Left ventricular synchrony, torsion, and recoil mechanics in Ebstein’s anomaly: insights from cardiovascular magnetic resonance View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12-14

AUTHORS

Michael Steinmetz, Simon Usenbenz, Johannes Tammo Kowallick, Olga Hösch, Wieland Staab, Torben Lange, Shelby Kutty, Joachim Lotz, Gerd Hasenfuß, Thomas Paul, Andreas Schuster

ABSTRACT

BackgroundDisease progression and heart failure development in Ebstein’s Anomaly (EA) of the tricuspid valve is characterized by both right and left ventricular (LV) deterioration. The mechanisms underlying LV dysfunction and their role in heart failure development are incompletely understood. We hypothesized that LV dyssynchrony and impaired torsion and recoil mechanics induced by paradoxical movement of the basal septum may play a role in heart failure development.Methods31 EA patients and 31 matched controls underwent prospective cardiovascular magnetic resonance (CMR). CMR feature tracking (CMR-FT) was performed on apical, midventricular and basal short-axis and 4D–volume analysis was performed using three long-axis views and a short axis cine stack employing dedicated software. Circumferential uniformity ratio estimates (CURE) time-to-peak-based circumferential systolic dyssynchrony index (C-SDI), 4D volume analysis derived SDI (4D–SDI), torsion (Tor) and systolic (sysTR) and diastolic torsion rate (diasTR) were calculated for the LV. QRS duration, brain natriuretic peptide, NYHA and Total R/L-Volume Index (R/L Index) were obtained.ResultsEA patients (31.5 years; controls 31.4 years) had significantly longer QRS duration (123.35 ms ± 26.36 vs. 97.33 ms ± 11.89 p < 0.01) and showed more LV dyssynchrony (4D–SDI 7.60% ± 4.58 vs. 2.54% ± 0.62, p < 0.001; CURE 0.77 ± 0.05 vs. 0.86 ± 0.03, p < 0.001; C-SDI 7.70 ± 3.38 vs. 3.80 ± 0.91, p = 0.001). There were significant associations of LV dyssynchrony with heart failure parameters and QRS duration. Although torsion and recoil mechanics did not differ significantly (p > 0.05) there was an association of torsion and recoil mechanics with dyssynchrony parameters CURE (sysTR r = −0.426; p = 0.017, diasTR r = 0.419; p = 0.019), 4D–SDI (sysTR r = 0.383; p = 0.044) and C-SDI (diasTR r = −0.364; p = 0.044).ConclusionsEA is characterized by LV intra-ventricular dyssynchrony, which is associated with heart failure and disease severity parameters. Markers of dyssynchrony can easily be quantified from CMR-FT, and may have a role in the assessment of altered cardiac function, carrying potential management implications for EA patients. More... »

PAGES

101

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12968-017-0414-y

DOI

http://dx.doi.org/10.1186/s12968-017-0414-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1099598114

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29237468


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomechanical Phenomena", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Case-Control Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cross-Sectional Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Progression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ebstein Anomaly", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heart Failure", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnetic Resonance Imaging, Cine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myocardial Contraction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Predictive Value of Tests", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Severity of Illness Index", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Torsion, Mechanical", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ventricular Dysfunction, Left", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ventricular Function, Left", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "DZHK (German Centre for Cardiovascular Research), partner site G\u00f6ttingen, G\u00f6ttingen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.452396.f", 
          "name": [
            "Department of Pediatric Cardiology and Intensive Care Medicine, Georg-August University G\u00f6ttingen, University Medical Center, Robert-Koch-Str. 40, D-37099, G\u00f6ttingen, Germany", 
            "DZHK (German Centre for Cardiovascular Research), partner site G\u00f6ttingen, G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Steinmetz", 
        "givenName": "Michael", 
