The effect of excess weight on circulating inflammatory cytokines in drug-naïve first-episode psychosis individuals View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

María Juncal-Ruiz, Laura Riesco-Dávila, Víctor Ortiz-García de la Foz, Mariluz Ramírez-Bonilla, Obdulia Martínez-García, Juan Irure-Ventura, Juan Carlos Leza, Marcos López-Hoyos, Benedicto Crespo-Facorro

ABSTRACT

BACKGROUND: Low-grade inflammation has been repeatedly associated with both excess weight and psychosis. However, no previous studies have addressed the direct effect of body mass index (BMI) on basal serum cytokines in individuals with first-episode psychosis (FEP). OBJECTIVES: The aim of this study is to analyze the effect of BMI on basal serum cytokine levels in FEP patients and control subjects, separating the total sample into two groups: normal-weight and overweight individuals. METHODS: This is a prospective and open-label study. We selected 75 FEP patients and 75 healthy controls with similar characteristics to patients according to the following variables: sex, age, and cannabis and tobacco consumption. Both controls and patients were separated into two groups according to their BMI: subjects with a BMI under 25 were considered as normal weight and those with a BMI equal to or more than 25 were considered as overweight. Serum levels of 21 cytokines/chemokines were measured at baseline using the Human High Sensitivity T Cell Magnetic Bead Panel protocol from the Milliplex® Map Kit. We compared the basal serum levels of the 21 cytokines between control and patient groups according to their BMI. RESULTS: In the normal-weight group, IL-8 was the only cytokine that was higher in patients than in the control group (p = 0.001), whereas in the overweight group, serum levels of two pro-inflammatory cytokines (IL-6, p = 0.000; IL-1β, p = 0.003), two chemokines (IL-8, p = 0.001; MIP-1β, p = 0.001), four Th-1 and Th-2 cytokines (IL-13, p = 0.009; IL-2, p = 0.001; IL-7, p = 0.001; IL-12p70, p = 0.010), and one Type-3 cytokine (IL-23, p = 0.010) were higher in patients than in controls. CONCLUSIONS: Most differences in the basal serum cytokine levels between patients and healthy volunteers were found in the overweight group. These findings suggest that excess weight can alter the homeostasis of the immune system and therefore may have an additive pro-inflammatory effect on the one produced by psychosis in the central nervous system. More... »

PAGES

63

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12974-018-1096-6

DOI

http://dx.doi.org/10.1186/s12974-018-1096-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1101279267

