Pro-epileptogenic effects of viral-like inflammation in both mature and immature brains View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Nina Dupuis, Andrey Mazarati, Béatrice Desnous, Vibol Chhor, Bobbi Fleiss, Tifenn Le Charpentier, Sophie Lebon, Zsolt Csaba, Pierre Gressens, Pascal Dournaud, Stéphane Auvin

ABSTRACT

BACKGROUND: Infectious encephalitides are most often associated with acute seizures during the infection period and are risk factors for the development of epilepsy at later times. Mechanisms of viral encephalitis-induced epileptogenesis are poorly understood. Here, we evaluated the contribution of viral encephalitis-associated inflammation to ictogenesis and epileptogenesis using a rapid kindling protocol in rats. In addition, we examined whether minocycline can improve outcomes of viral-like brain inflammation. METHODS: To produce viral-like inflammation, polyinosinic-polycytidylic acid (PIC), a toll-like receptor 3 (TLR3) agonist, was applied to microglial/macrophage cell cultures and to the hippocampus of postnatal day 13 (P13) and postnatal day 74 (P74) rats. Cell cultures permit the examination of the inflammation induced by PIC, while the in vivo setting better suits the analysis of cytokine production and the effects of inflammation on epileptogenesis. Minocycline (50 mg/kg) was injected intraperitoneally for 3 consecutive days prior to the kindling procedure to evaluate its effects on inflammation and epileptogenesis. RESULTS: PIC injection facilitated kindling epileptogenesis, which was evident as an increase in the number of full limbic seizures at both ages. Furthermore, in P14 rats, we observed a faster seizure onset and prolonged retention of the kindling state. PIC administration also led to an increase in interleukin 1β (IL-1β) levels in the hippocampus in P14 and P75 rats. Treatment with minocycline reversed neither the pro-epileptogenic effects of PIC nor the increase of IL-1β in the hippocampus in both P14 and P75 rats. CONCLUSIONS: Hippocampal injection of PIC facilitates rapid kindling epileptogenesis at both P14 and P75, suggesting that viral-induced inflammation increases epileptogenesis irrespective of brain maturation. Minocycline, however, was unable to reverse the increase of epileptogenesis, which might be linked to its absence of effect on hippocampal IL-1β levels at both ages. More... »

PAGES

307

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12974-016-0773-6

DOI

http://dx.doi.org/10.1186/s12974-016-0773-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049160702

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27955671


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Age Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals, Newborn", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anticonvulsants", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antiviral Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytokines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Encephalitis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Encephalitis, Viral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epilepsy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hippocampus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kindling, Neurologic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Macrophages", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microglia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Minocycline", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Poly I-C", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Wistar", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Statistics, Nonparametric", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Paris Diderot University", 
          "id": "https://www.grid.ac/institutes/grid.7452.4", 
          "name": [
            "INSERM, U1141, 75019, Paris, France", 
            "Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, INSERM UMR1141, 75019, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dupuis", 
        "givenName": "Nina", 
        "id": "sg:person.01255046700.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255046700.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California Los Angeles", 
          "id": "https://www.grid.ac/institutes/grid.19006.3e", 
          "name": [
            "Department of Pediatrics, Neurology division and Children\u2019s Discovery and Innovation Institute, David Geffen School of Medicine at UCLA, 90095, Los Angeles, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mazarati", 
        "givenName": "Andrey", 
        "id": "sg:person.014352756537.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014352756537.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Robert Debr\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.413235.2", 
          "name": [
            "INSERM, U1141, 75019, Paris, France", 
            "Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, INSERM UMR1141, 75019, Paris, France", 
            "AP-HP, H\u00f4pital Robert Debr\u00e9, Service de Neurologie P\u00e9diatrique, 75019, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Desnous", 
        "givenName": "B\u00e9atrice", 
        "id": "sg:person.01366250056.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366250056.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paris Diderot University", 
          "id": "https://www.grid.ac/institutes/grid.7452.4", 
          "name": [
            "INSERM, U1141, 75019, Paris, France", 
            "Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, INSERM UMR1141, 75019, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chhor", 
        "givenName": "Vibol", 
        "id": "sg:person.01352304034.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352304034.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paris Diderot University", 
          "id": "https://www.grid.ac/institutes/grid.7452.4", 
          "name": [
            "INSERM, U1141, 75019, Paris, France", 
            "Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, INSERM UMR1141, 75019, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fleiss", 
        "givenName": "Bobbi", 
        "id": "sg:person.0753527762.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753527762.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paris Diderot University", 
          "id": "https://www.grid.ac/institutes/grid.7452.4", 
          "name": [
            "INSERM, U1141, 75019, Paris, France", 
            "Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, INSERM UMR1141, 75019, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Le Charpentier", 
        "givenName": "Tifenn", 
        "id": "sg:person.01011241534.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011241534.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paris Diderot University", 
          "id": "https://www.grid.ac/institutes/grid.7452.4", 
          "name": [
