Clinical features of serous retinopathy observed with cobimetinib in patients with BRAF-mutated melanoma treated in the randomized coBRIM study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Luis de la Cruz-Merino, Lorenza Di Guardo, Jean-Jacques Grob, Alfredo Venosa, James Larkin, Grant A. McArthur, Antoni Ribas, Paolo A. Ascierto, Jeffrey T. R. Evans, Antonio Gomez-Escobar, Giulio Barteselli, Susan Eng, Jessie J. Hsu, Anne Uyei, Brigitte Dréno

ABSTRACT

BACKGROUND: Serous chorioretinopathy has been associated with MEK inhibitors, including cobimetinib. We describe the clinical features of serous retinopathy observed with cobimetinib in patients with BRAF V600-mutated melanoma treated in the Phase III coBRIM study. METHODS: In the coBRIM study, 493 patients were treated in two randomly assigned treatment groups: cobimetinib and vemurafenib (n = 247) or vemurafenib (n = 246). All patients underwent prospective ophthalmic examinations at screening, at regular intervals during the study, and whenever ocular symptoms developed. Patients with serous retinopathy were identified in the study database using a group of relevant and synonymous adverse event terms. RESULTS: Eighty-six serous retinopathy events were reported in 70 patients (79 events in 63 cobimetinib and vemurafenib-treated patients vs seven events in seven vemurafenib-treated patients). Most patients with serous retinopathy identified by ophthalmic examination had no symptoms or had mild symptoms, among them reduced visual acuity, blurred vision, dyschromatopsia, and photophobia. Serous retinopathy usually occurred early during cobimetinib and vemurafenib treatment; median time to onset was 1.0 month. Most events were managed by observation and continuation of cobimetinib without dose modification and resolved or were resolving by the data cutoff date (19 Sept 2014). CONCLUSIONS: Cobimetinib treatment was associated with serous retinopathy in patients with BRAF V600-mutated melanoma. Retinopathy was generally asymptomatic or mild. Periodic ophthalmologic evaluations at regular intervals and at the manifestation of any visual disturbance are recommended to facilitate early detection and resolution of serous retinopathy while patients are taking cobimetinib. Trial Registration Clinicaltrials.gov (NCT01689519). First received: September 18, 2012. More... »

PAGES

146

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12967-017-1246-0

DOI

http://dx.doi.org/10.1186/s12967-017-1246-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1086154241

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28646893


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Azetidines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Central Serous Chorioretinopathy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Indoles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Melanoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Piperidines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins B-raf", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recurrence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Skin Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sulfonamides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vemurafenib", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Hospital Universitario Virgen Macarena", 
          "id": "https://www.grid.ac/institutes/grid.411375.5", 
          "name": [
            "Servicio de Oncolog\u00eda M\u00e9dica, Hospital Universitario Virgen Macarena, Avenida Doctor Fedriani 3, 41071, Seville, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de la Cruz-Merino", 
        "givenName": "Luis", 
        "id": "sg:person.01307014706.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307014706.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale dei Tumori", 
          "id": "https://www.grid.ac/institutes/grid.417893.0", 
          "name": [
            "Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Di Guardo", 
        "givenName": "Lorenza", 
        "id": "sg:person.0625237211.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625237211.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Aix-Marseille University, H\u00f4pital de la Timone, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Grob", 
        "givenName": "Jean-Jacques", 
        "id": "sg:person.011671114717.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011671114717.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ospedale Monaldi", 
          "id": "https://www.grid.ac/institutes/grid.416052.4", 
          "name": [
            "Ospedale Monaldi, Naples, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Venosa", 
        "givenName": "Alfredo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal Marsden NHS Foundation Trust", 