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29490673


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Body Mass Index", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cohort Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytokines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Longitudinal Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Overweight", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Psychotic Disorders", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Weight Gain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Cantabria", 
          "id": "https://www.grid.ac/institutes/grid.7821.c", 
          "name": [
            "Department of Psychiatry, Sierrallana Hospital, IDIVAL, School of Medicine, University of Cantabria, Torrelavega, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Juncal-Ruiz", 
        "givenName": "Mar\u00eda", 
        "id": "sg:person.014115071457.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014115071457.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Immunology, Marqu\u00e9s de Valdecilla University Hospital, IDIVAL, School of Medicine, University of Cantabria, Santander, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Riesco-D\u00e1vila", 
        "givenName": "Laura", 
        "id": "sg:person.07712404460.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07712404460.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Psychiatry, Marqu\u00e9s de Valdecilla University Hospital, IDIVAL, School of Medicine, University of Cantabria, Santander, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de la Foz", 
        "givenName": "V\u00edctor Ortiz-Garc\u00eda", 
        "id": "sg:person.01230060137.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230060137.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Psychiatry, Marqu\u00e9s de Valdecilla University Hospital, IDIVAL, School of Medicine, University of Cantabria, Santander, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ram\u00edrez-Bonilla", 
        "givenName": "Mariluz", 
        "id": "sg:person.0705071034.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705071034.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Psychiatry, Marqu\u00e9s de Valdecilla University Hospital, IDIVAL, School of Medicine, University of Cantabria, Santander, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mart\u00ednez-Garc\u00eda", 
        "givenName": "Obdulia", 
        "id": "sg:person.01143564425.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143564425.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Immunology, Marqu\u00e9s de Valdecilla University Hospital, IDIVAL, School of Medicine, University of Cantabria, Santander, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Irure-Ventura", 
        "givenName": "Juan", 
        "id": "sg:person.014760151265.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014760151265.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universitario 12 De Octubre", 
          "id": "https://www.grid.ac/institutes/grid.144756.5", 
          "name": [
            "Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM), Complutense University, Madrid, Spain", 
            "Department of Pharmacology, Faculty of Medicine, Complutense University, Madrid, Spain", 
            "Instituto de Investigaci\u00f3n Sanitaria (IIS) Hospital 12 de Octubre (i+12), Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leza", 
        "givenName": "Juan Carlos", 
        "id": "sg:person.0575436273.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575436273.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Immunology, Marqu\u00e9s de Valdecilla University Hospital, IDIVAL, School of Medicine, University of Cantabria, Santander, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "L\u00f3pez-Hoyos", 
        "givenName": "Marcos", 
        "id": "sg:person.01144465070.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144465070.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental", 
          "id": "https://www.grid.ac/institutes/grid.469673.9", 
          "name": [
            "Department of Psychiatry, Marqu\u00e9s de Valdecilla University Hospital, IDIVAL, School of Medicine, University of Cantabria, Santander, Spain", 
            "Centro de investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM), Santander, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Crespo-Facorro", 
        "givenName": "Benedicto", 
        "id": "sg:person.0747720760.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747720760.05"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.bbi.2014.01.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000972164"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/mp.2012.110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002344102", 
          "https://doi.org/10.1038/mp.2012.110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni.2431", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003900785", 
          "https://doi.org/10.1038/ni.2431"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2010/289645", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004118364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-3223(97)85394-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005287095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jpsychores.2015.06.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006206228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00213-013-3382-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007921769", 
          "https://doi.org/10.1007/s00213-013-3382-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016014529", 
