Surgical peritoneal stress creates a pro-metastatic niche promoting resistance to apoptosis via IL-8 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Jennifer Pasquier, Fabien Vidal, Jessica Hoarau-Véchot, Claire Bonneau, Emile Daraï, Cyril Touboul, Arash Rafii

ABSTRACT

BACKGROUND: The mainstay of treatment of advanced ovarian cancer (AOC) involves chemotherapy, and debulking surgery. However, despite optimal surgical procedure and adjuvant chemotherapy, 60% of patients with AOC will relapse within 5 years. Most recurrences occur in the peritoneal cavity, suggesting the existence of occult sanctuaries where ovarian cancer cells (OCC) are protected. In murine models, surgical stress favors tumor growth; however, it has never been established that surgery may affect OCC sensitivity to subsequent chemotherapy. In this study, we investigated how the surgical stress could affect the chemosensitivity of OCC. METHODS: To avoid bias due to tumor burden in peritoneal cavity and duration of surgery, we used peritoneal biopsies from patients without a malignancy at precise time points. During laparotomies, peritoneal biopsies at the incision site were performed at the time of incision (H0 sample) and 1 h after initiation of surgery (H1 sample). We evaluated the chemoresistance to Taxol (0-20 µM) induced by H0 or H1 incubation (24 h) in two ovarian cancer cell lines OVCAR3 and SKOV3 and a primary cancer cell lines derived in our laboratory. RESULTS: Our results indicate that stressed peritoneum overexpressed cytokines, resulting in OCC increased resistance to therapy. Among these cytokines, IL8 was responsible for the resistance to apoptosis through the AKT pathway activation. Chemoresistance in OCC persists through the establishment of an autocrine IL8 loop. Finally, in a cohort of 32 patients, we showed an impact of IL8 tumoral overexpression on chemosensitivity and survival outcomes with a significant association to earlier recurrence. CONCLUSIONS: Our study demonstrated that precision surgery where targeted treatment would be used in combination with surgery is essential to obtain better tumor control. More... »

PAGES

271

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12967-018-1643-z

DOI

http://dx.doi.org/10.1186/s12967-018-1643-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1107381431

