Annexin A1-derived peptide Ac2-26 in a pilocarpine-induced status epilepticus model: anti-inflammatory and neuroprotective effects View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Alexandre D. Gimenes, Bruna F. D. Andrade, José Victor P. Pinotti, Sonia M. Oliani, Orfa Y. Galvis-Alonso, Cristiane D. Gil

ABSTRACT

BACKGROUND: The inflammatory process has been described as a crucial mechanism in the pathophysiology of temporal lobe epilepsy. The anti-inflammatory protein annexin A1 (ANXA1) represents an interesting target in the regulation of neuroinflammation through the inhibition of leukocyte transmigration and the release of proinflammatory mediators. In this study, the role of the ANXA1-derived peptide Ac2-26 in an experimental model of status epilepticus (SE) was evaluated. METHODS: Male Wistar rats were divided into Naive, Sham, SE and SE+Ac2-26 groups, and SE was induced by intrahippocampal injection of pilocarpine. In Sham animals, saline was applied into the hippocampus, and Naive rats were only handled. Three doses of Ac2-26 (1 mg/kg) were administered intraperitoneally (i.p.) after 2, 8 and 14 h of SE induction. Finally, 24 h after the experiment-onset, rats were euthanized for analyses of neuronal lesion and inflammation. RESULTS: Pilocarpine induced generalised SE in all animals, causing neuronal damage, and systemic treatment with Ac2-26 decreased neuronal degeneration and albumin levels in the hippocampus. Also, both SE groups showed an intense influx of microglia, which was corroborated by high levels of ionised calcium binding adaptor molecule 1(Iba-1) and monocyte chemoattractant protein-1 (MCP-1) in the hippocampus. Ac2-26 reduced the astrocyte marker (glial fibrillary acidic protein; GFAP) levels, as well as interleukin-1β (IL-1β), interleukin-6 (IL-6) and growth-regulated alpha protein (GRO/KC). These effects of the peptide were associated with the modulation of the levels of formyl peptide receptor 2, a G-protein-coupled receptor that binds to Ac2-26, and the phosphorylated extracellular signal-regulated kinase (ERK) in the hippocampal neurons. CONCLUSIONS: The data suggest a neuroprotective effect of Ac2-26 in the epileptogenic processes through downregulation of inflammatory mediators and neuronal loss. More... »

PAGES

32

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12974-019-1414-7

DOI

http://dx.doi.org/10.1186/s12974-019-1414-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112088827

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30755225


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Federal University of Sao Paulo", 
          "id": "https://www.grid.ac/institutes/grid.411249.b", 
          "name": [
            "Department of Morphology and Genetics, Federal University of S\u00e3o Paulo (UNIFESP), 04023-900, S\u00e3o Paulo, SP, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gimenes", 
        "givenName": "Alexandre D.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Faculdade de Medicina de S\u00e3o Jos\u00e9 do Rio Preto", 
          "id": "https://www.grid.ac/institutes/grid.419029.7", 
          "name": [
            "Department of Molecular Biology, S\u00e3o Jos\u00e9 do Rio Preto School of Medicine (FAMERP), 15090-000, S\u00e3o Jos\u00e9 do Rio Preto, SP, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Andrade", 
        "givenName": "Bruna F. D.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Sao Paulo", 
          "id": "https://www.grid.ac/institutes/grid.411249.b", 
          "name": [
            "Department of Morphology and Genetics, Federal University of S\u00e3o Paulo (UNIFESP), 04023-900, S\u00e3o Paulo, SP, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pinotti", 
        "givenName": "Jos\u00e9 Victor P.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sao Paulo State University", 
          "id": "https://www.grid.ac/institutes/grid.410543.7", 
          "name": [
            "Department of Morphology and Genetics, Federal University of S\u00e3o Paulo (UNIFESP), 04023-900, S\u00e3o Paulo, SP, Brazil", 
            "From the Post-Graduation in Biosciences, Instituto de Bioci\u00eancias, Letras e Ci\u00eancias Exatas, S\u00e3o Paulo State University (IBILCE/UNESP), 15054-000, S\u00e3o Jos\u00e9 do Rio Preto, SP, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oliani", 
        "givenName": "Sonia M.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Faculdade de Medicina de S\u00e3o Jos\u00e9 do Rio Preto", 
          "id": "https://www.grid.ac/institutes/grid.419029.7", 
          "name": [
            "Department of Molecular Biology, S\u00e3o Jos\u00e9 do Rio Preto School of Medicine (FAMERP), 15090-000, S\u00e3o Jos\u00e9 do Rio Preto, SP, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Galvis-Alonso", 
        "givenName": "Orfa Y.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sao Paulo State University", 
          "id": "https://www.grid.ac/institutes/grid.410543.7", 
          "name": [
            "Department of Morphology and Genetics, Federal University of S\u00e3o Paulo (UNIFESP), 04023-900, S\u00e3o Paulo, SP, Brazil", 
            "From the Post-Graduation in Biosciences, Instituto de Bioci\u00eancias, Letras e Ci\u00eancias Exatas, S\u00e3o Paulo State University (IBILCE/UNESP), 15054-000, S\u00e3o Jos\u00e9 do Rio Preto, SP, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gil", 