        "id": "sg:person.01271600754.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271600754.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "DZHK (German Centre for Cardiovascular Research), partner site G\u00f6ttingen, G\u00f6ttingen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.452396.f", 
          "name": [
            "Department of Pediatric Cardiology and Intensive Care Medicine, Georg-August University G\u00f6ttingen, University Medical Center, Robert-Koch-Str. 40, D-37099, G\u00f6ttingen, Germany", 
            "DZHK (German Centre for Cardiovascular Research), partner site G\u00f6ttingen, G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Usenbenz", 
        "givenName": "Simon", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "DZHK (German Centre for Cardiovascular Research), partner site G\u00f6ttingen, G\u00f6ttingen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.452396.f", 
          "name": [
            "Institute for Diagostic and Interventional Radiology, Georg-August-University G\u00f6ttingen, University Medical Center, G\u00f6ttingen, Germany", 
            "DZHK (German Centre for Cardiovascular Research), partner site G\u00f6ttingen, G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kowallick", 
        "givenName": "Johannes Tammo", 
        "id": "sg:person.01051403142.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051403142.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pediatric Cardiology and Intensive Care Medicine, Georg-August University G\u00f6ttingen, University Medical Center, Robert-Koch-Str. 40, D-37099, G\u00f6ttingen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.411984.1", 
          "name": [
            "Department of Pediatric Cardiology and Intensive Care Medicine, Georg-August University G\u00f6ttingen, University Medical Center, Robert-Koch-Str. 40, D-37099, G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "H\u00f6sch", 
        "givenName": "Olga", 
        "id": "sg:person.01117273132.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117273132.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "DZHK (German Centre for Cardiovascular Research), partner site G\u00f6ttingen, G\u00f6ttingen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.452396.f", 
          "name": [
            "Institute for Diagostic and Interventional Radiology, Georg-August-University G\u00f6ttingen, University Medical Center, G\u00f6ttingen, Germany", 
            "DZHK (German Centre for Cardiovascular Research), partner site G\u00f6ttingen, G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Staab", 
        "givenName": "Wieland", 
        "id": "sg:person.01244546367.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244546367.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "DZHK (German Centre for Cardiovascular Research), partner site G\u00f6ttingen, G\u00f6ttingen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.452396.f", 
          "name": [
            "Department of Cardiology and Pneumology, Georg-August-University G\u00f6ttingen, University Medical Center, Robert-Koch-Str. 40, D-37099, G\u00f6tttingen, Germany", 
            "DZHK (German Centre for Cardiovascular Research), partner site G\u00f6ttingen, G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lange", 
        "givenName": "Torben", 
        "id": "sg:person.012060353357.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012060353357.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Nebraska Medical Center/ Children\u2019s Hospital and Medical Center, Omaha, NE, USA", 
          "id": "http://www.grid.ac/institutes/grid.266813.8", 
          "name": [
            "University of Nebraska Medical Center/ Children\u2019s Hospital and Medical Center, Omaha, NE, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kutty", 
        "givenName": "Shelby", 
        "id": "sg:person.01325513730.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325513730.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "DZHK (German Centre for Cardiovascular Research), partner site G\u00f6ttingen, G\u00f6ttingen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.452396.f", 
          "name": [
            "Institute for Diagostic and Interventional Radiology, Georg-August-University G\u00f6ttingen, University Medical Center, G\u00f6ttingen, Germany", 
            "DZHK (German Centre for Cardiovascular Research), partner site G\u00f6ttingen, G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lotz", 
        "givenName": "Joachim", 
