IL-1β induces rod degeneration through the disruption of retinal glutamate homeostasis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-01-03

AUTHORS

Hugo Charles-Messance, Guillaume Blot, Aude Couturier, Lucile Vignaud, Sara Touhami, Fanny Beguier, Lourdes Siqueiros, Valérie Forster, Nour Barmo, Sébastien Augustin, Serge Picaud, José-Alain Sahel, Alvaro Rendon, Antje Grosche, Ramin Tadayoni, Florian Sennlaub, Xavier Guillonneau

ABSTRACT

BackgroundAge-related macular degeneration is characterized by the accumulation of subretinal macrophages and the degeneration of cones, but mainly of rods. We have previously shown that Mononuclear Phagocytes-derived IL-1β induces rod photoreceptor cell death during experimental subretinal inflammation and in retinal explants exposed to IL-1β but the mechanism is unknown.MethodsRetinal explants were culture in the presence of human monocytes or IL-1β and photoreceptor cell survival was analyzed by TUNEL labeling. Glutamate concentration and transcription levels of gene involved in the homeostasis of glutamate were analyzed in cell fractions of explant cultured or not in the presence of IL-1β. Glutamate receptor antagonists were evaluated for their ability to reduce photoreceptor cell death in the presence of IL1-β or monocytes.ResultsWe here show that IL-1β does not induce death in isolated photoreceptors, suggesting an indirect effect. We demonstrate that IL-1β leads to glutamate-induced rod photoreceptor cell death as it increases the extracellular glutamate concentrations in the retina through the inhibition of its conversion to glutamine in Müller cells, increased release from Müller cells, and diminished reuptake. The inhibition of non-NMDA receptors completely and efficiently prevented rod apoptosis in retinal explants cultured in the presence of IL-1β or, more importantly, in vivo, in a model of subretinal inflammation.ConclusionsOur study emphasizes the importance of inflammation in the deregulation of glutamate homeostasis and provides a comprehensive mechanism of action for IL-1β-induced rod degeneration. More... »

PAGES

1

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12974-019-1655-5

DOI

http://dx.doi.org/10.1186/s12974-019-1655-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1123814773