          "id": "https://www.grid.ac/institutes/grid.5072.0", 
          "name": [
            "Royal Marsden NHS Foundation Trust, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Larkin", 
        "givenName": "James", 
        "id": "sg:person.01255356274.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255356274.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia", 
            "University of Melbourne, Parkville, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "McArthur", 
        "givenName": "Grant A.", 
        "id": "sg:person.01101164743.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101164743.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California Los Angeles", 
          "id": "https://www.grid.ac/institutes/grid.19006.3e", 
          "name": [
            "Jonsson Comprehensive Cancer Center at the University of California, Los Angeles, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ribas", 
        "givenName": "Antoni", 
        "id": "sg:person.0627244670.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627244670.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale dei Tumori", 
          "id": "https://www.grid.ac/institutes/grid.417893.0", 
          "name": [
            "Istituto Nazionale Tumori Fondazione G. Pascale, Naples, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ascierto", 
        "givenName": "Paolo A.", 
        "id": "sg:person.01212502023.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212502023.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Glasgow", 
          "id": "https://www.grid.ac/institutes/grid.8756.c", 
          "name": [
            "Beatson West of Scotland Cancer Centre, University of Glasgow, Glasgow, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Evans", 
        "givenName": "Jeffrey T. R.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universitario Virgen Macarena", 
          "id": "https://www.grid.ac/institutes/grid.411375.5", 
          "name": [
            "Servicio de Oncolog\u00eda M\u00e9dica, Hospital Universitario Virgen Macarena, Avenida Doctor Fedriani 3, 41071, Seville, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gomez-Escobar", 
        "givenName": "Antonio", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Roche (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418158.1", 
          "name": [
            "Genentech, Inc., South San Francisco, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Barteselli", 
        "givenName": "Giulio", 
        "id": "sg:person.0716113544.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716113544.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Roche (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418158.1", 
          "name": [
            "Genentech, Inc., South San Francisco, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Eng", 
        "givenName": "Susan", 
        "id": "sg:person.011004575323.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011004575323.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Roche (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418158.1", 
          "name": [
            "Genentech, Inc., South San Francisco, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hsu", 
        "givenName": "Jessie J.", 
        "id": "sg:person.0575403115.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575403115.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Roche (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418158.1", 
          "name": [
            "Genentech, Inc., South San Francisco, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Uyei", 
        "givenName": "Anne", 
        "id": "sg:person.012541151667.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012541151667.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Nantes", 
          "id": "https://www.grid.ac/institutes/grid.4817.a", 
          "name": [
            "Nantes University, Nantes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dr\u00e9no", 
        "givenName": "Brigitte", 
        "id": "sg:person.01146563400.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146563400.12"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/978-1-60761-938-3_5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000369277", 
          "https://doi.org/10.1007/978-1-60761-938-3_5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-60761-938-3_5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000369277", 
