Activation of retinoid X receptor by bexarotene attenuates neuroinflammation via PPARγ/SIRT6/FoxO3a pathway after subarachnoid hemorrhage in rats View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Yuchun Zuo, Lei Huang, Budbazar Enkhjargal, Weilin Xu, Ocak Umut, Zachary D. Travis, Guangyu Zhang, Jiping Tang, Fei Liu, John H. Zhang

ABSTRACT

BACKGROUND: Subarachnoid hemorrhage (SAH) is a life-threatening subtype of stroke with high mortality and disabilities. Retinoid X receptor (RXR) has been shown to be neuroprotective against ischemia/reperfusion injury. This study aimed to investigate the effects of the selective RXR agonist bexarotene on neuroinflammation in a rat model of SAH. METHODS: Two hundred male Sprague-Dawley rats were used. The endovascular perforation induced SAH. Bexarotene was administered intraperitoneally at 1 h after SAH induction. To investigate the underlying mechanism, the selective RXR antagonist UVI3003 and RXR siRNA or SIRT6 inhibitor OSS128167 was administered via intracerebroventricular 1 h before SAH induction. Post-SAH assessments including SAH grade, neurological score, brain water content, Western blot, and immunofluorescence were performed. RESULTS: The endogenous RXR and sirtuin 6 (SIRT6) protein levels were increased after SAH. Bexarotene treatment significantly reduced brain edema and improved the short-/long-term neurological deficit after SAH. Mechanistically, bexarotene increased the levels of PPARγ and SIRT6; decreased the expression of phosphorylated FoxO3a (p-FoxO3a), IL-6, IL-1β, and TNF-a; and inhibited the microglia activation and neutrophils infiltration at 24 h after SAH. Either UVI3003, OSS128167, or RXR siRNA abolished the neuroprotective effects of bexarotene and its regulation on protein levels of PPARγ/SIRT6/p-FoxO3a after SAH. CONCLUSIONS: The activation of RXR by bexarotene attenuated neuroinflammation and improved neurological deficits after SAH. The anti-neuroinflammatory effect was at least partially through regulating PPARγ/SIRT6/FoxO3a pathway. Bexarotene may be a promising therapeutic strategy in the management of SAH patients. More... »

PAGES

47

References to SciGraph publications

  • 2002-11. Retinoid signalling in the development of the central nervous system in NATURE REVIEWS NEUROSCIENCE
  • 2012-01. Activin induces cortical interneuron identity and differentiation in embryonic stem cell-derived telencephalic neural precursors in NATURE COMMUNICATIONS
  • 2016-01. Relaunching an old drug: the potential role of bexarotene in neurodegenerative diseases in JOURNAL OF NEUROLOGY
  • 2007-10. RAR and RXR modulation in cancer and metabolic disease in NATURE REVIEWS DRUG DISCOVERY
  • 2017-12. 9-cis retinoic acid induces neurorepair in stroke brain in SCIENTIFIC REPORTS
  • 2016-03. SIRT6 protects cardiomyocytes against ischemia/reperfusion injury by augmenting FoxO3α-dependent antioxidant defense mechanisms in BASIC RESEARCH IN CARDIOLOGY
  • 2014-04. Intracisternal Administration of Tissue Plasminogen Activator Improves Cerebrospinal Fluid Flow and Cortical Perfusion After Subarachnoid Hemorrhage in Mice in TRANSLATIONAL STROKE RESEARCH
  • 2015-02. What is Early Brain Injury? in TRANSLATIONAL STROKE RESEARCH
  • 2018-12. Aggf1 attenuates neuroinflammation and BBB disruption via PI3K/Akt/NF-κB pathway after subarachnoid hemorrhage in rats in JOURNAL OF NEUROINFLAMMATION
  • 2018-12. Activation of melanocortin receptor 4 with RO27-3225 attenuates neuroinflammation through AMPK/JNK/p38 MAPK pathway after intracerebral hemorrhage in mice in JOURNAL OF NEUROINFLAMMATION
  • 2016-12. Bexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathy in SCIENTIFIC REPORTS
  • 2018-12. Bexarotene Modulates Retinoid-X-Receptor Expression and Is Protective Against Neurotoxic Endoplasmic Reticulum Stress Response and Apoptotic Pathway Activation in MOLECULAR NEUROBIOLOGY
  • 2018-11. Deficiency of Tenascin-C Alleviates Neuronal Apoptosis and Neuroinflammation After Experimental Subarachnoid Hemorrhage in Mice in MOLECULAR NEUROBIOLOGY
  • 2018-12. Nuclear receptor agonist-driven modification of inflammation and amyloid pathology enhances and sustains cognitive improvements in a mouse model of Alzheimer’s disease in JOURNAL OF NEUROINFLAMMATION
  • 2017-08. The High Cost of Stroke and Stroke Cytoprotection Research in TRANSLATIONAL STROKE RESEARCH
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12974-019-1432-5

    DOI

    http://dx.doi.org/10.1186/s12974-019-1432-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112292036

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30791908


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Neurosciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Loma Linda University", 
              "id": "https://www.grid.ac/institutes/grid.43582.38", 
              "name": [
                "Department of Neurosurgery, Third XiangYa Hospital, Central South University, No.138 Tongzipo Road, 410013, Changsha, China", 
                "Department of Physiology and Pharmacology, Loma Linda University, 11041 Campus St. Risley Hall, 92354, Loma Linda, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zuo", 
            "givenName": "Yuchun", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Loma Linda University", 