          "https://doi.org/10.1038/nature07201"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/schbul/sbu052", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017999393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/schbul/sbt001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024498014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.psyneuen.2012.04.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024801587"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.psyneuen.2012.04.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024801587"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ijnp/pyu042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025509275"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biopsych.2011.04.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034228537"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbi.2012.06.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037716692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cellimm.2012.01.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041138874"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ijnp/pyu037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041927620"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.schres.2013.02.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049041916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1751-7893.2008.00074.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049228876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0121971", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051429686"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pnpbp.2014.01.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052205496"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.psychres.2006.08.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053185318"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/schbul/sbv002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060023922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1503/jpn.150195", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067426866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1503/jpn.150195", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067426866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/tp.2017.4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084133426", 
          "https://doi.org/10.1038/tp.2017.4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.17305/bjbms.2017.1381", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084939976"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4239/wjd.v8.i8.390", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091196715"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/ijms18112238", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092339774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00406-017-0847-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092615899", 
          "https://doi.org/10.1007/s00406-017-0847-1"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "BACKGROUND: Low-grade inflammation has been repeatedly associated with both excess weight and psychosis. However, no previous studies have addressed the direct effect of body mass index (BMI) on basal serum cytokines in individuals with first-episode psychosis (FEP).\nOBJECTIVES: The aim of this study is to analyze the effect of BMI on basal serum cytokine levels in FEP patients and control subjects, separating the total sample into two groups: normal-weight and overweight individuals.\nMETHODS: This is a prospective and open-label study. We selected 75 FEP patients and 75 healthy controls with similar characteristics to patients according to the following variables: sex, age, and cannabis and tobacco consumption. Both controls and patients were separated into two groups according to their BMI: subjects with a BMI under 25 were considered as normal weight and those with a BMI equal to or more than 25 were considered as overweight. Serum levels of 21 cytokines/chemokines were measured at baseline using the Human High Sensitivity T Cell Magnetic Bead Panel protocol from the Milliplex\u00ae Map Kit. We compared the basal serum levels of the 21 cytokines between control and patient groups according to their BMI.\nRESULTS: In the normal-weight group, IL-8 was the only cytokine that was higher in patients than in the control group (p\u2009=\u20090.001), whereas in the overweight group, serum levels of two pro-inflammatory cytokines (IL-6, p\u2009=\u20090.000; IL-1\u03b2, p\u2009=\u20090.003), two chemokines (IL-8, p\u2009=\u20090.001; MIP-1\u03b2, p\u2009=\u20090.001), four Th-1 and Th-2 cytokines (IL-13, p\u2009=\u20090.009; IL-2, p\u2009=\u20090.001; IL-7, p\u2009=\u20090.001; IL-12p70, p\u2009=\u20090.010), and one Type-3 cytokine (IL-23, p\u2009=\u20090.010) were higher in patients than in controls.\nCONCLUSIONS: Most differences in the basal serum cytokine levels between patients and healthy volunteers were found in the overweight group. These findings suggest that excess weight can alter the homeostasis of the immune system and therefore may have an additive pro-inflammatory effect on the one produced by psychosis in the central nervous system.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12974-018-1096-6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1034001", 
        "issn": [
          "1742-2094"
        ], 
        "name": "Journal of Neuroinflammation", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "15"
      }
    ], 
    "name": "The effect of excess weight on circulating inflammatory cytokines in drug-na\u00efve first-episode psychosis individuals", 
    "pagination": "63", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12974-018-1096-6"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "ad094955d30cbbc677ee14ae27b727d705d67ef6e6e5daa127be87fd80869869"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1101279267"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101222974"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29490673"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12974-018-1096-6", 
      "https://app.dimensions.ai/details/publication/pub.1101279267"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-15T09:01", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000375_0000000375/records_91447_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs12974-018-1096-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12974-018-1096-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12974-018-1096-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12974-018-1096-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12974-018-1096-6'


