Basal cell carcinoma: 10-year experience with electrochemotherapy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Luca G. Campana, Roberto Marconato, Sara Valpione, Sara Galuppo, Mauro Alaibac, Carlo R. Rossi, Simone Mocellin

ABSTRACT

BACKGROUND: Electrochemotherapy (ECT), by combining manageable cytotoxic agents with short electric pulses, represents an effective palliative skin-directed therapy. The accumulated evidence indicates that ECT stands out as a safe and well-tolerated alternative treatment for patients with multiple or large basal cell carcinoma (BCC), who are not suitable for conventional treatments. However, long-term data and shared indications are lacking. METHODS: In this observational study, we retrospectively analyzed 84 prospectively collected patients with multiple, recurrent or locally advanced BCC who were not candidate for standard therapies and received bleomycin-based ECT according to the European Standard Operative Procedures of ECT, from 2006 to 2016. RESULTS: Disease extent was local, locally advanced and metastatic in 40 (48%), 41 (49%) and 3 (3%), respectively. Forty-four (52%) individuals had multiple BCCs. Grade 3 skin toxicity after ECT was observed in 6% of cases. Clearance rate was 50% (95% CI 39-61%). Primary presentation (p = 0.004), tumor size <3 cm (p < 0.001), well-defined borders (p = 0.021), absence of tumor ulceration (p = 0.001), non-aggressive BCC histology (p = 0.046) and age ≤69 years were associated with higher complete response rate. In patients with local BCC, the clearance rate was 72.5 and 85% after one or two ECT cycles, respectively. In the laBCC group, 32 patients (78%) achieved an objective response. Five-year recurrence rate for local and laBCC was 20 and 38%, respectively (p ≤ 0.001). CONCLUSIONS: One or two ECT cycles with bleomycin may be a valuable palliative treatment in well-selected patients with multiple BCCs and favorable tumor features. Validation of predictive factors will be imperative to match patients with optimal ECT treatment modalities. Management of laBCC with ECT warrants further investigation. Trial registration ISRCTN14633165 Registered 24 March 2017 (retrospectively registered). More... »

PAGES

122

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12967-017-1225-5

DOI

http://dx.doi.org/10.1186/s12967-017-1225-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1085733369