        "givenName": "Cristiane D.", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.tins.2013.11.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000278972"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/ijms17101770", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000898924"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.eplepsyres.2014.07.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002107649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroscience.2012.05.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003719691"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.0013-9580.2004.09004.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007102812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/ndt.s50371", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007339914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-8993(96)01387-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007442870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tips.2007.12.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008742913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.0013-9580.2005.66104.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014287110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0149-7634(05)80076-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016698191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neubiorev.2016.02.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016839418"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1202030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017097930"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cddis.2013.437", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017287437", 
          "https://doi.org/10.1038/cddis.2013.437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brainres.2010.12.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018189463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1528-1157.1991.tb05533.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018599314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jnr.23584", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018863851"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0079-6123(02)35023-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018933794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/acel.12530", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020189112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.14-263160", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021653771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.14-263160", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021653771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1528-1167.2012.03610.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023562979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.12659/msmbr.895487", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023894673"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1209362110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024867556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1528-1157.43.s.5.41.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024953056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2008.04.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025168115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jneumeth.2008.04.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027375001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yebeh.2015.04.047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027904216"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scitranslmed.aaa1065", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029592891"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(00)80323-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030779875"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.exer.2015.03.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031352331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cca.2010.07.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031863615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yebeh.2010.11.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034622288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12868-016-0308-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035208989", 
          "https://doi.org/10.1186/s12868-016-0308-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12868-016-0308-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035208989", 
          "https://doi.org/10.1186/s12868-016-0308-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12974-016-0692-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035545743", 
          "https://doi.org/10.1186/s12974-016-0692-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12974-016-0692-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035545743", 
          "https://doi.org/10.1186/s12974-016-0692-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.12-205971", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036789491"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuropharm.2012.04.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037968162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1098-1136(199906)26:4<333::aid-glia7>3.0.co;2-s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038119774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.06-7842com", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040125224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12035-015-9465-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045241056", 
          "https://doi.org/10.1007/s12035-015-9465-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ar.1090940210", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045405214"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1742-2094-8-11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046474719", 
          "https://doi.org/10.1186/1742-2094-8-11"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fncel.2013.00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047193368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0013-4694(72)90177-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047420585"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0013-4694(72)90177-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047420585"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1528-1167.2011.03242.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047990602"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2014.05.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048095070"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-4886(03)00086-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048887966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-4886(03)00086-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048887966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11064-010-0301-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049957767", 
