Left ventricular global function index assessed by cardiovascular magnetic resonance for the prediction of cardiovascular events in ST-elevation myocardial infarction View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-07-16

AUTHORS

Ingo Eitel, J. Pöss, A. Jobs, C. Eitel, S. de Waha, J. Barkhausen, S. Desch, H. Thiele

ABSTRACT

BackgroundThe left ventricular performance index (LVGFI) as a comprehensive marker of cardiac performance integrates LV structure with global function within one index. In a prospective cohort study of healthy individuals the LVGFI demonstrated a superior prognostic value as compared to LV ejection fraction (LVEF). In patients after ST-segment elevation myocardial infarction (STEMI), however, the role of the LVGFI is unknown. Aim of this study was to investigate the relationship between the LVGFI and infarct characteristics as well as prognosis in a large multicenter STEMI population.MethodsIn total 795 STEMI patients reperfused by primary angioplasty (<12 h after symptom onset) underwent cardiovascular magnetic resonance (CMR) at 8 centers. CMR was completed within one week after infarction using a standardized protocol including LV dimensions, mass and function for calculation of the LVGFI. The primary clinical endpoint of the study was the occurrence of major adverse cardiac events (MACE).ResultsThe median LVGFI was 31.2 % (interquartile range 25.7 to 36.6). Patients with LVGFI < median had significantly larger infarcts, less myocardial salvage, a larger extent of microvascular obstruction, higher incidence of intramyocardial hemorrhage and more pronounced LV dysfunction (p < 0.001 for all). MACE and mortality rates were significantly higher in the LVGFI < median group (p < 0.001 and p = 0.003, respectively). The LVGFI had an incremental prognostic value in addition to LVEF for prediction of all-cause mortality.ConclusionsThe LVGFI strongly correlates with markers of severe myocardial and microvascular damage in patients with STEMI, offering prognostic information beyond traditional cardiac risk factors including the LVEF.Trials registrationClinicalTrials.gov: NCT00712101 More... »

PAGES

62

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http://scigraph.springernature.com/pub.10.1186/s12968-015-0161-x

DOI

http://dx.doi.org/10.1186/s12968-015-0161-x

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https://app.dimensions.ai/details/publication/pub.1048170630

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26174798


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75 global function index
76 group
77 healthy individuals
78 hemorrhage
79 high incidence
80 incidence
81 incremental prognostic value
82 index
83 individuals
84 infarction
85 infarcts
86 information
87 intramyocardial hemorrhage
88 large extent
89 large infarcts
90 magnetic resonance
91 major adverse cardiac events
92 markers
93 mass
94 median
95 median group
96 microvascular damage
97 microvascular obstruction
98 mortality
99 mortality rate
100 myocardial infarction
101 myocardial salvage
102 obstruction
103 occurrence
104 patients
105 performance
106 performance index
107 population
108 prediction
109 primary angioplasty
110 primary clinical endpoint
111 prognosis
112 prognostic information
113 prognostic value
114 prospective cohort study
115 protocol
116 rate
117 relationship
118 resonance
119 risk factors
120 role
121 salvage
122 standardized protocol
123 structure
124 study
125 superior prognostic value
126 traditional cardiac risk factors
127 values
128 ventricular global function index
129 ventricular performance indices
130 weeks
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