 

This table displays all metadata directly associated to this object as RDF triples.

287 TRIPLES      21 PREDICATES      70 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12974-018-1096-6 schema:about N12c06e1e781a4acc8b7ef94b0c564052
2 N243bca6e58ec4ba5ad4aad29f25c2d15
3 N3c62248e338142acb20c26702dffeb55
4 N5feb7fee552f451fbd67b1b3ddabb96c
5 N87dd47d8ae504a2fb1489906f91a09a0
6 N89a241c163e9431483c0d0548b3e254f
7 N97880e26accb4d69933781da2558fd1a
8 N9c2458944ad3490a9f84c0385f4b8b26
9 N9d61f604fb8e4abba0caccf006c4638b
10 Na5aed9a023fd4f7cb15e19553f909c59
11 Na8fcbd11f1a5415a9dbd6904b0c29c6a
12 Nbbb48aeae1e24464be17d31cefaac344
13 Nbe5993458391455e97366813231fac99
14 anzsrc-for:11
15 anzsrc-for:1103
16 schema:author N1dafaf7d86584a7ea4e30360d252e957
17 schema:citation sg:pub.10.1007/s00213-013-3382-4
18 sg:pub.10.1007/s00406-017-0847-1
19 sg:pub.10.1038/mp.2012.110
20 sg:pub.10.1038/nature07201
21 sg:pub.10.1038/ni.2431
22 sg:pub.10.1038/tp.2017.4
23 https://doi.org/10.1016/j.bbi.2012.06.010
24 https://doi.org/10.1016/j.bbi.2014.01.018
25 https://doi.org/10.1016/j.biopsych.2011.04.013
26 https://doi.org/10.1016/j.cellimm.2012.01.001
27 https://doi.org/10.1016/j.jpsychores.2015.06.011
28 https://doi.org/10.1016/j.pnpbp.2014.01.001
29 https://doi.org/10.1016/j.psychres.2006.08.005
30 https://doi.org/10.1016/j.psyneuen.2012.04.001
31 https://doi.org/10.1016/j.schres.2013.02.017
32 https://doi.org/10.1016/s0006-3223(97)85394-2
33 https://doi.org/10.1093/ijnp/pyu037
34 https://doi.org/10.1093/ijnp/pyu042
35 https://doi.org/10.1093/schbul/sbt001
36 https://doi.org/10.1093/schbul/sbu052
37 https://doi.org/10.1093/schbul/sbv002
38 https://doi.org/10.1111/j.1751-7893.2008.00074.x
39 https://doi.org/10.1155/2010/289645
40 https://doi.org/10.1371/journal.pone.0121971
41 https://doi.org/10.1503/jpn.150195
42 https://doi.org/10.17305/bjbms.2017.1381
43 https://doi.org/10.3390/ijms18112238
44 https://doi.org/10.4239/wjd.v8.i8.390
45 schema:datePublished 2018-12
46 schema:datePublishedReg 2018-12-01
47 schema:description BACKGROUND: Low-grade inflammation has been repeatedly associated with both excess weight and psychosis. However, no previous studies have addressed the direct effect of body mass index (BMI) on basal serum cytokines in individuals with first-episode psychosis (FEP). OBJECTIVES: The aim of this study is to analyze the effect of BMI on basal serum cytokine levels in FEP patients and control subjects, separating the total sample into two groups: normal-weight and overweight individuals. METHODS: This is a prospective and open-label study. We selected 75 FEP patients and 75 healthy controls with similar characteristics to patients according to the following variables: sex, age, and cannabis and tobacco consumption. Both controls and patients were separated into two groups according to their BMI: subjects with a BMI under 25 were considered as normal weight and those with a BMI equal to or more than 25 were considered as overweight. Serum levels of 21 cytokines/chemokines were measured at baseline using the Human High Sensitivity T Cell Magnetic Bead Panel protocol from the Milliplex® Map Kit. We compared the basal serum levels of the 21 cytokines between control and patient groups according to their BMI. RESULTS: In the normal-weight group, IL-8 was the only cytokine that was higher in patients than in the control group (p = 0.001), whereas in the overweight group, serum levels of two pro-inflammatory cytokines (IL-6, p = 0.000; IL-1β, p = 0.003), two chemokines (IL-8, p = 0.001; MIP-1β, p = 0.001), four Th-1 and Th-2 cytokines (IL-13, p = 0.009; IL-2, p = 0.001; IL-7, p = 0.001; IL-12p70, p = 0.010), and one Type-3 cytokine (IL-23, p = 0.010) were higher in patients than in controls. CONCLUSIONS: Most differences in the basal serum cytokine levels between patients and healthy volunteers were found in the overweight group. These findings suggest that excess weight can alter the homeostasis of the immune system and therefore may have an additive pro-inflammatory effect on the one produced by psychosis in the central nervous system.
48 schema:genre research_article
49 schema:inLanguage en
50 schema:isAccessibleForFree true
51 schema:isPartOf Na6ffae8976e647b1b61c480c163b74c9
52 Nac50e4429e5e47e8bc00b8cca9311dae
53 sg:journal.1034001
54 schema:name The effect of excess weight on circulating inflammatory cytokines in drug-naïve first-episode psychosis individuals
55 schema:pagination 63
