Ontology type: schema:ScholarlyArticle Open Access: True
2016-03-10
AUTHORSDavid Heras-Sandoval, José Pedraza-Chaverri, Jazmin M. Pérez-Rojas
ABSTRACTDocosahexaenoic acid (DHA) is an omega-3 (ω-3) long-chain polyunsaturated fatty acid (LCPUFA) relevant for brain function. It has largely been explored as a potential candidate to treat Alzheimer’s disease (AD). Clinical evidence favors a role for DHA in the improvement of cognition in very early stages of the AD. In response to stress or damage, DHA generates oxygenated derivatives called docosanoids that can activate the peroxisome proliferator-activated receptor γ (PPARγ). In conjunction with activated retinoid X receptors (RXR), PPARγ modulates inflammation, cell survival, and lipid metabolism. As an early event in AD, inflammation is associated with an excess of amyloid β peptide (Aβ) that contributes to neural insult. Glial cells are recognized to be actively involved during AD, and their dysfunction is associated with the early appearance of this pathology. These cells give support to neurons, remove amyloid β peptides from the brain, and modulate inflammation. Since DHA can modulate glial cell activity, the present work reviews the evidence about this modulation as well as the effect of docosanoids on neuroinflammation and in some AD models. The evidence supports PPARγ as a preferred target for gene modulation. The effective use of DHA and/or its derivatives in a subgroup of people at risk of developing AD is discussed. More... »
PAGES61
http://scigraph.springernature.com/pub.10.1186/s12974-016-0525-7
DOIhttp://dx.doi.org/10.1186/s12974-016-0525-7
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1000475211
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/26965310
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1101",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical Biochemistry and Metabolomics",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Neurosciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Alzheimer Disease",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Amyloid beta-Peptides",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Docosahexaenoic Acids",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neuroglia",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "PPAR gamma",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Laboratorio de Farmacolog\u00eda, Subdirecci\u00f3n de Investigaci\u00f3n B\u00e1sica, Instituto Nacional de Cancerolog\u00eda (INCan), Av. San Fernando #22, Tlalpan 14080, Apartado Postal 22026, M\u00e9xico, DF, M\u00e9xico",
"id": "http://www.grid.ac/institutes/grid.419167.c",
"name": [
"Departamento de Biolog\u00eda, Facultad de Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad Universitaria, 04510, M\u00e9xico, DF, M\u00e9xico",
"Laboratorio de Farmacolog\u00eda, Subdirecci\u00f3n de Investigaci\u00f3n B\u00e1sica, Instituto Nacional de Cancerolog\u00eda (INCan), Av. San Fernando #22, Tlalpan 14080, Apartado Postal 22026, M\u00e9xico, DF, M\u00e9xico"
],
"type": "Organization"
},
"familyName": "Heras-Sandoval",
"givenName": "David",
"id": "sg:person.01333503041.82",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333503041.82"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Departamento de Biolog\u00eda, Facultad de Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad Universitaria, 04510, M\u00e9xico, DF, M\u00e9xico",
"id": "http://www.grid.ac/institutes/grid.9486.3",
"name": [
"Departamento de Biolog\u00eda, Facultad de Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad Universitaria, 04510, M\u00e9xico, DF, M\u00e9xico"
],
"type": "Organization"
},
"familyName": "Pedraza-Chaverri",
"givenName": "Jos\u00e9",
"id": "sg:person.0675676240.69",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675676240.69"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Laboratorio de Farmacolog\u00eda, Subdirecci\u00f3n de Investigaci\u00f3n B\u00e1sica, Instituto Nacional de Cancerolog\u00eda (INCan), Av. San Fernando #22, Tlalpan 14080, Apartado Postal 22026, M\u00e9xico, DF, M\u00e9xico",
"id": "http://www.grid.ac/institutes/grid.419167.c",
"name": [
"Laboratorio de Farmacolog\u00eda, Subdirecci\u00f3n de Investigaci\u00f3n B\u00e1sica, Instituto Nacional de Cancerolog\u00eda (INCan), Av. San Fernando #22, Tlalpan 14080, Apartado Postal 22026, M\u00e9xico, DF, M\u00e9xico"
],
"type": "Organization"
},
"familyName": "P\u00e9rez-Rojas",
"givenName": "Jazmin M.",
"id": "sg:person.0717732057.10",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717732057.10"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1385/jmn:16:2-3:195",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039266834",
"https://doi.org/10.1385/jmn:16:2-3:195"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10529-012-0891-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010486759",
"https://doi.org/10.1007/s10529-012-0891-x"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/srep07458",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008764459",
"https://doi.org/10.1038/srep07458"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10522-013-9461-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019479168",
"https://doi.org/10.1007/s10522-013-9461-4"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1476-511x-12-16",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033283292",
"https://doi.org/10.1186/1476-511x-12-16"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s12035-010-8131-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007038285",
"https://doi.org/10.1007/s12035-010-8131-7"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00213-012-2848-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049436905",
"https://doi.org/10.1007/s00213-012-2848-0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11745-013-3791-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043186722",
"https://doi.org/10.1007/s11745-013-3791-5"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11745-000-0646-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018194452",