          "https://doi.org/10.1007/s11064-010-0301-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11064-010-0301-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049957767", 
          "https://doi.org/10.1007/s11064-010-0301-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.emboj.7601911", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052025195"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1528-1167.2010.02681.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052286198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1528-1167.2010.02681.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052286198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.seizure.2015.01.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052286761"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnen/nlw008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059822190"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/0929867320666131119152201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069163433"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neulet.2017.02.049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083897142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-017-00314-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084130448", 
          "https://doi.org/10.1038/s41598-017-00314-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2017.06.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1086115599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/14728222.2017.1364363", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091089800"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/1381612823666170926113754", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091935316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/1381612823666170926113754", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091935316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/ijms19041045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101901362"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/bpa.12617", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103430649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.25485", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104354968"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "BACKGROUND: The inflammatory process has been described as a crucial mechanism in the pathophysiology of temporal lobe epilepsy. The anti-inflammatory protein annexin A1 (ANXA1) represents an interesting target in the regulation of neuroinflammation through the inhibition of leukocyte transmigration and the release of proinflammatory mediators. In this study, the role of the ANXA1-derived peptide Ac2-26 in an experimental model of status epilepticus (SE) was evaluated.\nMETHODS: Male Wistar rats were divided into Naive, Sham, SE and SE+Ac2-26 groups, and SE was induced by intrahippocampal injection of pilocarpine. In Sham animals, saline was applied into the hippocampus, and Naive rats were only handled. Three doses of Ac2-26 (1\u2009mg/kg) were administered intraperitoneally (i.p.) after 2, 8 and 14\u2009h of SE induction. Finally, 24\u2009h after the experiment-onset, rats were euthanized for analyses of neuronal lesion and inflammation.\nRESULTS: Pilocarpine induced generalised SE in all animals, causing neuronal damage, and systemic treatment with Ac2-26 decreased neuronal degeneration and albumin levels in the hippocampus. Also, both SE groups showed an intense influx of microglia, which was corroborated by high levels of ionised calcium binding adaptor molecule 1(Iba-1) and monocyte chemoattractant protein-1 (MCP-1) in the hippocampus. Ac2-26 reduced the astrocyte marker (glial fibrillary acidic protein; GFAP) levels, as well as interleukin-1\u03b2 (IL-1\u03b2), interleukin-6 (IL-6) and growth-regulated alpha protein (GRO/KC). These effects of the peptide were associated with the modulation of the levels of formyl peptide receptor 2, a G-protein-coupled receptor that binds to Ac2-26, and the phosphorylated extracellular signal-regulated kinase (ERK) in the hippocampal neurons.\nCONCLUSIONS: The data suggest a neuroprotective effect of Ac2-26 in the epileptogenic processes through downregulation of inflammatory mediators and neuronal loss.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12974-019-1414-7", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5489708", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7574417", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1034001", 
        "issn": [
          "1742-2094"
        ], 
        "name": "Journal of Neuroinflammation", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "16"
      }
    ], 
    "name": "Annexin A1-derived peptide Ac2-26 in a pilocarpine-induced status epilepticus model: anti-inflammatory and neuroprotective effects", 
    "pagination": "32", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "5299ee69a8e55403b0bfbfe5904d9f29fe4be3c42706bbb69d8f36691bc1b95b"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30755225"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101222974"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12974-019-1414-7"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112088827"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12974-019-1414-7", 
      "https://app.dimensions.ai/details/publication/pub.1112088827"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:32", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000346_0000000346/records_99809_00000004.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs12974-019-1414-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12974-019-1414-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12974-019-1414-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12974-019-1414-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12974-019-1414-7'


 

This table displays all metadata directly associated to this object as RDF triples.

