IL-33/ST2 plays a critical role in endothelial cell activation and microglia-mediated neuroinflammation modulation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Kelei Cao, Xiang Liao, Jiahui Lu, Shu Yao, Fengjiao Wu, Xingxing Zhu, Dongyan Shi, Shuang Wen, Lixin Liu, Hong Zhou

ABSTRACT

BACKGROUND: Interleukin-33 (IL-33) is increasingly being recognized as a key immunomodulatory cytokine in many neurological diseases. METHODS: In the present study, wild-type (WT) and IL-33-/- mice received intracerebroventricular (i.c.v.) injection of lipopolysaccharide (LPS) to induce neuroinflammation. Intravital microscopy was employed to examine leukocyte-endothelial interactions in the brain vasculature. The degree of neutrophil infiltration was determined by myeloperoxidase (MPO) staining. Real-time PCR and western blotting were used to detect endothelial activation. Enzyme-linked immunosorbent assay and quantitative PCR were conducted to detect pro-inflammatory cytokine levels in the brain. RESULTS: In IL-33-/- mice, neutrophil infiltration in the brain cortex and leukocyte-endothelial cell interactions in the cerebral microvessels were significantly decreased as compared to WT mice after LPS injection. In addition, IL-33-/- mice showed reduced activation of microglia and cerebral endothelial cells. In vitro results indicated that IL-33 directly activated cerebral endothelial cells and promoted pro-inflammatory cytokine production in LPS-stimulated microglia. CONCLUSIONS: Our study indicated that IL-33/ST2 signaling plays an important role in the activation of microglia and cerebral endothelial cells and, therefore, is essential in leukocyte recruitment in brain inflammation. The role of IL-33/ST2 in LPS induced neuroinflammation. More... »

PAGES

136

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12974-018-1169-6

DOI

http://dx.doi.org/10.1186/s12974-018-1169-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1103816176

