Cannabinoid CB2 receptors in the mouse brain: relevance for Alzheimer’s disease View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Alicia López, Noelia Aparicio, M. Ruth Pazos, M. Teresa Grande, M. Asunción Barreda-Manso, Irene Benito-Cuesta, Carmen Vázquez, Mario Amores, Gonzalo Ruiz-Pérez, Elena García-García, Margaret Beatka, Rosa M. Tolón, Bonnie N. Dittel, Cecilia J. Hillard, Julián Romero

ABSTRACT

BACKGROUND: Because of their low levels of expression and the inadequacy of current research tools, CB2 cannabinoid receptors (CB2R) have been difficult to study, particularly in the brain. This receptor is especially relevant in the context of neuroinflammation, so novel tools are needed to unveil its pathophysiological role(s). METHODS: We have generated a transgenic mouse model in which the expression of enhanced green fluorescent protein (EGFP) is under the control of the cnr2 gene promoter through the insertion of an Internal Ribosomal Entry Site followed by the EGFP coding region immediately 3' of the cnr2 gene and crossed these mice with mice expressing five familial Alzheimer's disease (AD) mutations (5xFAD). RESULTS: Expression of EGFP in control mice was below the level of detection in all regions of the central nervous system (CNS) that we examined. CB2R-dependent-EGFP expression was detected in the CNS of 3-month-old AD mice in areas of intense inflammation and amyloid deposition; expression was coincident with the appearance of plaques in the cortex, hippocampus, brain stem, and thalamus. The expression of EGFP increased as a function of plaque formation and subsequent microgliosis and was restricted to microglial cells located in close proximity to neuritic plaques. AD mice with CB2R deletion exhibited decreased neuritic plaques with no changes in IL1β expression. CONCLUSIONS: Using a novel reporter mouse line, we found no evidence for CB2R expression in the healthy CNS but clear up-regulation in the context of amyloid-triggered neuroinflammation. Data from CB2R null mice indicate that they play a complex role in the response to plaque formation. More... »

PAGES

158

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12974-018-1174-9

DOI

http://dx.doi.org/10.1186/s12974-018-1174-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1104168555

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29793509


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alzheimer Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amyloid beta-Peptides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Analysis of Variance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CD11b Antigen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcium-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Flow Cytometry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Green Fluorescent Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Transgenic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microfilament Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peptide Fragments", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphopyruvate Hydratase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plaque, Amyloid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptor, Cannabinoid, CB2", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "King Juan Carlos University", 
          "id": "https://www.grid.ac/institutes/grid.28479.30", 
          "name": [
            "Laboratorio de Apoyo a la Investigaci\u00f3n, Hospital Universitario Fundaci\u00f3n Alcorc\u00f3n, C/ Budapest 1, 28922, Alcorc\u00f3n, Madrid, Spain", 
            "Universidad Rey Juan Carlos, M\u00f3stoles, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "L\u00f3pez", 
        "givenName": "Alicia", 
        "id": "sg:person.015372217146.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015372217146.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universidad Francisco de Vitoria", 
          "id": "https://www.grid.ac/institutes/grid.449795.2", 
          "name": [
            "Laboratorio de Apoyo a la Investigaci\u00f3n, Hospital Universitario Fundaci\u00f3n Alcorc\u00f3n, C/ Budapest 1, 28922, Alcorc\u00f3n, Madrid, Spain", 
            "Faculty of Experimental Sciences, Universidad Francisco de Vitoria, 28223, Pozuelo de Alarc\u00f3n, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aparicio", 
        "givenName": "Noelia", 
        "id": "sg:person.010262106746.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010262106746.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universidad Francisco de Vitoria", 
          "id": "https://www.grid.ac/institutes/grid.449795.2", 
          "name": [
            "Laboratorio de Apoyo a la Investigaci\u00f3n, Hospital Universitario Fundaci\u00f3n Alcorc\u00f3n, C/ Budapest 1, 28922, Alcorc\u00f3n, Madrid, Spain", 
            "Faculty of Experimental Sciences, Universidad Francisco de Vitoria, 28223, Pozuelo de Alarc\u00f3n, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pazos", 
        "givenName": "M. Ruth", 
        "id": "sg:person.01017032635.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017032635.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universidad Francisco de Vitoria", 
          "id": "https://www.grid.ac/institutes/grid.449795.2", 
          "name": [
            "Faculty of Experimental Sciences, Universidad Francisco de Vitoria, 28223, Pozuelo de Alarc\u00f3n, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Grande", 
        "givenName": "M. Teresa", 
        "id": "sg:person.0634211425.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634211425.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universidad Francisco de Vitoria", 
          "id": "https://www.grid.ac/institutes/grid.449795.2", 
          "name": [
            "Laboratorio de Apoyo a la Investigaci\u00f3n, Hospital Universitario Fundaci\u00f3n Alcorc\u00f3n, C/ Budapest 1, 28922, Alcorc\u00f3n, Madrid, Spain", 
            "Faculty of Experimental Sciences, Universidad Francisco de Vitoria, 28223, Pozuelo de Alarc\u00f3n, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Barreda-Manso", 
        "givenName": "M. Asunci\u00f3n", 
        "id": "sg:person.0762216500.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762216500.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universidad Francisco de Vitoria", 
          "id": "https://www.grid.ac/institutes/grid.449795.2", 
          "name": [
            "Faculty of Experimental Sciences, Universidad Francisco de Vitoria, 28223, Pozuelo de Alarc\u00f3n, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Benito-Cuesta", 
        "givenName": "Irene", 
        "id": "sg:person.013777650645.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013777650645.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universitario Fundaci\u00f3n Alcorc\u00f3n", 
          "id": "https://www.grid.ac/institutes/grid.411316.0", 
          "name": [
            "Laboratorio de Apoyo a la Investigaci\u00f3n, Hospital Universitario Fundaci\u00f3n Alcorc\u00f3n, C/ Budapest 1, 28922, Alcorc\u00f3n, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "V\u00e1zquez", 
        "givenName": "Carmen", 