            "INSERM, U1141, 75019, Paris, France", 
            "Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, INSERM UMR1141, 75019, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lebon", 
        "givenName": "Sophie", 
        "id": "sg:person.01050737222.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050737222.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paris Diderot University", 
          "id": "https://www.grid.ac/institutes/grid.7452.4", 
          "name": [
            "INSERM, U1141, 75019, Paris, France", 
            "Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, INSERM UMR1141, 75019, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Csaba", 
        "givenName": "Zsolt", 
        "id": "sg:person.0762613765.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762613765.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Robert Debr\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.413235.2", 
          "name": [
            "INSERM, U1141, 75019, Paris, France", 
            "Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, INSERM UMR1141, 75019, Paris, France", 
            "AP-HP, H\u00f4pital Robert Debr\u00e9, Service de Neurologie P\u00e9diatrique, 75019, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gressens", 
        "givenName": "Pierre", 
        "id": "sg:person.0643134421.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643134421.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paris Diderot University", 
          "id": "https://www.grid.ac/institutes/grid.7452.4", 
          "name": [
            "INSERM, U1141, 75019, Paris, France", 
            "Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, INSERM UMR1141, 75019, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dournaud", 
        "givenName": "Pascal", 
        "id": "sg:person.01105222734.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105222734.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Robert Debr\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.413235.2", 
          "name": [
            "INSERM, U1141, 75019, Paris, France", 
            "Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, INSERM UMR1141, 75019, Paris, France", 
            "AP-HP, H\u00f4pital Robert Debr\u00e9, Service de Neurologie P\u00e9diatrique, 75019, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Auvin", 
        "givenName": "St\u00e9phane", 
        "id": "sg:person.01157744314.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157744314.35"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/ana.410210106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000802393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.2005.03219.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001582202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.2005.03219.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001582202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/b978-012088554-1/50043-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001812902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1528-1167.2007.00987.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001946890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0306239101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003064508"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.2007.05171.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003317003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000206281.77178.ac", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003473980"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000206281.77178.ac", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003473980"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000206281.77178.ac", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003473980"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/glia.22612", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004635929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1528-1167.2009.02390.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005904612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1528-1167.2009.02390.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005904612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nbd.2007.08.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006124457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1742-2094-10-30", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006155447", 
          "https://doi.org/10.1186/1742-2094-10-30"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.173.6.3916", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008927643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/b978-0-444-52898-8.00010-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009939148"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3201/eid0902.020218", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014498708"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/nen.0b013e3181ffc420", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014572401"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1528-1167.2005.00294.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018917175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1528-1167.2005.00294.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018917175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.23.13496", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019053748"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.c000405200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019886692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.02747-12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021032794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1528-1167.2008.01674.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021337405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.05738-11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022460506"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1742-2094-5-15", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022515428", 
          "https://doi.org/10.1186/1742-2094-5-15"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.00458-11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027408782"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nbd.2008.05.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027679800"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35099560", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031094923", 
          "https://doi.org/10.1038/35099560"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35099560", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031094923", 
          "https://doi.org/10.1038/35099560"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1528-1167.2010.02607.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031193402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1528-1167.2010.02607.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031193402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s13311-011-0039-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034790244", 