              "id": "https://www.grid.ac/institutes/grid.43582.38", 
              "name": [
                "Department of Physiology and Pharmacology, Loma Linda University, 11041 Campus St. Risley Hall, 92354, Loma Linda, CA, USA", 
                "Department of Neurosurgery, School of Medicine, Loma Linda University, 92354, Loma Linda, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Huang", 
            "givenName": "Lei", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Loma Linda University", 
              "id": "https://www.grid.ac/institutes/grid.43582.38", 
              "name": [
                "Department of Physiology and Pharmacology, Loma Linda University, 11041 Campus St. Risley Hall, 92354, Loma Linda, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Enkhjargal", 
            "givenName": "Budbazar", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Loma Linda University", 
              "id": "https://www.grid.ac/institutes/grid.43582.38", 
              "name": [
                "Department of Physiology and Pharmacology, Loma Linda University, 11041 Campus St. Risley Hall, 92354, Loma Linda, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Xu", 
            "givenName": "Weilin", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Loma Linda University", 
              "id": "https://www.grid.ac/institutes/grid.43582.38", 
              "name": [
                "Department of Physiology and Pharmacology, Loma Linda University, 11041 Campus St. Risley Hall, 92354, Loma Linda, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Umut", 
            "givenName": "Ocak", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Loma Linda University", 
              "id": "https://www.grid.ac/institutes/grid.43582.38", 
              "name": [
                "Department of Earth and Biological Sciences, School of Medicine, Loma Linda University, 92354, Loma Linda, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Travis", 
            "givenName": "Zachary D.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Loma Linda University", 
              "id": "https://www.grid.ac/institutes/grid.43582.38", 
              "name": [
                "Mass Spectrometry Core Facility, Loma Linda University, 92354, Loma Linda, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhang", 
            "givenName": "Guangyu", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Loma Linda University", 
              "id": "https://www.grid.ac/institutes/grid.43582.38", 
              "name": [
                "Department of Physiology and Pharmacology, Loma Linda University, 11041 Campus St. Risley Hall, 92354, Loma Linda, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tang", 
            "givenName": "Jiping", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Central South University", 
              "id": "https://www.grid.ac/institutes/grid.216417.7", 
              "name": [
                "Department of Neurosurgery, Third XiangYa Hospital, Central South University, No.138 Tongzipo Road, 410013, Changsha, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Liu", 
            "givenName": "Fei", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Loma Linda University", 
              "id": "https://www.grid.ac/institutes/grid.43582.38", 
              "name": [
                "Department of Physiology and Pharmacology, Loma Linda University, 11041 Campus St. Risley Hall, 92354, Loma Linda, CA, USA", 
                "Department of Neurosurgery, School of Medicine, Loma Linda University, 92354, Loma Linda, CA, USA", 
                "Department of Anesthesiology, School of Medicine, Loma Linda University, 92354, Loma Linda, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhang", 
            "givenName": "John H.", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s00415-015-8004-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000387919", 
              "https://doi.org/10.1007/s00415-015-8004-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/biof.117", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000431492"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/biof.117", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000431492"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.brainres.2015.07.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003093900"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuroscience.2016.05.033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005265166"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.nbd.2013.09.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005698172"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jnr.21865", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006686884"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/acer.12639", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008475273"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12975-016-0518-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009649816", 
              "https://doi.org/10.1007/s12975-016-0518-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12975-016-0518-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009649816", 
              "https://doi.org/10.1007/s12975-016-0518-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12975-016-0518-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009649816", 
