Serial T1 mapping of right ventricle in pulmonary hypertension: comparison with histology in an animal study View Full Text


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Article Info

DATE

2021-05-27

AUTHORS

Pan Ki Kim, Yoo Jin Hong, Hyo Sub Shim, Dong Jin Im, Young Joo Suh, Kye Ho Lee, Jin Hur, Young Jin Kim, Byoung Wook Choi, Hye-Jeong Lee

ABSTRACT

BackgroundRight ventricular (RV) free wall fibrosis is an important component of adverse remodeling with RV dysfunction in pulmonary hypertension (PH). However, no previous reports have compared cardiovascular magnetic resonance (CMR) findings and histological analysis for RV free wall fibrosis in PH. We aimed to assess the feasibility of CMR T1 mapping with extracellular volume fraction (ECV) for evaluating the progression of RV free wall fibrosis in PH, and compared imaging findings to histological collagen density through an animal study.MethodsAmong 42 6-week-old Wistar male rats, 30 were classified according to disease duration (baseline before monocrotaline injection, and 2, 4, 6 and 8 weeks after injection) and 12 were used to control for aging (4 and 8 weeks after the baseline). We obtained pre and post-contrast T1 maps for native T1 and ECV of RV and left ventricular (LV) free wall for six animals in each disease-duration group. Collagen density of RV free wall was calculated with Masson's trichrome staining. The Kruskall-Wallis test was performed to compare the groups. Native T1 and ECV to collagen density were analyzed with Spearman’s correlation.ResultsThe mean values of native T1, ECV and collagen density of the RV free wall at baseline were 1541 ± 33 ms, 17.2 ± 1.3%, and 4.7 ± 0.5%, respectively. The values of RV free wall did not differ according to aging (P = 0.244, 0.504 and 0.331, respectively). However, the values significantly increased according to disease duration (P < 0.001 for all). Significant correlations were observed between native T1 and collagen density (r = 0.770, P < 0.001), and between ECV and collagen density for the RV free wall (r = 0.815, P < 0.001) in PH. However, there was no significant difference in native T1 and ECV values for the LV free wall according to the disease duration from the baseline (P = 0.349 and 0.240, respectively).ConclusionsWe observed significantly increased values for native T1 and ECV of the RV free wall without significant increase of the LV free wall according to the disease duration of PH, and findings were well correlated with histological collagen density. More... »

PAGES

64

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http://scigraph.springernature.com/pub.10.1186/s12968-021-00755-y

DOI

http://dx.doi.org/10.1186/s12968-021-00755-y

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https://app.dimensions.ai/details/publication/pub.1138374491

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34039372


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24 schema:description BackgroundRight ventricular (RV) free wall fibrosis is an important component of adverse remodeling with RV dysfunction in pulmonary hypertension (PH). However, no previous reports have compared cardiovascular magnetic resonance (CMR) findings and histological analysis for RV free wall fibrosis in PH. We aimed to assess the feasibility of CMR T1 mapping with extracellular volume fraction (ECV) for evaluating the progression of RV free wall fibrosis in PH, and compared imaging findings to histological collagen density through an animal study.MethodsAmong 42 6-week-old Wistar male rats, 30 were classified according to disease duration (baseline before monocrotaline injection, and 2, 4, 6 and 8 weeks after injection) and 12 were used to control for aging (4 and 8 weeks after the baseline). We obtained pre and post-contrast T1 maps for native T1 and ECV of RV and left ventricular (LV) free wall for six animals in each disease-duration group. Collagen density of RV free wall was calculated with Masson's trichrome staining. The Kruskall-Wallis test was performed to compare the groups. Native T1 and ECV to collagen density were analyzed with Spearman’s correlation.ResultsThe mean values of native T1, ECV and collagen density of the RV free wall at baseline were 1541 ± 33 ms, 17.2 ± 1.3%, and 4.7 ± 0.5%, respectively. The values of RV free wall did not differ according to aging (P = 0.244, 0.504 and 0.331, respectively). However, the values significantly increased according to disease duration (P < 0.001 for all). Significant correlations were observed between native T1 and collagen density (r = 0.770, P < 0.001), and between ECV and collagen density for the RV free wall (r = 0.815, P < 0.001) in PH. However, there was no significant difference in native T1 and ECV values for the LV free wall according to the disease duration from the baseline (P = 0.349 and 0.240, respectively).ConclusionsWe observed significantly increased values for native T1 and ECV of the RV free wall without significant increase of the LV free wall according to the disease duration of PH, and findings were well correlated with histological collagen density.
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30 schema:keywords CMR T1 mapping
31 Cardiovascular magnetic resonance findings
32 ConclusionsWe
33 ECV values
34 Kruskall-Wallis test
35 LV free wall
36 Masson's trichrome staining
37 RV
38 RV dysfunction
39 RV free wall
40 Spearman correlation
41 T1
42 T1 mapping
43 T1 maps
44 Wistar male rats
45 analysis
46 animal studies
47 animals
48 baseline
49 collagen density
50 comparison
51 components
52 correlation
53 density
54 differences
55 disease duration
56 disease duration groups
57 duration
58 dysfunction
59 extracellular volume fraction
60 feasibility
61 fibrosis
62 findings
63 fraction
64 free wall
65 group
66 histological analysis
67 histology
68 hypertension
69 important component
70 increase
71 magnetic resonance findings
72 male rats
73 mapping
74 maps
75 ms
76 native T1
77 post-contrast T1 maps
78 previous reports
79 progression
80 pulmonary hypertension
81 rats
82 report
83 right ventricle
84 significant correlation
85 significant differences
86 significant increase
87 staining
88 study
89 test
90 trichrome staining
91 values
92 ventricle
93 ventricular free wall
94 volume fraction
95 wall
96 wall fibrosis
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