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29728120


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Nanjing Medical University", 
          "id": "https://www.grid.ac/institutes/grid.89957.3a", 
          "name": [
            "Department of Immunology, Nanjing Medical University, 101 Longmian Avenue, 211166, Nanjing, JS, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cao", 
        "givenName": "Kelei", 
        "id": "sg:person.014720552424.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014720552424.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nanjing Medical University", 
          "id": "https://www.grid.ac/institutes/grid.89957.3a", 
          "name": [
            "Department of Immunology, Nanjing Medical University, 101 Longmian Avenue, 211166, Nanjing, JS, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liao", 
        "givenName": "Xiang", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nanjing Medical University", 
          "id": "https://www.grid.ac/institutes/grid.89957.3a", 
          "name": [
            "Department of Immunology, Nanjing Medical University, 101 Longmian Avenue, 211166, Nanjing, JS, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lu", 
        "givenName": "Jiahui", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nanjing Medical University", 
          "id": "https://www.grid.ac/institutes/grid.89957.3a", 
          "name": [
            "Department of Immunology, Nanjing Medical University, 101 Longmian Avenue, 211166, Nanjing, JS, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yao", 
        "givenName": "Shu", 
        "id": "sg:person.012540462204.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012540462204.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bengbu Medical College", 
          "id": "https://www.grid.ac/institutes/grid.252957.e", 
          "name": [
            "Department of Immunology, Anhui Provincial Key Laboratory of Infection and Immunity, Bengbu Medical College, 233030, Bengbu, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wu", 
        "givenName": "Fengjiao", 
        "id": "sg:person.0764513521.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764513521.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nanjing Medical University", 
          "id": "https://www.grid.ac/institutes/grid.89957.3a", 
          "name": [
            "Department of Immunology, Nanjing Medical University, 101 Longmian Avenue, 211166, Nanjing, JS, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhu", 
        "givenName": "Xingxing", 
        "id": "sg:person.01215170521.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215170521.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nanjing Medical University", 
          "id": "https://www.grid.ac/institutes/grid.89957.3a", 
          "name": [
            "Department of Immunology, Nanjing Medical University, 101 Longmian Avenue, 211166, Nanjing, JS, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shi", 
        "givenName": "Dongyan", 
        "id": "sg:person.01147055321.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147055321.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nanjing Medical University", 
          "id": "https://www.grid.ac/institutes/grid.89957.3a", 
          "name": [
            "Department of Immunology, Nanjing Medical University, 101 Longmian Avenue, 211166, Nanjing, JS, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wen", 
        "givenName": "Shuang", 
        "id": "sg:person.015153164223.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015153164223.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Saskatchewan", 
          "id": "https://www.grid.ac/institutes/grid.25152.31", 
          "name": [
            "Department of Pharmacology, College of Medicine, University of Saskatchewan, S7N 5E5, Saskatoon, Saskatchewan, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Lixin", 
        "id": "sg:person.0677557304.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677557304.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nanjing Medical University", 
          "id": "https://www.grid.ac/institutes/grid.89957.3a", 
          "name": [
            "Department of Immunology, Nanjing Medical University, 101 Longmian Avenue, 211166, Nanjing, JS, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhou", 
        "givenName": "Hong", 
        "id": "sg:person.0606013021.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606013021.32"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.immuni.2005.09.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001616606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2005.09.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001616606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1003059107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002612993"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni1328", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004498104", 
          "https://doi.org/10.1038/ni1328"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni1328", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004498104", 
          "https://doi.org/10.1038/ni1328"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni.3370", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004790273", 
          "https://doi.org/10.1038/ni.3370"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jneumeth.2007.04.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006445350"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn1997", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006831469", 
          "https://doi.org/10.1038/nn1997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrn3722", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008765454", 
          "https://doi.org/10.1038/nrn3722"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12974-015-0447-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009239801", 
          "https://doi.org/10.1186/s12974-015-0447-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0166-2236(96)10047-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010350787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12974-015-0316-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014038667", 
          "https://doi.org/10.1186/s12974-015-0316-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12974-015-0316-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014038667", 