56 schema:productId N93aafba44293481dbef2d641f84750cd
57 N950e09a2b5d246ccb04aada05478dd35
58 Na24b5ed95cdc41cb84a16837f4649bec
59 Nbe1457e2ba4545859591b121e994848f
60 Nd57201baae824998a076c4aaf0003a4c
61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101279267
62 https://doi.org/10.1186/s12974-018-1096-6
63 schema:sdDatePublished 2019-04-15T09:01
64 schema:sdLicense https://scigraph.springernature.com/explorer/license/
65 schema:sdPublisher Nab89bec3bd0b43f197774895e7a4cad6
66 schema:url https://link.springer.com/10.1186%2Fs12974-018-1096-6
67 sgo:license sg:explorer/license/
68 sgo:sdDataset articles
69 rdf:type schema:ScholarlyArticle
70 N0608a5e18adb4b59aba86e72dc40dd24 rdf:first sg:person.01143564425.45
71 rdf:rest N7761fe52e41245738cd40e345b9ac937
72 N12c06e1e781a4acc8b7ef94b0c564052 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Humans
74 rdf:type schema:DefinedTerm
75 N1be807ac2c1345ea89c62e221ed0808b rdf:first sg:person.07712404460.31
76 rdf:rest N4017c6e81d0647bca7134d4bf268cee1
77 N1dafaf7d86584a7ea4e30360d252e957 rdf:first sg:person.014115071457.98
78 rdf:rest N1be807ac2c1345ea89c62e221ed0808b
79 N243bca6e58ec4ba5ad4aad29f25c2d15 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Female
81 rdf:type schema:DefinedTerm
82 N3c62248e338142acb20c26702dffeb55 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Young Adult
84 rdf:type schema:DefinedTerm
85 N4017c6e81d0647bca7134d4bf268cee1 rdf:first sg:person.01230060137.10
86 rdf:rest Nf796c00ea4464f4dbae5e444a32883b0
87 N403aa886659b46d584a2cf407fcb726e rdf:first sg:person.0747720760.05
88 rdf:rest rdf:nil
89 N50e8cd6ec1614b9dbbc93ed6f7f65309 schema:name Department of Immunology, Marqués de Valdecilla University Hospital, IDIVAL, School of Medicine, University of Cantabria, Santander, Spain
90 rdf:type schema:Organization
91 N5feb7fee552f451fbd67b1b3ddabb96c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Longitudinal Studies
93 rdf:type schema:DefinedTerm
94 N7761fe52e41245738cd40e345b9ac937 rdf:first sg:person.014760151265.26
95 rdf:rest Nb23250df0b7043db9ca85857634f17b0
96 N87dd47d8ae504a2fb1489906f91a09a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Body Mass Index
98 rdf:type schema:DefinedTerm
99 N89a241c163e9431483c0d0548b3e254f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Psychotic Disorders
101 rdf:type schema:DefinedTerm
102 N93aafba44293481dbef2d641f84750cd schema:name doi
103 schema:value 10.1186/s12974-018-1096-6
104 rdf:type schema:PropertyValue
105 N950e09a2b5d246ccb04aada05478dd35 schema:name readcube_id
106 schema:value ad094955d30cbbc677ee14ae27b727d705d67ef6e6e5daa127be87fd80869869
107 rdf:type schema:PropertyValue
108 N97880e26accb4d69933781da2558fd1a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Cytokines
110 rdf:type schema:DefinedTerm
111 N9c2458944ad3490a9f84c0385f4b8b26 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Weight Gain
113 rdf:type schema:DefinedTerm
114 N9d61f604fb8e4abba0caccf006c4638b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Overweight
116 rdf:type schema:DefinedTerm
117 Na24b5ed95cdc41cb84a16837f4649bec schema:name pubmed_id
118 schema:value 29490673
119 rdf:type schema:PropertyValue
120 Na5aed9a023fd4f7cb15e19553f909c59 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Adult
122 rdf:type schema:DefinedTerm
123 Na6ffae8976e647b1b61c480c163b74c9 schema:volumeNumber 15
124 rdf:type schema:PublicationVolume
125 Na8102cf577ba4a7497f81e3b4f0d85a8 schema:name Department of Psychiatry, Marqués de Valdecilla University Hospital, IDIVAL, School of Medicine, University of Cantabria, Santander, Spain
126 rdf:type schema:Organization
127 Na8ce782405724760b337f4bc2a9dc0ff schema:name Department of Immunology, Marqués de Valdecilla University Hospital, IDIVAL, School of Medicine, University of Cantabria, Santander, Spain
128 rdf:type schema:Organization
129 Na8fcbd11f1a5415a9dbd6904b0c29c6a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Prospective Studies
131 rdf:type schema:DefinedTerm
132 Nab89bec3bd0b43f197774895e7a4cad6 schema:name Springer Nature - SN SciGraph project
133 rdf:type schema:Organization
134 Nac50e4429e5e47e8bc00b8cca9311dae schema:issueNumber 1
135 rdf:type schema:PublicationIssue
136 Nb23250df0b7043db9ca85857634f17b0 rdf:first sg:person.0575436273.61
137 rdf:rest Nc5d032b73e4c43d8a19eea7dcc82fb10
138 Nb9903533670c43d580472e60f5885996 schema:name Department of Psychiatry, Marqués de Valdecilla University Hospital, IDIVAL, School of Medicine, University of Cantabria, Santander, Spain