              "https://doi.org/10.1007/s12975-016-0518-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.nbd.2015.07.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011643921"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.phrs.2015.10.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013511119"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd2397", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018115916", 
              "https://doi.org/10.1038/nrd2397"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fj.11-192914", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018935348"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jpba.2013.08.036", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019228081"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms1817", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031328895", 
              "https://doi.org/10.1038/ncomms1817"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.coph.2015.11.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031566674"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep33176", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032069169", 
              "https://doi.org/10.1038/srep33176"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jneumeth.2007.08.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032535739"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/jth.12511", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033325899"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1217697", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034801440"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00395-016-0531-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035073495", 
              "https://doi.org/10.1007/s00395-016-0531-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/atvbaha.109.191189", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036662220"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/atvbaha.109.191189", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036662220"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3233/jad-151020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038362309"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.expneurol.2015.04.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038681877"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0017057", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041309920"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awv289", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042691210"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tem.2013.04.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044126132"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaad.2013.08.033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044342265"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.1001-15.2015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045239513"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jstrokecerebrovasdis.2014.10.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046419912"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn963", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047554287", 
              "https://doi.org/10.1038/nrn963"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn963", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047554287", 
              "https://doi.org/10.1038/nrn963"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(07)60153-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047914996"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12975-014-0329-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047952706", 
              "https://doi.org/10.1007/s12975-014-0329-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/jnc.12190", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050068800"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/cns.12350", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052122030"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/strokeaha.115.009216", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052265078"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/strokeaha.115.009216", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052265078"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12975-014-0380-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053157263", 
              "https://doi.org/10.1007/s12975-014-0380-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12975-014-0380-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053157263", 
              "https://doi.org/10.1007/s12975-014-0380-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1753944708090924", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064075805"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1753944708090924", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064075805"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1616070114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083854655"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-017-04048-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090327571", 