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31900165


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Coculture Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glutamic Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Homeostasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-1beta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Transgenic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Monocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retinal Degeneration", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retinal Rod Photoreceptor Cells", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Sorbonne Universit\u00e9, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Sorbonne Universit\u00e9, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Charles-Messance", 
        "givenName": "Hugo", 
        "id": "sg:person.01257030015.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257030015.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sorbonne Universit\u00e9, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Sorbonne Universit\u00e9, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Blot", 
        "givenName": "Guillaume", 
        "id": "sg:person.014461431473.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014461431473.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Ophthalmology, H\u00f4pital Lariboisi\u00e8re, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.411296.9", 
          "name": [
            "Sorbonne Universit\u00e9, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France", 
            "Department of Ophthalmology, H\u00f4pital Lariboisi\u00e8re, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Couturier", 
        "givenName": "Aude", 
        "id": "sg:person.01155733220.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155733220.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sorbonne Universit\u00e9, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Sorbonne Universit\u00e9, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vignaud", 
        "givenName": "Lucile", 
        "id": "sg:person.014440532634.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014440532634.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Ophthalmology, H\u00f4pital Lariboisi\u00e8re, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.411296.9", 
          "name": [
            "Sorbonne Universit\u00e9, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France", 
            "Department of Ophthalmology, H\u00f4pital Lariboisi\u00e8re, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Touhami", 
        "givenName": "Sara", 
        "id": "sg:person.0610762232.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610762232.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sorbonne Universit\u00e9, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Sorbonne Universit\u00e9, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Beguier", 
        "givenName": "Fanny", 
        "id": "sg:person.010106703125.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010106703125.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sorbonne Universit\u00e9, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Sorbonne Universit\u00e9, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Siqueiros", 
        "givenName": "Lourdes", 
        "id": "sg:person.01035612533.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035612533.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sorbonne Universit\u00e9, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Sorbonne Universit\u00e9, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Forster", 
        "givenName": "Val\u00e9rie", 
        "id": "sg:person.0627750275.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627750275.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sorbonne Universit\u00e9, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Sorbonne Universit\u00e9, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Barmo", 
        "givenName": "Nour", 
        "id": "sg:person.012577724707.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012577724707.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sorbonne Universit\u00e9, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Sorbonne Universit\u00e9, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Augustin", 
        "givenName": "S\u00e9bastien", 
        "id": "sg:person.0721065165.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721065165.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sorbonne Universit\u00e9, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Sorbonne Universit\u00e9, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Picaud", 
        "givenName": "Serge", 
        "id": "sg:person.0642273724.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642273724.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Ophthalmology, The University of Pittsburgh School of Medicine, 15213, Pittsburgh, PA, USA", 
          "id": "http://www.grid.ac/institutes/grid.21925.3d", 
          "name": [
            "Sorbonne Universit\u00e9, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France", 
            "CHNO des Quinze-Vingts, DHU Sight Restore, INSERM-DGOS CIC 1423, 28 rue de Charenton, F-75012, Paris, France", 
            "Department of Ophthalmology, The University of Pittsburgh School of Medicine, 15213, Pittsburgh, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sahel", 
        "givenName": "Jos\u00e9-Alain", 
        "id": "sg:person.01104041722.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104041722.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sorbonne Universit\u00e9, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Sorbonne Universit\u00e9, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rendon", 
        "givenName": "Alvaro", 
        "id": "sg:person.01171304143.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171304143.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Physiological Genomics, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Grosshaderner Str. 9, D-82152, Planegg-Martinsried, Germany", 
          "id": "http://www.grid.ac/institutes/grid.5252.0", 
          "name": [
            "Department of Physiological Genomics, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Grosshaderner Str. 9, D-82152, Planegg-Martinsried, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Grosche", 
        "givenName": "Antje", 
        "id": "sg:person.01271165146.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271165146.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Ophthalmology, H\u00f4pital Lariboisi\u00e8re, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.411296.9", 
          "name": [
            "Sorbonne Universit\u00e9, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France", 
            "Department of Ophthalmology, H\u00f4pital Lariboisi\u00e8re, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tadayoni", 
        "givenName": "Ramin", 