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28569161


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bleomycin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Basal Cell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytotoxins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Electrochemotherapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Recurrence, Local", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Skin Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Padua", 
          "id": "https://www.grid.ac/institutes/grid.5608.b", 
          "name": [
            "Department of Surgery, Oncology and Gastroenterology (DISCOG), University of Padova, Padua, Italy", 
            "Surgical Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata, 64, 35128, Padua, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Campana", 
        "givenName": "Luca G.", 
        "id": "sg:person.01060352341.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060352341.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Padua", 
          "id": "https://www.grid.ac/institutes/grid.5608.b", 
          "name": [
            "University of Padova School of Medicine, Padua, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marconato", 
        "givenName": "Roberto", 
        "id": "sg:person.07504041705.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07504041705.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Christie Hospital NHS Foundation Trust", 
          "id": "https://www.grid.ac/institutes/grid.412917.8", 
          "name": [
            "Department of Surgery, Oncology and Gastroenterology (DISCOG), University of Padova, Padua, Italy", 
            "Christie NHS Foundation Trust, M20 4BX, Manchester, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Valpione", 
        "givenName": "Sara", 
        "id": "sg:person.01126465541.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126465541.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Oncologico Veneto", 
          "id": "https://www.grid.ac/institutes/grid.419546.b", 
          "name": [
            "Radiotherapy Unit, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Galuppo", 
        "givenName": "Sara", 
        "id": "sg:person.01363020664.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363020664.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Padua", 
          "id": "https://www.grid.ac/institutes/grid.5608.b", 
          "name": [
            "Dermatology Unit, University of Padova, Padua, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alaibac", 
        "givenName": "Mauro", 
        "id": "sg:person.0640110517.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640110517.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Padua", 
          "id": "https://www.grid.ac/institutes/grid.5608.b", 
          "name": [
            "Department of Surgery, Oncology and Gastroenterology (DISCOG), University of Padova, Padua, Italy", 
            "Surgical Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata, 64, 35128, Padua, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rossi", 
        "givenName": "Carlo R.", 
        "id": "sg:person.013321165112.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013321165112.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Padua", 
          "id": "https://www.grid.ac/institutes/grid.5608.b", 
          "name": [
            "Department of Surgery, Oncology and Gastroenterology (DISCOG), University of Padova, Padua, Italy", 
            "Surgical Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata, 64, 35128, Padua, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mocellin", 
        "givenName": "Simone", 
        "id": "sg:person.01370531503.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370531503.96"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/j.1524-4725.1989.tb03166.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000191348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1524-4725.1989.tb03166.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000191348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1524-4725.1989.tb03166.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000191348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.8749", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000513844"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2133.2012.10878.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001413099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bjps.2005.02.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002661673"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(15)70198-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004483287"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra044151", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008061194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra044151", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008061194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/ced.12016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008870491"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1113713", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011121733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archderm.144.9.1186", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011244049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bjps.2013.07.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012891539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e31824f68b2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013391952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e31824f68b2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013391952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1440-0960.2006.00216.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015120456"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1440-0960.2006.00216.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015120456"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejso.2016.06.399", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016342062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaad.2006.06.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018401838"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1524-4725.1989.tb03249.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018539050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1524-4725.1989.tb03249.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018539050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1515/raon-2016-0006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019774909"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0190-9622(97)70178-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020838303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejcsup.2006.08.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022288859"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.11798", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022403174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(08)70260-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022661602"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2133.2006.07474.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024263342"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2478/raon-2013-0002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024693803"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0190-9622(91)70001-i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025653354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6604168", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029086058", 
          "https://doi.org/10.1038/sj.bjc.6604168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejcsup.2006.08.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032599334"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1524-4725.1992.tb03508.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036497606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1524-4725.1992.tb03508.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036497606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/14651858.cd003412.pub2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036986805"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2133.2008.08666.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037306378"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2016.05.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040615090"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2133.2001.04085.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040884264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2004.08.040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041607311"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1524-4725.1991.tb03425.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043135980"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1524-4725.1991.tb03425.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043135980"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00403-013-1357-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043280530", 
          "https://doi.org/10.1007/s00403-013-1357-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00403-013-1357-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043280530", 
          "https://doi.org/10.1007/s00403-013-1357-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1524-4725.1992.tb03307.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044003800"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1524-4725.1992.tb03307.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044003800"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4103/0378-6323.136989", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046232906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bjoms.2014.08.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048772515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejso.2007.05.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049456222"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-012-2095-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050850695", 
          "https://doi.org/10.1007/s10549-012-2095-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2014.08.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051129271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2014.55.4634", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052235891"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2340/00015555-1134", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070751252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2340/00015555-1361", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070751470"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077115309", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1990.8.2.342", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078788973"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079150222", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-12", 
    "datePublishedReg": "2017-12-01", 
    "description": "BACKGROUND: Electrochemotherapy (ECT), by combining manageable cytotoxic agents with short electric pulses, represents an effective palliative skin-directed therapy. The accumulated evidence indicates that ECT stands out as a safe and well-tolerated alternative treatment for patients with multiple or large basal cell carcinoma (BCC), who are not suitable for conventional treatments. However, long-term data and shared indications are lacking.\nMETHODS: In this observational study, we retrospectively analyzed 84 prospectively collected patients with multiple, recurrent or locally advanced BCC who were not candidate for standard therapies and received bleomycin-based ECT according to the European Standard Operative Procedures of ECT, from 2006 to 2016.\nRESULTS: Disease extent was local, locally advanced and metastatic in 40 (48%), 41 (49%) and 3 (3%), respectively. Forty-four (52%) individuals had multiple BCCs. Grade 3 skin toxicity after ECT was observed in 6% of cases. Clearance rate was 50% (95% CI 39-61%). Primary presentation (p\u00a0=\u00a00.004), tumor size\u00a0<3\u00a0cm (p\u00a0<\u00a00.001), well-defined borders (p\u00a0=\u00a00.021), absence of tumor ulceration (p\u00a0=\u00a00.001), non-aggressive BCC histology (p\u00a0=\u00a00.046) and age\u00a0\u226469\u00a0years were associated with higher complete response rate. In patients with local BCC, the clearance rate was 72.5 and 85% after one or two ECT cycles, respectively. In the laBCC group, 32 patients (78%) achieved an objective response. Five-year recurrence rate for local and laBCC was 20 and 38%, respectively (p\u00a0\u2264\u00a00.001).\nCONCLUSIONS: One or two ECT cycles with bleomycin may be a valuable palliative treatment in well-selected patients with multiple BCCs and favorable tumor features. Validation of predictive factors will be imperative to match patients with optimal ECT treatment modalities. Management of laBCC with ECT warrants further investigation. Trial registration ISRCTN14633165 Registered 24 March 2017 (retrospectively registered).", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12967-017-1225-5", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1032886", 
        "issn": [
          "1479-5876"
        ], 
        "name": "Journal of Translational Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "15"
      }
    ], 
    "name": "Basal cell carcinoma: 10-year experience with electrochemotherapy", 
    "pagination": "122", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "7727b62be84bfff12ea7d08773fe8193bc11e1165b41e5f53f352cfcc6b5160d"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28569161"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101190741"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12967-017-1225-5"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1085733369"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12967-017-1225-5", 
      "https://app.dimensions.ai/details/publication/pub.1085733369"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:53", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000347_0000000347/records_89793_00000003.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs12967-017-1225-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12967-017-1225-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12967-017-1225-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12967-017-1225-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12967-017-1225-5'