        "id": "sg:person.01021020333.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021020333.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "DZHK (German Centre for Cardiovascular Research), partner site G\u00f6ttingen, G\u00f6ttingen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.452396.f", 
          "name": [
            "Department of Cardiology and Pneumology, Georg-August-University G\u00f6ttingen, University Medical Center, Robert-Koch-Str. 40, D-37099, G\u00f6tttingen, Germany", 
            "DZHK (German Centre for Cardiovascular Research), partner site G\u00f6ttingen, G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hasenfu\u00df", 
        "givenName": "Gerd", 
        "id": "sg:person.01121062312.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121062312.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "DZHK (German Centre for Cardiovascular Research), partner site G\u00f6ttingen, G\u00f6ttingen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.452396.f", 
          "name": [
            "Department of Pediatric Cardiology and Intensive Care Medicine, Georg-August University G\u00f6ttingen, University Medical Center, Robert-Koch-Str. 40, D-37099, G\u00f6ttingen, Germany", 
            "DZHK (German Centre for Cardiovascular Research), partner site G\u00f6ttingen, G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Paul", 
        "givenName": "Thomas", 
        "id": "sg:person.016537516522.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016537516522.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, Royal North Shore Hospital, The Kolling Institute, Nothern Clinical School, University of Sydney, Sydney, Australia", 
          "id": "http://www.grid.ac/institutes/grid.1013.3", 
          "name": [
            "Department of Cardiology and Pneumology, Georg-August-University G\u00f6ttingen, University Medical Center, Robert-Koch-Str. 40, D-37099, G\u00f6tttingen, Germany", 
            "DZHK (German Centre for Cardiovascular Research), partner site G\u00f6ttingen, G\u00f6ttingen, Germany", 
            "Department of Cardiology, Royal North Shore Hospital, The Kolling Institute, Nothern Clinical School, University of Sydney, Sydney, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schuster", 
        "givenName": "Andreas", 
        "id": "sg:person.0665415103.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665415103.47"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00246-015-1202-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039091625", 
          "https://doi.org/10.1007/s00246-015-1202-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1532-429x-13-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010385629", 
          "https://doi.org/10.1186/1532-429x-13-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1532-429x-15-51", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049568408", 
          "https://doi.org/10.1186/1532-429x-15-51"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11936-014-0338-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033569648", 
          "https://doi.org/10.1007/s11936-014-0338-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10554-012-0054-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025578328", 
          "https://doi.org/10.1007/s10554-012-0054-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1532-429x-18-s1-o119", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040021660", 
          "https://doi.org/10.1186/1532-429x-18-s1-o119"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12968-014-0058-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021426189", 
          "https://doi.org/10.1186/s12968-014-0058-0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-12-14", 
    "datePublishedReg": "2017-12-14", 
    "description": "BackgroundDisease progression and heart failure development in Ebstein\u2019s Anomaly (EA) of the tricuspid valve is characterized by both right and left ventricular (LV) deterioration. The mechanisms underlying LV dysfunction and their role in heart failure development are incompletely understood. We hypothesized that LV dyssynchrony and impaired torsion and recoil mechanics induced by paradoxical movement of the basal septum may play a role in heart failure development.Methods31 EA patients and 31 matched controls underwent prospective cardiovascular magnetic resonance (CMR). CMR feature tracking (CMR-FT) was performed on apical, midventricular and basal short-axis and 4D\u2013volume analysis was performed using three long-axis views