdf:type schema:CreativeWork
262 sg:pub.10.1038/nri3712 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011546421
263 https://doi.org/10.1038/nri3712
264 rdf:type schema:CreativeWork
265 https://app.dimensions.ai/details/publication/pub.1082893158 schema:CreativeWork
266 https://doi.org/10.1016/j.immuni.2012.10.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001824364
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/j.jneuroim.2004.08.039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019413951
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/j.virol.2006.10.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002603735
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/s0092-8674(00)80694-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005946082
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1046/j.1365-2249.2000.01144.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048580916
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1073/pnas.0506857102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009454563
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1073/pnas.1101684108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005958361
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1073/pnas.1201104109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049367877
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1073/pnas.1318249111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005652483
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1084/jem.20041236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016323983
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1089/aid.1991.7.375 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059223266
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1093/bioinformatics/bts635 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053365587
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1093/bioinformatics/btu638 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053282140
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1097/00002030-200203290-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040635539
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1097/00002030-200309050-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021801254
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1097/qai.0b013e3181664b60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052514666
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1126/science.1084238 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062448091
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1126/science.1352913 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062477283
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1126/science.274.5289.985 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062554761
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1128/jvi.01844-08 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019153840
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1128/jvi.02321-07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004375487
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1128/jvi.02572-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004788843
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1128/jvi.77.6.3777-3784.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001792445
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1128/jvi.79.16.10108-10125.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014523492
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1172/jci26032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005773148
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1182/blood-2008-07-170803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035415574
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1182/blood.v97.1.288 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002405883
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1371/journal.pbio.1001315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042405056
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1371/journal.pbio.1001448 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030123233
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1371/journal.pone.0000257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051834086
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1371/journal.pone.0001967 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008222293
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1371/journal.pone.0024559 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026215822
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1371/journal.ppat.1003291 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033303918
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1371/journal.ppat.1003530 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015322056
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1371/journal.ppat.1004156 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016568061
335 rdf:type schema:CreativeWork
336 https://www.grid.ac/institutes/grid.411438.b schema:alternateName Hospital Universitari Germans Trias i Pujol
337 schema:name Pathology Department, University Hospital Germans Trias i Pujol (HUGTIP), Badalona, Spain
338 rdf:type schema:Organization
339 https://www.grid.ac/institutes/grid.440820.a schema:alternateName University of Vic
340 schema:name AIDS Research Institute IrsiCaixa, Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol IGTP, Universitat Autònoma de Barcelona, Badalona, Spain
341 Institució Catalana de Recerca i Estudis Avançats ICREA, Barcelona, Spain
342 University of Vic-Central University of Catalonia (UVic-UCC), Vic, Spain
343 rdf:type schema:Organization
344 https://www.grid.ac/institutes/grid.469946.0 schema:alternateName J. Craig Venter Institute
345 schema:name Current address: The J. Craig Venter Institute, La Jolla, CA, USA
346 Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland
347 rdf:type schema:Organization
348 https://www.grid.ac/institutes/grid.5253.1 schema:alternateName University Hospital Heidelberg
349 schema:name Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany
350 Institute of Medical Virology, National Reference Center for Retroviruses, University of Frankfurt, Frankfurt, Germany
351 rdf:type schema:Organization
352 https://www.grid.ac/institutes/grid.7080.f schema:alternateName Autonomous University of Barcelona
353 schema:name AIDS Research Institute IrsiCaixa, Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol IGTP, Universitat Autònoma de Barcelona, Badalona, Spain
354 rdf:type schema:Organization
355 https://www.grid.ac/institutes/grid.7839.5 schema:alternateName Goethe University Frankfurt
356 schema:name Institute of Medical Virology, National Reference Center for Retroviruses, University of Frankfurt, Frankfurt, Germany
357 rdf:type schema:Organization
358 https://www.grid.ac/institutes/grid.9851.5 schema:alternateName University of Lausanne
359 schema:name Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland
360 Swiss Institute of Bioinformatics (SIB) - Vital-IT, Lausanne, Switzerland
361 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...