          "https://doi.org/10.1186/s12974-015-0316-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-065x.2006.00441.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014708116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.179.4.2551", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015677458"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.3567-08.2009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015708340"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-3940(03)00404-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015985832"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-3940(03)00404-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015985832"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jneuroim.2005.08.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016707776"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jneuroim.2005.08.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016707776"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.coi.2014.09.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016997249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000353645", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022733673"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brainres.2014.12.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023351926"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1604032113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026574639"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri3024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032231504", 
          "https://doi.org/10.1038/nri3024"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.107.151860b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037621407"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.107.151860b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037621407"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brainres.2011.02.045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038633751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.177.11.8103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038896492"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2015.01.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045182720"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1742-2094-8-11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046474719", 
          "https://doi.org/10.1186/1742-2094-8-11"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1201212", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047894633"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbi.2015.06.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047919285"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.0901309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048883559"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0705939104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049063460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1400807", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050371492"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.22-05-01763.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075009286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1400654", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079000156"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev-immunol-051116-052358", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083856878"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12974-017-0823-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084251528", 
          "https://doi.org/10.1186/s12974-017-0823-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12974-017-0823-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084251528", 
          "https://doi.org/10.1186/s12974-017-0823-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.3233-16.2017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084631277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/neu.2016.4900", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085464382"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri.2017.125", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092782786", 
          "https://doi.org/10.1038/nri.2017.125"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroscience.2017.11.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092987158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroscience.2017.11.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092987158"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "BACKGROUND: Interleukin-33 (IL-33) is increasingly being recognized as a key immunomodulatory cytokine in many neurological diseases.\nMETHODS: In the present study, wild-type (WT) and IL-33-/- mice received intracerebroventricular (i.c.v.) injection of lipopolysaccharide (LPS) to induce neuroinflammation. Intravital microscopy was employed to examine leukocyte-endothelial interactions in the brain vasculature. The degree of neutrophil infiltration was determined by myeloperoxidase (MPO) staining. Real-time PCR and western blotting were used to detect endothelial activation. Enzyme-linked immunosorbent assay and quantitative PCR were conducted to detect pro-inflammatory cytokine levels in the brain.\nRESULTS: In IL-33-/- mice, neutrophil infiltration in the brain cortex and leukocyte-endothelial cell interactions in the cerebral microvessels were significantly decreased as compared to WT mice after LPS injection. In addition, IL-33-/- mice showed reduced activation of microglia and cerebral endothelial cells. In vitro results indicated that IL-33 directly activated cerebral endothelial cells and promoted pro-inflammatory cytokine production in LPS-stimulated microglia.\nCONCLUSIONS: Our study indicated that IL-33/ST2 signaling plays an important role in the activation of microglia and cerebral endothelial cells and, therefore, is essential in leukocyte recruitment in brain inflammation. The role of IL-33/ST2 in LPS induced neuroinflammation.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12974-018-1169-6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1034001", 
        "issn": [
          "1742-2094"
        ], 
        "name": "Journal of Neuroinflammation", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "15"
      }
    ], 
    "name": "IL-33/ST2 plays a critical role in endothelial cell activation and microglia-mediated neuroinflammation modulation", 
    "pagination": "136", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "eb3b25a426b8b879d19f7601b8db420aba0e8de9d440faf189d56ccb7717742f"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29728120"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101222974"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12974-018-1169-6"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1103816176"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12974-018-1169-6", 
      "https://app.dimensions.ai/details/publication/pub.1103816176"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:39", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000349_0000000349/records_113679_00000004.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs12974-018-1169-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12974-018-1169-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12974-018-1169-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12974-018-1169-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12974-018-1169-6'