          "https://doi.org/10.1007/978-1-60761-938-3_5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1408868", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000859328"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa050092", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007050226"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa050092", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007050226"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(14)70301-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008132333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-12-3529", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015270187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.survophthal.2012.07.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017076127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature00766", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023536940", 
          "https://doi.org/10.1038/nature00766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature00766", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023536940", 
          "https://doi.org/10.1038/nature00766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ctrv.2013.01.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026369767"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdu169", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027318977"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrclinonc.2014.83", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037851851", 
          "https://doi.org/10.1038/nrclinonc.2014.83"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2013/673796", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040057844"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(12)70270-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045691543"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1406037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047704810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(15)60898-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050394790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1412690", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050664711"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jamaophthalmol.2014.976", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051142324"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/eye.2015.82", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051578955", 
          "https://doi.org/10.1038/eye.2015.82"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijmm_00000191", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071509721"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2011.29.15_suppl.3019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083947528"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-12", 
    "datePublishedReg": "2017-12-01", 
    "description": "BACKGROUND: Serous chorioretinopathy has been associated with MEK inhibitors, including cobimetinib. We describe the clinical features of serous retinopathy observed with cobimetinib in patients with BRAF V600-mutated melanoma treated in the Phase III coBRIM study.\nMETHODS: In the coBRIM study, 493 patients were treated in two randomly assigned treatment groups: cobimetinib and vemurafenib (n\u00a0=\u00a0247) or vemurafenib (n\u00a0=\u00a0246). All patients underwent prospective ophthalmic examinations at screening, at regular intervals during the study, and whenever ocular symptoms developed. Patients with serous retinopathy were identified in the study database using a group of relevant and synonymous adverse event terms.\nRESULTS: Eighty-six serous retinopathy events were reported in 70 patients (79 events in 63 cobimetinib and vemurafenib-treated patients vs seven events in seven vemurafenib-treated patients). Most patients with serous retinopathy identified by ophthalmic examination had no symptoms or had mild symptoms, among them reduced visual acuity, blurred vision, dyschromatopsia, and photophobia. Serous retinopathy usually occurred early during cobimetinib and vemurafenib treatment; median time to onset was 1.0\u00a0month. Most events were managed by observation and continuation of cobimetinib without dose modification and resolved or were resolving by the data cutoff date (19 Sept 2014).\nCONCLUSIONS: Cobimetinib treatment was associated with serous retinopathy in patients with BRAF V600-mutated melanoma. Retinopathy was generally asymptomatic or mild. Periodic ophthalmologic evaluations at regular intervals and at the manifestation of any visual disturbance are recommended to facilitate early detection and resolution of serous retinopathy while patients are taking cobimetinib. Trial Registration Clinicaltrials.gov (NCT01689519). First received: September 18, 2012.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12967-017-1246-0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5134240", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1032886", 
        "issn": [
          "1479-5876"
        ], 
        "name": "Journal of Translational Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "15"