292 TRIPLES      21 PREDICATES      88 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12974-019-1414-7 schema:about anzsrc-for:11
2 anzsrc-for:1109
3 schema:author N23fc74c5ad88457a9d16baec8c5ea0d7
4 schema:citation sg:pub.10.1007/s11064-010-0301-5
5 sg:pub.10.1007/s12035-015-9465-y
6 sg:pub.10.1038/cddis.2013.437
7 sg:pub.10.1038/s41598-017-00314-5
8 sg:pub.10.1186/1742-2094-8-11
9 sg:pub.10.1186/s12868-016-0308-1
10 sg:pub.10.1186/s12974-016-0692-6
11 https://doi.org/10.1002/(sici)1098-1136(199906)26:4<333::aid-glia7>3.0.co;2-s
12 https://doi.org/10.1002/ar.1090940210
13 https://doi.org/10.1002/jnr.23584
14 https://doi.org/10.1016/0013-4694(72)90177-0
15 https://doi.org/10.1016/j.biomaterials.2014.05.008
16 https://doi.org/10.1016/j.brainres.2010.12.012
17 https://doi.org/10.1016/j.cca.2010.07.006
18 https://doi.org/10.1016/j.eplepsyres.2014.07.003
19 https://doi.org/10.1016/j.exer.2015.03.013
20 https://doi.org/10.1016/j.immuni.2017.06.006
21 https://doi.org/10.1016/j.jneumeth.2008.04.019
22 https://doi.org/10.1016/j.neubiorev.2016.02.007
23 https://doi.org/10.1016/j.neulet.2017.02.049
24 https://doi.org/10.1016/j.neuron.2008.04.002
25 https://doi.org/10.1016/j.neuropharm.2012.04.004
26 https://doi.org/10.1016/j.neuroscience.2012.05.018
27 https://doi.org/10.1016/j.seizure.2015.01.009
28 https://doi.org/10.1016/j.tins.2013.11.002
29 https://doi.org/10.1016/j.tips.2007.12.003
30 https://doi.org/10.1016/j.yebeh.2010.11.024
31 https://doi.org/10.1016/j.yebeh.2015.04.047
32 https://doi.org/10.1016/s0006-8993(96)01387-x
33 https://doi.org/10.1016/s0014-4886(03)00086-4
34 https://doi.org/10.1016/s0079-6123(02)35023-4
35 https://doi.org/10.1016/s0149-7634(05)80076-4
36 https://doi.org/10.1016/s1097-2765(00)80323-8
37 https://doi.org/10.1038/sj.emboj.7601911
38 https://doi.org/10.1046/j.1528-1157.43.s.5.41.x
39 https://doi.org/10.1073/pnas.1209362110
40 https://doi.org/10.1080/14728222.2017.1364363
41 https://doi.org/10.1093/jnen/nlw008
42 https://doi.org/10.1096/fj.06-7842com
43 https://doi.org/10.1096/fj.12-205971
44 https://doi.org/10.1096/fj.14-263160
45 https://doi.org/10.1111/acel.12530
46 https://doi.org/10.1111/bpa.12617
47 https://doi.org/10.1111/j.0013-9580.2004.09004.x
48 https://doi.org/10.1111/j.0013-9580.2005.66104.x
49 https://doi.org/10.1111/j.1528-1157.1991.tb05533.x
50 https://doi.org/10.1111/j.1528-1167.2010.02681.x
51 https://doi.org/10.1111/j.1528-1167.2011.03242.x
52 https://doi.org/10.1111/j.1528-1167.2012.03610.x
53 https://doi.org/10.1126/scitranslmed.aaa1065
54 https://doi.org/10.12659/msmbr.895487
55 https://doi.org/10.18632/oncotarget.25485
56 https://doi.org/10.2147/ndt.s50371
57 https://doi.org/10.2174/0929867320666131119152201
58 https://doi.org/10.2174/1381612823666170926113754
59 https://doi.org/10.3389/fncel.2013.00003
60 https://doi.org/10.3390/ijms17101770
61 https://doi.org/10.3390/ijms19041045
62 https://doi.org/10.4049/jimmunol.1202030
63 schema:datePublished 2019-12
64 schema:datePublishedReg 2019-12-01
65 schema:description BACKGROUND: The inflammatory process has been described as a crucial mechanism in the pathophysiology of temporal lobe epilepsy. The anti-inflammatory protein annexin A1 (ANXA1) represents an interesting target in the regulation of neuroinflammation through the inhibition of leukocyte transmigration and the release of proinflammatory mediators. In this study, the role of the ANXA1-derived peptide Ac2-26 in an experimental model of status epilepticus (SE) was evaluated. METHODS: Male Wistar rats were divided into Naive, Sham, SE and SE+Ac2-26 groups, and SE was induced by intrahippocampal injection of pilocarpine. In Sham animals, saline was applied into the hippocampus, and Naive rats were only handled. Three doses of Ac2-26 (1 mg/kg) were administered intraperitoneally (i.p.) after 2, 8 and 14 h of SE induction. Finally, 24 h after the experiment-onset, rats were euthanized for analyses of neuronal lesion and inflammation. RESULTS: Pilocarpine induced generalised SE in all animals, causing neuronal damage, and systemic treatment with Ac2-26 decreased neuronal degeneration and albumin levels in the hippocampus. Also, both SE groups showed an intense influx of microglia, which was corroborated by high levels of ionised calcium binding adaptor molecule 1(Iba-1) and monocyte chemoattractant protein-1 (MCP-1) in the hippocampus. Ac2-26 reduced the astrocyte marker (glial fibrillary acidic protein; GFAP) levels, as well as interleukin-1β (IL-1β), interleukin-6 (IL-6) and growth-regulated alpha protein (GRO/KC). These effects of the peptide were associated with the modulation of the levels of formyl peptide receptor 2, a G-protein-coupled receptor that binds to Ac2-26, and the phosphorylated extracellular signal-regulated kinase (ERK) in the hippocampal neurons. CONCLUSIONS: The data suggest a neuroprotective effect of Ac2-26 in the epileptogenic processes through downregulation of inflammatory mediators and neuronal loss.