 

This table displays all metadata directly associated to this object as RDF triples.

259 TRIPLES      21 PREDICATES      67 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12974-018-1169-6 schema:about anzsrc-for:11
2 anzsrc-for:1107
3 schema:author N759bff32d690495597ea3440297644f1
4 schema:citation sg:pub.10.1038/ni.3370
5 sg:pub.10.1038/ni1328
6 sg:pub.10.1038/nn1997
7 sg:pub.10.1038/nri.2017.125
8 sg:pub.10.1038/nri3024
9 sg:pub.10.1038/nrn3722
10 sg:pub.10.1186/1742-2094-8-11
11 sg:pub.10.1186/s12974-015-0316-6
12 sg:pub.10.1186/s12974-015-0447-9
13 sg:pub.10.1186/s12974-017-0823-8
14 https://doi.org/10.1016/0166-2236(96)10047-3
15 https://doi.org/10.1016/j.bbi.2015.06.013
16 https://doi.org/10.1016/j.brainres.2011.02.045
17 https://doi.org/10.1016/j.brainres.2014.12.005
18 https://doi.org/10.1016/j.coi.2014.09.004
19 https://doi.org/10.1016/j.immuni.2005.09.015
20 https://doi.org/10.1016/j.jneumeth.2007.04.018
21 https://doi.org/10.1016/j.jneuroim.2005.08.006
22 https://doi.org/10.1016/j.neuron.2015.01.013
23 https://doi.org/10.1016/j.neuroscience.2017.11.028
24 https://doi.org/10.1016/s0304-3940(03)00404-x
25 https://doi.org/10.1073/pnas.0705939104
26 https://doi.org/10.1073/pnas.1003059107
27 https://doi.org/10.1073/pnas.1604032113
28 https://doi.org/10.1089/neu.2016.4900
29 https://doi.org/10.1111/j.1600-065x.2006.00441.x
30 https://doi.org/10.1146/annurev-immunol-051116-052358
31 https://doi.org/10.1159/000353645
32 https://doi.org/10.1161/circresaha.107.151860b
33 https://doi.org/10.1523/jneurosci.22-05-01763.2002
34 https://doi.org/10.1523/jneurosci.3233-16.2017
35 https://doi.org/10.1523/jneurosci.3567-08.2009
36 https://doi.org/10.4049/jimmunol.0901309
37 https://doi.org/10.4049/jimmunol.1201212
38 https://doi.org/10.4049/jimmunol.1400654
39 https://doi.org/10.4049/jimmunol.1400807
40 https://doi.org/10.4049/jimmunol.177.11.8103
41 https://doi.org/10.4049/jimmunol.179.4.2551
42 schema:datePublished 2018-12
43 schema:datePublishedReg 2018-12-01
44 schema:description BACKGROUND: Interleukin-33 (IL-33) is increasingly being recognized as a key immunomodulatory cytokine in many neurological diseases. METHODS: In the present study, wild-type (WT) and IL-33-/- mice received intracerebroventricular (i.c.v.) injection of lipopolysaccharide (LPS) to induce neuroinflammation. Intravital microscopy was employed to examine leukocyte-endothelial interactions in the brain vasculature. The degree of neutrophil infiltration was determined by myeloperoxidase (MPO) staining. Real-time PCR and western blotting were used to detect endothelial activation. Enzyme-linked immunosorbent assay and quantitative PCR were conducted to detect pro-inflammatory cytokine levels in the brain. RESULTS: In IL-33-/- mice, neutrophil infiltration in the brain cortex and leukocyte-endothelial cell interactions in the cerebral microvessels were significantly decreased as compared to WT mice after LPS injection. In addition, IL-33-/- mice showed reduced activation of microglia and cerebral endothelial cells. In vitro results indicated that IL-33 directly activated cerebral endothelial cells and promoted pro-inflammatory cytokine production in LPS-stimulated microglia. CONCLUSIONS: Our study indicated that IL-33/ST2 signaling plays an important role in the activation of microglia and cerebral endothelial cells and, therefore, is essential in leukocyte recruitment in brain inflammation. The role of IL-33/ST2 in LPS induced neuroinflammation.
45 schema:genre research_article
46 schema:inLanguage en
47 schema:isAccessibleForFree true
48 schema:isPartOf N290e6fe9ee0a458aab7f408ee440222c
49 N409e3b97c26442e195b28616c4c3d0d2
50 sg:journal.1034001
51 schema:name IL-33/ST2 plays a critical role in endothelial cell activation and microglia-mediated neuroinflammation modulation
52 schema:pagination 136
53 schema:productId N0199e24830d64295874ef365be12e6a0
54 N1416642fccb64d018d8f8cbb2473cfa3
55 N3a0ceffd82554e3286b570569ea9fd02
56 N3f88dbb642df43ed8fc1111a563ef466
57 N9bd1643d1e264b5ca15c61e5e023d342
58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103816176
59 https://doi.org/10.1186/s12974-018-1169-6
60 schema:sdDatePublished 2019-04-11T10:39
61 schema:sdLicense https://scigraph.springernature.com/explorer/license/
62 schema:sdPublisher N803153a5ea7d480ca37a188d445acadd
63 schema:url https://link.springer.com/10.1186%2Fs12974-018-1169-6
64 sgo:license sg:explorer/license/
65 sgo:sdDataset articles
66 rdf:type schema:ScholarlyArticle
67 N0116383939084f86bb3a93dd570b06e3 rdf:first sg:person.01147055321.49
68 rdf:rest Na0cf8a22a75e4ee4b41312c5dad1e331
69 N0199e24830d64295874ef365be12e6a0 schema:name nlm_unique_id
70 schema:value 101222974
71 rdf:type schema:PropertyValue
72 N1416642fccb64d018d8f8cbb2473cfa3 schema:name readcube_id
73 schema:value eb3b25a426b8b879d19f7601b8db420aba0e8de9d440faf189d56ccb7717742f
74 rdf:type schema:PropertyValue
75 N1df6354e4a3141b49bffa9a4a1974343 rdf:first sg:person.0764513521.35
76 rdf:rest Nc919f2d5a6d34702880bc998e271c133
77 N290e6fe9ee0a458aab7f408ee440222c schema:volumeNumber 15
78 rdf:type schema:PublicationVolume
79 N349b982524554e05bef5fc6066732f28 rdf:first sg:person.0677557304.13
80 rdf:rest Nb82816c263444340ae4924be692a166c
