Increased pericardial fat accumulation is associated with increased intramyocardial lipid content and duration of highly active antiretroviral therapy exposure in ... View Full Text


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Article Info

DATE

2015-10-31

AUTHORS

Mariana Diaz-Zamudio, Damini Dey, Troy LaBounty, Michael Nelson, Zhaoyang Fan, Lidia S. Szczepaniak, Bill Pei-Chin Hsieh, Ronak Rajani, Daniel Berman, Debiao Li, Rohan Dharmakumar, W. David Hardy, Antonio Hernandez Conte

ABSTRACT

BackgroundThe aim of the current study was to examine whether the use of highly active antiretroviral therapy (HAART) in patients with HIV is associated with changes in pericardial fat and myocardial lipid content measured by cardiovascular magnetic resonance (CMR).MethodsIn this prospective case-control study, we compared 27 HIV seropositive (+) male subjects receiving HAART to 22 control male subjects without HIV matched for age, ethnicity and body mass index. All participants underwent CMR imaging for determination of pericardial fat [as volume at the level of the origin of the left main coronary artery (LM) and at the right ventricular free wall] and magnetic resonance spectroscopy (MRS) for evaluation of intramyocardial lipid content (% of fat to water in a single voxel at the interventricular septum). All measurements were made by two experienced readers blinded to the clinical history of the study participants. Two-sample t-test, Spearman’s correlation coefficient or Pearson’s correlation coefficient and multivariable logistic regression were used for statistical analysis.ResultsPericardial fat volume at the level of LM origin was higher in HIV (+) subjects (33.4 cm3 vs. 27.4 cm3, p = 0.03). On multivariable analysis adjusted for age, Framingham risk score (FRS) and waist/hip ratio, pericardial fat remained significantly associated to HIV-status (OR 1.09, p = 0.047). For both HIV (+) and HIV (-) subjects, pericardial fat volume showed strong correlation with intramyocardial lipid content (r = 0.58, p < 0.0001) and FRS (r = 0.53, p = 0.0002). Among HIV (+) subjects, pericardial fat was significantly higher in patients with lipo-accumulation (37 cm3 vs. 27.1 cm3, p = 0.03) and showed significant correlation with duration of both HIV infection (r = 0.5, p = 0.01) and HAART (r = 0.46, p = 0.02).ConclusionsPericardial fat content is increased in HIV (+) subjects on chronic HAART (>5 years), who demonstrate HAART-related lipo-accumulation and prolonged HIV duration of infection. Further investigation is warranted to determine whether increased pericardial fat is associated with higher cardiovascular risk leading to premature cardiovascular events in this patient population. More... »

PAGES

91

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URI

http://scigraph.springernature.com/pub.10.1186/s12968-015-0193-2

DOI

http://dx.doi.org/10.1186/s12968-015-0193-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044832834

