Ontology type: schema:ScholarlyArticle Open Access: True
2015-02-21
AUTHORSRoxanne M Vogel, Jordan M Joy, Paul H Falcone, Matt M Mosman, Michael P Kim, Jordan R Moon
ABSTRACTBackgroundPre-workout supplements (PWS) have increased in popularity among athletic populations for their purported ergogenic benefits. Most PWS contain a “proprietary blend” of several ingredients, such as caffeine, beta-alanine, and nitrate in undisclosed dosages. Currently, little research exists on the safety and potential side effects of chronic consumption of PWS, and even less so involving female populations. Therefore, the purpose of the present study was to examine the safety of consuming a dose-escalated PWS over a 28-day period among active adult females.Methods34 recreationally active, adult females (27.1 ± 5.4 years, 165.2 ± 5.7 cm, 68.2 ± 16.0 kg) participated in this study. Participants were randomly assigned to consume either 1 (G1) or 2 (G2) servings of a PWS daily or remain unsupplemented (CRL) for a period of 28 days. All were instructed to maintain their habitual dietary and exercise routines for the duration of the study. Fasting blood samples, as well as resting blood pressure and heart rate, were taken prior to and following the supplementation period. Samples were analyzed for hematological and clinical chemistry panels, including lipids.ResultsSignificant (p < 0.05) group by time interactions were present for absolute monocytes (CRL −0.10 ± 0.10; G1 + 0.03 ± 0.13; G2 + 0.01 ± 0.12×10E3/uL), MCH (CRL −0.13 ± 0.46; G1 + 0.36 ± 0.52; G2 -0.19 ± 0.39 pg), creatinine (CRL 0.00 ± 0.05; G1 -0.06 ± 0.13; G2 -0.14 ± 0.08 mg/dL), eGFR (CRL −0.69 ± 5.97; G1 + 6.10 ± 15.89; G2 + 14.63 ± 7.11 mL/min/1.73), and total cholesterol (CRL −2.44 ± 13.63; G1 + 14.40 ± 27.32; G2 -10.38 ± 15.39 mg/dL). Each of these variables remained within the accepted physiological range. No other variables had significant interactions.ConclusionThe present study confirms the hypothesis that a PWS containing caffeine, beta-alanine, and nitrate will not cause abnormal changes in hematological markers or resting vital signs among adult females. Although there were statistically significant (p < 0.05) group by time interactions for absolute monocytes, MCH, creatinine, eGFR, and total cholesterol, all of the results remained well within accepted physiological ranges and were not clinically significant. In sum, it appears as though daily supplementation with up to 2 servings of the PWS under investigation, over an interval of 28 days, did not adversely affect markers of clinical safety among active adult females. More... »
PAGES12
http://scigraph.springernature.com/pub.10.1186/s12970-015-0074-y
DOIhttp://dx.doi.org/10.1186/s12970-015-0074-y
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1017728625
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/25762869
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Public Health and Health Services",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Metropolitan State University, Denver, CO, USA",
"id": "http://www.grid.ac/institutes/grid.411788.3",
"name": [
"MusclePharm Sports Science Institute, MusclePharm Corp., 4721 Ironton St. Building A, 80239, Denver, CO, USA",
"Metropolitan State University, Denver, CO, USA"
],
"type": "Organization"
},
"familyName": "Vogel",
"givenName": "Roxanne M",
"id": "sg:person.01323652422.47",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323652422.47"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "MusclePharm Sports Science Institute, MusclePharm Corp., 4721 Ironton St. Building A, 80239, Denver, CO, USA",
"id": "http://www.grid.ac/institutes/grid.489157.6",
"name": [
"MusclePharm Sports Science Institute, MusclePharm Corp., 4721 Ironton St. Building A, 80239, Denver, CO, USA"
],
"type": "Organization"
},
"familyName": "Joy",
"givenName": "Jordan M",
"id": "sg:person.01301075204.85",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301075204.85"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "MusclePharm Sports Science Institute, MusclePharm Corp., 4721 Ironton St. Building A, 80239, Denver, CO, USA",
"id": "http://www.grid.ac/institutes/grid.489157.6",
"name": [
"MusclePharm Sports Science Institute, MusclePharm Corp., 4721 Ironton St. Building A, 80239, Denver, CO, USA"
],
"type": "Organization"
},
"familyName": "Falcone",
"givenName": "Paul H",
"id": "sg:person.0600551562.94",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600551562.94"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "MusclePharm Sports Science Institute, MusclePharm Corp., 4721 Ironton St. Building A, 80239, Denver, CO, USA",
"id": "http://www.grid.ac/institutes/grid.489157.6",
"name": [
