High levels of serum soluble TWEAK are associated with neuroinflammation during multiple sclerosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Adil Maarouf, Delphine Stephan, Marie-Pierre Ranjeva, Jean-Philippe Ranjeva, Jean Pelletier, Bertrand Audoin, Michel Khrestchatisky, Sophie Desplat-Jégo

ABSTRACT

BACKGROUND: Inflammation and demyelination are the main processes in multiple sclerosis. Nevertheless, to date, blood biomarkers of inflammation are lacking. TWEAK, a transmembrane protein that belongs to the TNF ligand family, has been previously identified as a potential candidate. METHODS: Twenty-eight patients (9 males, 19 females) were prospectively included after a first clinical episode suggestive of multiple sclerosis and clinically followed during 3 years. Fifty-seven healthy controls were also included. TWEAK serum levels and MRI exams including magnetization transfer imaging were performed at baseline, 6- and 12-month follow-up. RESULTS: TWEAK serum levels were significantly increased in the patient group (mean baseline = 1086 ± 493 pg/mL, mean M6 = 624 ± 302 pg/mL and mean M12 = 578 ± 245 pg/mL) compared to healthy controls (mean = 467 ± 177 pg/mL; respectively p < 0.0001, 0.01 and 0.06). Serum levels of soluble TWEAK were significantly increased during relapses, compared to time periods without any relapse (respectively 935 ± 489 pg/mL and 611 ± 292 pg/mL, p = 0.0005). Moreover, patients presenting at least one gadolinium-enhanced CNS lesion at baseline (n = 7) displayed significantly increased serum TWEAK levels in comparison with patients without any gadolinium-enhanced lesion at baseline (n = 21) (respectively 1421 ± 657 pg/mL vs 975 ± 382 pg/mL; p = 0.02). Finally, no correlation was evidenced between TWEAK serum levels and the extent of brain tissue damage assessed by magnetization transfer ratio. CONCLUSIONS: The present study showed that TWEAK serum levels are increased in MS patients, in relation to the disease activity. This simple and reproducible serum test could be used as a marker of ongoing inflammation, contributing in the follow-up and the care of MS patients. Thus, TWEAK is a promising serum marker of the best window to perform brain MRI, optimizing the disease control in patients. More... »

PAGES

51

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12967-019-1789-3

DOI

http://dx.doi.org/10.1186/s12967-019-1789-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112259607

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30786899


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "H\u00f4pital de la Timone", 
          "id": "https://www.grid.ac/institutes/grid.411266.6", 
          "name": [
            "Aix-Marseille Univ, CNRS, CRMBM, Marseille, France", 
            "Assistance Publique-H\u00f4pitaux de Marseille, H\u00f4pital de la Timone, CEMEREM, Marseille, France", 
            "Assistance Publique-H\u00f4pitaux de Marseille, H\u00f4pital de la Timone, P\u00f4le de Neurosciences Cliniques, Service de Neurologie, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maarouf", 
        "givenName": "Adil", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Aix-Marseille University", 
          "id": "https://www.grid.ac/institutes/grid.5399.6", 
          "name": [
            "Aix-Marseille Universit\u00e9, CNRS, Facult\u00e9 de M\u00e9decine, Institut de NeuroPhysiopathologie (INP), Inst Neurophysiopathol, 51 Bd P. Drammard, 13015, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stephan", 
        "givenName": "Delphine", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital de la Timone", 
          "id": "https://www.grid.ac/institutes/grid.411266.6", 
          "name": [
            "Aix-Marseille Univ, CNRS, CRMBM, Marseille, France", 
            "Assistance Publique-H\u00f4pitaux de Marseille, H\u00f4pital de la Timone, CEMEREM, Marseille, France", 
            "Assistance Publique-H\u00f4pitaux de Marseille, H\u00f4pital de la Timone, P\u00f4le de Neurosciences Cliniques, Service de Neurologie, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ranjeva", 
        "givenName": "Marie-Pierre", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Aix-Marseille University", 
          "id": "https://www.grid.ac/institutes/grid.5399.6", 
          "name": [
            "Aix-Marseille Univ, CNRS, CRMBM, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ranjeva", 
        "givenName": "Jean-Philippe", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital de la Timone", 
          "id": "https://www.grid.ac/institutes/grid.411266.6", 
          "name": [
            "Aix-Marseille Univ, CNRS, CRMBM, Marseille, France", 
            "Assistance Publique-H\u00f4pitaux de Marseille, H\u00f4pital de la Timone, P\u00f4le de Neurosciences Cliniques, Service de Neurologie, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pelletier", 
        "givenName": "Jean", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital de la Timone", 
          "id": "https://www.grid.ac/institutes/grid.411266.6", 
          "name": [
            "Aix-Marseille Univ, CNRS, CRMBM, Marseille, France", 
            "Assistance Publique-H\u00f4pitaux de Marseille, H\u00f4pital de la Timone, P\u00f4le de Neurosciences Cliniques, Service de Neurologie, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Audoin", 
        "givenName": "Bertrand", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Aix-Marseille University", 
          "id": "https://www.grid.ac/institutes/grid.5399.6", 
          "name": [
            "Aix-Marseille Universit\u00e9, CNRS, Facult\u00e9 de M\u00e9decine, Institut de NeuroPhysiopathologie (INP), Inst Neurophysiopathol, 51 Bd P. Drammard, 13015, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Khrestchatisky", 
        "givenName": "Michel", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital de la Conception", 