      }
    ], 
    "name": "Clinical features of serous retinopathy observed with cobimetinib in patients with BRAF-mutated melanoma treated in the randomized coBRIM study", 
    "pagination": "146", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "5b42cf8a884d47d373b30c7a384ed82334eae6b3c8295de0d102c316807b2283"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28646893"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101190741"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12967-017-1246-0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1086154241"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12967-017-1246-0", 
      "https://app.dimensions.ai/details/publication/pub.1086154241"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:24", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87097_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs12967-017-1246-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12967-017-1246-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12967-017-1246-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12967-017-1246-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12967-017-1246-0'


 

This table displays all metadata directly associated to this object as RDF triples.

326 TRIPLES      21 PREDICATES      66 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12967-017-1246-0 schema:about N03cc22659c9b40ad9a9c2fdbf9c45eff
2 N0cef697389a441ce8467e58495ef7c16
3 N0d315c453cc34e0ca7c9f44d4f7023e4
4 N16f95f55273342d08478f8ce45a4ff80
5 N1cef9ce32e0e40c19ddc738d0dbad766
6 N241daca1106d42aab9bd9fbf04f18c0a
7 N314b06eac24e4d5c979175e735eb1a3f
8 N31bba9b8f9e94d6fafb7f2c3cc541c50
9 N3bd4cebd4c5344e89ff4a7445e7d580a
10 N4be9ba866549405f904d317e3e1cbdda
11 N567f0bc5413d4dc7a38a735082eedb80
12 N5699a9d9920a4ab2b7d2d06d2047495c
13 N97dcdd3bf7cb4790997ab24704be4c2c
14 Nca0752f290b543de944c659ef65dbc7f
15 Nd42064cb489f402c9b82e0247d637854
16 Ne1155c2031424cea86c8a11e7013dc04
17 Ne8a4a33282a34fa7ac1c6ac3ac734367
18 Nfe2230da7e114f16aa541dd2bda72186
19 anzsrc-for:11
20 anzsrc-for:1103
21 schema:author N77a8d2667a754d18960df1d58e214ea6
22 schema:citation sg:pub.10.1007/978-1-60761-938-3_5
23 sg:pub.10.1038/eye.2015.82
24 sg:pub.10.1038/nature00766
25 sg:pub.10.1038/nrclinonc.2014.83
26 https://doi.org/10.1001/jamaophthalmol.2014.976
27 https://doi.org/10.1016/j.ctrv.2013.01.003
28 https://doi.org/10.1016/j.survophthal.2012.07.004
29 https://doi.org/10.1016/s0140-6736(15)60898-4
30 https://doi.org/10.1016/s1470-2045(12)70270-x
31 https://doi.org/10.1016/s1470-2045(14)70301-8
32 https://doi.org/10.1056/nejmoa050092
33 https://doi.org/10.1056/nejmoa1406037
34 https://doi.org/10.1056/nejmoa1408868
35 https://doi.org/10.1056/nejmoa1412690
36 https://doi.org/10.1093/annonc/mdu169
37 https://doi.org/10.1155/2013/673796
38 https://doi.org/10.1158/1078-0432.ccr-12-3529
39 https://doi.org/10.1200/jco.2011.29.15_suppl.3019
40 https://doi.org/10.3892/ijmm_00000191
41 schema:datePublished 2017-12
42 schema:datePublishedReg 2017-12-01
43 schema:description BACKGROUND: Serous chorioretinopathy has been associated with MEK inhibitors, including cobimetinib. We describe the clinical features of serous retinopathy observed with cobimetinib in patients with BRAF V600-mutated melanoma treated in the Phase III coBRIM study. METHODS: In the coBRIM study, 493 patients were treated in two randomly assigned treatment groups: cobimetinib and vemurafenib (n = 247) or vemurafenib (n = 246). All patients underwent prospective ophthalmic examinations at screening, at regular intervals during the study, and whenever ocular symptoms developed. Patients with serous retinopathy were identified in the study database using a group of relevant and synonymous adverse event terms. RESULTS: Eighty-six serous retinopathy events were reported in 70 patients (79 events in 63 cobimetinib and vemurafenib-treated patients vs seven events in seven vemurafenib-treated patients). Most patients with serous retinopathy identified by ophthalmic examination had no symptoms or had mild symptoms, among them reduced visual acuity, blurred vision, dyschromatopsia, and photophobia. Serous retinopathy usually occurred early during cobimetinib and vemurafenib treatment; median time to onset was 1.0 month. Most events were managed by observation and continuation of cobimetinib without dose modification and resolved or were resolving by the data cutoff date (19 Sept 2014). CONCLUSIONS: Cobimetinib treatment was associated with serous retinopathy in patients with BRAF V600-mutated melanoma. Retinopathy was generally asymptomatic or mild. Periodic ophthalmologic evaluations at regular intervals and at the manifestation of any visual disturbance are recommended to facilitate early detection and resolution of serous retinopathy while patients are taking cobimetinib. Trial Registration Clinicaltrials.gov (NCT01689519). First received: September 18, 2012.
