Perspectives in melanoma: meeting report from the “Melanoma Bridge” (December 5th–7th, 2019, Naples, Italy) View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-09-07

AUTHORS

Paolo A. Ascierto, Igor Puzanov, Sanjiv S. Agarwala, Christian Blank, Richard D. Carvajal, Sandra Demaria, Reinhard Dummer, Marc Ernstoff, Soldano Ferrone, Bernard A. Fox, Thomas F. Gajewski, Claus Garbe, Patrick Hwu, Roger S. Lo, Georgina V. Long, Jason J. Luke, Iman Osman, Michael A. Postow, Ryan J. Sullivan, Janis M. Taube, Giorgio Trinchieri, Hassane M. Zarour, Corrado Caracò, Magdalena Thurin

ABSTRACT

The melanoma treatment landscape changed in 2011 with the approval of the first anti-cytotoxic T-lymphocyte-associated protein (CTLA)-4 checkpoint inhibitor and of the first BRAF-targeted monoclonal antibody, both of which significantly improved overall survival (OS). Since then, improved understanding of the tumor microenvironment (TME) and tumor immune-evasion mechanisms has resulted in new approaches to targeting and harnessing the host immune response. The approval of new immune and targeted therapies has further improved outcomes for patients with advanced melanoma and other combination modalities are also being explored such as chemotherapy, radiotherapy, electrochemotherapy and surgery. In addition, different strategies of drugs administration including sequential or combination treatment are being tested. Approaches to overcome resistance and to potentiate the immune response are being developed. Increasing evidence emerges that tissue and blood-based biomarkers can predict the response to a therapy. The latest findings in melanoma research, including insights into the tumor microenvironment and new biomarkers, improved understanding of tumor immune response and resistance, novel approaches for combination strategies and the role of neoadjuvant and adjuvant therapy, were the focus of discussions at the Melanoma Bridge meeting (5–7 December, 2019, Naples, Italy), which are summarized in this report. More... »

PAGES

346

References to SciGraph publications

Journal

TITLE

Journal of Translational Medicine

ISSUE

1

VOLUME

18

Author Affiliations

  • Unit of Melanoma, Cancer Immunotherapy and Innovative Therapy, Istituto Nazionale Tumori IRCCS “Fondazione G. Pascale”, Via Mariano Semmola, 80131, Naples, Italy
  • Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA
  • Temple University School of Medicine, Philadelphia, PA, USA
  • Netherlands Cancer Institute, Amsterdam, The Netherlands
  • Columbia University Irving Medical Center, Herbert Irving Comprehensive Cancer Center, New York, NY, USA
  • Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA
  • Department of Dermatology, University of Zurich Hospital, Zurich, Switzerland
  • Roswell Park Comprehensive Cancer Center, Jacobs School of Medicine and Biomedical Sciences, State University, Buffalo, NY, USA
  • Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
  • Earle A. Chiles Research Institute, Robert W. Franz Cancer Research Center, Providence Cancer Institute, Portland, OR, USA
  • Department of Medicine (Section of Haematology/Oncology), University of Chicago, Chicago, IL, USA
  • Center for Dermatooncology, Department of Dermatology, Eberhard Karls University, Tübingen, Germany
  • Department of Melanoma Medical Oncology, Division of Cancer Medicine, Anderson Cancer Center, Houston, TX, USA
  • Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
  • Melanoma Institute Australia, The University of Sydney and Royal North Shore and Mater Hospitals, Sydney, Australia
  • Medicine University of Chicago, Chicago, IL, USA
  • The Interdisciplinary Melanoma Program, New York University Langone Medical Center, NYU Grossman Medical School, New York, NY, USA
  • Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY, USA
  • Melanoma Program, Mass General Cancer Center, Boston, MA, USA
  • Division of Dermatopathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
  • Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
  • Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA
  • Department Melanoma, Soft Tissue, Muscle-Skeletal and Head-Neck, Istituto Nazionale Tumori IRCCS “Fondazione G. Pascale”, Naples, Italy
  • Cancer Diagnosis Program, Division of Cancer Treatment and Diagnosis, NCI, Bethesda, MD, USA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12967-020-02482-x

    DOI

    http://dx.doi.org/10.1186/s12967-020-02482-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1130649835

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/32894202


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