          "id": "https://www.grid.ac/institutes/grid.411535.7", 
          "name": [
            "Aix-Marseille Universit\u00e9, CNRS, Facult\u00e9 de M\u00e9decine, Institut de NeuroPhysiopathologie (INP), Inst Neurophysiopathol, 51 Bd P. Drammard, 13015, Marseille, France", 
            "Assistance Publique-H\u00f4pitaux de Marseille, H\u00f4pital de la Conception, P\u00f4le de Biologie, Service d\u2019Immunologie, 13005, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Desplat-J\u00e9go", 
        "givenName": "Sophie", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/1098-1136(200010)32:1<102::aid-glia100>3.0.co;2-u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000635824"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cyto.2007.09.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001366909"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1750-3639.2012.00614.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002311899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaut.2013.03.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002337153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1474-4422(12)70003-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003893960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1189/jlb.0608347", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004361628"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fimmu.2013.00489", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004374800"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.410430414", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005213188"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.33.11.1444", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005727777"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0000000000000560", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005812174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0000000000000560", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005812174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.13.8455", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006044069"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awv105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006973011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.410380514", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007353176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005072-199411000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007391109"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1750-3639.2007.00064.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008574162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/ar388", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009316009", 
          "https://doi.org/10.1186/ar388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mrm.1910300308", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010078963"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0404.1996.tb00052.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013627329"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20021730", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016965007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20021730", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016965007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1253/circj.68.396", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019523490"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.20202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020019178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1742-2094-10-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021957720", 
          "https://doi.org/10.1186/1742-2094-10-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1474-4422(14)70256-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026778798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fimmu.2013.00484", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028753401"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrneurol.2016.188", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029413403", 
          "https://doi.org/10.1038/nrneurol.2016.188"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.410130302", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030686038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00309630", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031412732", 
          "https://doi.org/10.1007/bf00309630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00309630", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031412732", 
          "https://doi.org/10.1007/bf00309630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1148/radiol.15150025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032163827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0165-5728(02)00368-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033166454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0165-5728(02)00368-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033166454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/nen.0b013e31818dab90", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033421793"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.3382-05.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034103517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mrm.1910240119", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034397214"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.jcbfm.9600368", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039937204"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.jcbfm.9600368", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039937204"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrn3275", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044502578", 