44 schema:genre research_article
45 schema:inLanguage en
46 schema:isAccessibleForFree true
47 schema:isPartOf N77715bd01c2a4230b91a91b6c0b115c1
48 Nf98c1fef09bd4b2d96158782a0e3e8b9
49 sg:journal.1032886
50 schema:name Clinical features of serous retinopathy observed with cobimetinib in patients with BRAF-mutated melanoma treated in the randomized coBRIM study
51 schema:pagination 146
52 schema:productId N0cba097300384978843dfc6ff4b36a91
53 N59e16130440043dd96becd0ba6847254
54 N8748fb1b6450481c83157771e32d376d
55 Ncf381efddd294133853b0b41296ab278
56 Nd965ae0c28df40c28a72668ff30871bf
57 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086154241
58 https://doi.org/10.1186/s12967-017-1246-0
59 schema:sdDatePublished 2019-04-11T12:24
60 schema:sdLicense https://scigraph.springernature.com/explorer/license/
61 schema:sdPublisher N17ec31c152c74855b108139561457fb6
62 schema:url https://link.springer.com/10.1186%2Fs12967-017-1246-0
63 sgo:license sg:explorer/license/
64 sgo:sdDataset articles
65 rdf:type schema:ScholarlyArticle
66 N00845840f43c4241973d1305b57fe21c rdf:first sg:person.0575403115.81
67 rdf:rest Ndd24ffdf9531402c859df995c3df5924
68 N03cc22659c9b40ad9a9c2fdbf9c45eff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
69 schema:name Proto-Oncogene Proteins B-raf
70 rdf:type schema:DefinedTerm
71 N0c8cbdb2e51d41c1a3d3db628c34ebac rdf:first sg:person.011671114717.29
72 rdf:rest N7e495470bd7244e49d0cb7bdf361d060
73 N0cba097300384978843dfc6ff4b36a91 schema:name doi
74 schema:value 10.1186/s12967-017-1246-0
75 rdf:type schema:PropertyValue
76 N0cef697389a441ce8467e58495ef7c16 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Humans
78 rdf:type schema:DefinedTerm
79 N0d315c453cc34e0ca7c9f44d4f7023e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Melanoma
81 rdf:type schema:DefinedTerm
82 N16f95f55273342d08478f8ce45a4ff80 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Female
84 rdf:type schema:DefinedTerm
85 N17ec31c152c74855b108139561457fb6 schema:name Springer Nature - SN SciGraph project
86 rdf:type schema:Organization
87 N1cef9ce32e0e40c19ddc738d0dbad766 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Sulfonamides
89 rdf:type schema:DefinedTerm
90 N241daca1106d42aab9bd9fbf04f18c0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Recurrence
92 rdf:type schema:DefinedTerm
93 N26046fd7ef4347e99fa850a3dac752dd rdf:first sg:person.01212502023.44
94 rdf:rest Nda9563f48256472a957d38cf331c469d
95 N314b06eac24e4d5c979175e735eb1a3f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Central Serous Chorioretinopathy
97 rdf:type schema:DefinedTerm
98 N31bba9b8f9e94d6fafb7f2c3cc541c50 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Aged
100 rdf:type schema:DefinedTerm
101 N3bd4cebd4c5344e89ff4a7445e7d580a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Vemurafenib
103 rdf:type schema:DefinedTerm
104 N427db52165a64288afd1063405f2524d rdf:first sg:person.0627244670.28
105 rdf:rest N26046fd7ef4347e99fa850a3dac752dd
106 N482acfa04d3646c4bae734e08298f63b rdf:first sg:person.01101164743.35
107 rdf:rest N427db52165a64288afd1063405f2524d
108 N4be9ba866549405f904d317e3e1cbdda schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Middle Aged
110 rdf:type schema:DefinedTerm
111 N567f0bc5413d4dc7a38a735082eedb80 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Mutation
113 rdf:type schema:DefinedTerm
114 N5699a9d9920a4ab2b7d2d06d2047495c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Skin Neoplasms
116 rdf:type schema:DefinedTerm
117 N582faa1e0e2045418ddbcfbab55e99ae rdf:first sg:person.01146563400.12
118 rdf:rest rdf:nil
119 N59e16130440043dd96becd0ba6847254 schema:name readcube_id
120 schema:value 5b42cf8a884d47d373b30c7a384ed82334eae6b3c8295de0d102c316807b2283
121 rdf:type schema:PropertyValue
122 N77715bd01c2a4230b91a91b6c0b115c1 schema:volumeNumber 15
123 rdf:type schema:PublicationVolume
124 N77a8d2667a754d18960df1d58e214ea6 rdf:first sg:person.01307014706.76
125 rdf:rest Ncfc7ead820504ad3bce633ffa2edd759
126 N7e495470bd7244e49d0cb7bdf361d060 rdf:first Nca31f14f0c0f4662ad3767be55ac23d8
127 rdf:rest Nadef59c338e346e6b2f9b6ac1bfe1cd3
128 N8573bae18c9b4f86a9857ed6b819fbab schema:affiliation https://www.grid.ac/institutes/grid.411375.5
129 schema:familyName Gomez-Escobar
130 schema:givenName Antonio
131 rdf:type schema:Person
132 N8748fb1b6450481c83157771e32d376d schema:name dimensions_id
133 schema:value pub.1086154241
134 rdf:type schema:PropertyValue
135 N89a97be421494f7ba325ca2a29f6ceae schema:name Aix-Marseille University, Hôpital de la Timone, Marseille, France
136 rdf:type schema:Organization
137 N97dcdd3bf7cb4790997ab24704be4c2c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Indoles
139 rdf:type schema:DefinedTerm