        "id": "sg:person.01354323465.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354323465.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universitario Fundaci\u00f3n Alcorc\u00f3n", 
          "id": "https://www.grid.ac/institutes/grid.411316.0", 
          "name": [
            "Laboratorio de Apoyo a la Investigaci\u00f3n, Hospital Universitario Fundaci\u00f3n Alcorc\u00f3n, C/ Budapest 1, 28922, Alcorc\u00f3n, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Amores", 
        "givenName": "Mario", 
        "id": "sg:person.015506445546.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015506445546.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universidad Francisco de Vitoria", 
          "id": "https://www.grid.ac/institutes/grid.449795.2", 
          "name": [
            "Faculty of Experimental Sciences, Universidad Francisco de Vitoria, 28223, Pozuelo de Alarc\u00f3n, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ruiz-P\u00e9rez", 
        "givenName": "Gonzalo", 
        "id": "sg:person.013307324112.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013307324112.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universitario Fundaci\u00f3n Alcorc\u00f3n", 
          "id": "https://www.grid.ac/institutes/grid.411316.0", 
          "name": [
            "Laboratorio de Apoyo a la Investigaci\u00f3n, Hospital Universitario Fundaci\u00f3n Alcorc\u00f3n, C/ Budapest 1, 28922, Alcorc\u00f3n, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Garc\u00eda-Garc\u00eda", 
        "givenName": "Elena", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical College of Wisconsin", 
          "id": "https://www.grid.ac/institutes/grid.30760.32", 
          "name": [
            "Blood Research Institute, BloodCenter of Wisconsin, 53226, Milwaukee, WI, USA", 
            "Department of Pharmacology and Neuroscience Research Center, Medical College of Wisconsin, 53226, Milwaukee, WI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Beatka", 
        "givenName": "Margaret", 
        "id": "sg:person.012244675423.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012244675423.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universidad Francisco de Vitoria", 
          "id": "https://www.grid.ac/institutes/grid.449795.2", 
          "name": [
            "Laboratorio de Apoyo a la Investigaci\u00f3n, Hospital Universitario Fundaci\u00f3n Alcorc\u00f3n, C/ Budapest 1, 28922, Alcorc\u00f3n, Madrid, Spain", 
            "Faculty of Experimental Sciences, Universidad Francisco de Vitoria, 28223, Pozuelo de Alarc\u00f3n, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tol\u00f3n", 
        "givenName": "Rosa M.", 
        "id": "sg:person.01055533265.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055533265.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bloodcenter of Wisconsin", 
          "id": "https://www.grid.ac/institutes/grid.280427.b", 
          "name": [
            "Blood Research Institute, BloodCenter of Wisconsin, 53226, Milwaukee, WI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dittel", 
        "givenName": "Bonnie N.", 
        "id": "sg:person.0653524726.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653524726.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical College of Wisconsin", 
          "id": "https://www.grid.ac/institutes/grid.30760.32", 
          "name": [
            "Department of Pharmacology and Neuroscience Research Center, Medical College of Wisconsin, 53226, Milwaukee, WI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hillard", 
        "givenName": "Cecilia J.", 
        "id": "sg:person.012420437477.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012420437477.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universidad Francisco de Vitoria", 
          "id": "https://www.grid.ac/institutes/grid.449795.2", 
          "name": [
            "Laboratorio de Apoyo a la Investigaci\u00f3n, Hospital Universitario Fundaci\u00f3n Alcorc\u00f3n, C/ Budapest 1, 28922, Alcorc\u00f3n, Madrid, Spain", 
            "Faculty of Experimental Sciences, Universidad Francisco de Vitoria, 28223, Pozuelo de Alarc\u00f3n, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Romero", 
        "givenName": "Juli\u00e1n", 
        "id": "sg:person.0677032565.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677032565.33"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/j.1582-4934.2012.01608.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000321818"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neurobiolaging.2015.08.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000850953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brainres.2005.11.035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001630748"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00018-006-6037-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002107006", 
          "https://doi.org/10.1007/s00018-006-6037-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-319-20825-1_6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002555523", 
          "https://doi.org/10.1007/978-3-319-20825-1_6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1413210111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006604071"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neurobiolaging.2014.09.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008508465"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/mol.111.071290", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009152815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1476-5381.2010.00729.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011406416"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1476-5381.2010.00729.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011406416"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.2005.03380.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012026915"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.2005.03380.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012026915"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2016.08.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014615576"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neurobiolaging.2012.06.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015763923"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/syn.20050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016449572"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/365061a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020160837", 
          "https://doi.org/10.1038/365061a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0138986", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022456325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0129618", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023665958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1115740", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025068466"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3233/jad-150913", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028076590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1567-5769(01)00147-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030280584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1097/00004647-200209000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031724636", 