          "https://doi.org/10.1038/nrn3275"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1352458515607649", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045681144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1352458515607649", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045681144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1352458515607649", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045681144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clim.2005.06.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046053258"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clim.2005.06.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046053258"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.272.51.32401", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046951503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199801293380502", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047871023"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/glia.20049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051080844"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/123.6.1174", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051807980"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.22366", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052372006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000046587.83503.1e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064344915"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000046587.83503.1e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064344915"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000046587.83503.1e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064344915"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074997049", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.177.4.2610", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077279283"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077419450", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "BACKGROUND: Inflammation and demyelination are the main processes in multiple sclerosis. Nevertheless, to date, blood biomarkers of inflammation are lacking. TWEAK, a transmembrane protein that belongs to the TNF ligand family, has been previously identified as a potential candidate.\nMETHODS: Twenty-eight patients (9 males, 19 females) were prospectively included after a first clinical episode suggestive of multiple sclerosis and clinically followed during 3\u00a0years. Fifty-seven healthy controls were also included. TWEAK serum levels and MRI exams including magnetization transfer imaging were performed at baseline, 6- and 12-month follow-up.\nRESULTS: TWEAK serum levels were significantly increased in the patient group (mean baseline\u2009=\u20091086\u2009\u00b1\u2009493\u00a0pg/mL, mean M6\u2009=\u2009624\u2009\u00b1\u2009302\u00a0pg/mL and mean M12\u2009=\u2009578\u2009\u00b1\u2009245\u00a0pg/mL) compared to healthy controls (mean\u2009=\u2009467\u2009\u00b1\u2009177\u00a0pg/mL; respectively p\u2009<\u20090.0001, 0.01 and 0.06). Serum levels of soluble TWEAK were significantly increased during relapses, compared to time periods without any relapse (respectively 935\u2009\u00b1\u2009489\u00a0pg/mL and 611\u2009\u00b1\u2009292\u00a0pg/mL, p\u2009=\u20090.0005). Moreover, patients presenting at least one gadolinium-enhanced CNS lesion at baseline (n\u2009=\u20097) displayed significantly increased serum TWEAK levels in comparison with patients without any gadolinium-enhanced lesion at baseline (n\u2009=\u200921) (respectively 1421\u2009\u00b1\u2009657\u00a0pg/mL vs 975\u2009\u00b1\u2009382\u00a0pg/mL; p\u2009=\u20090.02). Finally, no correlation was evidenced between TWEAK serum levels and the extent of brain tissue damage assessed by magnetization transfer ratio.\nCONCLUSIONS: The present study showed that TWEAK serum levels are increased in MS patients, in relation to the disease activity. This simple and reproducible serum test could be used as a marker of ongoing inflammation, contributing in the follow-up and the care of MS patients. Thus, TWEAK is a promising serum marker of the best window to perform brain MRI, optimizing the disease control in patients.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12967-019-1789-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1032886", 
        "issn": [
          "1479-5876"
        ], 
        "name": "Journal of Translational Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "17"
      }
    ], 
    "name": "High levels of serum soluble TWEAK are associated with neuroinflammation during multiple sclerosis", 
    "pagination": "51", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "415efb313f8007d7f24ff833d8619c13f250cb99b1735c8d1b2d84e61afb9419"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30786899"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101190741"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12967-019-1789-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112259607"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12967-019-1789-3", 
      "https://app.dimensions.ai/details/publication/pub.1112259607"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:50", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000350_0000000350/records_77574_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs12967-019-1789-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12967-019-1789-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12967-019-1789-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12967-019-1789-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12967-019-1789-3'


 

This table displays all metadata directly associated to this object as RDF triples.