              "https://doi.org/10.1038/s41598-017-04048-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuroscience.2017.09.035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091903425"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fneur.2017.00511", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091922279"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuropharm.2017.09.040", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092055775"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.yexcr.2017.10.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092179472"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.yexcr.2017.10.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092179472"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbi.2017.11.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092866636"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbi.2017.11.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092866636"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12974-018-1091-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101066818", 
              "https://doi.org/10.1186/s12974-018-1091-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fneur.2018.00096", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101221257"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.biotechadv.2018.03.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101522870"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12035-018-1006-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101553050", 
              "https://doi.org/10.1007/s12035-018-1006-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12035-018-1006-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101553050", 
              "https://doi.org/10.1007/s12035-018-1006-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12035-018-1006-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101553050", 
              "https://doi.org/10.1007/s12035-018-1006-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12035-018-1041-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103209589", 
              "https://doi.org/10.1007/s12035-018-1041-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12974-018-1140-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103210953", 
              "https://doi.org/10.1186/s12974-018-1140-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12974-018-1140-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103210953", 
              "https://doi.org/10.1186/s12974-018-1140-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/01616412.2018.1463900", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103612041"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12974-018-1211-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104496883", 
              "https://doi.org/10.1186/s12974-018-1211-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.redox.2018.09.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107274898"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.redox.2018.09.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107274898"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.redox.2018.09.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107274898"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-12", 
        "datePublishedReg": "2019-12-01", 
        "description": "BACKGROUND: Subarachnoid hemorrhage (SAH) is a life-threatening subtype of stroke with high mortality and disabilities. Retinoid X receptor (RXR) has been shown to be neuroprotective against ischemia/reperfusion injury. This study aimed to investigate the effects of the selective RXR agonist bexarotene on neuroinflammation in a rat model of SAH.\nMETHODS: Two hundred male Sprague-Dawley rats were used. The endovascular perforation induced SAH. Bexarotene was administered intraperitoneally at 1\u00a0h after SAH induction. To investigate the underlying mechanism, the selective RXR antagonist UVI3003 and RXR siRNA or SIRT6 inhibitor OSS128167 was administered via intracerebroventricular 1\u00a0h before SAH induction. Post-SAH assessments including SAH grade, neurological score, brain water content, Western blot, and immunofluorescence were performed.\nRESULTS: The endogenous RXR and sirtuin 6 (SIRT6) protein levels were increased after SAH. Bexarotene treatment significantly reduced brain edema and improved the short-/long-term neurological deficit after SAH. Mechanistically, bexarotene increased the levels of PPAR\u03b3 and SIRT6; decreased the expression of phosphorylated FoxO3a (p-FoxO3a), IL-6, IL-1\u03b2, and TNF-a; and inhibited the microglia activation and neutrophils infiltration at 24\u00a0h after SAH. Either UVI3003, OSS128167, or RXR siRNA abolished the neuroprotective effects of bexarotene and its regulation on protein levels of PPAR\u03b3/SIRT6/p-FoxO3a after SAH.\nCONCLUSIONS: The activation of RXR by bexarotene attenuated neuroinflammation and improved neurological deficits after SAH. The anti-neuroinflammatory effect was at least partially through regulating PPAR\u03b3/SIRT6/FoxO3a pathway. Bexarotene may be a promising therapeutic strategy in the management of SAH patients.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1186/s12974-019-1432-5", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1034001", 
            "issn": [