 

This table displays all metadata directly associated to this object as RDF triples.

320 TRIPLES      21 PREDICATES      90 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12967-017-1225-5 schema:about N08e652023c8b4555b9cccad4e380bbd7
2 N17401027427643479f73148504805d71
3 N23a7e9f206034647bba60907ccc7afe5
4 N254157434a954f88a4f56c58bb74ee44
5 N2afe875cdb6f493a8adb573449b863c5
6 N449ed247fe23498089cf353f4d3ae2e1
7 N4512e00c7c354c9586aa0bfa464dac43
8 N6897252df12841b2b846a49a5214b1fc
9 N793ea535bbd74b3ca6cd55b8dce9fb1e
10 Naadb5301aec64f56b15493125e159987
11 Nabaee6ff0a1045a7a926556a79bcec3e
12 Nad59676a5c974e20ac0a260b1013ee07
13 Nd5a4f0b288e44ea39153e55341d43cc9
14 Ne73783210c8e472ca464edb0f7f292f0
15 Nea9d0d9b93f546b0ae5d573df203c8f0
16 Nf9d3f5f5a08447d0a779aab36315d854
17 anzsrc-for:11
18 anzsrc-for:1103
19 schema:author N7238d7ccd2c346eaa43d4f3f2823271f
20 schema:citation sg:pub.10.1007/s00403-013-1357-2
21 sg:pub.10.1007/s10549-012-2095-4
22 sg:pub.10.1038/sj.bjc.6604168
23 https://app.dimensions.ai/details/publication/pub.1077115309
24 https://app.dimensions.ai/details/publication/pub.1079150222
25 https://doi.org/10.1001/archderm.144.9.1186
26 https://doi.org/10.1002/14651858.cd003412.pub2
27 https://doi.org/10.1002/bjs.8749
28 https://doi.org/10.1002/cncr.11798
29 https://doi.org/10.1016/0190-9622(91)70001-i
30 https://doi.org/10.1016/j.bjoms.2014.08.004
31 https://doi.org/10.1016/j.bjps.2005.02.010
32 https://doi.org/10.1016/j.bjps.2013.07.019
33 https://doi.org/10.1016/j.ejca.2014.08.018
34 https://doi.org/10.1016/j.ejca.2016.05.001
35 https://doi.org/10.1016/j.ejcsup.2006.08.002
36 https://doi.org/10.1016/j.ejcsup.2006.08.003
37 https://doi.org/10.1016/j.ejso.2007.05.016
38 https://doi.org/10.1016/j.ejso.2016.06.399
39 https://doi.org/10.1016/j.jaad.2006.06.006
40 https://doi.org/10.1016/s0190-9622(97)70178-6
41 https://doi.org/10.1016/s1470-2045(08)70260-2
42 https://doi.org/10.1016/s1470-2045(15)70198-1
43 https://doi.org/10.1046/j.1365-2133.2001.04085.x
44 https://doi.org/10.1056/nejmoa1113713
45 https://doi.org/10.1056/nejmra044151
46 https://doi.org/10.1097/sla.0b013e31824f68b2
47 https://doi.org/10.1111/ced.12016
48 https://doi.org/10.1111/j.1365-2133.2006.07474.x
49 https://doi.org/10.1111/j.1365-2133.2008.08666.x
50 https://doi.org/10.1111/j.1365-2133.2012.10878.x
51 https://doi.org/10.1111/j.1440-0960.2006.00216.x
52 https://doi.org/10.1111/j.1524-4725.1989.tb03166.x
53 https://doi.org/10.1111/j.1524-4725.1989.tb03249.x
54 https://doi.org/10.1111/j.1524-4725.1991.tb03425.x
55 https://doi.org/10.1111/j.1524-4725.1992.tb03307.x
56 https://doi.org/10.1111/j.1524-4725.1992.tb03508.x
57 https://doi.org/10.1200/jco.1990.8.2.342
58 https://doi.org/10.1200/jco.2004.08.040
59 https://doi.org/10.1200/jco.2014.55.4634
60 https://doi.org/10.1515/raon-2016-0006
61 https://doi.org/10.2340/00015555-1134
62 https://doi.org/10.2340/00015555-1361
63 https://doi.org/10.2478/raon-2013-0002
64 https://doi.org/10.4103/0378-6323.136989
65 schema:datePublished 2017-12
66 schema:datePublishedReg 2017-12-01
67 schema:description BACKGROUND: Electrochemotherapy (ECT), by combining manageable cytotoxic agents with short electric pulses, represents an effective palliative skin-directed therapy. The accumulated evidence indicates that ECT stands out as a safe and well-tolerated alternative treatment for patients with multiple or large basal cell carcinoma (BCC), who are not suitable for conventional treatments. However, long-term data and shared indications are lacking. METHODS: In this observational study, we retrospectively analyzed 84 prospectively collected patients with multiple, recurrent or locally advanced BCC who were not candidate for standard therapies and received bleomycin-based ECT according to the European Standard Operative Procedures of ECT, from 2006 to 2016. RESULTS: Disease extent was local, locally advanced and metastatic in 40 (48%), 41 (49%) and 3 (3%), respectively. Forty-four (52%) individuals had multiple BCCs. Grade 3 skin toxicity after ECT was observed in 6% of cases. Clearance rate was 50% (95% CI 39-61%). Primary presentation (p = 0.004), tumor size <3 cm (p < 0.001), well-defined borders (p = 0.021), absence of tumor ulceration (p = 0.001), non-aggressive BCC histology (p = 0.046) and age ≤69 years were associated with higher complete response rate. In patients with