257 TRIPLES      21 PREDICATES      74 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12967-019-1789-3 schema:about anzsrc-for:11
2 anzsrc-for:1109
3 schema:author Nf5e405d649824ea1815704e7cb845cb1
4 schema:citation sg:pub.10.1007/bf00309630
5 sg:pub.10.1038/nrn3275
6 sg:pub.10.1038/nrneurol.2016.188
7 sg:pub.10.1186/1742-2094-10-9
8 sg:pub.10.1186/ar388
9 https://app.dimensions.ai/details/publication/pub.1074997049
10 https://app.dimensions.ai/details/publication/pub.1077419450
11 https://doi.org/10.1002/1098-1136(200010)32:1<102::aid-glia100>3.0.co;2-u
12 https://doi.org/10.1002/ana.20202
13 https://doi.org/10.1002/ana.22366
14 https://doi.org/10.1002/ana.410130302
15 https://doi.org/10.1002/ana.410380514
16 https://doi.org/10.1002/ana.410430414
17 https://doi.org/10.1002/glia.20049
18 https://doi.org/10.1002/mrm.1910240119
19 https://doi.org/10.1002/mrm.1910300308
20 https://doi.org/10.1016/j.clim.2005.06.005
21 https://doi.org/10.1016/j.cyto.2007.09.007
22 https://doi.org/10.1016/j.jaut.2013.03.002
23 https://doi.org/10.1016/s0165-5728(02)00368-5
24 https://doi.org/10.1016/s1474-4422(12)70003-0
25 https://doi.org/10.1016/s1474-4422(14)70256-x
26 https://doi.org/10.1038/sj.jcbfm.9600368
27 https://doi.org/10.1042/bj20021730
28 https://doi.org/10.1056/nejm199801293380502
29 https://doi.org/10.1074/jbc.272.51.32401
30 https://doi.org/10.1074/jbc.274.13.8455
31 https://doi.org/10.1093/brain/123.6.1174
32 https://doi.org/10.1093/brain/awv105
33 https://doi.org/10.1097/00005072-199411000-00010
34 https://doi.org/10.1097/nen.0b013e31818dab90
35 https://doi.org/10.1111/j.1600-0404.1996.tb00052.x
36 https://doi.org/10.1111/j.1750-3639.2007.00064.x
37 https://doi.org/10.1111/j.1750-3639.2012.00614.x
38 https://doi.org/10.1148/radiol.15150025
39 https://doi.org/10.1177/1352458515607649
40 https://doi.org/10.1189/jlb.0608347
41 https://doi.org/10.1212/01.wnl.0000046587.83503.1e
42 https://doi.org/10.1212/wnl.0000000000000560
43 https://doi.org/10.1212/wnl.33.11.1444
44 https://doi.org/10.1253/circj.68.396
45 https://doi.org/10.1523/jneurosci.3382-05.2005
46 https://doi.org/10.3389/fimmu.2013.00484
47 https://doi.org/10.3389/fimmu.2013.00489
48 https://doi.org/10.4049/jimmunol.177.4.2610
49 schema:datePublished 2019-12
50 schema:datePublishedReg 2019-12-01
51 schema:description BACKGROUND: Inflammation and demyelination are the main processes in multiple sclerosis. Nevertheless, to date, blood biomarkers of inflammation are lacking. TWEAK, a transmembrane protein that belongs to the TNF ligand family, has been previously identified as a potential candidate. METHODS: Twenty-eight patients (9 males, 19 females) were prospectively included after a first clinical episode suggestive of multiple sclerosis and clinically followed during 3 years. Fifty-seven healthy controls were also included. TWEAK serum levels and MRI exams including magnetization transfer imaging were performed at baseline, 6- and 12-month follow-up. RESULTS: TWEAK serum levels were significantly increased in the patient group (mean baseline = 1086 ± 493 pg/mL, mean M6 = 624 ± 302 pg/mL and mean M12 = 578 ± 245 pg/mL) compared to healthy controls (mean = 467 ± 177 pg/mL; respectively p < 0.0001, 0.01 and 0.06). Serum levels of soluble TWEAK were significantly increased during relapses, compared to time periods without any relapse (respectively 935 ± 489 pg/mL and 611 ± 292 pg/mL, p = 0.0005). Moreover, patients presenting at least one gadolinium-enhanced CNS lesion at baseline (n = 7) displayed significantly increased serum TWEAK levels in comparison with patients without any gadolinium-enhanced lesion at baseline (n = 21) (respectively 1421 ± 657 pg/mL vs 975 ± 382 pg/mL; p = 0.02). Finally, no correlation was evidenced between TWEAK serum levels and the extent of brain tissue damage assessed by magnetization transfer ratio. CONCLUSIONS: The present study showed that TWEAK serum levels are increased in MS patients, in relation to the disease activity. This simple and reproducible serum test could be used as a marker of ongoing inflammation, contributing in the follow-up and the care of MS patients. Thus, TWEAK is a promising serum marker of the best window to perform brain MRI, optimizing the disease control in patients.