        "id": "sg:person.0713714734.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713714734.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sorbonne Universit\u00e9, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Sorbonne Universit\u00e9, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sennlaub", 
        "givenName": "Florian", 
        "id": "sg:person.01356263054.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356263054.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sorbonne Universit\u00e9, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Sorbonne Universit\u00e9, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guillonneau", 
        "givenName": "Xavier", 
        "id": "sg:person.0736717332.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736717332.12"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/1742-2094-5-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046097877", 
          "https://doi.org/10.1186/1742-2094-5-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/eye.1988.106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028401543", 
          "https://doi.org/10.1038/eye.1988.106"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn.2234", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039125224", 
          "https://doi.org/10.1038/nn.2234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1742-2094-9-221", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046575601", 
          "https://doi.org/10.1186/1742-2094-9-221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00417-013-2516-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024569840", 
          "https://doi.org/10.1007/s00417-013-2516-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1742-2094-5-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019648721", 
          "https://doi.org/10.1186/1742-2094-5-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12031-015-0505-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038210833", 
          "https://doi.org/10.1007/s12031-015-0505-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri3087", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048092830", 
          "https://doi.org/10.1038/nri3087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1750-1326-7-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047446231", 
          "https://doi.org/10.1186/1750-1326-7-7"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2020-01-03", 
    "datePublishedReg": "2020-01-03", 
    "description": "BackgroundAge-related macular degeneration is characterized by the accumulation of subretinal macrophages and the degeneration of cones, but mainly of rods. We have previously shown that Mononuclear Phagocytes-derived IL-1\u03b2 induces rod photoreceptor cell death during experimental subretinal inflammation and in retinal explants exposed to IL-1\u03b2 but the mechanism is unknown.MethodsRetinal explants were culture in the presence of human monocytes or IL-1\u03b2 and photoreceptor cell survival was analyzed by TUNEL labeling. Glutamate concentration and transcription levels of gene involved in the homeostasis of glutamate were analyzed in cell fractions of explant cultured or not in the presence of IL-1\u03b2. Glutamate receptor antagonists were evaluated for their ability to reduce photoreceptor cell death in the presence of IL1-\u03b2 or monocytes.ResultsWe here show that IL-1\u03b2 does not induce death in isolated photoreceptors, suggesting an indirect effect. We demonstrate that IL-1\u03b2 leads to glutamate-induced rod photoreceptor cell death as it increases the extracellular glutamate concentrations in the retina through the inhibition of its conversion to glutamine in M\u00fcller cells, increased release from M\u00fcller cells, and diminished reuptake. The inhibition of non-NMDA receptors completely and efficiently prevented rod apoptosis in retinal explants cultured in the presence of IL-1\u03b2 or, more importantly, in vivo, in a model of subretinal inflammation.ConclusionsOur study emphasizes the importance of inflammation in the deregulation of glutamate homeostasis and provides a comprehensive mechanism of action for IL-1\u03b2-induced rod degeneration.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s12974-019-1655-5", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1034001", 
        "issn": [
          "1742-2094"
        ], 
        "name": "Journal of Neuroinflammation", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "17"
      }
    ], 
    "keywords": [
      "photoreceptor cell death", 
      "IL-1\u03b2 induces", 
      "IL-1\u03b2", 
      "subretinal inflammation", 
      "M\u00fcller cells", 
      "glutamate homeostasis", 
      "retinal explants", 
      "glutamate concentration", 
      "rod photoreceptor cell death", 
      "degeneration of cones", 
      "non-NMDA receptors", 
      "glutamate receptor antagonists", 
      "importance of inflammation", 
      "cell death", 
      "extracellular glutamate concentration", 
      "homeostasis of glutamate", 
      "photoreceptor cell survival", 
      "subretinal macrophages", 
      "receptor antagonist", 
      "rod degeneration", 
      "macular degeneration", 
      "rod apoptosis", 
      "ConclusionsOur study", 
      "human monocytes", 
      "inflammation", 
      "degeneration", 
      "isolated photoreceptors", 
      "TUNEL labeling", 
      "presence of IL1", 
      "death", 
      "cell fraction", 
      "monocytes", 
      "cell survival", 
      "homeostasis", 
      "inhibition", 
      "BackgroundAge", 
      "cells", 
      "induces", 
      "explants", 
      "reuptake", 
      "antagonist", 
      "transcription levels", 
      "IL1", 
      "retina", 
      "macrophages", 
      "ResultsWe", 
      "receptors", 
      "survival", 
      "glutamate", 
      "apoptosis", 
      "vivo", 
      "presence", 
      "photoreceptors", 
      "indirect effects", 
      "concentration", 
      "mechanism", 
      "release", 
      "disruption", 
      "levels", 
      "labeling", 
      "genes", 
      "study", 
      "action", 
      "accumulation", 
      "deregulation", 
      "effect", 
      "culture", 
      "comprehensive mechanism", 
      "ability", 
      "fraction", 
      "importance", 
      "cone", 
      "model", 
      "rods", 
      "conversion"
    ], 
    "name": "IL-1\u03b2 induces rod degeneration through the disruption of retinal glutamate homeostasis", 
    "pagination": "1", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1123814773"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12974-019-1655-5"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "31900165"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12974-019-1655-5", 
      "https://app.dimensions.ai/details/publication/pub.1123814773"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-10T10:26", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/article/article_870.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s12974-019-1655-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12974-019-1655-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12974-019-1655-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12974-019-1655-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12974-019-1655-5'