66 schema:genre research_article
67 schema:inLanguage en
68 schema:isAccessibleForFree true
69 schema:isPartOf N73c41c2e54cf4076960c472c0b7b1a78
70 N8e51fadb88594e3d87b273a7509bc0f9
71 sg:journal.1034001
72 schema:name Annexin A1-derived peptide Ac2-26 in a pilocarpine-induced status epilepticus model: anti-inflammatory and neuroprotective effects
73 schema:pagination 32
74 schema:productId N08413a482f4945aebfee53043c9fada5
75 N30704d7025b948c788c02be1fab4e27e
76 N97d7b5858f404d26a0118f3adf7d4be2
77 Nd30fd1c7fdbb46d9a737ef6fbbd8de80
78 Nd3fa91352f8c4358bb82224cd6457942
79 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112088827
80 https://doi.org/10.1186/s12974-019-1414-7
81 schema:sdDatePublished 2019-04-11T09:32
82 schema:sdLicense https://scigraph.springernature.com/explorer/license/
83 schema:sdPublisher Nd2fab11ab3a748f8bea09d8517e36069
84 schema:url https://link.springer.com/10.1186%2Fs12974-019-1414-7
85 sgo:license sg:explorer/license/
86 sgo:sdDataset articles
87 rdf:type schema:ScholarlyArticle
88 N08413a482f4945aebfee53043c9fada5 schema:name doi
89 schema:value 10.1186/s12974-019-1414-7
90 rdf:type schema:PropertyValue
91 N160b9274142d4c968e5fe81abe51ea06 schema:affiliation https://www.grid.ac/institutes/grid.419029.7
92 schema:familyName Galvis-Alonso
93 schema:givenName Orfa Y.
94 rdf:type schema:Person
95 N22ff413326ac4b7ea55fb9b0fbd6369c schema:affiliation https://www.grid.ac/institutes/grid.411249.b
96 schema:familyName Pinotti
97 schema:givenName José Victor P.
98 rdf:type schema:Person
99 N23fc74c5ad88457a9d16baec8c5ea0d7 rdf:first N9a52accd44fc4b5b92972ba1f0b0a95a
100 rdf:rest Nf8ddc26f75944a1ba1be790db0034719
101 N2d5e9886558545479067b4fd52c46634 rdf:first N53eb9c874cae470fbe3bb687804e4f24
102 rdf:rest rdf:nil
103 N30704d7025b948c788c02be1fab4e27e schema:name nlm_unique_id
104 schema:value 101222974
105 rdf:type schema:PropertyValue
106 N53eb9c874cae470fbe3bb687804e4f24 schema:affiliation https://www.grid.ac/institutes/grid.410543.7
107 schema:familyName Gil
108 schema:givenName Cristiane D.
109 rdf:type schema:Person
110 N73c41c2e54cf4076960c472c0b7b1a78 schema:issueNumber 1
111 rdf:type schema:PublicationIssue
112 N8e51fadb88594e3d87b273a7509bc0f9 schema:volumeNumber 16
113 rdf:type schema:PublicationVolume
114 N8f1cb8eeced846e6bb32626d6338b698 rdf:first N22ff413326ac4b7ea55fb9b0fbd6369c
115 rdf:rest Ne713e788e97d44d8b6bab83e448877c9
116 N97c474ddbe8140aea8095369d31864ce schema:affiliation https://www.grid.ac/institutes/grid.419029.7
117 schema:familyName Andrade
118 schema:givenName Bruna F. D.