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30285881


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Mondor Institute of Biomedical Research", 
          "id": "https://www.grid.ac/institutes/grid.462410.5", 
          "name": [
            "Stem Cell and Microenvironment Laboratory, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, PO: 24144, Doha, Qatar", 
            "Department Genetic Medicine, Weill Cornell Medical College, New York, NY, USA", 
            "INSERM U955, Equipe 7, Cr\u00e9teil, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pasquier", 
        "givenName": "Jennifer", 
        "id": "sg:person.01227307370.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227307370.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cornell University", 
          "id": "https://www.grid.ac/institutes/grid.5386.8", 
          "name": [
            "Stem Cell and Microenvironment Laboratory, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, PO: 24144, Doha, Qatar", 
            "Department Genetic Medicine, Weill Cornell Medical College, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vidal", 
        "givenName": "Fabien", 
        "id": "sg:person.01140014765.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140014765.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Qatar Foundation", 
          "id": "https://www.grid.ac/institutes/grid.418818.c", 
          "name": [
            "Stem Cell and Microenvironment Laboratory, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, PO: 24144, Doha, Qatar"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hoarau-V\u00e9chot", 
        "givenName": "Jessica", 
        "id": "sg:person.01365245617.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365245617.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tenon Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413483.9", 
          "name": [
            "Service de Gyn\u00e9cologie Obst\u00e9trique, Hopital Tenon (Assistance Publique\u2013H\u00f4pitaux de Paris), 4 rue de la Chine, 75020, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bonneau", 
        "givenName": "Claire", 
        "id": "sg:person.0633603547.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633603547.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tenon Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413483.9", 
          "name": [
            "Service de Gyn\u00e9cologie Obst\u00e9trique, Hopital Tenon (Assistance Publique\u2013H\u00f4pitaux de Paris), 4 rue de la Chine, 75020, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dara\u00ef", 
        "givenName": "Emile", 
        "id": "sg:person.01166567564.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166567564.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Intercommunal de Cr\u00e9teil", 
          "id": "https://www.grid.ac/institutes/grid.414145.1", 
          "name": [
            "Service de Gyn\u00e9cologie-Obst\u00e9trique et M\u00e9decine de la Reproduction, Facult\u00e9 de m\u00e9decine de Cr\u00e9teil UPEC\u2013Paris XII, Centre Hospitalier Intercommunal de Cr\u00e9teil, 40 Avenue de Verdun, 94000, Cr\u00e9teil, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Touboul", 
        "givenName": "Cyril", 
        "id": "sg:person.01100511405.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100511405.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Foch", 
          "id": "https://www.grid.ac/institutes/grid.414106.6", 
          "name": [
            "Stem Cell and Microenvironment Laboratory, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, PO: 24144, Doha, Qatar", 
            "Department Genetic Medicine, Weill Cornell Medical College, New York, NY, USA", 
            "Service de chirurgie Gyn\u00e9cologique, H\u00f4pital Foch, 92100, Suresnes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rafii", 
        "givenName": "Arash", 
        "id": "sg:person.0644765310.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644765310.08"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.jss.2008.12.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000454199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12885-015-1556-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000828135", 
          "https://doi.org/10.1186/s12885-015-1556-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12885-015-1556-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000828135", 
          "https://doi.org/10.1186/s12885-015-1556-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10495-012-0772-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005694303", 
          "https://doi.org/10.1007/s10495-012-0772-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0003894", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006300003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1479-5876-11-94", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006901112", 
          "https://doi.org/10.1186/1479-5876-11-94"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/qjmed/hcr039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012672269"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00464-008-0174-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014389127", 
          "https://doi.org/10.1007/s00464-008-0174-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00464-008-0174-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014389127", 
          "https://doi.org/10.1007/s00464-008-0174-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2013/676845", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015939465"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12967-014-0271-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016204125", 
          "https://doi.org/10.1186/s12967-014-0271-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12967-014-0271-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016204125", 
          "https://doi.org/10.1186/s12967-014-0271-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jjco/hye088", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019979428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1479-5876-11-28", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024589053", 
          "https://doi.org/10.1186/1479-5876-11-28"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0112424", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025747572"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/igc.0000000000000361", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027830593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/igc.0000000000000361", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027830593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.3415", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035562712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejogrb.2012.05.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035715422"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.6677", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036715945"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/igc.0b013e31826a3559", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040231550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/igc.0b013e31826a3559", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040231550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/igc.0b013e31826a3559", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040231550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cyto.2012.04.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040332531"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-08-2966", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040555576"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygyno.2014.10.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046574503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ygyno.2014.10.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046574503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12967-015-0386-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047134774", 