 

This table displays all metadata directly associated to this object as RDF triples.

356 TRIPLES      22 PREDICATES      125 URIs      106 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12974-019-1655-5 schema:about N0334971b29454a68b869a2c542a1c49e
2 N119ffa94d7614eb2a68e196a2dfe5e74
3 N3c7dc3296acc47bd87bbf4c75a46a15c
4 N4e87c4c6202646f98cb8816e6b443486
5 N57a5d75e54084eee923ab8bbcf1d86d4
6 N65d482a3c67448b18b05b6e0dbefbe5f
7 N6dd15b104a3b499fa46e834e2d4c20e5
8 N6eb9fa217c7c407185e644fabe11e6a9
9 Nb4795f45512345139b60da59265e33f4
10 Nca0cabd9ef4c4ea29e24f1131d39c3cf
11 Nd37e24b44c2f40f09b9dd6f02a6fdaf8
12 Nea55760752574cb6a879ce359702988e
13 Neb2e0654cabc47269d3ec8d5deb541a6
14 anzsrc-for:11
15 anzsrc-for:1103
16 anzsrc-for:1107
17 anzsrc-for:1109
18 schema:author Nb9e0c904df3644bfa2f1cc8a3864cc36
19 schema:citation sg:pub.10.1007/s00417-013-2516-z
20 sg:pub.10.1007/s12031-015-0505-x
21 sg:pub.10.1038/eye.1988.106
22 sg:pub.10.1038/nn.2234
23 sg:pub.10.1038/nri3087
24 sg:pub.10.1186/1742-2094-5-7
25 sg:pub.10.1186/1742-2094-5-8
26 sg:pub.10.1186/1742-2094-9-221
27 sg:pub.10.1186/1750-1326-7-7
28 schema:datePublished 2020-01-03
29 schema:datePublishedReg 2020-01-03
30 schema:description BackgroundAge-related macular degeneration is characterized by the accumulation of subretinal macrophages and the degeneration of cones, but mainly of rods. We have previously shown that Mononuclear Phagocytes-derived IL-1β induces rod photoreceptor cell death during experimental subretinal inflammation and in retinal explants exposed to IL-1β but the mechanism is unknown.MethodsRetinal explants were culture in the presence of human monocytes or IL-1β and photoreceptor cell survival was analyzed by TUNEL labeling. Glutamate concentration and transcription levels of gene involved in the homeostasis of glutamate were analyzed in cell fractions of explant cultured or not in the presence of IL-1β. Glutamate receptor antagonists were evaluated for their ability to reduce photoreceptor cell death in the presence of IL1-β or monocytes.ResultsWe here show that IL-1β does not induce death in isolated photoreceptors, suggesting an indirect effect. We demonstrate that IL-1β leads to glutamate-induced rod photoreceptor cell death as it increases the extracellular glutamate concentrations in the retina through the inhibition of its conversion to glutamine in Müller cells, increased release from Müller cells, and diminished reuptake. The inhibition of non-NMDA receptors completely and efficiently prevented rod apoptosis in retinal explants cultured in the presence of IL-1β or, more importantly, in vivo, in a model of subretinal inflammation.ConclusionsOur study emphasizes the importance of inflammation in the deregulation of glutamate homeostasis and provides a comprehensive mechanism of action for IL-1β-induced rod degeneration.
31 schema:genre article
32 schema:inLanguage en
33 schema:isAccessibleForFree true
34 schema:isPartOf N0f1c1436857e4e90b63647674ca43c39
35 N9066d2e932ca4b87895a6d1ec0beaaf3
36 sg:journal.1034001
37 schema:keywords BackgroundAge
38 ConclusionsOur study
39 IL-1β
40 IL-1β induces
41 IL1
42 Müller cells
43 ResultsWe
44 TUNEL labeling
45 ability
46 accumulation
47 action
48 antagonist
49 apoptosis
50 cell death
51 cell fraction
52 cell survival
53 cells
54 comprehensive mechanism
55 concentration
56 cone
57 conversion
58 culture
59 death
60 degeneration
61 degeneration of cones
62 deregulation
63 disruption
64 effect
65 explants
66 extracellular glutamate concentration
67 fraction
68 genes
69 glutamate
70 glutamate concentration
71 glutamate homeostasis
72 glutamate receptor antagonists
73 homeostasis
74 homeostasis of glutamate
75 human monocytes
76 importance
77 importance of inflammation
78 indirect effects
79 induces
80 inflammation
81 inhibition
82 isolated photoreceptors
83 labeling
84 levels
85 macrophages
86 macular degeneration
87 mechanism
88 model
89 monocytes
90 non-NMDA receptors
91 photoreceptor cell death
92 photoreceptor cell survival
93 photoreceptors
94 presence
95 presence of IL1
96 receptor antagonist
97 receptors
98 release
99 retina
100 retinal explants
101 reuptake
102 rod apoptosis
103 rod degeneration
104 rod photoreceptor cell death
105 rods
106 study