          "https://doi.org/10.1007/s13311-011-0039-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yebeh.2012.03.035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035926346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.20358", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036606959"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.seizure.2013.05.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037873239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuropharm.2012.04.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037968162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nbd.2012.02.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041340565"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yrtph.2013.10.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041718752"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199007263230406", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042629554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-7613(02)00390-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043398905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1460-9568.1991.tb00050.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043490100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1460-9568.1991.tb00050.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043490100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nbd.2009.07.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045897743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbi.2013.02.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046240350"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.phrs.2012.10.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046352600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/0471142735.im1401s83", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046506768"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2217/fvl.11.107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047009993"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1528-1167.2008.01751.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053577511"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/infdis/154.3.399", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059700056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.38.9.1407", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064368003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2741/3847", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070916008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.19-12-05054.1999", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074475407"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.21-08-02580.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074800503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.166.12.7527", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074829796"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.176.6.3804", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077197509"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-12", 
    "datePublishedReg": "2016-12-01", 
    "description": "BACKGROUND: Infectious encephalitides are most often associated with acute seizures during the infection period and are risk factors for the development of epilepsy at later times. Mechanisms of viral encephalitis-induced epileptogenesis are poorly understood. Here, we evaluated the contribution of viral encephalitis-associated inflammation to ictogenesis and epileptogenesis using a rapid kindling protocol in rats. In addition, we examined whether minocycline can improve outcomes of viral-like brain inflammation.\nMETHODS: To produce viral-like inflammation, polyinosinic-polycytidylic acid (PIC), a toll-like receptor 3 (TLR3) agonist, was applied to microglial/macrophage cell cultures and to the hippocampus of postnatal day 13 (P13) and postnatal day 74 (P74) rats. Cell cultures permit the examination of the inflammation induced by PIC, while the in vivo setting better suits the analysis of cytokine production and the effects of inflammation on epileptogenesis. Minocycline (50\u00a0mg/kg) was injected intraperitoneally for 3 consecutive days prior to the kindling procedure to evaluate its effects on inflammation and epileptogenesis.\nRESULTS: PIC injection facilitated kindling epileptogenesis, which was evident as an increase in the number of full limbic seizures at both ages. Furthermore, in P14 rats, we observed a faster seizure onset and prolonged retention of the kindling state. PIC administration also led to an increase in interleukin 1\u03b2 (IL-1\u03b2) levels in the hippocampus in P14 and P75 rats. Treatment with minocycline reversed neither the pro-epileptogenic effects of PIC nor the increase of IL-1\u03b2 in the hippocampus in both P14 and P75 rats.\nCONCLUSIONS: Hippocampal injection of PIC facilitates rapid kindling epileptogenesis at both P14 and P75, suggesting that viral-induced inflammation increases epileptogenesis irrespective of brain maturation. Minocycline, however, was unable to reverse the increase of epileptogenesis, which might be linked to its absence of effect on hippocampal IL-1\u03b2 levels at both ages.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12974-016-0773-6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2562547", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1034001", 
        "issn": [
          "1742-2094"
        ], 
        "name": "Journal of Neuroinflammation", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "13"
      }
    ], 
    "name": "Pro-epileptogenic effects of viral-like inflammation in both mature and immature brains", 
    "pagination": "307", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "ea318a529ee0248403d95a3ceacd7f3f5b4d63eff9140d5a729782570acae529"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27955671"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101222974"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12974-016-0773-6"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1049160702"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12974-016-0773-6", 
      "https://app.dimensions.ai/details/publication/pub.1049160702"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:43", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000363_0000000363/records_70061_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs12974-016-0773-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12974-016-0773-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12974-016-0773-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12974-016-0773-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12974-016-0773-6'


 

This table displays all metadata directly associated to this object as RDF triples.