          "https://doi.org/10.1097/00004647-200209000-00001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004647-200209000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031724636"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1561", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031965120", 
          "https://doi.org/10.1038/nm1561"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1561", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031965120", 
          "https://doi.org/10.1038/nm1561"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni.3102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036887716", 
          "https://doi.org/10.1038/ni.3102"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brainres.2009.05.098", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037139236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05453", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037343636", 
          "https://doi.org/10.1038/nature05453"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05453", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037343636", 
          "https://doi.org/10.1038/nature05453"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2016.03.034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040595061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1742-2094-9-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044445511", 
          "https://doi.org/10.1186/1742-2094-9-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4684-5925-8_8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044451787", 
          "https://doi.org/10.1007/978-1-4684-5925-8_8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/jpet.107.121566", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044826332"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1432-1033.1995.tb20780.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044968618"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.bjp.0707505", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045994692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.1202-06.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047102131"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/glia.20983", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047261929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/glia.20983", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047261929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.4540-04.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049775522"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fimmu.2015.00480", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050469553"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1500153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053166190"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.23-04-01398.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075241258"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.23-35-11136.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076608030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3233/jad-130137", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078706740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2119/molmed.2013.00140.revised", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078894762", 
          "https://doi.org/10.2119/molmed.2013.00140.revised"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2119/molmed.2013.00140.revised", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078894762", 
          "https://doi.org/10.2119/molmed.2013.00140.revised"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082669002", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "BACKGROUND: Because of their low levels of expression and the inadequacy of current research tools, CB2 cannabinoid receptors (CB2R) have been difficult to study, particularly in the brain. This receptor is especially relevant in the context of neuroinflammation, so novel tools are needed to unveil its pathophysiological role(s).\nMETHODS: We have generated a transgenic mouse model in which the expression of enhanced green fluorescent protein (EGFP) is under the control of the cnr2 gene promoter through the insertion of an Internal Ribosomal Entry Site followed by the EGFP coding region immediately 3' of the cnr2 gene and crossed these mice with mice expressing five familial Alzheimer's disease (AD) mutations (5xFAD).\nRESULTS: Expression of EGFP in control mice was below the level of detection in all regions of the central nervous system (CNS) that we examined. CB2R-dependent-EGFP expression was detected in the CNS of 3-month-old AD mice in areas of intense inflammation and amyloid deposition; expression was coincident with the appearance of plaques in the cortex, hippocampus, brain stem, and thalamus. The expression of EGFP increased as a function of plaque formation and subsequent microgliosis and was restricted to microglial cells located in close proximity to neuritic plaques. AD mice with CB2R deletion exhibited decreased neuritic plaques with no changes in IL1\u03b2 expression.\nCONCLUSIONS: Using a novel reporter mouse line, we found no evidence for CB2R expression in the healthy CNS but clear up-regulation in the context of amyloid-triggered neuroinflammation. Data from CB2R null mice indicate that they play a complex role in the response to plaque formation.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12974-018-1174-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5054655", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1034001", 
        "issn": [
          "1742-2094"
        ], 
        "name": "Journal of Neuroinflammation", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "15"
      }
    ], 
    "name": "Cannabinoid CB2 receptors in the mouse brain: relevance for Alzheimer\u2019s disease", 
    "pagination": "158", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12974-018-1174-9"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "5957f93ad1d9908ebca73a7208f737bb8520ddb2004eaeeaf3cd0c50809aaba3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1104168555"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101222974"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29793509"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12974-018-1174-9", 
      "https://app.dimensions.ai/details/publication/pub.1104168555"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-15T08:51", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000374_0000000374/records_119738_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs12974-018-1174-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12974-018-1174-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12974-018-1174-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12974-018-1174-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12974-018-1174-9'


 

This table displays all metadata directly associated to this object as RDF triples.