140 Na80084cfb3604926a6e08b4d41db4ffe rdf:first N8573bae18c9b4f86a9857ed6b819fbab
141 rdf:rest Nb9dc36cc7ea9472eb75388aac4f050f9
142 Nadef59c338e346e6b2f9b6ac1bfe1cd3 rdf:first sg:person.01255356274.07
143 rdf:rest N482acfa04d3646c4bae734e08298f63b
144 Nb9dc36cc7ea9472eb75388aac4f050f9 rdf:first sg:person.0716113544.64
145 rdf:rest Nd8e5a284499e42e9b0014efc7c13a4eb
146 Nca0752f290b543de944c659ef65dbc7f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Azetidines
148 rdf:type schema:DefinedTerm
149 Nca31f14f0c0f4662ad3767be55ac23d8 schema:affiliation https://www.grid.ac/institutes/grid.416052.4
150 schema:familyName Venosa
151 schema:givenName Alfredo
152 rdf:type schema:Person
153 Ncf381efddd294133853b0b41296ab278 schema:name pubmed_id
154 schema:value 28646893
155 rdf:type schema:PropertyValue
156 Ncfc7ead820504ad3bce633ffa2edd759 rdf:first sg:person.0625237211.06
157 rdf:rest N0c8cbdb2e51d41c1a3d3db628c34ebac
158 Nd42064cb489f402c9b82e0247d637854 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Male
160 rdf:type schema:DefinedTerm
161 Nd8e5a284499e42e9b0014efc7c13a4eb rdf:first sg:person.011004575323.86
162 rdf:rest N00845840f43c4241973d1305b57fe21c
163 Nd965ae0c28df40c28a72668ff30871bf schema:name nlm_unique_id
164 schema:value 101190741
165 rdf:type schema:PropertyValue
166 Nda9563f48256472a957d38cf331c469d rdf:first Nfc0e752c2a6142468eaa263022e90c8a
167 rdf:rest Na80084cfb3604926a6e08b4d41db4ffe
168 Ndd24ffdf9531402c859df995c3df5924 rdf:first sg:person.012541151667.36
169 rdf:rest N582faa1e0e2045418ddbcfbab55e99ae
170 Ne1155c2031424cea86c8a11e7013dc04 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Adult
172 rdf:type schema:DefinedTerm
173 Ne8a4a33282a34fa7ac1c6ac3ac734367 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Piperidines
175 rdf:type schema:DefinedTerm
176 Nf98c1fef09bd4b2d96158782a0e3e8b9 schema:issueNumber 1
177 rdf:type schema:PublicationIssue
178 Nfc0e752c2a6142468eaa263022e90c8a schema:affiliation https://www.grid.ac/institutes/grid.8756.c
179 schema:familyName Evans
180 schema:givenName Jeffrey T. R.
181 rdf:type schema:Person
182 Nfe2230da7e114f16aa541dd2bda72186 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Time Factors
184 rdf:type schema:DefinedTerm
185 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
186 schema:name Medical and Health Sciences
187 rdf:type schema:DefinedTerm
188 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
189 schema:name Clinical Sciences
190 rdf:type schema:DefinedTerm
191 sg:grant.5134240 http://pending.schema.org/fundedItem sg:pub.10.1186/s12967-017-1246-0
192 rdf:type schema:MonetaryGrant
193 sg:journal.1032886 schema:issn 1479-5876
194 schema:name Journal of Translational Medicine
195 rdf:type schema:Periodical
196 sg:person.011004575323.86 schema:affiliation https://www.grid.ac/institutes/grid.418158.1
197 schema:familyName Eng
198 schema:givenName Susan
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011004575323.86
200 rdf:type schema:Person
201 sg:person.01101164743.35 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
202 schema:familyName McArthur
203 schema:givenName Grant A.
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101164743.35
205 rdf:type schema:Person
206 sg:person.01146563400.12 schema:affiliation https://www.grid.ac/institutes/grid.4817.a
207 schema:familyName Dréno
208 schema:givenName Brigitte
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146563400.12
210 rdf:type schema:Person
211 sg:person.011671114717.29 schema:affiliation N89a97be421494f7ba325ca2a29f6ceae
212 schema:familyName Grob
213 schema:givenName Jean-Jacques
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011671114717.29
215 rdf:type schema:Person
216 sg:person.01212502023.44 schema:affiliation https://www.grid.ac/institutes/grid.417893.0
217 schema:familyName Ascierto
218 schema:givenName Paolo A.
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212502023.44
220 rdf:type schema:Person
221 sg:person.012541151667.36 schema:affiliation https://www.grid.ac/institutes/grid.418158.1
222 schema:familyName Uyei
223 schema:givenName Anne
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012541151667.36
225 rdf:type schema:Person
226 sg:person.01255356274.07 schema:affiliation https://www.grid.ac/institutes/grid.5072.0
227 schema:familyName Larkin
228 schema:givenName James
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255356274.07
230 rdf:type schema:Person
231 sg:person.01307014706.76 schema:affiliation https://www.grid.ac/institutes/grid.411375.5
232 schema:familyName de la Cruz-Merino
233 schema:givenName Luis
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307014706.76
235 rdf:type schema:Person
236 sg:person.0575403115.81 schema:affiliation https://www.grid.ac/institutes/grid.418158.1
237 schema:familyName Hsu
238 schema:givenName Jessie J.