"MusclePharm Sports Science Institute, MusclePharm Corp., 4721 Ironton St. Building A, 80239, Denver, CO, USA"
],
"type": "Organization"
},
"familyName": "Mosman",
"givenName": "Matt M",
"id": "sg:person.01311255132.04",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311255132.04"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "MusclePharm Sports Science Institute, MusclePharm Corp., 4721 Ironton St. Building A, 80239, Denver, CO, USA",
"id": "http://www.grid.ac/institutes/grid.489157.6",
"name": [
"MusclePharm Sports Science Institute, MusclePharm Corp., 4721 Ironton St. Building A, 80239, Denver, CO, USA"
],
"type": "Organization"
},
"familyName": "Kim",
"givenName": "Michael P",
"id": "sg:person.0633764232.21",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633764232.21"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Sports Exercise Science, United States Sports Academy, Daphne, AL, USA",
"id": "http://www.grid.ac/institutes/grid.454691.b",
"name": [
"MusclePharm Sports Science Institute, MusclePharm Corp., 4721 Ironton St. Building A, 80239, Denver, CO, USA",
"Department of Sports Exercise Science, United States Sports Academy, Daphne, AL, USA"
],
"type": "Organization"
},
"familyName": "Moon",
"givenName": "Jordan R",
"id": "sg:person.01133414235.98",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133414235.98"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.2165/11530310-000000000-00000",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007834324",
"https://doi.org/10.2165/11530310-000000000-00000"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00726-012-1233-y",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038386687",
"https://doi.org/10.1007/s00726-012-1233-y"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1550-2783-7-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023425121",
"https://doi.org/10.1186/1550-2783-7-5"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.2165/00007256-200131110-00002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033443820",
"https://doi.org/10.2165/00007256-200131110-00002"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1550-2783-6-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008004994",
"https://doi.org/10.1186/1550-2783-6-2"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s12970-014-0040-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011771402",
"https://doi.org/10.1186/s12970-014-0040-0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1550-2783-10-44",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024517610",
"https://doi.org/10.1186/1550-2783-10-44"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1743-7075-8-78",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024175062",
"https://doi.org/10.1186/1743-7075-8-78"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1550-2783-5-17",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017861592",
"https://doi.org/10.1186/1550-2783-5-17"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1743-7075-9-28",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043444735",
"https://doi.org/10.1186/1743-7075-9-28"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1550-2783-11-30",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041004611",
"https://doi.org/10.1186/1550-2783-11-30"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1550-2783-11-s1-p30",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020582324",
"https://doi.org/10.1186/1550-2783-11-s1-p30"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1550-2783-7-10",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044150159",
"https://doi.org/10.1186/1550-2783-7-10"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1550-2783-6-16",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035390763",
"https://doi.org/10.1186/1550-2783-6-16"
],
"type": "CreativeWork"
}
],
"datePublished": "2015-02-21",
"datePublishedReg": "2015-02-21",
"description": "BackgroundPre-workout supplements (PWS) have increased in popularity among athletic populations for their purported ergogenic benefits. Most PWS contain a \u201cproprietary blend\u201d of several ingredients, such as caffeine, beta-alanine, and nitrate in undisclosed dosages. Currently, little research exists on the safety and potential side effects of chronic consumption of PWS, and even less so involving female populations. Therefore, the purpose of the present study was to examine the safety of consuming a dose-escalated PWS over a 28-day period among active adult females.Methods34 recreationally active, adult females (27.1\u2009\u00b1\u20095.4\u00a0years, 165.2\u2009\u00b1\u20095.7\u00a0cm, 68.2\u2009\u00b1\u200916.0\u00a0kg) participated in this study. Participants were