392 TRIPLES      21 PREDICATES      101 URIs      44 LITERALS      32 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12974-016-0773-6 schema:about N06b05e13be4b4eecbb331f362c9d1df5
2 N212399efcefa457b97a2be39c7f08403
3 N22f2f19b41d44a32a1d0eea40ff25435
4 N26560a9f10354f5f945cdb488c8c0842
5 N27e8ad37fda544c0bc99fcdb51425a09
6 N51409e273cc84671804baa5a5094bffa
7 N51c936cf52f7449c9ecba0faf703fd4f
8 N545db49cb1a041438bdcaeab0b199b25
9 N6f33f2469c3e4e7cb056c175daffb31a
10 N7244674ce8ff46d88ff0f4e7823e45bf
11 N73df263315ac4eb1b86d96e6da1e7d2d
12 N8151248f4a124fccb4e53906677cf852
13 N9a17a5fb7a2b493c94dcde2ed2f84628
14 Na15cf9131bab41deaf62a6cf5d75ac7b
15 Nc6c8cdd02b3442229561626daa30e752
16 Ncae065478b61463c9de2b2fa1c04eb44
17 Ncc1a735104ae460a97e43d3eccf72e72
18 Nd24dfba96e51466aae03d8cc44d12dd6
19 Nd65b95f2e1744f2fbe9b720a7293672e
20 Nddc2f3540eaf4954a16593dfedab16b5
21 Neeb8b8643c01478e87142a7e23d3d303
22 Nf5b3479df7984e74a122b882840d472f
23 Nfd2faa33ae74461aab2f0ff3037b2fab
24 anzsrc-for:11
25 anzsrc-for:1109
26 schema:author Ne569cdfde6e047bc81b45b0c5a8bad5f
27 schema:citation sg:pub.10.1007/s13311-011-0039-z
28 sg:pub.10.1038/35099560
29 sg:pub.10.1186/1742-2094-10-30
30 sg:pub.10.1186/1742-2094-5-15
31 https://doi.org/10.1002/0471142735.im1401s83
32 https://doi.org/10.1002/ana.20358
33 https://doi.org/10.1002/ana.410210106
34 https://doi.org/10.1002/glia.22612
35 https://doi.org/10.1016/b978-0-444-52898-8.00010-0
36 https://doi.org/10.1016/b978-012088554-1/50043-8
37 https://doi.org/10.1016/j.bbi.2013.02.005
38 https://doi.org/10.1016/j.nbd.2007.08.012
39 https://doi.org/10.1016/j.nbd.2008.05.007
40 https://doi.org/10.1016/j.nbd.2009.07.025
41 https://doi.org/10.1016/j.nbd.2012.02.006
42 https://doi.org/10.1016/j.neuropharm.2012.04.004
43 https://doi.org/10.1016/j.phrs.2012.10.006
44 https://doi.org/10.1016/j.seizure.2013.05.005
45 https://doi.org/10.1016/j.yebeh.2012.03.035
46 https://doi.org/10.1016/j.yrtph.2013.10.003
47 https://doi.org/10.1016/s1074-7613(02)00390-4
48 https://doi.org/10.1056/nejm199007263230406
49 https://doi.org/10.1073/pnas.0306239101
50 https://doi.org/10.1073/pnas.96.23.13496
51 https://doi.org/10.1074/jbc.c000405200
52 https://doi.org/10.1093/infdis/154.3.399
53 https://doi.org/10.1097/nen.0b013e3181ffc420
54 https://doi.org/10.1111/j.1460-9568.1991.tb00050.x
55 https://doi.org/10.1111/j.1471-4159.2005.03219.x
56 https://doi.org/10.1111/j.1471-4159.2007.05171.x
57 https://doi.org/10.1111/j.1528-1167.2005.00294.x
58 https://doi.org/10.1111/j.1528-1167.2007.00987.x
59 https://doi.org/10.1111/j.1528-1167.2008.01674.x
60 https://doi.org/10.1111/j.1528-1167.2008.01751.x
61 https://doi.org/10.1111/j.1528-1167.2009.02390.x
62 https://doi.org/10.1111/j.1528-1167.2010.02607.x
63 https://doi.org/10.1128/jvi.00458-11
64 https://doi.org/10.1128/jvi.02747-12
65 https://doi.org/10.1128/jvi.05738-11
66 https://doi.org/10.1161/01.str.0000206281.77178.ac
67 https://doi.org/10.1212/wnl.38.9.1407
68 https://doi.org/10.1523/jneurosci.19-12-05054.1999
69 https://doi.org/10.1523/jneurosci.21-08-02580.2001
70 https://doi.org/10.2217/fvl.11.107
71 https://doi.org/10.2741/3847
72 https://doi.org/10.3201/eid0902.020218
73 https://doi.org/10.4049/jimmunol.166.12.7527
74 https://doi.org/10.4049/jimmunol.173.6.3916
75 https://doi.org/10.4049/jimmunol.176.6.3804
76 schema:datePublished 2016-12
77 schema:datePublishedReg 2016-12-01
78 schema:description BACKGROUND: Infectious encephalitides are most often associated with acute seizures during the infection period and are risk factors for the development of epilepsy at later times. Mechanisms of viral encephalitis-induced epileptogenesis are poorly understood. Here, we evaluated the contribution of viral encephalitis-associated inflammation to ictogenesis and epileptogenesis using a rapid kindling protocol in rats. In addition, we examined whether minocycline can improve outcomes of viral-like brain inflammation. METHODS: To produce viral-like inflammation, polyinosinic-polycytidylic acid (PIC), a toll-like receptor 3 (TLR3) agonist, was applied to microglial/macrophage cell cultures and to the hippocampus of postnatal day 13 (P13) and postnatal day 74 (P74) rats. Cell cultures permit the examination of the inflammation induced by PIC, while the in vivo setting better suits the analysis of cytokine production and the effects of inflammation on epileptogenesis. Minocycline (50 mg/kg) was injected intraperitoneally for 3 consecutive days prior to the kindling procedure to evaluate its effects on inflammation and epileptogenesis. RESULTS: PIC injection facilitated