The use of the tyrosine kinase inhibitor Nilotinib in Spondyloarthritis: does targeting inflammatory pathways with a treatment lead to vascular ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Loukman Omarjee, Vincent Jaquinandi, Guillaume Mahe

ABSTRACT

Spondylarthritis (SpA) is an inflammatory rheumatic disease associated with increased incidence of major adverse cardiovascular events (MACEs). Recently, Paramarta et al. proposed the use of the tyrosine kinase inhibitor Nilotinib in Spondyloarthritis to target certain inflammatory pathways. However, Nilotinib, which is highly effective for the treatment of patients with chronic myeloid leukaemia (CML), is also associated with an increased risk of MACEs. The authors suggest that Nilotinib may be effective in peripheral SpA by modulating inflammation, but not in axial SpA. Considering the vascular toxicity of Nilotinib and the acceleration of atherosclerosis in SpA patients, we suggest taking MACEs as an end-point in future trials. More... »

PAGES

255

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12967-017-1334-1

DOI

http://dx.doi.org/10.1186/s12967-017-1334-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1099685448

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29246242


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