390 TRIPLES      21 PREDICATES      89 URIs      40 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12974-018-1174-9 schema:about N02120d65d9f1483893441a9f546792fc
2 N0349ad677f7f4c8dadbc37b0e4f79059
3 N3aa77daa48af4e4d829c45b69437134e
4 N3f3787698be74f32a7d8b17512a0b20b
5 N9935ad67eadf4e82aa401b77a83c16a7
6 N9cd514020065418486acc9b045858084
7 N9d4a1ddc8df841b787a395dfffb97714
8 N9df50417df1d4f679f7e84a0726d6670
9 Na09055b5f4f84b64b82e386479e34f69
10 Na3b10315360145e2873635b421615b96
11 Na8beeab8f90b4b3d9e5be84eb7bf8d37
12 Nac0f161d04e3476face75051fbd63161
13 Nb546f76add634f03b9420932c3d0e8d0
14 Nba7a27c4dac3407c889cd2893da8c9d6
15 Nc1ffc7fe5c91499b9d0c7563e67e0d11
16 Nd3b9cf2851b34c44b3b8480ab1d58beb
17 Nd571f325bdb0475ba3ec432ef76163a4
18 Neb3cdc86e1e94095a02fb5a34f7bd8e3
19 Nf89939219f124107967e115196f66f7e
20 anzsrc-for:11
21 anzsrc-for:1109
22 schema:author N14e4df3b0f09413aa3f1ef12b3058542
23 schema:citation sg:pub.10.1007/978-1-4684-5925-8_8
24 sg:pub.10.1007/978-3-319-20825-1_6
25 sg:pub.10.1007/s00018-006-6037-3
26 sg:pub.10.1038/365061a0
27 sg:pub.10.1038/nature05453
28 sg:pub.10.1038/ni.3102
29 sg:pub.10.1038/nm1561
30 sg:pub.10.1097/00004647-200209000-00001
31 sg:pub.10.1186/1742-2094-9-8
32 sg:pub.10.2119/molmed.2013.00140.revised
33 https://app.dimensions.ai/details/publication/pub.1082669002
34 https://doi.org/10.1002/glia.20983
35 https://doi.org/10.1002/syn.20050
36 https://doi.org/10.1016/j.brainres.2005.11.035
37 https://doi.org/10.1016/j.brainres.2009.05.098
38 https://doi.org/10.1016/j.neurobiolaging.2012.06.011
39 https://doi.org/10.1016/j.neurobiolaging.2014.09.019
40 https://doi.org/10.1016/j.neurobiolaging.2015.08.003
41 https://doi.org/10.1016/j.neuron.2016.03.034
42 https://doi.org/10.1016/j.neuron.2016.08.017
43 https://doi.org/10.1016/s1567-5769(01)00147-3
44 https://doi.org/10.1038/sj.bjp.0707505
45 https://doi.org/10.1073/pnas.1413210111
46 https://doi.org/10.1097/00004647-200209000-00001
47 https://doi.org/10.1111/j.1432-1033.1995.tb20780.x
48 https://doi.org/10.1111/j.1471-4159.2005.03380.x
49 https://doi.org/10.1111/j.1476-5381.2010.00729.x
50 https://doi.org/10.1111/j.1582-4934.2012.01608.x
51 https://doi.org/10.1124/jpet.107.121566
52 https://doi.org/10.1124/mol.111.071290
53 https://doi.org/10.1126/science.1115740
54 https://doi.org/10.1371/journal.pone.0129618
55 https://doi.org/10.1371/journal.pone.0138986
56 https://doi.org/10.1523/jneurosci.1202-06.2006
57 https://doi.org/10.1523/jneurosci.23-04-01398.2003
58 https://doi.org/10.1523/jneurosci.23-35-11136.2003
59 https://doi.org/10.1523/jneurosci.4540-04.2005
60 https://doi.org/10.3233/jad-130137
61 https://doi.org/10.3233/jad-150913
62 https://doi.org/10.3389/fimmu.2015.00480
63 https://doi.org/10.4049/jimmunol.1500153
64 schema:datePublished 2018-12
65 schema:datePublishedReg 2018-12-01
66 schema:description BACKGROUND: Because of their low levels of expression and the inadequacy of current research tools, CB2 cannabinoid receptors (CB2R) have been difficult to study, particularly in the brain. This receptor is especially relevant in the context of neuroinflammation, so novel tools are needed to unveil its pathophysiological role(s). METHODS: We have generated a transgenic mouse model in which the expression of enhanced green fluorescent protein (EGFP) is under the control of the cnr2 gene promoter through the insertion of an Internal Ribosomal Entry Site followed by the EGFP coding region immediately 3' of the cnr2 gene and crossed these mice with mice expressing five familial Alzheimer's disease (AD) mutations (5xFAD). RESULTS: Expression of EGFP in control mice was below the level of detection in all regions of the central nervous system (CNS) that we examined. CB2R-dependent-EGFP expression was detected in the CNS of 3-month-old AD mice in areas of intense inflammation and amyloid deposition; expression was coincident with the appearance of plaques in the cortex, hippocampus, brain stem, and thalamus. The expression of EGFP increased as a function of plaque formation and subsequent microgliosis and was restricted to microglial cells located in close proximity to neuritic plaques. AD mice with CB2R deletion exhibited decreased neuritic plaques with no changes in IL1β expression. CONCLUSIONS: Using a novel reporter mouse line, we found no evidence for CB2R expression in the healthy CNS but clear up-regulation in the context of amyloid-triggered neuroinflammation. Data from CB2R null mice indicate that they play a complex role in the response to plaque formation.