          "https://doi.org/10.1186/s12967-015-0386-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12967-015-0386-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047134774", 
          "https://doi.org/10.1186/s12967-015-0386-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cyto.2011.06.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048288219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/humrep/der055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050999623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0147787", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052414599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0029-7844(98)00145-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054597519"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo_00000797", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071518777"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077582402", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078763309", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10585-018-9873-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100403790", 
          "https://doi.org/10.1007/s10585-018-9873-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10585-018-9873-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100403790", 
          "https://doi.org/10.1007/s10585-018-9873-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10585-018-9873-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100403790", 
          "https://doi.org/10.1007/s10585-018-9873-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1708618", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100467275"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1708618", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100467275"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1708618", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100467275"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12967-018-1389-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100472775", 
          "https://doi.org/10.1186/s12967-018-1389-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12967-018-1389-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100472775", 
          "https://doi.org/10.1186/s12967-018-1389-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12943-018-0787-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101066788", 
          "https://doi.org/10.1186/s12943-018-0787-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12943-018-0787-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101066788", 
          "https://doi.org/10.1186/s12943-018-0787-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4103/jmas.jmas_217_17", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101121481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4103/jmas.jmas_217_17", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101121481"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "BACKGROUND: The mainstay of treatment of advanced ovarian cancer (AOC) involves chemotherapy, and debulking surgery. However, despite optimal surgical procedure and adjuvant chemotherapy, 60% of patients with AOC will relapse within 5\u00a0years. Most recurrences occur in the peritoneal cavity, suggesting the existence of occult sanctuaries where ovarian cancer cells (OCC) are protected. In murine models, surgical stress favors tumor growth; however, it has never been established that surgery may affect OCC sensitivity to subsequent chemotherapy. In this study, we investigated how the surgical stress could affect the chemosensitivity of OCC.\nMETHODS: To avoid bias due to tumor burden in peritoneal cavity and duration of surgery, we used peritoneal biopsies from patients without a malignancy at precise time points. During laparotomies, peritoneal biopsies at the incision site were performed at the time of incision (H0 sample) and 1\u00a0h after initiation of surgery (H1 sample). We evaluated the chemoresistance to Taxol (0-20\u00a0\u00b5M) induced by H0 or H1 incubation (24\u00a0h) in two ovarian cancer cell lines OVCAR3 and SKOV3 and a primary cancer cell lines derived in our laboratory.\nRESULTS: Our results indicate that stressed peritoneum overexpressed cytokines, resulting in OCC increased resistance to therapy. Among these cytokines, IL8 was responsible for the resistance to apoptosis through the AKT pathway activation. Chemoresistance in OCC persists through the establishment of an autocrine IL8 loop. Finally, in a cohort of 32 patients, we showed an impact of IL8 tumoral overexpression on chemosensitivity and survival outcomes with a significant association to earlier recurrence.\nCONCLUSIONS: Our study demonstrated that precision surgery where targeted treatment would be used in combination with surgery is essential to obtain better tumor control.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12967-018-1643-z", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.4186350", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4187307", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1032886", 
        "issn": [
          "1479-5876"
        ], 
        "name": "Journal of Translational Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "16"
      }
    ], 
    "name": "Surgical peritoneal stress creates a pro-metastatic niche promoting resistance to apoptosis via IL-8", 
    "pagination": "271", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "6daad8d8858997d31e497a59ab94226d1bdb24da0f5b664be88d3db532ab5e9a"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30285881"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101190741"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12967-018-1643-z"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1107381431"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12967-018-1643-z", 
      "https://app.dimensions.ai/details/publication/pub.1107381431"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:50", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000350_0000000350/records_77583_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs12967-018-1643-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12967-018-1643-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12967-018-1643-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12967-018-1643-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12967-018-1643-z'