139 rdf:type schema:Organization
140 Nbbb48aeae1e24464be17d31cefaac344 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Male
142 rdf:type schema:DefinedTerm
143 Nbe1457e2ba4545859591b121e994848f schema:name nlm_unique_id
144 schema:value 101222974
145 rdf:type schema:PropertyValue
146 Nbe5993458391455e97366813231fac99 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Cohort Studies
148 rdf:type schema:DefinedTerm
149 Nc09e0224dbac45e5a22e7b06d2b259e4 schema:name Department of Psychiatry, Marqués de Valdecilla University Hospital, IDIVAL, School of Medicine, University of Cantabria, Santander, Spain
150 rdf:type schema:Organization
151 Nc5d032b73e4c43d8a19eea7dcc82fb10 rdf:first sg:person.01144465070.55
152 rdf:rest N403aa886659b46d584a2cf407fcb726e
153 Nd57201baae824998a076c4aaf0003a4c schema:name dimensions_id
154 schema:value pub.1101279267
155 rdf:type schema:PropertyValue
156 Nda91df8b6d584bdc9e1b7471fbf17b6a schema:name Department of Immunology, Marqués de Valdecilla University Hospital, IDIVAL, School of Medicine, University of Cantabria, Santander, Spain
157 rdf:type schema:Organization
158 Nf796c00ea4464f4dbae5e444a32883b0 rdf:first sg:person.0705071034.59
159 rdf:rest N0608a5e18adb4b59aba86e72dc40dd24
160 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
161 schema:name Medical and Health Sciences
162 rdf:type schema:DefinedTerm
163 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
164 schema:name Clinical Sciences
165 rdf:type schema:DefinedTerm
166 sg:journal.1034001 schema:issn 1742-2094
167 schema:name Journal of Neuroinflammation
168 rdf:type schema:Periodical
169 sg:person.01143564425.45 schema:affiliation Na8102cf577ba4a7497f81e3b4f0d85a8
170 schema:familyName Martínez-García
171 schema:givenName Obdulia
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143564425.45
173 rdf:type schema:Person
174 sg:person.01144465070.55 schema:affiliation N50e8cd6ec1614b9dbbc93ed6f7f65309
175 schema:familyName López-Hoyos
176 schema:givenName Marcos
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144465070.55
178 rdf:type schema:Person
179 sg:person.01230060137.10 schema:affiliation Nc09e0224dbac45e5a22e7b06d2b259e4
180 schema:familyName de la Foz
181 schema:givenName Víctor Ortiz-García
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230060137.10
183 rdf:type schema:Person
184 sg:person.014115071457.98 schema:affiliation https://www.grid.ac/institutes/grid.7821.c
185 schema:familyName Juncal-Ruiz
186 schema:givenName María
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014115071457.98
188 rdf:type schema:Person
189 sg:person.014760151265.26 schema:affiliation Nda91df8b6d584bdc9e1b7471fbf17b6a
190 schema:familyName Irure-Ventura
191 schema:givenName Juan
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014760151265.26
193 rdf:type schema:Person
194 sg:person.0575436273.61 schema:affiliation https://www.grid.ac/institutes/grid.144756.5
195 schema:familyName Leza
196 schema:givenName Juan Carlos
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575436273.61
198 rdf:type schema:Person
199 sg:person.0705071034.59 schema:affiliation Nb9903533670c43d580472e60f5885996
200 schema:familyName Ramírez-Bonilla
201 schema:givenName Mariluz
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705071034.59
203 rdf:type schema:Person
204 sg:person.0747720760.05 schema:affiliation https://www.grid.ac/institutes/grid.469673.9
205 schema:familyName Crespo-Facorro
206 schema:givenName Benedicto
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747720760.05
208 rdf:type schema:Person
209 sg:person.07712404460.31 schema:affiliation Na8ce782405724760b337f4bc2a9dc0ff
210 schema:familyName Riesco-Dávila
211 schema:givenName Laura
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07712404460.31
213 rdf:type schema:Person
214 sg:pub.10.1007/s00213-013-3382-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007921769
215 https://doi.org/10.1007/s00213-013-3382-4
216 rdf:type schema:CreativeWork
217 sg:pub.10.1007/s00406-017-0847-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092615899
218 https://doi.org/10.1007/s00406-017-0847-1
219 rdf:type schema:CreativeWork
220 sg:pub.10.1038/mp.2012.110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002344102
221 https://doi.org/10.1038/mp.2012.110
222 rdf:type schema:CreativeWork
223 sg:pub.10.1038/nature07201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016014529
224 https://doi.org/10.1038/nature07201