107 subretinal inflammation
108 subretinal macrophages
109 survival
110 transcription levels
111 vivo
112 schema:name IL-1β induces rod degeneration through the disruption of retinal glutamate homeostasis
113 schema:pagination 1
114 schema:productId N6a6cca214b0d4b9781d93f4d0b90fe90
115 N70423fd71e524a868497ead4ce4b1058
116 Nffac5e57bcd44837bf6169b10de1fe9e
117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1123814773
118 https://doi.org/10.1186/s12974-019-1655-5
119 schema:sdDatePublished 2022-05-10T10:26
120 schema:sdLicense https://scigraph.springernature.com/explorer/license/
121 schema:sdPublisher N7b812c3d9ce140ceb07e508e93e4931c
122 schema:url https://doi.org/10.1186/s12974-019-1655-5
123 sgo:license sg:explorer/license/
124 sgo:sdDataset articles
125 rdf:type schema:ScholarlyArticle
126 N013b7a750ecf4fa1a3cabdc80f428d98 rdf:first sg:person.01356263054.39
127 rdf:rest Na324d60e809e4ea4af675c8deabb9b3b
128 N0334971b29454a68b869a2c542a1c49e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Mice, Transgenic
130 rdf:type schema:DefinedTerm
131 N0f1c1436857e4e90b63647674ca43c39 schema:volumeNumber 17
132 rdf:type schema:PublicationVolume
133 N119ffa94d7614eb2a68e196a2dfe5e74 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Animals
135 rdf:type schema:DefinedTerm
136 N14756f2ae2d9476da4b563e573500aef rdf:first sg:person.0713714734.30
137 rdf:rest N013b7a750ecf4fa1a3cabdc80f428d98
138 N20de38b0aa2a418cba65a6299f07c5ca rdf:first sg:person.014440532634.39
139 rdf:rest N29bde74d79dd45ea8044e2dc6bb20d0b
140 N29bde74d79dd45ea8044e2dc6bb20d0b rdf:first sg:person.0610762232.25
141 rdf:rest Nc9bcbbf1845a482081cd7942a75f91c1
142 N3c7dc3296acc47bd87bbf4c75a46a15c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Humans
144 rdf:type schema:DefinedTerm
145 N4e87c4c6202646f98cb8816e6b443486 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Glutamic Acid
147 rdf:type schema:DefinedTerm
148 N516e2b493cb647caa11af833656997ae rdf:first sg:person.01155733220.75
149 rdf:rest N20de38b0aa2a418cba65a6299f07c5ca
150 N57a5d75e54084eee923ab8bbcf1d86d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Monocytes
152 rdf:type schema:DefinedTerm
153 N65d482a3c67448b18b05b6e0dbefbe5f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Retinal Rod Photoreceptor Cells
155 rdf:type schema:DefinedTerm
156 N6a6cca214b0d4b9781d93f4d0b90fe90 schema:name doi
157 schema:value 10.1186/s12974-019-1655-5
158 rdf:type schema:PropertyValue
159 N6dd15b104a3b499fa46e834e2d4c20e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Interleukin-1beta
161 rdf:type schema:DefinedTerm
162 N6eb9fa217c7c407185e644fabe11e6a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Mice, Inbred C57BL
164 rdf:type schema:DefinedTerm
165 N70423fd71e524a868497ead4ce4b1058 schema:name dimensions_id
166 schema:value pub.1123814773
167 rdf:type schema:PropertyValue
168 N72957a10c57b4cd1a1b5aaa50121baaa rdf:first sg:person.01271165146.17
169 rdf:rest N14756f2ae2d9476da4b563e573500aef
170 N7b812c3d9ce140ceb07e508e93e4931c schema:name Springer Nature - SN SciGraph project
171 rdf:type schema:Organization
172 N8f5c098afd4443d9a307071720cc1bc5 rdf:first sg:person.0721065165.28
173 rdf:rest Nd6192f98077d4d1991dcedd75c012567
174 N9066d2e932ca4b87895a6d1ec0beaaf3 schema:issueNumber 1
175 rdf:type schema:PublicationIssue
176 N91549b66fb724f43aa724c9aeaed8bf4 rdf:first sg:person.01104041722.66
177 rdf:rest Nea6e1e49e420476d9fd0bd2297ab112d
178 N9de1c1be0b664e5ba44cf0184577d9e6 rdf:first sg:person.0627750275.79
179 rdf:rest Nf871db90e78c441c82c3274a29bc1d1f
180 Na324d60e809e4ea4af675c8deabb9b3b rdf:first sg:person.0736717332.12
181 rdf:rest rdf:nil
182 Nb4795f45512345139b60da59265e33f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Retinal Degeneration
184 rdf:type schema:DefinedTerm
185 Nb9e0c904df3644bfa2f1cc8a3864cc36 rdf:first sg:person.01257030015.38
186 rdf:rest Nceaf748e88bc4ed2acfb5cab667cfe85
187 Nc9bcbbf1845a482081cd7942a75f91c1 rdf:first sg:person.010106703125.51
188 rdf:rest Nf63edce61f50410b82a3061a5bb27d2c
189 Nca0cabd9ef4c4ea29e24f1131d39c3cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Male
191 rdf:type schema:DefinedTerm
192 Nceaf748e88bc4ed2acfb5cab667cfe85 rdf:first sg:person.014461431473.45
193 rdf:rest N516e2b493cb647caa11af833656997ae