 

This table displays all metadata directly associated to this object as RDF triples.

241 TRIPLES      21 PREDICATES      62 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12967-018-1643-z schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author N8e3cfd79fa414fc7b14c7fbb8ebdcc7a
4 schema:citation sg:pub.10.1007/s00464-008-0174-8
5 sg:pub.10.1007/s10495-012-0772-8
6 sg:pub.10.1007/s10585-018-9873-2
7 sg:pub.10.1186/1479-5876-11-28
8 sg:pub.10.1186/1479-5876-11-94
9 sg:pub.10.1186/s12885-015-1556-7
10 sg:pub.10.1186/s12943-018-0787-z
11 sg:pub.10.1186/s12967-014-0271-5
12 sg:pub.10.1186/s12967-015-0386-3
13 sg:pub.10.1186/s12967-018-1389-7
14 https://app.dimensions.ai/details/publication/pub.1077582402
15 https://app.dimensions.ai/details/publication/pub.1078763309
16 https://doi.org/10.1016/j.cyto.2011.06.005
17 https://doi.org/10.1016/j.cyto.2012.04.013
18 https://doi.org/10.1016/j.ejogrb.2012.05.011
19 https://doi.org/10.1016/j.jss.2008.12.026
20 https://doi.org/10.1016/j.ygyno.2014.10.024
21 https://doi.org/10.1016/s0029-7844(98)00145-8
22 https://doi.org/10.1056/nejmoa1708618
23 https://doi.org/10.1093/humrep/der055
24 https://doi.org/10.1093/jjco/hye088
25 https://doi.org/10.1093/qjmed/hcr039
26 https://doi.org/10.1097/igc.0000000000000361
27 https://doi.org/10.1097/igc.0b013e31826a3559
28 https://doi.org/10.1155/2013/676845
29 https://doi.org/10.1158/1078-0432.ccr-08-2966
30 https://doi.org/10.1371/journal.pone.0003894
31 https://doi.org/10.1371/journal.pone.0112424
32 https://doi.org/10.1371/journal.pone.0147787
33 https://doi.org/10.18632/oncotarget.3415
34 https://doi.org/10.18632/oncotarget.6677
35 https://doi.org/10.3892/ijo_00000797
36 https://doi.org/10.4103/jmas.jmas_217_17
37 schema:datePublished 2018-12
38 schema:datePublishedReg 2018-12-01
39 schema:description BACKGROUND: The mainstay of treatment of advanced ovarian cancer (AOC) involves chemotherapy, and debulking surgery. However, despite optimal surgical procedure and adjuvant chemotherapy, 60% of patients with AOC will relapse within 5 years. Most recurrences occur in the peritoneal cavity, suggesting the existence of occult sanctuaries where ovarian cancer cells (OCC) are protected. In murine models, surgical stress favors tumor growth; however, it has never been established that surgery may affect OCC sensitivity to subsequent chemotherapy. In this study, we investigated how the surgical stress could affect the chemosensitivity of OCC. METHODS: To avoid bias due to tumor burden in peritoneal cavity and duration of surgery, we used peritoneal biopsies from patients without a malignancy at precise time points. During laparotomies, peritoneal biopsies at the incision site were performed at the time of incision (H0 sample) and 1 h after initiation of surgery (H1 sample). We evaluated the chemoresistance to Taxol (0-20 µM) induced by H0 or H1 incubation (24 h) in two ovarian cancer cell lines OVCAR3 and SKOV3 and a primary cancer cell lines derived in our laboratory. RESULTS: Our results indicate that stressed peritoneum overexpressed cytokines, resulting in OCC increased resistance to therapy. Among these cytokines, IL8 was responsible for the resistance to apoptosis through the AKT pathway activation. Chemoresistance in OCC persists through the establishment of an autocrine IL8 loop. Finally, in a cohort of 32 patients, we showed an impact of IL8 tumoral overexpression on chemosensitivity and survival outcomes with a significant association to earlier recurrence. CONCLUSIONS: Our study demonstrated that precision surgery where targeted treatment would be used in combination with surgery is essential to obtain better tumor control.
40 schema:genre research_article
41 schema:inLanguage en
42 schema:isAccessibleForFree true
43 schema:isPartOf N668ca4eebc9649a484872e17a94509ee
44 Nd9872808e6db445f9b3f8110b3c0a76d
45 sg:journal.1032886
46 schema:name Surgical peritoneal stress creates a pro-metastatic niche promoting resistance to apoptosis via IL-8
47 schema:pagination 271
48 schema:productId N0f0859503be24a6bba6d27d9ced758ef
49 N312bb530acf84f498b8346fbcb8f2972
50 N44756f3959474c18850ecf08ed0cab1a
51 N48132dddb5c24bad8c4f052b6d6f0244
52 N481a818df3d84a1e8fea5006be89fbd6
53 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107381431
54 https://doi.org/10.1186/s12967-018-1643-z
55 schema:sdDatePublished 2019-04-11T10:50
56 schema:sdLicense https://scigraph.springernature.com/explorer/license/
57 schema:sdPublisher Nd4ae08078ad34dad8486ace8e7fc125c
58 schema:url https://link.springer.com/10.1186%2Fs12967-018-1643-z
59 sgo:license sg:explorer/license/
60 sgo:sdDataset articles
61 rdf:type schema:ScholarlyArticle
62 N07dcd24cc2a440a58f48342db3db7d43 rdf:first sg:person.01140014765.04
63 rdf:rest N5b8a5fa76f964e6dac7d98f973fd6afb
64 N0f0859503be24a6bba6d27d9ced758ef schema:name readcube_id
65 schema:value 6daad8d8858997d31e497a59ab94226d1bdb24da0f5b664be88d3db532ab5e9a
66 rdf:type schema:PropertyValue
67 N312bb530acf84f498b8346fbcb8f2972 schema:name nlm_unique_id
68 schema:value 101190741
69 rdf:type schema:PropertyValue
70 N44756f3959474c18850ecf08ed0cab1a schema:name pubmed_id
71 schema:value 30285881
72 rdf:type schema:PropertyValue
73 N48132dddb5c24bad8c4f052b6d6f0244 schema:name dimensions_id