and a short axis cine stack employing dedicated software. Circumferential uniformity ratio estimates (CURE) time-to-peak-based circumferential systolic dyssynchrony index (C-SDI), 4D volume analysis derived SDI (4D\u2013SDI), torsion (Tor) and systolic (sysTR) and diastolic torsion rate (diasTR) were calculated for the LV. QRS duration, brain natriuretic peptide, NYHA and Total R/L-Volume Index (R/L Index) were obtained.ResultsEA patients (31.5\u00a0years; controls 31.4\u00a0years) had significantly longer QRS duration (123.35\u00a0ms\u2009\u00b1\u200926.36 vs. 97.33\u00a0ms\u00a0\u00b1\u200911.89 p\u00a0<\u20090.01) and showed more LV dyssynchrony (4D\u2013SDI 7.60%\u2009\u00b1\u20094.58 vs. 2.54%\u2009\u00b1\u20090.62, p\u00a0<\u20090.001; CURE 0.77\u2009\u00b1\u20090.05 vs. 0.86\u2009\u00b1\u20090.03, p\u2009<\u20090.001; C-SDI 7.70\u2009\u00b1\u20093.38 vs. 3.80\u2009\u00b1\u20090.91, p\u00a0=\u20090.001). There were significant associations of LV dyssynchrony with heart failure parameters and QRS duration. Although torsion and recoil mechanics did not differ significantly (p\u00a0>\u20090.05) there was an association of torsion and recoil mechanics with dyssynchrony parameters CURE (sysTR r\u00a0=\u2009\u22120.426; p\u00a0=\u20090.017, diasTR r\u00a0=\u20090.419; p\u00a0=\u20090.019), 4D\u2013SDI (sysTR r\u00a0=\u20090.383; p\u00a0=\u20090.044) and C-SDI (diasTR r\u00a0=\u2009\u22120.364; p\u2009=\u20090.044).ConclusionsEA is characterized by LV intra-ventricular dyssynchrony, which is associated with heart failure and disease severity parameters. Markers of dyssynchrony can easily be quantified from CMR-FT, and may have a role in the assessment of altered cardiac function, carrying potential management implications for EA patients.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s12968-017-0414-y", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1030439", 
        "issn": [
          "1548-7679", 
          "1879-2855"
        ], 
        "name": "Journal of Cardiovascular Magnetic Resonance", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "19"
      }
    ], 
    "keywords": [
      "heart failure development", 
      "cardiovascular magnetic resonance", 
      "Ebstein's anomaly", 
      "LV dyssynchrony", 
      "QRS duration", 
      "EA patients", 
      "failure development", 
      "more LV dyssynchrony", 
      "heart failure parameters", 
      "markers of dyssynchrony", 
      "left ventricular synchrony", 
      "brain natriuretic peptide", 
      "systolic dyssynchrony index", 
      "longer QRS duration", 
      "short-axis cine stacks", 
      "intra-ventricular dyssynchrony", 
      "disease severity parameters", 
      "CMR feature tracking", 
      "long-axis view", 
      "ventricular deterioration", 
      "LV dysfunction", 
      "ventricular synchrony", 
      "heart failure", 
      "tricuspid valve", 
      "dyssynchrony index", 
      "natriuretic peptide", 
      "cardiac function", 
      "dyssynchrony", 
      "magnetic resonance", 
      "paradoxical movement", 
      "CMR-FT", 
      "significant association", 
      "patients", 
      "basal septum", 
      "duration", 
      "torsion rate", 
      "association", 
      "potential management implications", 
      "severity parameters", 
      "ConclusionsEA", 
      "NYHA", 
      "systolic", 
      "dysfunction", 
      "volume analysis", 
      "progression", 
      "LV", 
      "role", 
      "septum", 
      "cure", 
      "index", 
      "markers", 
      "anomalies", 
      "estimate time", 
      "failure", 
      "valve", 
      "peptides", 
      "development", 
      "torsion", 
      "deterioration", 
      "assessment", 
      "control", 
      "synchrony", 
      "rate", 
      "analysis", 
      "mechanism", 
      "feature tracking", 
      "axis", 
      "function", 
      "time", 
      "implications", 
      "movement", 
      "resonance", 
      "SDI", 
      "parameters", 
      "insights", 
      "management implications", 
      "view", 
      "mechanics", 
      "failure parameters", 
      "software", 
      "tracking", 
      "stack"
    ], 
    "name": "Left ventricular synchrony, torsion, and recoil mechanics in Ebstein\u2019s anomaly: insights from cardiovascular magnetic resonance", 
    "pagination": "101", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1099598114"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12968-017-0414-y"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29237468"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12968-017-0414-y", 