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26520571


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    "description": "BackgroundThe aim of the current study was to examine whether the use of highly active antiretroviral therapy (HAART) in patients with HIV is associated with changes in pericardial fat and myocardial lipid content measured by cardiovascular magnetic resonance (CMR).MethodsIn this prospective case-control study, we compared 27 HIV seropositive (+) male subjects receiving HAART to 22 control male subjects without HIV matched for age, ethnicity and body mass index. All participants underwent CMR imaging for determination of pericardial fat [as volume at the level of the origin of the left main coronary artery (LM) and at the right ventricular free wall] and magnetic resonance spectroscopy (MRS) for evaluation of intramyocardial lipid content (% of fat to water in a single voxel at the interventricular septum). All measurements were made by two experienced readers blinded to the clinical history of the study participants. Two-sample t-test, Spearman\u2019s correlation coefficient or Pearson\u2019s correlation coefficient and multivariable logistic regression were used for statistical analysis.ResultsPericardial fat volume at the level of LM origin was higher in HIV (+) subjects (33.4\u00a0cm3 vs. 27.4\u00a0cm3, p\u2009=\u20090.03). On multivariable analysis adjusted for age, Framingham risk score (FRS) and waist/hip ratio, pericardial fat remained significantly associated to HIV-status (OR 1.09, p\u2009=\u20090.047). For both HIV (+) and HIV (-) subjects, pericardial fat volume showed strong correlation with intramyocardial lipid content (r\u2009=\u20090.58, p\u2009<\u20090.0001) and FRS (r\u2009=\u20090.53, p\u2009=\u20090.0002). Among HIV (+) subjects, pericardial fat was significantly higher in patients with lipo-accumulation (37\u00a0cm3 vs. 27.1\u00a0cm3, p\u2009=\u20090.03) and showed significant correlation with duration of both HIV infection (r\u2009=\u20090.5, p\u2009=\u20090.01) and HAART (r\u2009=\u20090.46, p\u2009=\u20090.02).ConclusionsPericardial fat content is increased in HIV (+) subjects on chronic HAART (>5\u00a0years), who demonstrate HAART-related lipo-accumulation and prolonged HIV duration of infection. Further investigation is warranted to determine whether increased pericardial fat is associated with higher cardiovascular risk leading to premature cardiovascular events in this patient population.", 
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33 schema:description BackgroundThe aim of the current study was to examine whether the use of highly active antiretroviral therapy (HAART) in patients with HIV is associated with changes in pericardial fat and myocardial lipid content measured by cardiovascular magnetic resonance (CMR).MethodsIn this prospective case-control study, we compared 27 HIV seropositive (+) male subjects receiving HAART to 22 control male subjects without HIV matched for age, ethnicity and body mass index. All participants underwent CMR imaging for determination of pericardial fat [as volume at the level of the origin of the left main coronary artery (LM) and at the right ventricular free wall] and magnetic resonance spectroscopy (MRS) for evaluation of intramyocardial lipid content (% of fat to water in a single voxel at the interventricular septum). All measurements were made by two experienced readers blinded to the clinical history of the study participants. Two-sample t-test, Spearman’s correlation coefficient or Pearson’s correlation coefficient and multivariable logistic regression were used for statistical analysis.ResultsPericardial fat volume at the level of LM origin was higher in HIV (+) subjects (33.4 cm3 vs. 27.4 cm3, p = 0.03). On multivariable analysis adjusted for age, Framingham risk score (FRS) and waist/hip ratio, pericardial fat remained significantly associated to HIV-status (OR 1.09, p = 0.047). For both HIV (+) and HIV (-) subjects, pericardial fat volume showed strong correlation with intramyocardial lipid content (r = 0.58, p < 0.0001) and FRS (r = 0.53, p = 0.0002). Among HIV (+) subjects, pericardial fat was significantly higher in patients with lipo-accumulation (37 cm3 vs. 27.1 cm3, p = 0.03) and showed significant correlation with duration of both HIV infection (r = 0.5, p = 0.01) and HAART (r = 0.46, p = 0.02).ConclusionsPericardial fat content is increased in HIV (+) subjects on chronic HAART (>5 years), who demonstrate HAART-related lipo-accumulation and prolonged HIV duration of infection. Further investigation is warranted to determine whether increased pericardial fat is associated with higher cardiovascular risk leading to premature cardiovascular events in this patient population.
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39 schema:keywords Framingham risk score
40 HAART
41 HIV
42 HIV duration
43 HIV infection
44 HIV status
45 HIV subjects
46 MethodsIn
47 Pearson correlation coefficient
48 Spearman correlation coefficient
49 accumulation
50 active antiretroviral therapy
51 active antiretroviral therapy exposure
52 age
53 aim
54 analysis
55 antiretroviral therapy
56 antiretroviral therapy exposure
57 body mass index
58 cardiovascular events
59 cardiovascular magnetic resonance
60 cardiovascular risk
61 case-control study
62 changes
63 chronic HAART
64 clinical history
65 coefficient
66 content
67 correlation
68 correlation coefficient
69 current study
70 determination
71 duration
72 ethnicity
73 evaluation
74 events
75 experienced readers
76 exposure
77 fat
78 fat accumulation
79 fat content
80 fat volume
81 feasibility study
82 further investigation
83 high cardiovascular risk
84 hip ratio
85 history
86 human immunodeficiency virus
87 immunodeficiency virus
88 index
89 infection
90 intramyocardial lipid content
91 investigation
92 levels
93 lipid content
94 logistic regression
95 magnetic resonance
96 magnetic resonance spectroscopy
97 male subjects
98 mass index
99 measurements
100 multivariable analysis
101 multivariable logistic regression
102 myocardial lipid content
103 origin
104 participants
105 patient population
106 patients
107 pericardial fat
108 pericardial fat accumulation
109 pericardial fat volume
110 population
111 premature cardiovascular events
112 prospective case-control study
113 ratio
114 readers
115 regression
116 resonance
117 resonance spectroscopy
118 risk
119 risk score
120 scores
121 significant correlation
122 spectroscopy
123 statistical analysis
124 strong correlation
125 study
126 study participants
127 subjects
128 t-test
129 therapy
130 therapy exposure
131 two-sample t-test
132 use
133 virus
134 volume
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