52 schema:genre research_article
53 schema:inLanguage en
54 schema:isAccessibleForFree true
55 schema:isPartOf N9c56bbe6660349248cecb9f902232975
56 Nd0c6850f689a4e2d9db51e3834a23a17
57 sg:journal.1032886
58 schema:name High levels of serum soluble TWEAK are associated with neuroinflammation during multiple sclerosis
59 schema:pagination 51
60 schema:productId N923e6bfeef484d0b81173d1b9d16610a
61 Nb4d1ca66a2984f10ba07a26b551c5aff
62 Nbbd475f79e0e40c6a39bfa8f6174e753
63 Ne519598864d9477f8193b1afd6788bdc
64 Ned727578536d47d9ac49aa79a9989afd
65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112259607
66 https://doi.org/10.1186/s12967-019-1789-3
67 schema:sdDatePublished 2019-04-11T10:50
68 schema:sdLicense https://scigraph.springernature.com/explorer/license/
69 schema:sdPublisher N92a4cc0cd0df4cf68e9eadce5f3c3729
70 schema:url https://link.springer.com/10.1186%2Fs12967-019-1789-3
71 sgo:license sg:explorer/license/
72 sgo:sdDataset articles
73 rdf:type schema:ScholarlyArticle
74 N1eb8c27914124c64967b66c315ecaf80 schema:affiliation https://www.grid.ac/institutes/grid.411266.6
75 schema:familyName Audoin
76 schema:givenName Bertrand
77 rdf:type schema:Person
78 N317ccb738a7947d1ab681ec5a3d61b09 schema:affiliation https://www.grid.ac/institutes/grid.5399.6
79 schema:familyName Stephan
80 schema:givenName Delphine
81 rdf:type schema:Person
82 N32f0b259ff414a7e91332195f24cecb7 rdf:first N7b45adcfec8840fa895a3c7a71b07655
83 rdf:rest N5fd52d19dd0448009d3a17f52c1614a9
84 N54d6e955a23e45f882c238b9087e33f1 schema:affiliation https://www.grid.ac/institutes/grid.411266.6
85 schema:familyName Maarouf
86 schema:givenName Adil
87 rdf:type schema:Person
88 N5fd52d19dd0448009d3a17f52c1614a9 rdf:first N7231d8cf121943d4b00efb57759b34a7
89 rdf:rest Nc9546f9ec10a414da29cd0aeb8aa65c9
90 N60d5833ee65f419e835f47f5ceaac70d rdf:first Ncc9d2bb0fb7e49bfbeeae310d63bcfd3
91 rdf:rest Ne7982c514f1249b5bcb26c1cceced34d
92 N61731b743c6e44c692cba9639df32a46 schema:affiliation https://www.grid.ac/institutes/grid.411266.6
93 schema:familyName Ranjeva
94 schema:givenName Marie-Pierre
95 rdf:type schema:Person
96 N7231d8cf121943d4b00efb57759b34a7 schema:affiliation https://www.grid.ac/institutes/grid.411266.6
97 schema:familyName Pelletier
98 schema:givenName Jean
99 rdf:type schema:Person
100 N7b45adcfec8840fa895a3c7a71b07655 schema:affiliation https://www.grid.ac/institutes/grid.5399.6
101 schema:familyName Ranjeva
102 schema:givenName Jean-Philippe
103 rdf:type schema:Person
104 N805e6aa65e6f45a4a14799d16669b3ef rdf:first N61731b743c6e44c692cba9639df32a46
105 rdf:rest N32f0b259ff414a7e91332195f24cecb7
106 N911aa6946631467e857a1615de0da17e rdf:first N317ccb738a7947d1ab681ec5a3d61b09
107 rdf:rest N805e6aa65e6f45a4a14799d16669b3ef
108 N923e6bfeef484d0b81173d1b9d16610a schema:name pubmed_id
109 schema:value 30786899
110 rdf:type schema:PropertyValue
111 N92a4cc0cd0df4cf68e9eadce5f3c3729 schema:name Springer Nature - SN SciGraph project
112 rdf:type schema:Organization
113 N9c56bbe6660349248cecb9f902232975 schema:issueNumber 1
114 rdf:type schema:PublicationIssue
115 Nb3be1509e15846ef9c229f1d1bd32c21 schema:affiliation https://www.grid.ac/institutes/grid.411535.7
116 schema:familyName Desplat-Jégo
117 schema:givenName Sophie
118 rdf:type schema:Person
119 Nb4d1ca66a2984f10ba07a26b551c5aff schema:name doi
120 schema:value 10.1186/s12967-019-1789-3
121 rdf:type schema:PropertyValue
122 Nbbd475f79e0e40c6a39bfa8f6174e753 schema:name dimensions_id
123 schema:value pub.1112259607
124 rdf:type schema:PropertyValue
125 Nc9546f9ec10a414da29cd0aeb8aa65c9 rdf:first N1eb8c27914124c64967b66c315ecaf80
126 rdf:rest N60d5833ee65f419e835f47f5ceaac70d
127 Ncc9d2bb0fb7e49bfbeeae310d63bcfd3 schema:affiliation https://www.grid.ac/institutes/grid.5399.6
128 schema:familyName Khrestchatisky
129 schema:givenName Michel
130 rdf:type schema:Person
131 Nd0c6850f689a4e2d9db51e3834a23a17 schema:volumeNumber 17
132 rdf:type schema:PublicationVolume
133 Ne519598864d9477f8193b1afd6788bdc schema:name readcube_id
134 schema:value 415efb313f8007d7f24ff833d8619c13f250cb99b1735c8d1b2d84e61afb9419
135 rdf:type schema:PropertyValue