      "https://app.dimensions.ai/details/publication/pub.1099598114"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:35", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_722.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s12968-017-0414-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12968-017-0414-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12968-017-0414-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12968-017-0414-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12968-017-0414-y'


 

This table displays all metadata directly associated to this object as RDF triples.

342 TRIPLES      21 PREDICATES      136 URIs      121 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12968-017-0414-y schema:about N0a5d76f39cb54f35bbcfb0286852ae1c
2 N13ad3e0375d1411d8843516a053c0b35
3 N1d12c0fe615b4a5d92a6c5ee6d6cf42b
4 N2fd7014da52c42919c1d4b0d47b9a244
5 N3bcec79c29254aad968c7e40a2e75a76
6 N3f8f9db8fd034137a12dd858e0d4568b
7 N49ca292d2f4b4decab53e9127c0c9aea
8 N4e74458d04a548f287e503e26daf62b3
9 N529389a20f9c42f58408bc88514f5808
10 N778fe072ab254abaaec7cb0d00ce7962
11 N7b4e1ec7d84a4257bde188596f0c5cbc
12 N881511cd7dce4e50951940765e464807
13 N8a9b173eb7c0483e81604594d21da2a4
14 N8d8f3ddb8ac94c0fb2d0fe333151d7b8
15 N91b19276d08240df8fc0058c64707eda
16 N940edb37f2d44cada6de42706a5c358f
17 Na6b0c285161244eba3852107e244202b
18 Na74319c18c6b442daf2792852a9403e5
19 Nb9acd44703a047a38b61e4eacbf98bf1
20 Ned48d4fd4b7749219bf0151436d5465e
21 Neecc2604fb73459e82f38e36311aea44
22 Nf72bb25d27474997b1581335c9008ddf
23 anzsrc-for:11
24 anzsrc-for:1102
25 schema:author Nb84beeb608364faeb330f923ca39bffb
26 schema:citation sg:pub.10.1007/s00246-015-1202-9
27 sg:pub.10.1007/s10554-012-0054-0
28 sg:pub.10.1007/s11936-014-0338-x
29 sg:pub.10.1186/1532-429x-13-3
30 sg:pub.10.1186/1532-429x-15-51
31 sg:pub.10.1186/1532-429x-18-s1-o119
32 sg:pub.10.1186/s12968-014-0058-0
33 schema:datePublished 2017-12-14
34 schema:datePublishedReg 2017-12-14
35 schema:description BackgroundDisease progression and heart failure development in Ebstein’s Anomaly (EA) of the tricuspid valve is characterized by both right and left ventricular (LV) deterioration. The mechanisms underlying LV dysfunction and their role in heart failure development are incompletely understood. We hypothesized that LV dyssynchrony and impaired torsion and recoil mechanics induced by paradoxical movement of the basal septum may play a role in heart failure development.Methods31 EA patients and 31 matched controls underwent prospective cardiovascular magnetic resonance (CMR). CMR feature tracking (CMR-FT) was performed on apical, midventricular and basal short-axis and 4D–volume analysis was performed using three long-axis views and a short axis cine stack employing dedicated software. Circumferential uniformity ratio estimates (CURE) time-to-peak-based circumferential systolic dyssynchrony index (C-SDI), 4D volume analysis derived SDI (4D–SDI), torsion (Tor) and systolic (sysTR) and diastolic torsion rate (diasTR) were calculated for the LV. QRS duration, brain natriuretic peptide, NYHA and Total R/L-Volume Index (R/L Index) were obtained.ResultsEA patients (31.5 years; controls 31.4 years) had significantly longer QRS duration (123.35 ms ± 26.36 vs. 97.33 ms ± 11.89 p < 0.01) and showed more LV dyssynchrony (4D–SDI 7.60% ± 4.58 vs. 2.54% ± 0.62, p < 0.001; CURE 0.77 ± 0.05 vs. 0.86 ± 0.03, p < 0.001; C-SDI 7.70 ± 3.38 vs. 3.80 ± 0.91, p = 0.001). There were significant associations of LV dyssynchrony with heart failure parameters and QRS duration. Although torsion and recoil mechanics did not differ significantly (p > 0.05) there was an association of torsion and recoil mechanics with dyssynchrony parameters CURE (sysTR r = −0.426; p = 0.017, diasTR r = 0.419; p = 0.019), 4D–SDI (sysTR r = 0.383; p = 0.044) and C-SDI (diasTR r = −0.364; p = 0.044).ConclusionsEA is characterized by LV intra-ventricular dyssynchrony, which is associated with heart failure and disease severity parameters. Markers of dyssynchrony can easily be quantified from CMR-FT, and may have a role in the assessment of altered cardiac function, carrying potential management implications for EA patients.
36 schema:genre article
37 schema:isAccessibleForFree true
38 schema:isPartOf N87771ce4f91342f6adf3a5569c6dfdc3
39 Ndfd929b2fe8944bf9870f9ddedf8d8be
40 sg:journal.1030439
41 schema:keywords CMR feature tracking
42 CMR-FT
43 ConclusionsEA
44 EA patients
45 Ebstein's anomaly
46 LV
47 LV dysfunction