local BCC, the clearance rate was 72.5 and 85% after one or two ECT cycles, respectively. In the laBCC group, 32 patients (78%) achieved an objective response. Five-year recurrence rate for local and laBCC was 20 and 38%, respectively (p ≤ 0.001). CONCLUSIONS: One or two ECT cycles with bleomycin may be a valuable palliative treatment in well-selected patients with multiple BCCs and favorable tumor features. Validation of predictive factors will be imperative to match patients with optimal ECT treatment modalities. Management of laBCC with ECT warrants further investigation. Trial registration ISRCTN14633165 Registered 24 March 2017 (retrospectively registered).
68 schema:genre research_article
69 schema:inLanguage en
70 schema:isAccessibleForFree true
71 schema:isPartOf Ndedbe30786ee4d12bccd81a1f0b0afb8
72 Neee188370db144e6a29c192c832189da
73 sg:journal.1032886
74 schema:name Basal cell carcinoma: 10-year experience with electrochemotherapy
75 schema:pagination 122
76 schema:productId N32aba81d85964ff7b5c6051f433f7267
77 N4904ef0f6bc64f598d3284641cd1b31f
78 N9b582b22143743828dc73be318316242
79 Ne4b33768e2d44a2dbbec57ff7f4ef6b4
80 Nf2937fcfc1ec48d6b8c7e874dca7a967
81 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085733369
82 https://doi.org/10.1186/s12967-017-1225-5
83 schema:sdDatePublished 2019-04-11T09:53
84 schema:sdLicense https://scigraph.springernature.com/explorer/license/
85 schema:sdPublisher N1b9f9f71f3c04544b1cea8236badbc73
86 schema:url https://link.springer.com/10.1186%2Fs12967-017-1225-5
87 sgo:license sg:explorer/license/
88 sgo:sdDataset articles
89 rdf:type schema:ScholarlyArticle
90 N06bb789b0cc84d4e8b8b65f530ab8677 rdf:first sg:person.01126465541.31
91 rdf:rest Ncbc9331329e540aca8a72bb4e25c6089
92 N08e652023c8b4555b9cccad4e380bbd7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Carcinoma, Basal Cell
94 rdf:type schema:DefinedTerm
95 N0bbdd5025d0447a79ac52e2d085ad727 rdf:first sg:person.01370531503.96
96 rdf:rest rdf:nil
97 N17401027427643479f73148504805d71 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Female
99 rdf:type schema:DefinedTerm
100 N1b9f9f71f3c04544b1cea8236badbc73 schema:name Springer Nature - SN SciGraph project
101 rdf:type schema:Organization
102 N23a7e9f206034647bba60907ccc7afe5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Aged, 80 and over
104 rdf:type schema:DefinedTerm
105 N254157434a954f88a4f56c58bb74ee44 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Middle Aged
107 rdf:type schema:DefinedTerm
108 N2afe875cdb6f493a8adb573449b863c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Neoplasm Recurrence, Local
110 rdf:type schema:DefinedTerm
111 N32aba81d85964ff7b5c6051f433f7267 schema:name dimensions_id
112 schema:value pub.1085733369
113 rdf:type schema:PropertyValue
114 N449ed247fe23498089cf353f4d3ae2e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Male
116 rdf:type schema:DefinedTerm
117 N4512e00c7c354c9586aa0bfa464dac43 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Adult
119 rdf:type schema:DefinedTerm
120 N4904ef0f6bc64f598d3284641cd1b31f schema:name readcube_id
121 schema:value 7727b62be84bfff12ea7d08773fe8193bc11e1165b41e5f53f352cfcc6b5160d
122 rdf:type schema:PropertyValue
123 N6897252df12841b2b846a49a5214b1fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Electrochemotherapy
125 rdf:type schema:DefinedTerm
126 N7238d7ccd2c346eaa43d4f3f2823271f rdf:first sg:person.01060352341.74
127 rdf:rest Nfd749c2125d74a7a9b3c77083ac6a98c
128 N793ea535bbd74b3ca6cd55b8dce9fb1e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Treatment Outcome
130 rdf:type schema:DefinedTerm
131 N9b582b22143743828dc73be318316242 schema:name pubmed_id
132 schema:value 28569161
133 rdf:type schema:PropertyValue
134 Na646c4ab9fd94bfbb14e90ce65c0e14d rdf:first sg:person.013321165112.41
135 rdf:rest N0bbdd5025d0447a79ac52e2d085ad727
136 Naadb5301aec64f56b15493125e159987 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Skin Neoplasms
138 rdf:type schema:DefinedTerm
139 Nabaee6ff0a1045a7a926556a79bcec3e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Prospective Studies
141 rdf:type schema:DefinedTerm
142 Nad59676a5c974e20ac0a260b1013ee07 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Humans
144 rdf:type schema:DefinedTerm
145 Nb575b82e3e5b4f5488c2dc6cddccc070 rdf:first sg:person.0640110517.12
146 rdf:rest Na646c4ab9fd94bfbb14e90ce65c0e14d