kindling epileptogenesis, which was evident as an increase in the number of full limbic seizures at both ages. Furthermore, in P14 rats, we observed a faster seizure onset and prolonged retention of the kindling state. PIC administration also led to an increase in interleukin 1β (IL-1β) levels in the hippocampus in P14 and P75 rats. Treatment with minocycline reversed neither the pro-epileptogenic effects of PIC nor the increase of IL-1β in the hippocampus in both P14 and P75 rats. CONCLUSIONS: Hippocampal injection of PIC facilitates rapid kindling epileptogenesis at both P14 and P75, suggesting that viral-induced inflammation increases epileptogenesis irrespective of brain maturation. Minocycline, however, was unable to reverse the increase of epileptogenesis, which might be linked to its absence of effect on hippocampal IL-1β levels at both ages.
79 schema:genre research_article
80 schema:inLanguage en
81 schema:isAccessibleForFree true
82 schema:isPartOf Ndf3342169bf5475cabddf1e0093a7534
83 Ne753407f6f354bc69c9ff2f1e089d98f
84 sg:journal.1034001
85 schema:name Pro-epileptogenic effects of viral-like inflammation in both mature and immature brains
86 schema:pagination 307
87 schema:productId N6077d51180e54beb9921d169f157ca26
88 N83663a8272674105b74df1f6dbc69d9a
89 N8ff0a1e5e8d741e8af77f72e372319af
90 Nc85ae75b1aea49c49359aa063092089c
91 Ndffa57d3003542c8be1c685cb8b66e99
92 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049160702
93 https://doi.org/10.1186/s12974-016-0773-6
94 schema:sdDatePublished 2019-04-11T12:43
95 schema:sdLicense https://scigraph.springernature.com/explorer/license/
96 schema:sdPublisher N3341a3d815144727b45be59029fdc4d3
97 schema:url https://link.springer.com/10.1186%2Fs12974-016-0773-6
98 sgo:license sg:explorer/license/
99 sgo:sdDataset articles
100 rdf:type schema:ScholarlyArticle
101 N06b05e13be4b4eecbb331f362c9d1df5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Cells, Cultured
103 rdf:type schema:DefinedTerm
104 N212399efcefa457b97a2be39c7f08403 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Age Factors
106 rdf:type schema:DefinedTerm
107 N22f2f19b41d44a32a1d0eea40ff25435 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Epilepsy
109 rdf:type schema:DefinedTerm
110 N26560a9f10354f5f945cdb488c8c0842 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Encephalitis, Viral
112 rdf:type schema:DefinedTerm
113 N27e8ad37fda544c0bc99fcdb51425a09 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Anticonvulsants
115 rdf:type schema:DefinedTerm
116 N3341a3d815144727b45be59029fdc4d3 schema:name Springer Nature - SN SciGraph project
117 rdf:type schema:Organization
118 N51409e273cc84671804baa5a5094bffa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Rats
120 rdf:type schema:DefinedTerm
121 N51c936cf52f7449c9ecba0faf703fd4f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Male
123 rdf:type schema:DefinedTerm
124 N545db49cb1a041438bdcaeab0b199b25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Kindling, Neurologic
126 rdf:type schema:DefinedTerm
127 N6077d51180e54beb9921d169f157ca26 schema:name doi
128 schema:value 10.1186/s12974-016-0773-6
129 rdf:type schema:PropertyValue
130 N69c8061c626641c2a9cda697822aa8b6 rdf:first sg:person.0753527762.82
131 rdf:rest Nb51607a4f49142f79ed327d4067f0023
132 N6f33f2469c3e4e7cb056c175daffb31a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Microglia
134 rdf:type schema:DefinedTerm
135 N7244674ce8ff46d88ff0f4e7823e45bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Cytokines
137 rdf:type schema:DefinedTerm
138 N73df263315ac4eb1b86d96e6da1e7d2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Poly I-C
140 rdf:type schema:DefinedTerm
141 N8151248f4a124fccb4e53906677cf852 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Rats, Wistar
143 rdf:type schema:DefinedTerm
144 N83663a8272674105b74df1f6dbc69d9a schema:name dimensions_id
145 schema:value pub.1049160702
146 rdf:type schema:PropertyValue
147 N8c4a144f851f4a3487b3709fbf7d0efe rdf:first sg:person.0643134421.39
148 rdf:rest N9efa113200a8459ba5ced4c8ebae72dd
149 N8ff0a1e5e8d741e8af77f72e372319af schema:name pubmed_id
150 schema:value 27955671
151 rdf:type schema:PropertyValue
152 N9a17a5fb7a2b493c94dcde2ed2f84628 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Animals
154 rdf:type schema:DefinedTerm
155 N9c676446737744cbad6b03b42c6165d2 rdf:first sg:person.01050737222.15
156 rdf:rest Na75efcf31c014d4fa2faf17e573b7ca6
157 N9efa113200a8459ba5ced4c8ebae72dd rdf:first sg:person.01105222734.85
158 rdf:rest Nfc9d02265acb4c68b4d725659d27fd2b