194 Nd37e24b44c2f40f09b9dd6f02a6fdaf8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Homeostasis
196 rdf:type schema:DefinedTerm
197 Nd6192f98077d4d1991dcedd75c012567 rdf:first sg:person.0642273724.04
198 rdf:rest N91549b66fb724f43aa724c9aeaed8bf4
199 Nea55760752574cb6a879ce359702988e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Coculture Techniques
201 rdf:type schema:DefinedTerm
202 Nea6e1e49e420476d9fd0bd2297ab112d rdf:first sg:person.01171304143.81
203 rdf:rest N72957a10c57b4cd1a1b5aaa50121baaa
204 Neb2e0654cabc47269d3ec8d5deb541a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name Mice
206 rdf:type schema:DefinedTerm
207 Nf63edce61f50410b82a3061a5bb27d2c rdf:first sg:person.01035612533.42
208 rdf:rest N9de1c1be0b664e5ba44cf0184577d9e6
209 Nf871db90e78c441c82c3274a29bc1d1f rdf:first sg:person.012577724707.05
210 rdf:rest N8f5c098afd4443d9a307071720cc1bc5
211 Nffac5e57bcd44837bf6169b10de1fe9e schema:name pubmed_id
212 schema:value 31900165
213 rdf:type schema:PropertyValue
214 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
215 schema:name Medical and Health Sciences
216 rdf:type schema:DefinedTerm
217 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
218 schema:name Clinical Sciences
219 rdf:type schema:DefinedTerm
220 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
221 schema:name Immunology
222 rdf:type schema:DefinedTerm
223 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
224 schema:name Neurosciences
225 rdf:type schema:DefinedTerm
226 sg:journal.1034001 schema:issn 1742-2094
227 schema:name Journal of Neuroinflammation
228 schema:publisher Springer Nature
229 rdf:type schema:Periodical
230 sg:person.010106703125.51 schema:affiliation grid-institutes:None
231 schema:familyName Beguier
232 schema:givenName Fanny
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010106703125.51
234 rdf:type schema:Person
235 sg:person.01035612533.42 schema:affiliation grid-institutes:None
236 schema:familyName Siqueiros
237 schema:givenName Lourdes
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035612533.42
239 rdf:type schema:Person
240 sg:person.01104041722.66 schema:affiliation grid-institutes:grid.21925.3d
241 schema:familyName Sahel
242 schema:givenName José-Alain
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104041722.66
244 rdf:type schema:Person
245 sg:person.01155733220.75 schema:affiliation grid-institutes:grid.411296.9
246 schema:familyName Couturier
247 schema:givenName Aude
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155733220.75
249 rdf:type schema:Person
250 sg:person.01171304143.81 schema:affiliation grid-institutes:None
251 schema:familyName Rendon
252 schema:givenName Alvaro
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171304143.81
254 rdf:type schema:Person
255 sg:person.01257030015.38 schema:affiliation grid-institutes:None
256 schema:familyName Charles-Messance
257 schema:givenName Hugo
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257030015.38
259 rdf:type schema:Person
260 sg:person.012577724707.05 schema:affiliation grid-institutes:None
261 schema:familyName Barmo
262 schema:givenName Nour
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012577724707.05
264 rdf:type schema:Person
265 sg:person.01271165146.17 schema:affiliation grid-institutes:grid.5252.0
266 schema:familyName Grosche
267 schema:givenName Antje
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271165146.17
269 rdf:type schema:Person
270 sg:person.01356263054.39 schema:affiliation grid-institutes:None
271 schema:familyName Sennlaub
272 schema:givenName Florian
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356263054.39
274 rdf:type schema:Person
275 sg:person.014440532634.39 schema:affiliation grid-institutes:None
276 schema:familyName Vignaud
277 schema:givenName Lucile
278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014440532634.39
279 rdf:type schema:Person
280 sg:person.014461431473.45 schema:affiliation grid-institutes:None
281 schema:familyName Blot
282 schema:givenName Guillaume
283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014461431473.45
284 rdf:type schema:Person
285 sg:person.0610762232.25 schema:affiliation grid-institutes:grid.411296.9
286 schema:familyName Touhami
287 schema:givenName Sara