81 N3a0ceffd82554e3286b570569ea9fd02 schema:name pubmed_id
82 schema:value 29728120
83 rdf:type schema:PropertyValue
84 N3a5995ccf1a24fe78a2d1d58c0247b2b rdf:first sg:person.012540462204.57
85 rdf:rest N1df6354e4a3141b49bffa9a4a1974343
86 N3f88dbb642df43ed8fc1111a563ef466 schema:name doi
87 schema:value 10.1186/s12974-018-1169-6
88 rdf:type schema:PropertyValue
89 N409e3b97c26442e195b28616c4c3d0d2 schema:issueNumber 1
90 rdf:type schema:PublicationIssue
91 N759bff32d690495597ea3440297644f1 rdf:first sg:person.014720552424.59
92 rdf:rest Nf00d4d1b39b540b8b37becec0d8e5513
93 N803153a5ea7d480ca37a188d445acadd schema:name Springer Nature - SN SciGraph project
94 rdf:type schema:Organization
95 N9a2e67099d164ec4824f4f32bfd0b773 rdf:first Nd8dc3eb5664e4db9874f77d116c3b410
96 rdf:rest N3a5995ccf1a24fe78a2d1d58c0247b2b
97 N9bd1643d1e264b5ca15c61e5e023d342 schema:name dimensions_id
98 schema:value pub.1103816176
99 rdf:type schema:PropertyValue
100 Na0cf8a22a75e4ee4b41312c5dad1e331 rdf:first sg:person.015153164223.00
101 rdf:rest N349b982524554e05bef5fc6066732f28
102 Na60823bff6204722822263f84a2c6436 schema:affiliation https://www.grid.ac/institutes/grid.89957.3a
103 schema:familyName Liao
104 schema:givenName Xiang
105 rdf:type schema:Person
106 Nb82816c263444340ae4924be692a166c rdf:first sg:person.0606013021.32
107 rdf:rest rdf:nil
108 Nc919f2d5a6d34702880bc998e271c133 rdf:first sg:person.01215170521.64
109 rdf:rest N0116383939084f86bb3a93dd570b06e3
110 Nd8dc3eb5664e4db9874f77d116c3b410 schema:affiliation https://www.grid.ac/institutes/grid.89957.3a
111 schema:familyName Lu
112 schema:givenName Jiahui
113 rdf:type schema:Person
114 Nf00d4d1b39b540b8b37becec0d8e5513 rdf:first Na60823bff6204722822263f84a2c6436
115 rdf:rest N9a2e67099d164ec4824f4f32bfd0b773
116 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
117 schema:name Medical and Health Sciences
118 rdf:type schema:DefinedTerm
119 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
120 schema:name Immunology
121 rdf:type schema:DefinedTerm
122 sg:journal.1034001 schema:issn 1742-2094
123 schema:name Journal of Neuroinflammation
124 rdf:type schema:Periodical
125 sg:person.01147055321.49 schema:affiliation https://www.grid.ac/institutes/grid.89957.3a
126 schema:familyName Shi
127 schema:givenName Dongyan
128 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147055321.49
129 rdf:type schema:Person
130 sg:person.01215170521.64 schema:affiliation https://www.grid.ac/institutes/grid.89957.3a
131 schema:familyName Zhu
132 schema:givenName Xingxing
133 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215170521.64
134 rdf:type schema:Person
135 sg:person.012540462204.57 schema:affiliation https://www.grid.ac/institutes/grid.89957.3a
136 schema:familyName Yao
137 schema:givenName Shu
138 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012540462204.57
139 rdf:type schema:Person
140 sg:person.014720552424.59 schema:affiliation https://www.grid.ac/institutes/grid.89957.3a
141 schema:familyName Cao
142 schema:givenName Kelei
143 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014720552424.59
144 rdf:type schema:Person
145 sg:person.015153164223.00 schema:affiliation https://www.grid.ac/institutes/grid.89957.3a
146 schema:familyName Wen
147 schema:givenName Shuang
148 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015153164223.00
149 rdf:type schema:Person
150 sg:person.0606013021.32 schema:affiliation https://www.grid.ac/institutes/grid.89957.3a
151 schema:familyName Zhou
152 schema:givenName Hong
153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606013021.32
154 rdf:type schema:Person
155 sg:person.0677557304.13 schema:affiliation https://www.grid.ac/institutes/grid.25152.31
156 schema:familyName Liu
157 schema:givenName Lixin
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677557304.13
159 rdf:type schema:Person
160 sg:person.0764513521.35 schema:affiliation https://www.grid.ac/institutes/grid.252957.e
161 schema:familyName Wu
162 schema:givenName Fengjiao
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764513521.35
164 rdf:type schema:Person
165 sg:pub.10.1038/ni.3370 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004790273
166 https://doi.org/10.1038/ni.3370
167 rdf:type schema:CreativeWork
168 sg:pub.10.1038/ni1328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004498104
169 https://doi.org/10.1038/ni1328
170 rdf:type schema:CreativeWork
171 sg:pub.10.1038/nn1997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006831469
172 https://doi.org/10.1038/nn1997
173 rdf:type schema:CreativeWork
174 sg:pub.10.1038/nri.2017.125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092782786
175 https://doi.org/10.1038/nri.2017.125
176 rdf:type schema:CreativeWork
177 sg:pub.10.1038/nri3024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032231504
178 https://doi.org/10.1038/nri3024
179 rdf:type schema:CreativeWork
180 sg:pub.10.1038/nrn3722 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008765454
181 https://doi.org/10.1038/nrn3722
182 rdf:type schema:CreativeWork
183 sg:pub.10.1186/1742-2094-8-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046474719
184 https://doi.org/10.1186/1742-2094-8-11
185 rdf:type schema:CreativeWork