159 Na15cf9131bab41deaf62a6cf5d75ac7b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Statistics, Nonparametric
161 rdf:type schema:DefinedTerm
162 Na75efcf31c014d4fa2faf17e573b7ca6 rdf:first sg:person.0762613765.27
163 rdf:rest N8c4a144f851f4a3487b3709fbf7d0efe
164 Nb51607a4f49142f79ed327d4067f0023 rdf:first sg:person.01011241534.97
165 rdf:rest N9c676446737744cbad6b03b42c6165d2
166 Nc6c8cdd02b3442229561626daa30e752 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Minocycline
168 rdf:type schema:DefinedTerm
169 Nc85ae75b1aea49c49359aa063092089c schema:name nlm_unique_id
170 schema:value 101222974
171 rdf:type schema:PropertyValue
172 Ncae065478b61463c9de2b2fa1c04eb44 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Hippocampus
174 rdf:type schema:DefinedTerm
175 Ncc1a735104ae460a97e43d3eccf72e72 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Antiviral Agents
177 rdf:type schema:DefinedTerm
178 Ncdb32e8594c34f17aa0a1cb0fbb67b91 rdf:first sg:person.014352756537.54
179 rdf:rest Ne180276d96bb45089616b414f5ba6a71
180 Nd24dfba96e51466aae03d8cc44d12dd6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Encephalitis
182 rdf:type schema:DefinedTerm
183 Nd65b95f2e1744f2fbe9b720a7293672e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name RNA, Messenger
185 rdf:type schema:DefinedTerm
186 Nddc2f3540eaf4954a16593dfedab16b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Animals, Newborn
188 rdf:type schema:DefinedTerm
189 Ndf3342169bf5475cabddf1e0093a7534 schema:issueNumber 1
190 rdf:type schema:PublicationIssue
191 Ndffa57d3003542c8be1c685cb8b66e99 schema:name readcube_id
192 schema:value ea318a529ee0248403d95a3ceacd7f3f5b4d63eff9140d5a729782570acae529
193 rdf:type schema:PropertyValue
194 Ne180276d96bb45089616b414f5ba6a71 rdf:first sg:person.01366250056.12
195 rdf:rest Nf6b701a3b0a148c8aad8f32445bb1ad3
196 Ne569cdfde6e047bc81b45b0c5a8bad5f rdf:first sg:person.01255046700.29
197 rdf:rest Ncdb32e8594c34f17aa0a1cb0fbb67b91
198 Ne753407f6f354bc69c9ff2f1e089d98f schema:volumeNumber 13
199 rdf:type schema:PublicationVolume
200 Neeb8b8643c01478e87142a7e23d3d303 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Brain
202 rdf:type schema:DefinedTerm
203 Nf5b3479df7984e74a122b882840d472f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
204 schema:name Macrophages
205 rdf:type schema:DefinedTerm
206 Nf6b701a3b0a148c8aad8f32445bb1ad3 rdf:first sg:person.01352304034.01
207 rdf:rest N69c8061c626641c2a9cda697822aa8b6
208 Nfc9d02265acb4c68b4d725659d27fd2b rdf:first sg:person.01157744314.35
209 rdf:rest rdf:nil
210 Nfd2faa33ae74461aab2f0ff3037b2fab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name Gene Expression Regulation
212 rdf:type schema:DefinedTerm
213 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
214 schema:name Medical and Health Sciences
215 rdf:type schema:DefinedTerm
216 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
217 schema:name Neurosciences
218 rdf:type schema:DefinedTerm
219 sg:grant.2562547 http://pending.schema.org/fundedItem sg:pub.10.1186/s12974-016-0773-6
220 rdf:type schema:MonetaryGrant
221 sg:journal.1034001 schema:issn 1742-2094
222 schema:name Journal of Neuroinflammation
223 rdf:type schema:Periodical
224 sg:person.01011241534.97 schema:affiliation https://www.grid.ac/institutes/grid.7452.4
225 schema:familyName Le Charpentier
226 schema:givenName Tifenn
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011241534.97
228 rdf:type schema:Person
229 sg:person.01050737222.15 schema:affiliation https://www.grid.ac/institutes/grid.7452.4
230 schema:familyName Lebon
231 schema:givenName Sophie
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050737222.15
233 rdf:type schema:Person
234 sg:person.01105222734.85 schema:affiliation https://www.grid.ac/institutes/grid.7452.4
235 schema:familyName Dournaud
236 schema:givenName Pascal
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105222734.85
238 rdf:type schema:Person
239 sg:person.01157744314.35 schema:affiliation https://www.grid.ac/institutes/grid.413235.2
240 schema:familyName Auvin
241 schema:givenName Stéphane
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157744314.35
243 rdf:type schema:Person
244 sg:person.01255046700.29 schema:affiliation https://www.grid.ac/institutes/grid.7452.4
245 schema:familyName Dupuis
246 schema:givenName Nina
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255046700.29
248 rdf:type schema:Person
249 sg:person.01352304034.01 schema:affiliation https://www.grid.ac/institutes/grid.7452.4
250 schema:familyName Chhor
251 schema:givenName Vibol
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352304034.01