288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610762232.25
289 rdf:type schema:Person
290 sg:person.0627750275.79 schema:affiliation grid-institutes:None
291 schema:familyName Forster
292 schema:givenName Valérie
293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627750275.79
294 rdf:type schema:Person
295 sg:person.0642273724.04 schema:affiliation grid-institutes:None
296 schema:familyName Picaud
297 schema:givenName Serge
298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642273724.04
299 rdf:type schema:Person
300 sg:person.0713714734.30 schema:affiliation grid-institutes:grid.411296.9
301 schema:familyName Tadayoni
302 schema:givenName Ramin
303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713714734.30
304 rdf:type schema:Person
305 sg:person.0721065165.28 schema:affiliation grid-institutes:None
306 schema:familyName Augustin
307 schema:givenName Sébastien
308 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721065165.28
309 rdf:type schema:Person
310 sg:person.0736717332.12 schema:affiliation grid-institutes:None
311 schema:familyName Guillonneau
312 schema:givenName Xavier
313 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736717332.12
314 rdf:type schema:Person
315 sg:pub.10.1007/s00417-013-2516-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1024569840
316 https://doi.org/10.1007/s00417-013-2516-z
317 rdf:type schema:CreativeWork
318 sg:pub.10.1007/s12031-015-0505-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038210833
319 https://doi.org/10.1007/s12031-015-0505-x
320 rdf:type schema:CreativeWork
321 sg:pub.10.1038/eye.1988.106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028401543
322 https://doi.org/10.1038/eye.1988.106
323 rdf:type schema:CreativeWork
324 sg:pub.10.1038/nn.2234 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039125224
325 https://doi.org/10.1038/nn.2234
326 rdf:type schema:CreativeWork
327 sg:pub.10.1038/nri3087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048092830
328 https://doi.org/10.1038/nri3087
329 rdf:type schema:CreativeWork
330 sg:pub.10.1186/1742-2094-5-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046097877
331 https://doi.org/10.1186/1742-2094-5-7
332 rdf:type schema:CreativeWork
333 sg:pub.10.1186/1742-2094-5-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019648721
334 https://doi.org/10.1186/1742-2094-5-8
335 rdf:type schema:CreativeWork
336 sg:pub.10.1186/1742-2094-9-221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046575601
337 https://doi.org/10.1186/1742-2094-9-221
338 rdf:type schema:CreativeWork
339 sg:pub.10.1186/1750-1326-7-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047446231
340 https://doi.org/10.1186/1750-1326-7-7
341 rdf:type schema:CreativeWork
342 grid-institutes:None schema:alternateName Sorbonne Université, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France
343 schema:name Sorbonne Université, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France
344 rdf:type schema:Organization
345 grid-institutes:grid.21925.3d schema:alternateName Department of Ophthalmology, The University of Pittsburgh School of Medicine, 15213, Pittsburgh, PA, USA
346 schema:name CHNO des Quinze-Vingts, DHU Sight Restore, INSERM-DGOS CIC 1423, 28 rue de Charenton, F-75012, Paris, France
347 Department of Ophthalmology, The University of Pittsburgh School of Medicine, 15213, Pittsburgh, PA, USA
348 Sorbonne Université, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France
349 rdf:type schema:Organization
350 grid-institutes:grid.411296.9 schema:alternateName Department of Ophthalmology, Hôpital Lariboisière, Paris, France
351 schema:name Department of Ophthalmology, Hôpital Lariboisière, Paris, France
352 Sorbonne Université, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, F-75012, Paris, France
353 rdf:type schema:Organization
354 grid-institutes:grid.5252.0 schema:alternateName Department of Physiological Genomics, Ludwig-Maximilians-Universität München, Grosshaderner Str. 9, D-82152, Planegg-Martinsried, Germany
355 schema:name Department of Physiological Genomics, Ludwig-Maximilians-Universität München, Grosshaderner Str. 9, D-82152, Planegg-Martinsried, Germany
356 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...