67 schema:genre research_article
68 schema:inLanguage en
69 schema:isAccessibleForFree true
70 schema:isPartOf N61436c73735a41c8b2b60e97a70cd1b5
71 Nc4e9630abd92461ebbca400bf963eec3
72 sg:journal.1034001
73 schema:name Cannabinoid CB2 receptors in the mouse brain: relevance for Alzheimer’s disease
74 schema:pagination 158
75 schema:productId N124c6f045c80494fa9a64f307302399c
76 N3625a3066fd743f1964783f63a730a7c
77 Na12e642ad57b40c3bda60715378d4839
78 Nb1ed617ef0d04caa889364a3e25d14be
79 Ncb560df882854ce09003d347bc0fd826
80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104168555
81 https://doi.org/10.1186/s12974-018-1174-9
82 schema:sdDatePublished 2019-04-15T08:51
83 schema:sdLicense https://scigraph.springernature.com/explorer/license/
84 schema:sdPublisher N656e43d0593b4d1aa72582288a57929e
85 schema:url https://link.springer.com/10.1186%2Fs12974-018-1174-9
86 sgo:license sg:explorer/license/
87 sgo:sdDataset articles
88 rdf:type schema:ScholarlyArticle
89 N02120d65d9f1483893441a9f546792fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Alzheimer Disease
91 rdf:type schema:DefinedTerm
92 N0349ad677f7f4c8dadbc37b0e4f79059 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Plaque, Amyloid
94 rdf:type schema:DefinedTerm
95 N0e6d901b9eb64d7191d15059a0a85d73 rdf:first sg:person.0653524726.01
96 rdf:rest N216bd517eb5646c6b01cdf7827370a02
97 N124c6f045c80494fa9a64f307302399c schema:name nlm_unique_id
98 schema:value 101222974
99 rdf:type schema:PropertyValue
100 N14e4df3b0f09413aa3f1ef12b3058542 rdf:first sg:person.015372217146.41
101 rdf:rest Nd64184e985e3454c868e6a2f40d9cb7c
102 N216bd517eb5646c6b01cdf7827370a02 rdf:first sg:person.012420437477.63
103 rdf:rest Nf0f1fd4a6c384a0bb5d34619fa0a92c0
104 N2c0187a6f69c4e82a4972ab873c7a506 rdf:first sg:person.01055533265.31
105 rdf:rest N0e6d901b9eb64d7191d15059a0a85d73
106 N3625a3066fd743f1964783f63a730a7c schema:name pubmed_id
107 schema:value 29793509
108 rdf:type schema:PropertyValue
109 N3aa77daa48af4e4d829c45b69437134e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Gene Expression Regulation
111 rdf:type schema:DefinedTerm
112 N3f3787698be74f32a7d8b17512a0b20b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Phosphopyruvate Hydratase
114 rdf:type schema:DefinedTerm
115 N48e1901d0a1f44b7a40e3117e44be37d schema:affiliation https://www.grid.ac/institutes/grid.411316.0
116 schema:familyName García-García
117 schema:givenName Elena
118 rdf:type schema:Person
119 N4ad9a2758f5d4c2dac9d8441e2408590 rdf:first sg:person.013307324112.01
120 rdf:rest Nfca3ea6d0aca4fb3afc6bc4a19ace936
121 N61436c73735a41c8b2b60e97a70cd1b5 schema:volumeNumber 15
122 rdf:type schema:PublicationVolume
123 N656e43d0593b4d1aa72582288a57929e schema:name Springer Nature - SN SciGraph project
124 rdf:type schema:Organization
125 N79e134cf6f5c428aae1572ced27f7147 rdf:first sg:person.0634211425.87
126 rdf:rest N9f35f49efb0946cb95118b3ec9ce6a5e
127 N9935ad67eadf4e82aa401b77a83c16a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Disease Models, Animal
129 rdf:type schema:DefinedTerm
130 N9cd514020065418486acc9b045858084 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Mice
132 rdf:type schema:DefinedTerm
133 N9d4a1ddc8df841b787a395dfffb97714 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Receptor, Cannabinoid, CB2
135 rdf:type schema:DefinedTerm
136 N9df50417df1d4f679f7e84a0726d6670 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Calcium-Binding Proteins
138 rdf:type schema:DefinedTerm
139 N9f35f49efb0946cb95118b3ec9ce6a5e rdf:first sg:person.0762216500.80
140 rdf:rest Nb20e71cd51924f60ac3bd8ea1081cb16
