Expression of suppressor of cytokine signaling 3 in cerebrospinal fluid after subarachnoid hemorrhage View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-08-14

AUTHORS

Koji Osuka, Yasuo Watanabe, Masahiro Aoyama, Takahiro Nakura, Naoki Matsuo, Masakazu Takayasu

ABSTRACT

BACKGROUND: IL-6 is a proinflammatory cytokine reported to play an important role in the induction of cerebral vasospasm after subarachnoid hemorrhage (SAH). Suppressor of cytokine signaling 3 (SOCS3) is known to act as an inhibitor of signal transduction of IL-6. However, there have been no reports on the expression of SOCS3 in cerebrospinal fluid (CSF) after SAH. FINDINGS: The concentration of IL-6 was measured serially up until day 10, in CSF of eight patients with SAH. CSF samples obtained from patients suffering from an unruptured aneurysm were used as controls. The expression of SOCS3 in CSF was further examined by immunoprecipitation methods. Concentrations of IL-6 in CSF increased immediately after the onset of SAH and remained chronically elevated over control values. SOCS3 was significantly expressed in CSF on days 1 to 3 after SAH. CONCLUSIONS: Our findings suggest that SOCS3 regulates IL-6 signaling as an antagonist in CSF, immediately following SAH. As the expression of SOCS3 decreases after day 5, IL-6 signals might then be more easily transmitted, presumably resulting in cerebral vasospasm. More... »

PAGES

142

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Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12974-014-0142-2

DOI

http://dx.doi.org/10.1186/s12974-014-0142-2

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https://app.dimensions.ai/details/publication/pub.1026768131

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25125049


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