136 Ne7982c514f1249b5bcb26c1cceced34d rdf:first Nb3be1509e15846ef9c229f1d1bd32c21
137 rdf:rest rdf:nil
138 Ned727578536d47d9ac49aa79a9989afd schema:name nlm_unique_id
139 schema:value 101190741
140 rdf:type schema:PropertyValue
141 Nf5e405d649824ea1815704e7cb845cb1 rdf:first N54d6e955a23e45f882c238b9087e33f1
142 rdf:rest N911aa6946631467e857a1615de0da17e
143 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
144 schema:name Medical and Health Sciences
145 rdf:type schema:DefinedTerm
146 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
147 schema:name Neurosciences
148 rdf:type schema:DefinedTerm
149 sg:journal.1032886 schema:issn 1479-5876
150 schema:name Journal of Translational Medicine
151 rdf:type schema:Periodical
152 sg:pub.10.1007/bf00309630 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031412732
153 https://doi.org/10.1007/bf00309630
154 rdf:type schema:CreativeWork
155 sg:pub.10.1038/nrn3275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044502578
156 https://doi.org/10.1038/nrn3275
157 rdf:type schema:CreativeWork
158 sg:pub.10.1038/nrneurol.2016.188 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029413403
159 https://doi.org/10.1038/nrneurol.2016.188
160 rdf:type schema:CreativeWork
161 sg:pub.10.1186/1742-2094-10-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021957720
162 https://doi.org/10.1186/1742-2094-10-9
163 rdf:type schema:CreativeWork
164 sg:pub.10.1186/ar388 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009316009
165 https://doi.org/10.1186/ar388
166 rdf:type schema:CreativeWork
167 https://app.dimensions.ai/details/publication/pub.1074997049 schema:CreativeWork
168 https://app.dimensions.ai/details/publication/pub.1077419450 schema:CreativeWork
169 https://doi.org/10.1002/1098-1136(200010)32:1<102::aid-glia100>3.0.co;2-u schema:sameAs https://app.dimensions.ai/details/publication/pub.1000635824
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1002/ana.20202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020019178
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1002/ana.22366 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052372006
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1002/ana.410130302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030686038
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1002/ana.410380514 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007353176
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1002/ana.410430414 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005213188
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1002/glia.20049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051080844
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1002/mrm.1910240119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034397214
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1002/mrm.1910300308 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010078963
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1016/j.clim.2005.06.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046053258
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1016/j.cyto.2007.09.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001366909
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1016/j.jaut.2013.03.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002337153
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1016/s0165-5728(02)00368-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033166454
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1016/s1474-4422(12)70003-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003893960
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1016/s1474-4422(14)70256-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026778798
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1038/sj.jcbfm.9600368 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039937204
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1042/bj20021730 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016965007
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1056/nejm199801293380502 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047871023