225 rdf:type schema:CreativeWork
226 sg:pub.10.1038/ni.2431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003900785
227 https://doi.org/10.1038/ni.2431
228 rdf:type schema:CreativeWork
229 sg:pub.10.1038/tp.2017.4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084133426
230 https://doi.org/10.1038/tp.2017.4
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/j.bbi.2012.06.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037716692
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/j.bbi.2014.01.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000972164
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/j.biopsych.2011.04.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034228537
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/j.cellimm.2012.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041138874
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/j.jpsychores.2015.06.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006206228
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1016/j.pnpbp.2014.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052205496
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1016/j.psychres.2006.08.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053185318
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1016/j.psyneuen.2012.04.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024801587
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1016/j.schres.2013.02.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049041916
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/s0006-3223(97)85394-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005287095
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1093/ijnp/pyu037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041927620
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1093/ijnp/pyu042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025509275
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1093/schbul/sbt001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024498014
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1093/schbul/sbu052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017999393
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1093/schbul/sbv002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060023922
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1111/j.1751-7893.2008.00074.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049228876
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1155/2010/289645 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004118364
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1371/journal.pone.0121971 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051429686
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1503/jpn.150195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067426866
269 rdf:type schema:CreativeWork
270 https://doi.org/10.17305/bjbms.2017.1381 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084939976
271 rdf:type schema:CreativeWork
272 https://doi.org/10.3390/ijms18112238 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092339774
273 rdf:type schema:CreativeWork
274 https://doi.org/10.4239/wjd.v8.i8.390 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091196715
275 rdf:type schema:CreativeWork
276 https://www.grid.ac/institutes/grid.144756.5 schema:alternateName Hospital Universitario 12 De Octubre
277 schema:name Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Complutense University, Madrid, Spain
278 Department of Pharmacology, Faculty of Medicine, Complutense University, Madrid, Spain
279 Instituto de Investigación Sanitaria (IIS) Hospital 12 de Octubre (i+12), Madrid, Spain
280 rdf:type schema:Organization
281 https://www.grid.ac/institutes/grid.469673.9 schema:alternateName Centro de Investigación Biomédica en Red de Salud Mental
282 schema:name Centro de investigación Biomédica en Red de Salud Mental (CIBERSAM), Santander, Spain
283 Department of Psychiatry, Marqués de Valdecilla University Hospital, IDIVAL, School of Medicine, University of Cantabria, Santander, Spain
284 rdf:type schema:Organization
285 https://www.grid.ac/institutes/grid.7821.c schema:alternateName University of Cantabria
286 schema:name Department of Psychiatry, Sierrallana Hospital, IDIVAL, School of Medicine, University of Cantabria, Torrelavega, Spain
287 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...