48 LV dyssynchrony
49 NYHA
50 QRS duration
51 SDI
52 analysis
53 anomalies
54 assessment
55 association
56 axis
57 basal septum
58 brain natriuretic peptide
59 cardiac function
60 cardiovascular magnetic resonance
61 control
62 cure
63 deterioration
64 development
65 disease severity parameters
66 duration
67 dysfunction
68 dyssynchrony
69 dyssynchrony index
70 estimate time
71 failure
72 failure development
73 failure parameters
74 feature tracking
75 function
76 heart failure
77 heart failure development
78 heart failure parameters
79 implications
80 index
81 insights
82 intra-ventricular dyssynchrony
83 left ventricular synchrony
84 long-axis view
85 longer QRS duration
86 magnetic resonance
87 management implications
88 markers
89 markers of dyssynchrony
90 mechanics
91 mechanism
92 more LV dyssynchrony
93 movement
94 natriuretic peptide
95 paradoxical movement
96 parameters
97 patients
98 peptides
99 potential management implications
100 progression
101 rate
102 resonance
103 role
104 septum
105 severity parameters
106 short-axis cine stacks
107 significant association
108 software
109 stack
110 synchrony
111 systolic
112 systolic dyssynchrony index
113 time
114 torsion
115 torsion rate
116 tracking
117 tricuspid valve
118 valve
119 ventricular deterioration
120 ventricular synchrony
121 view
122 volume analysis
123 schema:name Left ventricular synchrony, torsion, and recoil mechanics in Ebstein’s anomaly: insights from cardiovascular magnetic resonance
124 schema:pagination 101
125 schema:productId Nbaf57a1413fb4ed695975ed657ab9844
126 Nc0a29efecfcb481a9c067516265f6c68
127 Ncc4d212133724bb0b677482224760cfe
128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099598114
129 https://doi.org/10.1186/s12968-017-0414-y
130 schema:sdDatePublished 2022-12-01T06:35
131 schema:sdLicense https://scigraph.springernature.com/explorer/license/
132 schema:sdPublisher Na211699cd7dd4867a3465a41cd5aafd7
133 schema:url https://doi.org/10.1186/s12968-017-0414-y
134 sgo:license sg:explorer/license/
135 sgo:sdDataset articles
136 rdf:type schema:ScholarlyArticle
137 N0323438273944337850c331bc3db7108 rdf:first Nd8a9992cb23c4426b772e66c7a84fb4b
138 rdf:rest Ne22a0207a3be46109bbc102f7315cbf6
139 N0a5d76f39cb54f35bbcfb0286852ae1c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Cross-Sectional Studies
141 rdf:type schema:DefinedTerm
142 N13ad3e0375d1411d8843516a053c0b35 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Adult
144 rdf:type schema:DefinedTerm
145 N1d12c0fe615b4a5d92a6c5ee6d6cf42b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Biomechanical Phenomena
147 rdf:type schema:DefinedTerm
148 N22aeb1a61d7544febcce7aa147641700 rdf:first sg:person.01325513730.96
149 rdf:rest Na4fe3693bc8444a2a91910c66b51b96d
150 N244751c9273e4abd8b0505c00a22d1f4 rdf:first sg:person.01244546367.27
151 rdf:rest N4f350077ac004f97ab1cf05bab9d35ea
152 N2fd7014da52c42919c1d4b0d47b9a244 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Ventricular Function, Left
154 rdf:type schema:DefinedTerm
155 N3bcec79c29254aad968c7e40a2e75a76 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Male
157 rdf:type schema:DefinedTerm
158 N3f8f9db8fd034137a12dd858e0d4568b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Predictive Value of Tests
160 rdf:type schema:DefinedTerm
161 N46025ce0a54e4296882a8ad676b499ad rdf:first sg:person.01117273132.66
162 rdf:rest N244751c9273e4abd8b0505c00a22d1f4
163 N49ca292d2f4b4decab53e9127c0c9aea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Severity of Illness Index
165 rdf:type schema:DefinedTerm
166 N4e74458d04a548f287e503e26daf62b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Female
168 rdf:type schema:DefinedTerm
169 N4f350077ac004f97ab1cf05bab9d35ea rdf:first sg:person.012060353357.04
170 rdf:rest N22aeb1a61d7544febcce7aa147641700
171 N529389a20f9c42f58408bc88514f5808 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Myocardial Contraction
173 rdf:type schema:DefinedTerm
174 N5fc305f859a3405f9d4ea9ada039ce58 rdf:first sg:person.01121062312.25
175 rdf:rest Nc34b3b47123b4431a802c991df29b67e
176 N778fe072ab254abaaec7cb0d00ce7962 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Middle Aged
178 rdf:type schema:DefinedTerm
179 N7b4e1ec7d84a4257bde188596f0c5cbc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Ventricular Dysfunction, Left
181 rdf:type schema:DefinedTerm
182 N87771ce4f91342f6adf3a5569c6dfdc3 schema:issueNumber 1
183 rdf:type schema:PublicationIssue
184 N881511cd7dce4e50951940765e464807 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Disease Progression