253 rdf:type schema:Person
254 sg:person.01366250056.12 schema:affiliation https://www.grid.ac/institutes/grid.413235.2
255 schema:familyName Desnous
256 schema:givenName Béatrice
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366250056.12
258 rdf:type schema:Person
259 sg:person.014352756537.54 schema:affiliation https://www.grid.ac/institutes/grid.19006.3e
260 schema:familyName Mazarati
261 schema:givenName Andrey
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014352756537.54
263 rdf:type schema:Person
264 sg:person.0643134421.39 schema:affiliation https://www.grid.ac/institutes/grid.413235.2
265 schema:familyName Gressens
266 schema:givenName Pierre
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643134421.39
268 rdf:type schema:Person
269 sg:person.0753527762.82 schema:affiliation https://www.grid.ac/institutes/grid.7452.4
270 schema:familyName Fleiss
271 schema:givenName Bobbi
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753527762.82
273 rdf:type schema:Person
274 sg:person.0762613765.27 schema:affiliation https://www.grid.ac/institutes/grid.7452.4
275 schema:familyName Csaba
276 schema:givenName Zsolt
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762613765.27
278 rdf:type schema:Person
279 sg:pub.10.1007/s13311-011-0039-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1034790244
280 https://doi.org/10.1007/s13311-011-0039-z
281 rdf:type schema:CreativeWork
282 sg:pub.10.1038/35099560 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031094923
283 https://doi.org/10.1038/35099560
284 rdf:type schema:CreativeWork
285 sg:pub.10.1186/1742-2094-10-30 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006155447
286 https://doi.org/10.1186/1742-2094-10-30
287 rdf:type schema:CreativeWork
288 sg:pub.10.1186/1742-2094-5-15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022515428
289 https://doi.org/10.1186/1742-2094-5-15
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1002/0471142735.im1401s83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046506768
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1002/ana.20358 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036606959
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1002/ana.410210106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000802393
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1002/glia.22612 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004635929
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1016/b978-0-444-52898-8.00010-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009939148
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1016/b978-012088554-1/50043-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001812902
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1016/j.bbi.2013.02.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046240350
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1016/j.nbd.2007.08.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006124457
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1016/j.nbd.2008.05.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027679800
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1016/j.nbd.2009.07.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045897743
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1016/j.nbd.2012.02.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041340565
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1016/j.neuropharm.2012.04.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037968162
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1016/j.phrs.2012.10.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046352600
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1016/j.seizure.2013.05.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037873239
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1016/j.yebeh.2012.03.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035926346
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1016/j.yrtph.2013.10.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041718752
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1016/s1074-7613(02)00390-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043398905
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1056/nejm199007263230406 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042629554
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1073/pnas.0306239101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003064508