              "1742-2094"
            ], 
            "name": "Journal of Neuroinflammation", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "16"
          }
        ], 
        "name": "Activation of retinoid X receptor by bexarotene attenuates neuroinflammation via PPAR\u03b3/SIRT6/FoxO3a pathway after subarachnoid hemorrhage in rats", 
        "pagination": "47", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "f9a68bc8040b9f803ac53769fd58ff5a08cbe403af8f1d4eb4311508d33d34f4"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30791908"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101222974"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s12974-019-1432-5"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1112292036"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s12974-019-1432-5", 
          "https://app.dimensions.ai/details/publication/pub.1112292036"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T10:49", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000350_0000000350/records_77567_00000001.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1186%2Fs12974-019-1432-5"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12974-019-1432-5'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12974-019-1432-5'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12974-019-1432-5'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12974-019-1432-5'


     

    This table displays all metadata directly associated to this object as RDF triples.

    303 TRIPLES      21 PREDICATES      82 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s12974-019-1432-5 schema:about anzsrc-for:11
    2 anzsrc-for:1109
    3 schema:author N8d246fd8c6b649dc933ebda9e61923c9
    4 schema:citation sg:pub.10.1007/s00395-016-0531-z
    5 sg:pub.10.1007/s00415-015-8004-0
    6 sg:pub.10.1007/s12035-018-1006-z
    7 sg:pub.10.1007/s12035-018-1041-9
    8 sg:pub.10.1007/s12975-014-0329-y
    9 sg:pub.10.1007/s12975-014-0380-8
    10 sg:pub.10.1007/s12975-016-0518-y
    11 sg:pub.10.1038/ncomms1817
    12 sg:pub.10.1038/nrd2397
    13 sg:pub.10.1038/nrn963
    14 sg:pub.10.1038/s41598-017-04048-2
    15 sg:pub.10.1038/srep33176
    16 sg:pub.10.1186/s12974-018-1091-y
    17 sg:pub.10.1186/s12974-018-1140-6
    18 sg:pub.10.1186/s12974-018-1211-8
    19 https://doi.org/10.1002/biof.117
    20 https://doi.org/10.1002/jnr.21865
    21 https://doi.org/10.1016/j.bbi.2017.11.012
    22 https://doi.org/10.1016/j.biotechadv.2018.03.003
    23 https://doi.org/10.1016/j.brainres.2015.07.025
    24 https://doi.org/10.1016/j.coph.2015.11.006
    25 https://doi.org/10.1016/j.expneurol.2015.04.016
    26 https://doi.org/10.1016/j.jaad.2013.08.033
    27 https://doi.org/10.1016/j.jneumeth.2007.08.004
    28 https://doi.org/10.1016/j.jpba.2013.08.036
    29 https://doi.org/10.1016/j.jstrokecerebrovasdis.2014.10.006
    30 https://doi.org/10.1016/j.nbd.2013.09.016
    31 https://doi.org/10.1016/j.nbd.2015.07.001
    32 https://doi.org/10.1016/j.neuropharm.2017.09.040
    33 https://doi.org/10.1016/j.neuroscience.2016.05.033
    34 https://doi.org/10.1016/j.neuroscience.2017.09.035
    35 https://doi.org/10.1016/j.phrs.2015.10.009
    36 https://doi.org/10.1016/j.redox.2018.09.022
    37 https://doi.org/10.1016/j.tem.2013.04.004
    38 https://doi.org/10.1016/j.yexcr.2017.10.007
    39 https://doi.org/10.1016/s0140-6736(07)60153-6
    40 https://doi.org/10.1073/pnas.1616070114
    41 https://doi.org/10.1080/01616412.2018.1463900
    42 https://doi.org/10.1093/brain/awv289
    43 https://doi.org/10.1096/fj.11-192914
    44 https://doi.org/10.1111/acer.12639
    45 https://doi.org/10.1111/cns.12350
    46 https://doi.org/10.1111/jnc.12190
    47 https://doi.org/10.1111/jth.12511
    48 https://doi.org/10.1126/science.1217697
    49 https://doi.org/10.1161/atvbaha.109.191189
    50 https://doi.org/10.1161/strokeaha.115.009216
    51 https://doi.org/10.1177/1753944708090924
    52 https://doi.org/10.1371/journal.pone.0017057
    53 https://doi.org/10.1523/jneurosci.1001-15.2015
    54 https://doi.org/10.3233/jad-151020
    55 https://doi.org/10.3389/fneur.2017.00511
    56 https://doi.org/10.3389/fneur.2018.00096
    57 schema:datePublished 2019-12
    58 schema:datePublishedReg 2019-12-01
    59 schema:description BACKGROUND: Subarachnoid hemorrhage (SAH) is a life-threatening subtype of stroke with high mortality and disabilities. Retinoid X receptor (RXR) has been shown to be neuroprotective against ischemia/reperfusion injury. This study aimed to investigate the effects of the selective RXR agonist bexarotene on neuroinflammation in a rat model of SAH. METHODS: Two hundred male Sprague-Dawley rats were used. The endovascular perforation induced SAH. Bexarotene was administered intraperitoneally at 1 h after SAH induction. To investigate the underlying mechanism, the selective RXR antagonist UVI3003 and RXR siRNA or SIRT6 inhibitor OSS128167 was administered via intracerebroventricular 1 h before SAH induction. Post-SAH assessments including SAH grade, neurological score, brain water content, Western blot, and immunofluorescence were performed. RESULTS: The endogenous RXR and sirtuin 6 (SIRT6) protein levels were increased after SAH. Bexarotene treatment significantly reduced brain edema and improved the short-/long-term neurological deficit after SAH. Mechanistically, bexarotene increased the levels of PPARγ and SIRT6; decreased the expression of phosphorylated FoxO3a (p-FoxO3a), IL-6, IL-1β, and TNF-a; and inhibited the microglia activation and neutrophils infiltration at 24 h after SAH. Either UVI3003, OSS128167, or RXR siRNA abolished the neuroprotective effects of bexarotene and its regulation on protein levels of PPARγ/SIRT6/p-FoxO3a after SAH. CONCLUSIONS: The activation of RXR by bexarotene attenuated neuroinflammation and improved neurological deficits after SAH. The anti-neuroinflammatory effect was at least partially through regulating PPARγ/SIRT6/FoxO3a pathway. Bexarotene may be a promising therapeutic strategy in the management of SAH patients.