randomly assigned to consume either 1 (G1) or 2 (G2) servings of a PWS daily or remain unsupplemented (CRL) for a period of 28\u00a0days. All were instructed to maintain their habitual dietary and exercise routines for the duration of the study. Fasting blood samples, as well as resting blood pressure and heart rate, were taken prior to and following the supplementation period. Samples were analyzed for hematological and clinical chemistry panels, including lipids.ResultsSignificant (p\u2009<\u20090.05) group by time interactions were present for absolute monocytes (CRL \u22120.10\u2009\u00b1\u20090.10; G1\u2009+\u20090.03\u2009\u00b1\u20090.13; G2\u2009+\u20090.01\u2009\u00b1\u20090.12\u00d710E3/uL), MCH (CRL \u22120.13\u2009\u00b1\u20090.46; G1\u2009+\u20090.36\u2009\u00b1\u20090.52; G2 -0.19\u2009\u00b1\u20090.39\u00a0pg), creatinine (CRL 0.00\u2009\u00b1\u20090.05; G1 -0.06\u2009\u00b1\u20090.13; G2 -0.14\u2009\u00b1\u20090.08\u00a0mg/dL), eGFR (CRL \u22120.69\u2009\u00b1\u20095.97; G1\u2009+\u20096.10\u2009\u00b1\u200915.89; G2\u2009+\u200914.63\u2009\u00b1\u20097.11\u00a0mL/min/1.73), and total cholesterol (CRL \u22122.44\u2009\u00b1\u200913.63; G1\u2009+\u200914.40\u2009\u00b1\u200927.32; G2 -10.38\u2009\u00b1\u200915.39\u00a0mg/dL). Each of these variables remained within the accepted physiological range. No other variables had significant interactions.ConclusionThe present study confirms the hypothesis that a PWS containing caffeine, beta-alanine, and nitrate will not cause abnormal changes in hematological markers or resting vital signs among adult females. Although there were statistically significant (p\u2009<\u20090.05) group by time interactions for absolute monocytes, MCH, creatinine, eGFR, and total cholesterol, all of the results remained well within accepted physiological ranges and were not clinically significant. In sum, it appears as though daily supplementation with up to 2 servings of the PWS under investigation, over an interval of 28\u00a0days, did not adversely affect markers of clinical safety among active adult females.",
"genre": "article",
"id": "sg:pub.10.1186/s12970-015-0074-y",
"inLanguage": "en",
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1034609",
"issn": [
"1550-2783"
],
"name": "Journal of the International Society of Sports Nutrition",
"publisher": "Taylor & Francis",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "12"
}
],
"keywords": [
"total cholesterol",
"absolute monocytes",
"time interaction",
"clinical chemistry panels",
"potential side effects",
"pre-workout supplement",
"ConclusionThe present study",
"physiological range",
"habitual dietary",
"blood pressure",
"chronic consumption",
"present study",
"daily supplementation",
"clinical safety",
"ergogenic benefits",
"supplementation period",
"hematological markers",
"athletic population",
"chemistry panel",
"heart rate",
"blood samples",
"side effects",
"exercise routine",
"vital signs",
"female population",
"adult females",
"active adult females",
"abnormal changes",
"active females",
"proprietary blend",
"creatinine",
"monocytes",
"EGFR",
"cholesterol",
"females",
"servings",
"safety",
"significant interaction",
"MCH",
"markers",
"PWS",
"supplements",
"days",
"caffeine",
"group",
"population",
"dietary",
"period",
"study",
"supplementation",
"signs",
"duration",
"dosage",
"participants",
"little research",
"lipids",
"interval",
"samples",
"variables",
"benefits",
"rate",
"effect",
"panel",
"hypothesis",
"pressure",
"changes",
"purpose",
"routines",
"consumption",
"interaction",
"ingredients",
"investigation",
"results",
"research",
"range",
"PW",
"popularity",
"sum",
"nitrate",
"blends"
],
"name": "Safety of a dose-escalated pre-workout supplement in recreationally active females",
"pagination": "12",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1017728625"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1186/s12970-015-0074-y"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"25762869"
]
}
],
"sameAs": [
"https://doi.org/10.1186/s12970-015-0074-y",
"https://app.dimensions.ai/details/publication/pub.1017728625"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-20T07:30",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_657.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1186/s12970-015-0074-y"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12970-015-0074-y'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12970-015-0074-y'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12970-015-0074-y'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12970-015-0074-y'
This table displays all metadata directly associated to this object as RDF triples.
240 TRIPLES
22 PREDICATES
120 URIs
98 LITERALS
7 BLANK NODES