119 rdf:type schema:Person
120 N97d7b5858f404d26a0118f3adf7d4be2 schema:name pubmed_id
121 schema:value 30755225
122 rdf:type schema:PropertyValue
123 N9a52accd44fc4b5b92972ba1f0b0a95a schema:affiliation https://www.grid.ac/institutes/grid.411249.b
124 schema:familyName Gimenes
125 schema:givenName Alexandre D.
126 rdf:type schema:Person
127 Nd2fab11ab3a748f8bea09d8517e36069 schema:name Springer Nature - SN SciGraph project
128 rdf:type schema:Organization
129 Nd30fd1c7fdbb46d9a737ef6fbbd8de80 schema:name readcube_id
130 schema:value 5299ee69a8e55403b0bfbfe5904d9f29fe4be3c42706bbb69d8f36691bc1b95b
131 rdf:type schema:PropertyValue
132 Nd3fa91352f8c4358bb82224cd6457942 schema:name dimensions_id
133 schema:value pub.1112088827
134 rdf:type schema:PropertyValue
135 Ne713e788e97d44d8b6bab83e448877c9 rdf:first Ne7bea446d060409da0620769864b1cca
136 rdf:rest Nf9ed5e9c7ac14421957b053d091bb47d
137 Ne7bea446d060409da0620769864b1cca schema:affiliation https://www.grid.ac/institutes/grid.410543.7
138 schema:familyName Oliani
139 schema:givenName Sonia M.
140 rdf:type schema:Person
141 Nf8ddc26f75944a1ba1be790db0034719 rdf:first N97c474ddbe8140aea8095369d31864ce
142 rdf:rest N8f1cb8eeced846e6bb32626d6338b698
143 Nf9ed5e9c7ac14421957b053d091bb47d rdf:first N160b9274142d4c968e5fe81abe51ea06
144 rdf:rest N2d5e9886558545479067b4fd52c46634
145 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
146 schema:name Medical and Health Sciences
147 rdf:type schema:DefinedTerm
148 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
149 schema:name Neurosciences
150 rdf:type schema:DefinedTerm
151 sg:grant.5489708 http://pending.schema.org/fundedItem sg:pub.10.1186/s12974-019-1414-7
152 rdf:type schema:MonetaryGrant
153 sg:grant.7574417 http://pending.schema.org/fundedItem sg:pub.10.1186/s12974-019-1414-7
154 rdf:type schema:MonetaryGrant
155 sg:journal.1034001 schema:issn 1742-2094
156 schema:name Journal of Neuroinflammation
157 rdf:type schema:Periodical
158 sg:pub.10.1007/s11064-010-0301-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049957767
159 https://doi.org/10.1007/s11064-010-0301-5
160 rdf:type schema:CreativeWork
161 sg:pub.10.1007/s12035-015-9465-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1045241056
162 https://doi.org/10.1007/s12035-015-9465-y
163 rdf:type schema:CreativeWork
164 sg:pub.10.1038/cddis.2013.437 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017287437
165 https://doi.org/10.1038/cddis.2013.437
166 rdf:type schema:CreativeWork
167 sg:pub.10.1038/s41598-017-00314-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084130448
168 https://doi.org/10.1038/s41598-017-00314-5
169 rdf:type schema:CreativeWork
170 sg:pub.10.1186/1742-2094-8-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046474719
171 https://doi.org/10.1186/1742-2094-8-11
172 rdf:type schema:CreativeWork
173 sg:pub.10.1186/s12868-016-0308-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035208989
174 https://doi.org/10.1186/s12868-016-0308-1
175 rdf:type schema:CreativeWork
176 sg:pub.10.1186/s12974-016-0692-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035545743
177 https://doi.org/10.1186/s12974-016-0692-6
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1002/(sici)1098-1136(199906)26:4<333::aid-glia7>3.0.co;2-s schema:sameAs https://app.dimensions.ai/details/publication/pub.1038119774
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1002/ar.1090940210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045405214
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1002/jnr.23584 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018863851
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1016/0013-4694(72)90177-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047420585
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1016/j.biomaterials.2014.05.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048095070
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1016/j.brainres.2010.12.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018189463
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1016/j.cca.2010.07.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031863615
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1016/j.eplepsyres.2014.07.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002107649
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1016/j.exer.2015.03.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031352331
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1016/j.immuni.2017.06.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086115599
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1016/j.jneumeth.2008.04.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027375001
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1016/j.neubiorev.2016.02.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016839418
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1016/j.neulet.2017.02.049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083897142
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1016/j.neuron.2008.04.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025168115
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1016/j.neuropharm.2012.04.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037968162
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/j.neuroscience.2012.05.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003719691
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/j.seizure.2015.01.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052286761
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/j.tins.2013.11.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000278972