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1073/pnas.96.23.13496 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019053748
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1074/jbc.c000405200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019886692
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1093/infdis/154.3.399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059700056
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1097/nen.0b013e3181ffc420 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014572401
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1111/j.1460-9568.1991.tb00050.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043490100
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1111/j.1471-4159.2005.03219.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001582202
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1111/j.1471-4159.2007.05171.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003317003
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1111/j.1528-1167.2005.00294.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018917175
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1111/j.1528-1167.2007.00987.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001946890
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1111/j.1528-1167.2008.01674.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021337405
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1111/j.1528-1167.2008.01751.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1053577511
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1111/j.1528-1167.2009.02390.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005904612
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1111/j.1528-1167.2010.02607.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031193402
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1128/jvi.00458-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027408782
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1128/jvi.02747-12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021032794
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1128/jvi.05738-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022460506
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1161/01.str.0000206281.77178.ac schema:sameAs https://app.dimensions.ai/details/publication/pub.1003473980
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1212/wnl.38.9.1407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064368003
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1523/jneurosci.19-12-05054.1999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074475407
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1523/jneurosci.21-08-02580.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074800503
368 rdf:type schema:CreativeWork
369 https://doi.org/10.2217/fvl.11.107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047009993
370 rdf:type schema:CreativeWork
371 https://doi.org/10.2741/3847 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070916008
372 rdf:type schema:CreativeWork
373 https://doi.org/10.3201/eid0902.020218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014498708
374 rdf:type schema:CreativeWork
375 https://doi.org/10.4049/jimmunol.166.12.7527 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074829796
376 rdf:type schema:CreativeWork
377 https://doi.org/10.4049/jimmunol.173.6.3916 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008927643
378 rdf:type schema:CreativeWork
379 https://doi.org/10.4049/jimmunol.176.6.3804 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077197509
380 rdf:type schema:CreativeWork
381 https://www.grid.ac/institutes/grid.19006.3e schema:alternateName University of California Los Angeles
382 schema:name Department of Pediatrics, Neurology division and Children’s Discovery and Innovation Institute, David Geffen School of Medicine at UCLA, 90095, Los Angeles, CA, USA
383 rdf:type schema:Organization
384 https://www.grid.ac/institutes/grid.413235.2 schema:alternateName Hôpital Robert Debré
385 schema:name AP-HP, Hôpital Robert Debré, Service de Neurologie Pédiatrique, 75019, Paris, France
386 INSERM, U1141, 75019, Paris, France
387 Université Paris Diderot, Sorbonne Paris Cité, INSERM UMR1141, 75019, Paris, France
388 rdf:type schema:Organization
389 https://www.grid.ac/institutes/grid.7452.4 schema:alternateName Paris Diderot University
390 schema:name INSERM, U1141, 75019, Paris, France
391 Université Paris Diderot, Sorbonne Paris Cité, INSERM UMR1141, 75019, Paris, France
392 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...