    60 schema:genre research_article
    61 schema:inLanguage en
    62 schema:isAccessibleForFree true
    63 schema:isPartOf N81c00fd16a214f699668a2ba0b809e45
    64 Nf3b5bae145d04bfdbbdacc348a4cbd74
    65 sg:journal.1034001
    66 schema:name Activation of retinoid X receptor by bexarotene attenuates neuroinflammation via PPARγ/SIRT6/FoxO3a pathway after subarachnoid hemorrhage in rats
    67 schema:pagination 47
    68 schema:productId N1a8dfdebf24c4ca0b5a58ecb413ff3be
    69 N61aafde84e3442ba8b51485c57747fef
    70 Na0c57a3ce12245d9bc5641fe11451702
    71 Nbac08e4a473d46a6b06a357cbab8e7ab
    72 Ncd6a0dd166e24f529fdbb8fe1cf3a7d7
    73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112292036
    74 https://doi.org/10.1186/s12974-019-1432-5
    75 schema:sdDatePublished 2019-04-11T10:49
    76 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    77 schema:sdPublisher N1487dbc5d9cf452cb46daafeeb713977
    78 schema:url https://link.springer.com/10.1186%2Fs12974-019-1432-5
    79 sgo:license sg:explorer/license/
    80 sgo:sdDataset articles
    81 rdf:type schema:ScholarlyArticle
    82 N1487dbc5d9cf452cb46daafeeb713977 schema:name Springer Nature - SN SciGraph project
    83 rdf:type schema:Organization
    84 N19fa25616adf4f64a9c9859ced55ceda rdf:first Nd280db24a01b4769a67d7bf0341b939f
    85 rdf:rest Nac91fa174a2c4849a42db63a8bcafb50
    86 N1a8dfdebf24c4ca0b5a58ecb413ff3be schema:name dimensions_id
    87 schema:value pub.1112292036
    88 rdf:type schema:PropertyValue
    89 N2028f81865394e4b9a9529d94b479369 rdf:first N2b47e5cfdaa740b5a7a079a94ce06223
    90 rdf:rest N5c701603cb974de696e9ba76f6467d4f
    91 N252946c895de4010b994360335b88665 rdf:first N69cbbd3524e04ff988300e040d190862
    92 rdf:rest N19fa25616adf4f64a9c9859ced55ceda
    93 N2b47e5cfdaa740b5a7a079a94ce06223 schema:affiliation https://www.grid.ac/institutes/grid.43582.38
    94 schema:familyName Enkhjargal
    95 schema:givenName Budbazar
    96 rdf:type schema:Person
    97 N3f03b60a176941d6bdd0f1622c1cd400 rdf:first N8b66da3da1174d558a808550d2c81867
    98 rdf:rest N2028f81865394e4b9a9529d94b479369
    99 N4985c37624234647b9c128d3d0db08d0 schema:affiliation https://www.grid.ac/institutes/grid.43582.38
    100 schema:familyName Zhang
    101 schema:givenName Guangyu
    102 rdf:type schema:Person
    103 N5066abe1bfaf41dba7bc6a9c9a8ad0c4 schema:affiliation https://www.grid.ac/institutes/grid.43582.38
    104 schema:familyName Umut
    105 schema:givenName Ocak
    106 rdf:type schema:Person
    107 N53c41041dc8f41e88faae64e357c50a9 schema:affiliation https://www.grid.ac/institutes/grid.43582.38
    108 schema:familyName Travis
    109 schema:givenName Zachary D.
    110 rdf:type schema:Person
    111 N5c701603cb974de696e9ba76f6467d4f rdf:first Ne73bb027096a4ebcb8f9afc34d90e0a3
    112 rdf:rest Nc9c0858a6a9c4a29af95f7f52f9739bc
    113 N61aafde84e3442ba8b51485c57747fef schema:name pubmed_id
    114 schema:value 30791908
    115 rdf:type schema:PropertyValue
    116 N69cbbd3524e04ff988300e040d190862 schema:affiliation https://www.grid.ac/institutes/grid.43582.38
    117 schema:familyName Tang
    118 schema:givenName Jiping
    119 rdf:type schema:Person
    120 N81c00fd16a214f699668a2ba0b809e45 schema:volumeNumber 16
    121 rdf:type schema:PublicationVolume
    122 N8a9d197f48d34bc4a6b1a5c3359cfe81 schema:affiliation https://www.grid.ac/institutes/grid.43582.38
    123 schema:familyName Zuo
    124 schema:givenName Yuchun
    125 rdf:type schema:Person
    126 N8b66da3da1174d558a808550d2c81867 schema:affiliation https://www.grid.ac/institutes/grid.43582.38
    127 schema:familyName Huang
    128 schema:givenName Lei
    129 rdf:type schema:Person
    130 N8d246fd8c6b649dc933ebda9e61923c9 rdf:first N8a9d197f48d34bc4a6b1a5c3359cfe81
    131 rdf:rest N3f03b60a176941d6bdd0f1622c1cd400
    132 Na0c57a3ce12245d9bc5641fe11451702 schema:name doi
    133 schema:value 10.1186/s12974-019-1432-5
    134 rdf:type schema:PropertyValue
    135 Nac91fa174a2c4849a42db63a8bcafb50 rdf:first Nfe6e6bd5557c4779afc4253f002e9158
    136 rdf:rest rdf:nil
    137 Nacffd6a9c8da450aabf35b3670cbacdf rdf:first N53c41041dc8f41e88faae64e357c50a9
    138 rdf:rest Nbdc2a589ee0d440dbb6ec6217f939ee7
    139 Nbac08e4a473d46a6b06a357cbab8e7ab schema:name nlm_unique_id
    140 schema:value 101222974
    141 rdf:type schema:PropertyValue
    142 Nbdc2a589ee0d440dbb6ec6217f939ee7 rdf:first N4985c37624234647b9c128d3d0db08d0
    143 rdf:rest N252946c895de4010b994360335b88665
    144 Nc9c0858a6a9c4a29af95f7f52f9739bc rdf:first N5066abe1bfaf41dba7bc6a9c9a8ad0c4
    145 rdf:rest Nacffd6a9c8da450aabf35b3670cbacdf