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/j.tips.2007.12.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008742913
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/j.yebeh.2010.11.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034622288
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/j.yebeh.2015.04.047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027904216
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/s0006-8993(96)01387-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007442870
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/s0014-4886(03)00086-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048887966
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/s0079-6123(02)35023-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018933794
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/s0149-7634(05)80076-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016698191
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/s1097-2765(00)80323-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030779875
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1038/sj.emboj.7601911 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052025195
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1046/j.1528-1157.43.s.5.41.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024953056
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1073/pnas.1209362110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024867556
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1080/14728222.2017.1364363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091089800
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1093/jnen/nlw008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059822190
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1096/fj.06-7842com schema:sameAs https://app.dimensions.ai/details/publication/pub.1040125224
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1096/fj.12-205971 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036789491
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1096/fj.14-263160 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021653771
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1111/acel.12530 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020189112
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1111/bpa.12617 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103430649
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1111/j.0013-9580.2004.09004.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007102812
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1111/j.0013-9580.2005.66104.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014287110
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1111/j.1528-1157.1991.tb05533.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018599314
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1111/j.1528-1167.2010.02681.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052286198
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1111/j.1528-1167.2011.03242.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047990602
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1111/j.1528-1167.2012.03610.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023562979
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1126/scitranslmed.aaa1065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029592891
264 rdf:type schema:CreativeWork
265 https://doi.org/10.12659/msmbr.895487 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023894673
266 rdf:type schema:CreativeWork
267 https://doi.org/10.18632/oncotarget.25485 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104354968
268 rdf:type schema:CreativeWork
269 https://doi.org/10.2147/ndt.s50371 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007339914
270 rdf:type schema:CreativeWork
271 https://doi.org/10.2174/0929867320666131119152201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069163433
272 rdf:type schema:CreativeWork
273 https://doi.org/10.2174/1381612823666170926113754 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091935316
274 rdf:type schema:CreativeWork
275 https://doi.org/10.3389/fncel.2013.00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047193368
276 rdf:type schema:CreativeWork
277 https://doi.org/10.3390/ijms17101770 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000898924
278 rdf:type schema:CreativeWork
279 https://doi.org/10.3390/ijms19041045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101901362
280 rdf:type schema:CreativeWork
281 https://doi.org/10.4049/jimmunol.1202030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017097930
282 rdf:type schema:CreativeWork
283 https://www.grid.ac/institutes/grid.410543.7 schema:alternateName Sao Paulo State University
284 schema:name Department of Morphology and Genetics, Federal University of São Paulo (UNIFESP), 04023-900, São Paulo, SP, Brazil
285 From the Post-Graduation in Biosciences, Instituto de Biociências, Letras e Ciências Exatas, São Paulo State University (IBILCE/UNESP), 15054-000, São José do Rio Preto, SP, Brazil
286 rdf:type schema:Organization
287 https://www.grid.ac/institutes/grid.411249.b schema:alternateName Federal University of Sao Paulo
288 schema:name Department of Morphology and Genetics, Federal University of São Paulo (UNIFESP), 04023-900, São Paulo, SP, Brazil
289 rdf:type schema:Organization
290 https://www.grid.ac/institutes/grid.419029.7 schema:alternateName Faculdade de Medicina de São José do Rio Preto
291 schema:name Department of Molecular Biology, São José do Rio Preto School of Medicine (FAMERP), 15090-000, São José do Rio Preto, SP, Brazil
292 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...