141 Na09055b5f4f84b64b82e386479e34f69 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Green Fluorescent Proteins
143 rdf:type schema:DefinedTerm
144 Na12e642ad57b40c3bda60715378d4839 schema:name readcube_id
145 schema:value 5957f93ad1d9908ebca73a7208f737bb8520ddb2004eaeeaf3cd0c50809aaba3
146 rdf:type schema:PropertyValue
147 Na3b10315360145e2873635b421615b96 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Flow Cytometry
149 rdf:type schema:DefinedTerm
150 Na8beeab8f90b4b3d9e5be84eb7bf8d37 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Mice, Transgenic
152 rdf:type schema:DefinedTerm
153 Nac0f161d04e3476face75051fbd63161 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Microfilament Proteins
155 rdf:type schema:DefinedTerm
156 Nb1ed617ef0d04caa889364a3e25d14be schema:name dimensions_id
157 schema:value pub.1104168555
158 rdf:type schema:PropertyValue
159 Nb20e71cd51924f60ac3bd8ea1081cb16 rdf:first sg:person.013777650645.94
160 rdf:rest Nd08f9075068c4923a6c3275efb7c2b9f
161 Nb546f76add634f03b9420932c3d0e8d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Peptide Fragments
163 rdf:type schema:DefinedTerm
164 Nb7ba5438a8b04b4fb8c42d96fe992e36 rdf:first sg:person.015506445546.21
165 rdf:rest N4ad9a2758f5d4c2dac9d8441e2408590
166 Nba7a27c4dac3407c889cd2893da8c9d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Amyloid beta-Peptides
168 rdf:type schema:DefinedTerm
169 Nbd06a7934e1e4bcda902ec88b81362df rdf:first sg:person.012244675423.59
170 rdf:rest N2c0187a6f69c4e82a4972ab873c7a506
171 Nc1ffc7fe5c91499b9d0c7563e67e0d11 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Analysis of Variance
173 rdf:type schema:DefinedTerm
174 Nc4e9630abd92461ebbca400bf963eec3 schema:issueNumber 1
175 rdf:type schema:PublicationIssue
176 Ncb560df882854ce09003d347bc0fd826 schema:name doi
177 schema:value 10.1186/s12974-018-1174-9
178 rdf:type schema:PropertyValue
179 Nd08f9075068c4923a6c3275efb7c2b9f rdf:first sg:person.01354323465.25
180 rdf:rest Nb7ba5438a8b04b4fb8c42d96fe992e36
181 Nd3b9cf2851b34c44b3b8480ab1d58beb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Mice, Inbred C57BL
183 rdf:type schema:DefinedTerm
184 Nd571f325bdb0475ba3ec432ef76163a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Animals
186 rdf:type schema:DefinedTerm
187 Nd64184e985e3454c868e6a2f40d9cb7c rdf:first sg:person.010262106746.35
188 rdf:rest Nedadbc9f61844abd85741a6b7a17a96e
189 Neb3cdc86e1e94095a02fb5a34f7bd8e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name CD11b Antigen
191 rdf:type schema:DefinedTerm
192 Nedadbc9f61844abd85741a6b7a17a96e rdf:first sg:person.01017032635.93
193 rdf:rest N79e134cf6f5c428aae1572ced27f7147
194 Nf0f1fd4a6c384a0bb5d34619fa0a92c0 rdf:first sg:person.0677032565.33
195 rdf:rest rdf:nil
196 Nf89939219f124107967e115196f66f7e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Brain
198 rdf:type schema:DefinedTerm
199 Nfca3ea6d0aca4fb3afc6bc4a19ace936 rdf:first N48e1901d0a1f44b7a40e3117e44be37d
200 rdf:rest Nbd06a7934e1e4bcda902ec88b81362df
201 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
202 schema:name Medical and Health Sciences
203 rdf:type schema:DefinedTerm
204 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
205 schema:name Neurosciences
206 rdf:type schema:DefinedTerm
207 sg:grant.5054655 http://pending.schema.org/fundedItem sg:pub.10.1186/s12974-018-1174-9
208 rdf:type schema:MonetaryGrant
209 sg:journal.1034001 schema:issn 1742-2094
210 schema:name Journal of Neuroinflammation
211 rdf:type schema:Periodical
212 sg:person.01017032635.93 schema:affiliation https://www.grid.ac/institutes/grid.449795.2
213 schema:familyName Pazos
214 schema:givenName M. Ruth
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017032635.93
216 rdf:type schema:Person
217 sg:person.010262106746.35 schema:affiliation https://www.grid.ac/institutes/grid.449795.2
218 schema:familyName Aparicio
219 schema:givenName Noelia
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010262106746.35
221 rdf:type schema:Person
222 sg:person.01055533265.31 schema:affiliation https://www.grid.ac/institutes/grid.449795.2
223 schema:familyName Tolón
224 schema:givenName Rosa M.