    146 Ncd6a0dd166e24f529fdbb8fe1cf3a7d7 schema:name readcube_id
    147 schema:value f9a68bc8040b9f803ac53769fd58ff5a08cbe403af8f1d4eb4311508d33d34f4
    148 rdf:type schema:PropertyValue
    149 Nd280db24a01b4769a67d7bf0341b939f schema:affiliation https://www.grid.ac/institutes/grid.216417.7
    150 schema:familyName Liu
    151 schema:givenName Fei
    152 rdf:type schema:Person
    153 Ne73bb027096a4ebcb8f9afc34d90e0a3 schema:affiliation https://www.grid.ac/institutes/grid.43582.38
    154 schema:familyName Xu
    155 schema:givenName Weilin
    156 rdf:type schema:Person
    157 Nf3b5bae145d04bfdbbdacc348a4cbd74 schema:issueNumber 1
    158 rdf:type schema:PublicationIssue
    159 Nfe6e6bd5557c4779afc4253f002e9158 schema:affiliation https://www.grid.ac/institutes/grid.43582.38
    160 schema:familyName Zhang
    161 schema:givenName John H.
    162 rdf:type schema:Person
    163 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    164 schema:name Medical and Health Sciences
    165 rdf:type schema:DefinedTerm
    166 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
    167 schema:name Neurosciences
    168 rdf:type schema:DefinedTerm
    169 sg:journal.1034001 schema:issn 1742-2094
    170 schema:name Journal of Neuroinflammation
    171 rdf:type schema:Periodical
    172 sg:pub.10.1007/s00395-016-0531-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1035073495
    173 https://doi.org/10.1007/s00395-016-0531-z
    174 rdf:type schema:CreativeWork
    175 sg:pub.10.1007/s00415-015-8004-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000387919
    176 https://doi.org/10.1007/s00415-015-8004-0
    177 rdf:type schema:CreativeWork
    178 sg:pub.10.1007/s12035-018-1006-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1101553050
    179 https://doi.org/10.1007/s12035-018-1006-z
    180 rdf:type schema:CreativeWork
    181 sg:pub.10.1007/s12035-018-1041-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103209589
    182 https://doi.org/10.1007/s12035-018-1041-9
    183 rdf:type schema:CreativeWork
    184 sg:pub.10.1007/s12975-014-0329-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1047952706
    185 https://doi.org/10.1007/s12975-014-0329-y
    186 rdf:type schema:CreativeWork
    187 sg:pub.10.1007/s12975-014-0380-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053157263
    188 https://doi.org/10.1007/s12975-014-0380-8
    189 rdf:type schema:CreativeWork
    190 sg:pub.10.1007/s12975-016-0518-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1009649816
    191 https://doi.org/10.1007/s12975-016-0518-y
    192 rdf:type schema:CreativeWork
    193 sg:pub.10.1038/ncomms1817 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031328895
    194 https://doi.org/10.1038/ncomms1817
    195 rdf:type schema:CreativeWork
    196 sg:pub.10.1038/nrd2397 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018115916
    197 https://doi.org/10.1038/nrd2397
    198 rdf:type schema:CreativeWork
    199 sg:pub.10.1038/nrn963 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047554287
    200 https://doi.org/10.1038/nrn963
    201 rdf:type schema:CreativeWork
    202 sg:pub.10.1038/s41598-017-04048-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090327571
    203 https://doi.org/10.1038/s41598-017-04048-2
    204 rdf:type schema:CreativeWork
    205 sg:pub.10.1038/srep33176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032069169
    206 https://doi.org/10.1038/srep33176
    207 rdf:type schema:CreativeWork
    208 sg:pub.10.1186/s12974-018-1091-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1101066818
    209 https://doi.org/10.1186/s12974-018-1091-y
    210 rdf:type schema:CreativeWork
    211 sg:pub.10.1186/s12974-018-1140-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103210953
    212 https://doi.org/10.1186/s12974-018-1140-6
    213 rdf:type schema:CreativeWork
    214 sg:pub.10.1186/s12974-018-1211-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104496883
    215 https://doi.org/10.1186/s12974-018-1211-8
    216 rdf:type schema:CreativeWork
    217 https://doi.org/10.1002/biof.117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000431492
    218 rdf:type schema:CreativeWork
    219 https://doi.org/10.1002/jnr.21865 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006686884
    220 rdf:type schema:CreativeWork
    221 https://doi.org/10.1016/j.bbi.2017.11.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092866636
    222 rdf:type schema:CreativeWork
    223 https://doi.org/10.1016/j.biotechadv.2018.03.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101522870
    224 rdf:type schema:CreativeWork
    225 https://doi.org/10.1016/j.brainres.2015.07.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003093900
    226 rdf:type schema:CreativeWork
    227 https://doi.org/10.1016/j.coph.2015.11.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031566674
    228 rdf:type schema:CreativeWork
    229 https://doi.org/10.1016/j.expneurol.2015.04.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038681877
    230 rdf:type schema:CreativeWork
    231 https://doi.org/10.1016/j.jaad.2013.08.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044342265
    232 rdf:type schema:CreativeWork
    233 https://doi.org/10.1016/j.jneumeth.2007.08.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032535739