74 schema:value pub.1107381431
75 rdf:type schema:PropertyValue
76 N481a818df3d84a1e8fea5006be89fbd6 schema:name doi
77 schema:value 10.1186/s12967-018-1643-z
78 rdf:type schema:PropertyValue
79 N49797d70d5a24f4aa75ea55a7992b150 rdf:first sg:person.0644765310.08
80 rdf:rest rdf:nil
81 N5b8a5fa76f964e6dac7d98f973fd6afb rdf:first sg:person.01365245617.44
82 rdf:rest N8793bfc1ac9347a3993acfa26f04b31d
83 N668ca4eebc9649a484872e17a94509ee schema:volumeNumber 16
84 rdf:type schema:PublicationVolume
85 N8793bfc1ac9347a3993acfa26f04b31d rdf:first sg:person.0633603547.76
86 rdf:rest Nd833d06684b7482c8de30e47db4ec6bc
87 N8e3cfd79fa414fc7b14c7fbb8ebdcc7a rdf:first sg:person.01227307370.53
88 rdf:rest N07dcd24cc2a440a58f48342db3db7d43
89 Nc247d047986c43229088c0d51583c0ef rdf:first sg:person.01100511405.21
90 rdf:rest N49797d70d5a24f4aa75ea55a7992b150
91 Nd4ae08078ad34dad8486ace8e7fc125c schema:name Springer Nature - SN SciGraph project
92 rdf:type schema:Organization
93 Nd833d06684b7482c8de30e47db4ec6bc rdf:first sg:person.01166567564.74
94 rdf:rest Nc247d047986c43229088c0d51583c0ef
95 Nd9872808e6db445f9b3f8110b3c0a76d schema:issueNumber 1
96 rdf:type schema:PublicationIssue
97 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
98 schema:name Medical and Health Sciences
99 rdf:type schema:DefinedTerm
100 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
101 schema:name Oncology and Carcinogenesis
102 rdf:type schema:DefinedTerm
103 sg:grant.4186350 http://pending.schema.org/fundedItem sg:pub.10.1186/s12967-018-1643-z
104 rdf:type schema:MonetaryGrant
105 sg:grant.4187307 http://pending.schema.org/fundedItem sg:pub.10.1186/s12967-018-1643-z
106 rdf:type schema:MonetaryGrant
107 sg:journal.1032886 schema:issn 1479-5876
108 schema:name Journal of Translational Medicine
109 rdf:type schema:Periodical
110 sg:person.01100511405.21 schema:affiliation https://www.grid.ac/institutes/grid.414145.1
111 schema:familyName Touboul
112 schema:givenName Cyril
113 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100511405.21
114 rdf:type schema:Person
115 sg:person.01140014765.04 schema:affiliation https://www.grid.ac/institutes/grid.5386.8
116 schema:familyName Vidal
117 schema:givenName Fabien
118 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140014765.04
119 rdf:type schema:Person
120 sg:person.01166567564.74 schema:affiliation https://www.grid.ac/institutes/grid.413483.9
121 schema:familyName Daraï
122 schema:givenName Emile
123 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166567564.74
124 rdf:type schema:Person
125 sg:person.01227307370.53 schema:affiliation https://www.grid.ac/institutes/grid.462410.5
126 schema:familyName Pasquier
127 schema:givenName Jennifer
128 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227307370.53
129 rdf:type schema:Person
130 sg:person.01365245617.44 schema:affiliation https://www.grid.ac/institutes/grid.418818.c
131 schema:familyName Hoarau-Véchot
132 schema:givenName Jessica
133 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365245617.44
134 rdf:type schema:Person
135 sg:person.0633603547.76 schema:affiliation https://www.grid.ac/institutes/grid.413483.9
136 schema:familyName Bonneau
137 schema:givenName Claire
138 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633603547.76
139 rdf:type schema:Person
140 sg:person.0644765310.08 schema:affiliation https://www.grid.ac/institutes/grid.414106.6
141 schema:familyName Rafii
142 schema:givenName Arash
143 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644765310.08
144 rdf:type schema:Person
145 sg:pub.10.1007/s00464-008-0174-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014389127
146 https://doi.org/10.1007/s00464-008-0174-8
147 rdf:type schema:CreativeWork
148 sg:pub.10.1007/s10495-012-0772-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005694303
149 https://doi.org/10.1007/s10495-012-0772-8
150 rdf:type schema:CreativeWork
151 sg:pub.10.1007/s10585-018-9873-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100403790
152 https://doi.org/10.1007/s10585-018-9873-2
153 rdf:type schema:CreativeWork
154 sg:pub.10.1186/1479-5876-11-28 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024589053
155 https://doi.org/10.1186/1479-5876-11-28
156 rdf:type schema:CreativeWork
157 sg:pub.10.1186/1479-5876-11-94 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006901112
158 https://doi.org/10.1186/1479-5876-11-94
159 rdf:type schema:CreativeWork
160 sg:pub.10.1186/s12885-015-1556-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000828135
161 https://doi.org/10.1186/s12885-015-1556-7
162 rdf:type schema:CreativeWork
163 sg:pub.10.1186/s12943-018-0787-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1101066788
164 https://doi.org/10.1186/s12943-018-0787-z
165 rdf:type schema:CreativeWork
166 sg:pub.10.1186/s12967-014-0271-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016204125
167 https://doi.org/10.1186/s12967-014-0271-5
168 rdf:type schema:CreativeWork
169 sg:pub.10.1186/s12967-015-0386-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047134774
170 https://doi.org/10.1186/s12967-015-0386-3
171 rdf:type schema:CreativeWork
172 sg:pub.10.1186/s12967-018-1389-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100472775