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055533265.31
226 rdf:type schema:Person
227 sg:person.012244675423.59 schema:affiliation https://www.grid.ac/institutes/grid.30760.32
228 schema:familyName Beatka
229 schema:givenName Margaret
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012244675423.59
231 rdf:type schema:Person
232 sg:person.012420437477.63 schema:affiliation https://www.grid.ac/institutes/grid.30760.32
233 schema:familyName Hillard
234 schema:givenName Cecilia J.
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012420437477.63
236 rdf:type schema:Person
237 sg:person.013307324112.01 schema:affiliation https://www.grid.ac/institutes/grid.449795.2
238 schema:familyName Ruiz-Pérez
239 schema:givenName Gonzalo
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013307324112.01
241 rdf:type schema:Person
242 sg:person.01354323465.25 schema:affiliation https://www.grid.ac/institutes/grid.411316.0
243 schema:familyName Vázquez
244 schema:givenName Carmen
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354323465.25
246 rdf:type schema:Person
247 sg:person.013777650645.94 schema:affiliation https://www.grid.ac/institutes/grid.449795.2
248 schema:familyName Benito-Cuesta
249 schema:givenName Irene
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013777650645.94
251 rdf:type schema:Person
252 sg:person.015372217146.41 schema:affiliation https://www.grid.ac/institutes/grid.28479.30
253 schema:familyName López
254 schema:givenName Alicia
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015372217146.41
256 rdf:type schema:Person
257 sg:person.015506445546.21 schema:affiliation https://www.grid.ac/institutes/grid.411316.0
258 schema:familyName Amores
259 schema:givenName Mario
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015506445546.21
261 rdf:type schema:Person
262 sg:person.0634211425.87 schema:affiliation https://www.grid.ac/institutes/grid.449795.2
263 schema:familyName Grande
264 schema:givenName M. Teresa
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634211425.87
266 rdf:type schema:Person
267 sg:person.0653524726.01 schema:affiliation https://www.grid.ac/institutes/grid.280427.b
268 schema:familyName Dittel
269 schema:givenName Bonnie N.