186 rdf:type schema:DefinedTerm
187 N8a9b173eb7c0483e81604594d21da2a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Young Adult
189 rdf:type schema:DefinedTerm
190 N8d8f3ddb8ac94c0fb2d0fe333151d7b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Torsion, Mechanical
192 rdf:type schema:DefinedTerm
193 N91b19276d08240df8fc0058c64707eda schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Prospective Studies
195 rdf:type schema:DefinedTerm
196 N940edb37f2d44cada6de42706a5c358f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Ebstein Anomaly
198 rdf:type schema:DefinedTerm
199 N96b4d9bd39fd42eca6350b125205fc2c rdf:first sg:person.0665415103.47
200 rdf:rest rdf:nil
201 Na211699cd7dd4867a3465a41cd5aafd7 schema:name Springer Nature - SN SciGraph project
202 rdf:type schema:Organization
203 Na4fe3693bc8444a2a91910c66b51b96d rdf:first sg:person.01021020333.35
204 rdf:rest N5fc305f859a3405f9d4ea9ada039ce58
205 Na6b0c285161244eba3852107e244202b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Adolescent
207 rdf:type schema:DefinedTerm
208 Na74319c18c6b442daf2792852a9403e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
209 schema:name Humans
210 rdf:type schema:DefinedTerm
211 Nb84beeb608364faeb330f923ca39bffb rdf:first sg:person.01271600754.89
212 rdf:rest N0323438273944337850c331bc3db7108
213 Nb9acd44703a047a38b61e4eacbf98bf1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
214 schema:name Case-Control Studies
215 rdf:type schema:DefinedTerm
216 Nbaf57a1413fb4ed695975ed657ab9844 schema:name dimensions_id
217 schema:value pub.1099598114
218 rdf:type schema:PropertyValue
219 Nc0a29efecfcb481a9c067516265f6c68 schema:name doi
220 schema:value 10.1186/s12968-017-0414-y
221 rdf:type schema:PropertyValue
222 Nc34b3b47123b4431a802c991df29b67e rdf:first sg:person.016537516522.25
223 rdf:rest N96b4d9bd39fd42eca6350b125205fc2c
224 Ncc4d212133724bb0b677482224760cfe schema:name pubmed_id
225 schema:value 29237468
226 rdf:type schema:PropertyValue
227 Nd8a9992cb23c4426b772e66c7a84fb4b schema:affiliation grid-institutes:grid.452396.f
228 schema:familyName Usenbenz
229 schema:givenName Simon
230 rdf:type schema:Person
231 Ndfd929b2fe8944bf9870f9ddedf8d8be schema:volumeNumber 19
232 rdf:type schema:PublicationVolume
233 Ne22a0207a3be46109bbc102f7315cbf6 rdf:first sg:person.01051403142.44
234 rdf:rest N46025ce0a54e4296882a8ad676b499ad
235 Ned48d4fd4b7749219bf0151436d5465e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
236 schema:name Risk Factors
237 rdf:type schema:DefinedTerm
238 Neecc2604fb73459e82f38e36311aea44 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
239 schema:name Heart Failure
240 rdf:type schema:DefinedTerm
241 Nf72bb25d27474997b1581335c9008ddf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
242 schema:name Magnetic Resonance Imaging, Cine
243 rdf:type schema:DefinedTerm
244 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
245 schema:name Medical and Health Sciences
246 rdf:type schema:DefinedTerm
247 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
248 schema:name Cardiorespiratory Medicine and Haematology
249 rdf:type schema:DefinedTerm
250 sg:journal.1030439 schema:issn 1548-7679
251 1879-2855
252 schema:name Journal of Cardiovascular Magnetic Resonance
253 schema:publisher Springer Nature
254 rdf:type schema:Periodical
255 sg:person.01021020333.35 schema:affiliation grid-institutes:grid.452396.f
256 schema:familyName Lotz
257 schema:givenName Joachim
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021020333.35
259 rdf:type schema:Person
260 sg:person.01051403142.44 schema:affiliation grid-institutes:grid.452396.f
261 schema:familyName Kowallick
262 schema:givenName Johannes Tammo
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051403142.44
264 rdf:type schema:Person
265 sg:person.01117273132.66 schema:affiliation grid-institutes:grid.411984.1
266 schema:familyName Hösch
267 schema:givenName Olga
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117273132.66
269 rdf:type schema:Person
270 sg:person.01121062312.25 schema:affiliation grid-institutes:grid.452396.f
271 schema:familyName Hasenfuß
272 schema:givenName Gerd
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121062312.25
274 rdf:type schema:Person
275 sg:person.012060353357.04 schema:affiliation grid-institutes:grid.452396.f
276 schema:familyName Lange
277 schema:givenName Torben
278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012060353357.04
279 rdf:type schema:Person