173 https://doi.org/10.1186/s12967-018-1389-7
174 rdf:type schema:CreativeWork
175 https://app.dimensions.ai/details/publication/pub.1077582402 schema:CreativeWork
176 https://app.dimensions.ai/details/publication/pub.1078763309 schema:CreativeWork
177 https://doi.org/10.1016/j.cyto.2011.06.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048288219
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1016/j.cyto.2012.04.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040332531
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1016/j.ejogrb.2012.05.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035715422
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1016/j.jss.2008.12.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000454199
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1016/j.ygyno.2014.10.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046574503
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1016/s0029-7844(98)00145-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054597519
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1056/nejmoa1708618 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100467275
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1093/humrep/der055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050999623
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1093/jjco/hye088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019979428
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1093/qjmed/hcr039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012672269
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1097/igc.0000000000000361 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027830593
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1097/igc.0b013e31826a3559 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040231550
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1155/2013/676845 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015939465
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1158/1078-0432.ccr-08-2966 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040555576
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1371/journal.pone.0003894 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006300003
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1371/journal.pone.0112424 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025747572
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1371/journal.pone.0147787 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052414599
210 rdf:type schema:CreativeWork
211 https://doi.org/10.18632/oncotarget.3415 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035562712
212 rdf:type schema:CreativeWork
213 https://doi.org/10.18632/oncotarget.6677 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036715945
214 rdf:type schema:CreativeWork
215 https://doi.org/10.3892/ijo_00000797 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071518777
216 rdf:type schema:CreativeWork
217 https://doi.org/10.4103/jmas.jmas_217_17 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101121481
218 rdf:type schema:CreativeWork
219 https://www.grid.ac/institutes/grid.413483.9 schema:alternateName Tenon Hospital
220 schema:name Service de Gynécologie Obstétrique, Hopital Tenon (Assistance Publique–Hôpitaux de Paris), 4 rue de la Chine, 75020, Paris, France
221 rdf:type schema:Organization
222 https://www.grid.ac/institutes/grid.414106.6 schema:alternateName Hôpital Foch
223 schema:name Department Genetic Medicine, Weill Cornell Medical College, New York, NY, USA
224 Service de chirurgie Gynécologique, Hôpital Foch, 92100, Suresnes, France
225 Stem Cell and Microenvironment Laboratory, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, PO: 24144, Doha, Qatar
226 rdf:type schema:Organization
227 https://www.grid.ac/institutes/grid.414145.1 schema:alternateName Hôpital Intercommunal de Créteil
228 schema:name Service de Gynécologie-Obstétrique et Médecine de la Reproduction, Faculté de médecine de Créteil UPEC–Paris XII, Centre Hospitalier Intercommunal de Créteil, 40 Avenue de Verdun, 94000, Créteil, France
229 rdf:type schema:Organization
230 https://www.grid.ac/institutes/grid.418818.c schema:alternateName Qatar Foundation
231 schema:name Stem Cell and Microenvironment Laboratory, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, PO: 24144, Doha, Qatar
232 rdf:type schema:Organization
233 https://www.grid.ac/institutes/grid.462410.5 schema:alternateName Mondor Institute of Biomedical Research
234 schema:name Department Genetic Medicine, Weill Cornell Medical College, New York, NY, USA
235 INSERM U955, Equipe 7, Créteil, France
236 Stem Cell and Microenvironment Laboratory, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, PO: 24144, Doha, Qatar
237 rdf:type schema:Organization
238 https://www.grid.ac/institutes/grid.5386.8 schema:alternateName Cornell University
239 schema:name Department Genetic Medicine, Weill Cornell Medical College, New York, NY, USA
240 Stem Cell and Microenvironment Laboratory, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, PO: 24144, Doha, Qatar
241 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...