186 sg:pub.10.1186/s12974-015-0316-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014038667
187 https://doi.org/10.1186/s12974-015-0316-6
188 rdf:type schema:CreativeWork
189 sg:pub.10.1186/s12974-015-0447-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009239801
190 https://doi.org/10.1186/s12974-015-0447-9
191 rdf:type schema:CreativeWork
192 sg:pub.10.1186/s12974-017-0823-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084251528
193 https://doi.org/10.1186/s12974-017-0823-8
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1016/0166-2236(96)10047-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010350787
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1016/j.bbi.2015.06.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047919285
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1016/j.brainres.2011.02.045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038633751
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1016/j.brainres.2014.12.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023351926
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1016/j.coi.2014.09.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016997249
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1016/j.immuni.2005.09.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001616606
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1016/j.jneumeth.2007.04.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006445350
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/j.jneuroim.2005.08.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016707776
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/j.neuron.2015.01.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045182720
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/j.neuroscience.2017.11.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092987158
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/s0304-3940(03)00404-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015985832
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1073/pnas.0705939104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049063460
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1073/pnas.1003059107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002612993
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1073/pnas.1604032113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026574639
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1089/neu.2016.4900 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085464382
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1111/j.1600-065x.2006.00441.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014708116
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1146/annurev-immunol-051116-052358 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083856878
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1159/000353645 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022733673
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1161/circresaha.107.151860b schema:sameAs https://app.dimensions.ai/details/publication/pub.1037621407
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1523/jneurosci.22-05-01763.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075009286
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1523/jneurosci.3233-16.2017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084631277
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1523/jneurosci.3567-08.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015708340
238 rdf:type schema:CreativeWork
239 https://doi.org/10.4049/jimmunol.0901309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048883559
240 rdf:type schema:CreativeWork
241 https://doi.org/10.4049/jimmunol.1201212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047894633
242 rdf:type schema:CreativeWork
243 https://doi.org/10.4049/jimmunol.1400654 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079000156
244 rdf:type schema:CreativeWork
245 https://doi.org/10.4049/jimmunol.1400807 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050371492
246 rdf:type schema:CreativeWork
247 https://doi.org/10.4049/jimmunol.177.11.8103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038896492
248 rdf:type schema:CreativeWork
249 https://doi.org/10.4049/jimmunol.179.4.2551 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015677458
250 rdf:type schema:CreativeWork
251 https://www.grid.ac/institutes/grid.25152.31 schema:alternateName University of Saskatchewan
252 schema:name Department of Pharmacology, College of Medicine, University of Saskatchewan, S7N 5E5, Saskatoon, Saskatchewan, Canada
253 rdf:type schema:Organization
254 https://www.grid.ac/institutes/grid.252957.e schema:alternateName Bengbu Medical College
255 schema:name Department of Immunology, Anhui Provincial Key Laboratory of Infection and Immunity, Bengbu Medical College, 233030, Bengbu, China
256 rdf:type schema:Organization
257 https://www.grid.ac/institutes/grid.89957.3a schema:alternateName Nanjing Medical University
258 schema:name Department of Immunology, Nanjing Medical University, 101 Longmian Avenue, 211166, Nanjing, JS, China
259 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...