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575403115.81
240 rdf:type schema:Person
241 sg:person.0625237211.06 schema:affiliation https://www.grid.ac/institutes/grid.417893.0
242 schema:familyName Di Guardo
243 schema:givenName Lorenza
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625237211.06
245 rdf:type schema:Person
246 sg:person.0627244670.28 schema:affiliation https://www.grid.ac/institutes/grid.19006.3e
247 schema:familyName Ribas
248 schema:givenName Antoni
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627244670.28
250 rdf:type schema:Person
251 sg:person.0716113544.64 schema:affiliation https://www.grid.ac/institutes/grid.418158.1
252 schema:familyName Barteselli
253 schema:givenName Giulio
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716113544.64
255 rdf:type schema:Person
256 sg:pub.10.1007/978-1-60761-938-3_5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000369277
257 https://doi.org/10.1007/978-1-60761-938-3_5
258 rdf:type schema:CreativeWork
259 sg:pub.10.1038/eye.2015.82 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051578955
260 https://doi.org/10.1038/eye.2015.82
261 rdf:type schema:CreativeWork
262 sg:pub.10.1038/nature00766 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023536940
263 https://doi.org/10.1038/nature00766
264 rdf:type schema:CreativeWork
265 sg:pub.10.1038/nrclinonc.2014.83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037851851
266 https://doi.org/10.1038/nrclinonc.2014.83
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1001/jamaophthalmol.2014.976 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051142324
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/j.ctrv.2013.01.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026369767
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/j.survophthal.2012.07.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017076127
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1016/s0140-6736(15)60898-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050394790
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1016/s1470-2045(12)70270-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045691543
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1016/s1470-2045(14)70301-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008132333
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1056/nejmoa050092 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007050226
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1056/nejmoa1406037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047704810
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1056/nejmoa1408868 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000859328
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1056/nejmoa1412690 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050664711
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1093/annonc/mdu169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027318977
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1155/2013/673796 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040057844
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1158/1078-0432.ccr-12-3529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015270187
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1200/jco.2011.29.15_suppl.3019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083947528
295 rdf:type schema:CreativeWork
296 https://doi.org/10.3892/ijmm_00000191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071509721
297 rdf:type schema:CreativeWork
298 https://www.grid.ac/institutes/grid.1008.9 schema:alternateName University of Melbourne
299 schema:name Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia
300 University of Melbourne, Parkville, VIC, Australia
301 rdf:type schema:Organization
302 https://www.grid.ac/institutes/grid.19006.3e schema:alternateName University of California Los Angeles
303 schema:name Jonsson Comprehensive Cancer Center at the University of California, Los Angeles, CA, USA
304 rdf:type schema:Organization
305 https://www.grid.ac/institutes/grid.411375.5 schema:alternateName Hospital Universitario Virgen Macarena
306 schema:name Servicio de Oncología Médica, Hospital Universitario Virgen Macarena, Avenida Doctor Fedriani 3, 41071, Seville, Spain
307 rdf:type schema:Organization
308 https://www.grid.ac/institutes/grid.416052.4 schema:alternateName Ospedale Monaldi
309 schema:name Ospedale Monaldi, Naples, Italy
310 rdf:type schema:Organization
311 https://www.grid.ac/institutes/grid.417893.0 schema:alternateName Istituto Nazionale dei Tumori
312 schema:name Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
313 Istituto Nazionale Tumori Fondazione G. Pascale, Naples, Italy
314 rdf:type schema:Organization
315 https://www.grid.ac/institutes/grid.418158.1 schema:alternateName Roche (United States)
316 schema:name Genentech, Inc., South San Francisco, CA, USA
317 rdf:type schema:Organization
318 https://www.grid.ac/institutes/grid.4817.a schema:alternateName University of Nantes
319 schema:name Nantes University, Nantes, France
320 rdf:type schema:Organization
321 https://www.grid.ac/institutes/grid.5072.0 schema:alternateName Royal Marsden NHS Foundation Trust
322 schema:name Royal Marsden NHS Foundation Trust, London, UK
323 rdf:type schema:Organization
324 https://www.grid.ac/institutes/grid.8756.c schema:alternateName University of Glasgow
325 schema:name Beatson West of Scotland Cancer Centre, University of Glasgow, Glasgow, UK
326 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...