147 Ncbc9331329e540aca8a72bb4e25c6089 rdf:first sg:person.01363020664.21
148 rdf:rest Nb575b82e3e5b4f5488c2dc6cddccc070
149 Nd5a4f0b288e44ea39153e55341d43cc9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Cytotoxins
151 rdf:type schema:DefinedTerm
152 Ndedbe30786ee4d12bccd81a1f0b0afb8 schema:issueNumber 1
153 rdf:type schema:PublicationIssue
154 Ne4b33768e2d44a2dbbec57ff7f4ef6b4 schema:name doi
155 schema:value 10.1186/s12967-017-1225-5
156 rdf:type schema:PropertyValue
157 Ne73783210c8e472ca464edb0f7f292f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Retrospective Studies
159 rdf:type schema:DefinedTerm
160 Nea9d0d9b93f546b0ae5d573df203c8f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Aged
162 rdf:type schema:DefinedTerm
163 Neee188370db144e6a29c192c832189da schema:volumeNumber 15
164 rdf:type schema:PublicationVolume
165 Nf2937fcfc1ec48d6b8c7e874dca7a967 schema:name nlm_unique_id
166 schema:value 101190741
167 rdf:type schema:PropertyValue
168 Nf9d3f5f5a08447d0a779aab36315d854 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Bleomycin
170 rdf:type schema:DefinedTerm
171 Nfd749c2125d74a7a9b3c77083ac6a98c rdf:first sg:person.07504041705.76
172 rdf:rest N06bb789b0cc84d4e8b8b65f530ab8677
173 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
174 schema:name Medical and Health Sciences
175 rdf:type schema:DefinedTerm
176 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
177 schema:name Clinical Sciences
178 rdf:type schema:DefinedTerm
179 sg:journal.1032886 schema:issn 1479-5876
180 schema:name Journal of Translational Medicine
181 rdf:type schema:Periodical
182 sg:person.01060352341.74 schema:affiliation https://www.grid.ac/institutes/grid.5608.b
183 schema:familyName Campana
184 schema:givenName Luca G.
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060352341.74
186 rdf:type schema:Person
187 sg:person.01126465541.31 schema:affiliation https://www.grid.ac/institutes/grid.412917.8
188 schema:familyName Valpione
189 schema:givenName Sara
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126465541.31
191 rdf:type schema:Person
192 sg:person.013321165112.41 schema:affiliation https://www.grid.ac/institutes/grid.5608.b
193 schema:familyName Rossi
194 schema:givenName Carlo R.
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013321165112.41
196 rdf:type schema:Person
197 sg:person.01363020664.21 schema:affiliation https://www.grid.ac/institutes/grid.419546.b
198 schema:familyName Galuppo
199 schema:givenName Sara
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363020664.21
201 rdf:type schema:Person
202 sg:person.01370531503.96 schema:affiliation https://www.grid.ac/institutes/grid.5608.b
203 schema:familyName Mocellin
204 schema:givenName Simone
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370531503.96
206 rdf:type schema:Person
207 sg:person.0640110517.12 schema:affiliation https://www.grid.ac/institutes/grid.5608.b
208 schema:familyName Alaibac
209 schema:givenName Mauro
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640110517.12
211 rdf:type schema:Person
212 sg:person.07504041705.76 schema:affiliation https://www.grid.ac/institutes/grid.5608.b
213 schema:familyName Marconato
214 schema:givenName Roberto
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07504041705.76
216 rdf:type schema:Person
217 sg:pub.10.1007/s00403-013-1357-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043280530
218 https://doi.org/10.1007/s00403-013-1357-2
219 rdf:type schema:CreativeWork
220 sg:pub.10.1007/s10549-012-2095-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050850695
221 https://doi.org/10.1007/s10549-012-2095-4
222 rdf:type schema:CreativeWork
223 sg:pub.10.1038/sj.bjc.6604168 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029086058
224 https://doi.org/10.1038/sj.bjc.6604168
225 rdf:type schema:CreativeWork
226 https://app.dimensions.ai/details/publication/pub.1077115309 schema:CreativeWork
227 https://app.dimensions.ai/details/publication/pub.1079150222 schema:CreativeWork
228 https://doi.org/10.1001/archderm.144.9.1186 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011244049
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1002/14651858.cd003412.pub2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036986805
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1002/bjs.8749 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000513844