    234 rdf:type schema:CreativeWork
    235 https://doi.org/10.1016/j.jpba.2013.08.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019228081
    236 rdf:type schema:CreativeWork
    237 https://doi.org/10.1016/j.jstrokecerebrovasdis.2014.10.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046419912
    238 rdf:type schema:CreativeWork
    239 https://doi.org/10.1016/j.nbd.2013.09.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005698172
    240 rdf:type schema:CreativeWork
    241 https://doi.org/10.1016/j.nbd.2015.07.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011643921
    242 rdf:type schema:CreativeWork
    243 https://doi.org/10.1016/j.neuropharm.2017.09.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092055775
    244 rdf:type schema:CreativeWork
    245 https://doi.org/10.1016/j.neuroscience.2016.05.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005265166
    246 rdf:type schema:CreativeWork
    247 https://doi.org/10.1016/j.neuroscience.2017.09.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091903425
    248 rdf:type schema:CreativeWork
    249 https://doi.org/10.1016/j.phrs.2015.10.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013511119
    250 rdf:type schema:CreativeWork
    251 https://doi.org/10.1016/j.redox.2018.09.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107274898
    252 rdf:type schema:CreativeWork
    253 https://doi.org/10.1016/j.tem.2013.04.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044126132
    254 rdf:type schema:CreativeWork
    255 https://doi.org/10.1016/j.yexcr.2017.10.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092179472
    256 rdf:type schema:CreativeWork
    257 https://doi.org/10.1016/s0140-6736(07)60153-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047914996
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1073/pnas.1616070114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083854655
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1080/01616412.2018.1463900 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103612041
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1093/brain/awv289 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042691210
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1096/fj.11-192914 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018935348
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1111/acer.12639 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008475273
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1111/cns.12350 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052122030
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1111/jnc.12190 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050068800
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1111/jth.12511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033325899
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1126/science.1217697 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034801440
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1161/atvbaha.109.191189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036662220
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1161/strokeaha.115.009216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052265078
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1177/1753944708090924 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064075805
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1371/journal.pone.0017057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041309920
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1523/jneurosci.1001-15.2015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045239513
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.3233/jad-151020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038362309
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.3389/fneur.2017.00511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091922279
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.3389/fneur.2018.00096 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101221257
    292 rdf:type schema:CreativeWork
    293 https://www.grid.ac/institutes/grid.216417.7 schema:alternateName Central South University
    294 schema:name Department of Neurosurgery, Third XiangYa Hospital, Central South University, No.138 Tongzipo Road, 410013, Changsha, China
    295 rdf:type schema:Organization
    296 https://www.grid.ac/institutes/grid.43582.38 schema:alternateName Loma Linda University
    297 schema:name Department of Anesthesiology, School of Medicine, Loma Linda University, 92354, Loma Linda, CA, USA
    298 Department of Earth and Biological Sciences, School of Medicine, Loma Linda University, 92354, Loma Linda, CA, USA
    299 Department of Neurosurgery, School of Medicine, Loma Linda University, 92354, Loma Linda, CA, USA
    300 Department of Neurosurgery, Third XiangYa Hospital, Central South University, No.138 Tongzipo Road, 410013, Changsha, China
    301 Department of Physiology and Pharmacology, Loma Linda University, 11041 Campus St. Risley Hall, 92354, Loma Linda, CA, USA
    302 Mass Spectrometry Core Facility, Loma Linda University, 92354, Loma Linda, CA, USA
    303 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...