280 sg:person.01244546367.27 schema:affiliation grid-institutes:grid.452396.f
281 schema:familyName Staab
282 schema:givenName Wieland
283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244546367.27
284 rdf:type schema:Person
285 sg:person.01271600754.89 schema:affiliation grid-institutes:grid.452396.f
286 schema:familyName Steinmetz
287 schema:givenName Michael
288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271600754.89
289 rdf:type schema:Person
290 sg:person.01325513730.96 schema:affiliation grid-institutes:grid.266813.8
291 schema:familyName Kutty
292 schema:givenName Shelby
293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325513730.96
294 rdf:type schema:Person
295 sg:person.016537516522.25 schema:affiliation grid-institutes:grid.452396.f
296 schema:familyName Paul
297 schema:givenName Thomas
298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016537516522.25
299 rdf:type schema:Person
300 sg:person.0665415103.47 schema:affiliation grid-institutes:grid.1013.3
301 schema:familyName Schuster
302 schema:givenName Andreas
303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665415103.47
304 rdf:type schema:Person
305 sg:pub.10.1007/s00246-015-1202-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039091625
306 https://doi.org/10.1007/s00246-015-1202-9
307 rdf:type schema:CreativeWork
308 sg:pub.10.1007/s10554-012-0054-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025578328
309 https://doi.org/10.1007/s10554-012-0054-0
310 rdf:type schema:CreativeWork
311 sg:pub.10.1007/s11936-014-0338-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033569648
312 https://doi.org/10.1007/s11936-014-0338-x
313 rdf:type schema:CreativeWork
314 sg:pub.10.1186/1532-429x-13-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010385629
315 https://doi.org/10.1186/1532-429x-13-3
316 rdf:type schema:CreativeWork
317 sg:pub.10.1186/1532-429x-15-51 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049568408
318 https://doi.org/10.1186/1532-429x-15-51
319 rdf:type schema:CreativeWork
320 sg:pub.10.1186/1532-429x-18-s1-o119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040021660
321 https://doi.org/10.1186/1532-429x-18-s1-o119
322 rdf:type schema:CreativeWork
323 sg:pub.10.1186/s12968-014-0058-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021426189
324 https://doi.org/10.1186/s12968-014-0058-0
325 rdf:type schema:CreativeWork
326 grid-institutes:grid.1013.3 schema:alternateName Department of Cardiology, Royal North Shore Hospital, The Kolling Institute, Nothern Clinical School, University of Sydney, Sydney, Australia
327 schema:name DZHK (German Centre for Cardiovascular Research), partner site Göttingen, Göttingen, Germany
328 Department of Cardiology and Pneumology, Georg-August-University Göttingen, University Medical Center, Robert-Koch-Str. 40, D-37099, Götttingen, Germany
329 Department of Cardiology, Royal North Shore Hospital, The Kolling Institute, Nothern Clinical School, University of Sydney, Sydney, Australia
330 rdf:type schema:Organization
331 grid-institutes:grid.266813.8 schema:alternateName University of Nebraska Medical Center/ Children’s Hospital and Medical Center, Omaha, NE, USA
332 schema:name University of Nebraska Medical Center/ Children’s Hospital and Medical Center, Omaha, NE, USA
333 rdf:type schema:Organization
334 grid-institutes:grid.411984.1 schema:alternateName Department of Pediatric Cardiology and Intensive Care Medicine, Georg-August University Göttingen, University Medical Center, Robert-Koch-Str. 40, D-37099, Göttingen, Germany
335 schema:name Department of Pediatric Cardiology and Intensive Care Medicine, Georg-August University Göttingen, University Medical Center, Robert-Koch-Str. 40, D-37099, Göttingen, Germany
336 rdf:type schema:Organization
337 grid-institutes:grid.452396.f schema:alternateName DZHK (German Centre for Cardiovascular Research), partner site Göttingen, Göttingen, Germany
338 schema:name DZHK (German Centre for Cardiovascular Research), partner site Göttingen, Göttingen, Germany
339 Department of Cardiology and Pneumology, Georg-August-University Göttingen, University Medical Center, Robert-Koch-Str. 40, D-37099, Götttingen, Germany
340 Department of Pediatric Cardiology and Intensive Care Medicine, Georg-August University Göttingen, University Medical Center, Robert-Koch-Str. 40, D-37099, Göttingen, Germany
341 Institute for Diagostic and Interventional Radiology, Georg-August-University Göttingen, University Medical Center, Göttingen, Germany
342 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...