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1074/jbc.272.51.32401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046951503
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1074/jbc.274.13.8455 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006044069
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1093/brain/123.6.1174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051807980
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1093/brain/awv105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006973011
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1097/00005072-199411000-00010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007391109
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1097/nen.0b013e31818dab90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033421793
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1111/j.1600-0404.1996.tb00052.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013627329
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1111/j.1750-3639.2007.00064.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008574162
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1111/j.1750-3639.2012.00614.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002311899
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1148/radiol.15150025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032163827
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1177/1352458515607649 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045681144
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1189/jlb.0608347 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004361628
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1212/01.wnl.0000046587.83503.1e schema:sameAs https://app.dimensions.ai/details/publication/pub.1064344915
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1212/wnl.0000000000000560 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005812174
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1212/wnl.33.11.1444 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005727777
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1253/circj.68.396 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019523490
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1523/jneurosci.3382-05.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034103517
238 rdf:type schema:CreativeWork
239 https://doi.org/10.3389/fimmu.2013.00484 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028753401
240 rdf:type schema:CreativeWork
241 https://doi.org/10.3389/fimmu.2013.00489 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004374800
242 rdf:type schema:CreativeWork
243 https://doi.org/10.4049/jimmunol.177.4.2610 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077279283
244 rdf:type schema:CreativeWork
245 https://www.grid.ac/institutes/grid.411266.6 schema:alternateName Hôpital de la Timone
246 schema:name Aix-Marseille Univ, CNRS, CRMBM, Marseille, France
247 Assistance Publique-Hôpitaux de Marseille, Hôpital de la Timone, CEMEREM, Marseille, France
248 Assistance Publique-Hôpitaux de Marseille, Hôpital de la Timone, Pôle de Neurosciences Cliniques, Service de Neurologie, Marseille, France
249 rdf:type schema:Organization
250 https://www.grid.ac/institutes/grid.411535.7 schema:alternateName Hôpital de la Conception
251 schema:name Aix-Marseille Université, CNRS, Faculté de Médecine, Institut de NeuroPhysiopathologie (INP), Inst Neurophysiopathol, 51 Bd P. Drammard, 13015, Marseille, France
252 Assistance Publique-Hôpitaux de Marseille, Hôpital de la Conception, Pôle de Biologie, Service d’Immunologie, 13005, Marseille, France
253 rdf:type schema:Organization
254 https://www.grid.ac/institutes/grid.5399.6 schema:alternateName Aix-Marseille University
255 schema:name Aix-Marseille Univ, CNRS, CRMBM, Marseille, France
256 Aix-Marseille Université, CNRS, Faculté de Médecine, Institut de NeuroPhysiopathologie (INP), Inst Neurophysiopathol, 51 Bd P. Drammard, 13015, Marseille, France
257 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...