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653524726.01
271 rdf:type schema:Person
272 sg:person.0677032565.33 schema:affiliation https://www.grid.ac/institutes/grid.449795.2
273 schema:familyName Romero
274 schema:givenName Julián
275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677032565.33
276 rdf:type schema:Person
277 sg:person.0762216500.80 schema:affiliation https://www.grid.ac/institutes/grid.449795.2
278 schema:familyName Barreda-Manso
279 schema:givenName M. Asunción
280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762216500.80
281 rdf:type schema:Person
282 sg:pub.10.1007/978-1-4684-5925-8_8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044451787
283 https://doi.org/10.1007/978-1-4684-5925-8_8
284 rdf:type schema:CreativeWork
285 sg:pub.10.1007/978-3-319-20825-1_6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002555523
286 https://doi.org/10.1007/978-3-319-20825-1_6
287 rdf:type schema:CreativeWork
288 sg:pub.10.1007/s00018-006-6037-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002107006
289 https://doi.org/10.1007/s00018-006-6037-3
290 rdf:type schema:CreativeWork
291 sg:pub.10.1038/365061a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020160837
292 https://doi.org/10.1038/365061a0
293 rdf:type schema:CreativeWork
294 sg:pub.10.1038/nature05453 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037343636
295 https://doi.org/10.1038/nature05453
296 rdf:type schema:CreativeWork
297 sg:pub.10.1038/ni.3102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036887716
298 https://doi.org/10.1038/ni.3102
299 rdf:type schema:CreativeWork
300 sg:pub.10.1038/nm1561 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031965120
301 https://doi.org/10.1038/nm1561
302 rdf:type schema:CreativeWork
303 sg:pub.10.1097/00004647-200209000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031724636
304 https://doi.org/10.1097/00004647-200209000-00001
305 rdf:type schema:CreativeWork
306 sg:pub.10.1186/1742-2094-9-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044445511
307 https://doi.org/10.1186/1742-2094-9-8
308 rdf:type schema:CreativeWork
309 sg:pub.10.2119/molmed.2013.00140.revised schema:sameAs https://app.dimensions.ai/details/publication/pub.1078894762
310 https://doi.org/10.2119/molmed.2013.00140.revised
311 rdf:type schema:CreativeWork
312 https://app.dimensions.ai/details/publication/pub.1082669002 schema:CreativeWork
313 https://doi.org/10.1002/glia.20983 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047261929
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1002/syn.20050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016449572
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1016/j.brainres.2005.11.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001630748
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1016/j.brainres.2009.05.098 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037139236
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1016/j.neurobiolaging.2012.06.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015763923
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1016/j.neurobiolaging.2014.09.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008508465
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1016/j.neurobiolaging.2015.08.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000850953
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1016/j.neuron.2016.03.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040595061
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1016/j.neuron.2016.08.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014615576
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1016/s1567-5769(01)00147-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030280584
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1038/sj.bjp.0707505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045994692
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1073/pnas.1413210111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006604071
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1097/00004647-200209000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031724636
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1111/j.1432-1033.1995.tb20780.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044968618
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1111/j.1471-4159.2005.03380.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012026915
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1111/j.1476-5381.2010.00729.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011406416
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1111/j.1582-4934.2012.01608.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000321818
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1124/jpet.107.121566 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044826332
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1124/mol.111.071290 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009152815
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1126/science.1115740 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025068466
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1371/journal.pone.0129618 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023665958
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1371/journal.pone.0138986 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022456325
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1523/jneurosci.1202-06.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047102131
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1523/jneurosci.23-04-01398.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075241258
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1523/jneurosci.23-35-11136.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076608030
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1523/jneurosci.4540-04.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049775522
364 rdf:type schema:CreativeWork
365 https://doi.org/10.3233/jad-130137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078706740
366 rdf:type schema:CreativeWork
367 https://doi.org/10.3233/jad-150913 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028076590
368 rdf:type schema:CreativeWork
369 https://doi.org/10.3389/fimmu.2015.00480 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050469553
370 rdf:type schema:CreativeWork
371 https://doi.org/10.4049/jimmunol.1500153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053166190
372 rdf:type schema:CreativeWork
373 https://www.grid.ac/institutes/grid.280427.b schema:alternateName Bloodcenter of Wisconsin
374 schema:name Blood Research Institute, BloodCenter of Wisconsin, 53226, Milwaukee, WI, USA
375 rdf:type schema:Organization
376 https://www.grid.ac/institutes/grid.28479.30 schema:alternateName King Juan Carlos University
377 schema:name Laboratorio de Apoyo a la Investigación, Hospital Universitario Fundación Alcorcón, C/ Budapest 1, 28922, Alcorcón, Madrid, Spain
378 Universidad Rey Juan Carlos, Móstoles, Spain
379 rdf:type schema:Organization
380 https://www.grid.ac/institutes/grid.30760.32 schema:alternateName Medical College of Wisconsin
381 schema:name Blood Research Institute, BloodCenter of Wisconsin, 53226, Milwaukee, WI, USA
382 Department of Pharmacology and Neuroscience Research Center, Medical College of Wisconsin, 53226, Milwaukee, WI, USA
383 rdf:type schema:Organization
384 https://www.grid.ac/institutes/grid.411316.0 schema:alternateName Hospital Universitario Fundación Alcorcón
385 schema:name Laboratorio de Apoyo a la Investigación, Hospital Universitario Fundación Alcorcón, C/ Budapest 1, 28922, Alcorcón, Madrid, Spain
386 rdf:type schema:Organization
387 https://www.grid.ac/institutes/grid.449795.2 schema:alternateName Universidad Francisco de Vitoria
388 schema:name Faculty of Experimental Sciences, Universidad Francisco de Vitoria, 28223, Pozuelo de Alarcón, Madrid, Spain
389 Laboratorio de Apoyo a la Investigación, Hospital Universitario Fundación Alcorcón, C/ Budapest 1, 28922, Alcorcón, Madrid, Spain
390 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...