"https://doi.org/10.1007/s11745-000-0646-3"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature06616",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024411455",
"https://doi.org/10.1038/nature06616"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00210-007-0251-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038699058",
"https://doi.org/10.1007/s00210-007-0251-x"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1742-2094-11-72",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009567660",
"https://doi.org/10.1186/1742-2094-11-72"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s12974-015-0244-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013815656",
"https://doi.org/10.1186/s12974-015-0244-5"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf02829951",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033046875",
"https://doi.org/10.1007/bf02829951"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1016/j.jasms.2006.09.002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044649575",
"https://doi.org/10.1016/j.jasms.2006.09.002"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1476-511x-12-79",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002631002",
"https://doi.org/10.1186/1476-511x-12-79"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrn3880",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005784241",
"https://doi.org/10.1038/nrn3880"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature13241",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034559721",
"https://doi.org/10.1038/nature13241"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/npp.2010.98",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047518575",
"https://doi.org/10.1038/npp.2010.98"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/srep01940",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048435946",
"https://doi.org/10.1038/srep01940"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1476-511x-13-148",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049012531",
"https://doi.org/10.1186/1476-511x-13-148"
],
"type": "CreativeWork"
}
],
"datePublished": "2016-03-10",
"datePublishedReg": "2016-03-10",
"description": "Docosahexaenoic acid (DHA) is an omega-3 (\u03c9-3) long-chain polyunsaturated fatty acid (LCPUFA) relevant for brain function. It has largely been explored as a potential candidate to treat Alzheimer\u2019s disease (AD). Clinical evidence favors a role for DHA in the improvement of cognition in very early stages of the AD. In response to stress or damage, DHA generates oxygenated derivatives called docosanoids that can activate the peroxisome proliferator-activated receptor \u03b3 (PPAR\u03b3). In conjunction with activated retinoid X receptors (RXR), PPAR\u03b3 modulates inflammation, cell survival, and lipid metabolism. As an early event in AD, inflammation is associated with an excess of amyloid \u03b2 peptide (A\u03b2) that contributes to neural insult. Glial cells are recognized to be actively involved during AD, and their dysfunction is associated with the early appearance of this pathology. These cells give support to neurons, remove amyloid \u03b2 peptides from the brain, and modulate inflammation. Since DHA can modulate glial cell activity, the present work reviews the evidence about this modulation as well as the effect of docosanoids on neuroinflammation and in some AD models. The evidence supports PPAR\u03b3 as a preferred target for gene modulation. The effective use of DHA and/or its derivatives in a subgroup of people at risk of developing AD is discussed.",
"genre": "article",
"id": "sg:pub.10.1186/s12974-016-0525-7",
"inLanguage": "en",
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1034001",
"issn": [
"1742-2094"
],
"name": "Journal of Neuroinflammation",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "13"
}
],
"keywords": [
"Alzheimer's disease",
"docosahexaenoic acid",
"retinoid X receptor",
"glial cells",
"amyloid \u03b2-peptide",
"peroxisome proliferator-activated receptor \u03b3",
"proliferator-activated receptor \u03b3",
"glial cell activity",
"improvement of cognition",
"subgroups of people",
"clinical evidence",
"neural insults",
"\u03b2-peptide",
"AD model",
"receptor \u03b3",
"lipid metabolism",
"cell activity",
"X receptor",
"brain function",
"inflammation",
"disease",
"early events",
"docosanoids",
"gene modulation",
"cell survival",
"PPAR\u03b3",
"early appearance",
"fatty acids",
"cells",
"early stages",
"preferred target",
"neuroinflammation",
"evidence",
"dysfunction",
"modulation",
"peptides",
"insult",
"pathology",
"neurons",
"brain",
"receptors",
"survival",
"subgroups",
"risk",
"metabolism",
"role",
"acid",
"potential candidate",
"damage",
"response",
"target",
"activity",
"cognition",
"appearance",
"events",
"effect",
"improvement",
"people",
"effective use",
"use",
"stage",
"candidates",
"function",
"stress",
"support",
"derivatives",
"excess",
"conjunction",
"model",
"present work",
"work"
],
"name": "Role of docosahexaenoic acid in the modulation of glial cells in Alzheimer\u2019s disease",
"pagination": "61",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1000475211"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1186/s12974-016-0525-7"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"26965310"
]
}
],
"sameAs": [
"https://doi.org/10.1186/s12974-016-0525-7",
"https://app.dimensions.ai/details/publication/pub.1000475211"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-20T07:32",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_703.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1186/s12974-016-0525-7"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12974-016-0525-7'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12974-016-0525-7'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12974-016-0525-7'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12974-016-0525-7'
This table displays all metadata directly associated to this object as RDF triples.
266 TRIPLES
22 PREDICATES
126 URIs
96 LITERALS
14 BLANK NODES