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1002/cncr.11798 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022403174
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/0190-9622(91)70001-i schema:sameAs https://app.dimensions.ai/details/publication/pub.1025653354
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/j.bjoms.2014.08.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048772515
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/j.bjps.2005.02.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002661673
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1016/j.bjps.2013.07.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012891539
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1016/j.ejca.2014.08.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051129271
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1016/j.ejca.2016.05.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040615090
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1016/j.ejcsup.2006.08.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032599334
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/j.ejcsup.2006.08.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022288859
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/j.ejso.2007.05.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049456222
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/j.ejso.2016.06.399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016342062
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/j.jaad.2006.06.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018401838
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/s0190-9622(97)70178-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020838303
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/s1470-2045(08)70260-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022661602
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1016/s1470-2045(15)70198-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004483287
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1046/j.1365-2133.2001.04085.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040884264
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1056/nejmoa1113713 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011121733
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1056/nejmra044151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008061194
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1097/sla.0b013e31824f68b2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013391952
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1111/ced.12016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008870491
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1111/j.1365-2133.2006.07474.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024263342
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1111/j.1365-2133.2008.08666.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037306378
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1111/j.1365-2133.2012.10878.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001413099
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1111/j.1440-0960.2006.00216.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015120456
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1111/j.1524-4725.1989.tb03166.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000191348
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1111/j.1524-4725.1989.tb03249.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018539050
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1111/j.1524-4725.1991.tb03425.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043135980
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1111/j.1524-4725.1992.tb03307.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044003800
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1111/j.1524-4725.1992.tb03508.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036497606
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1200/jco.1990.8.2.342 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078788973
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1200/jco.2004.08.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041607311
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1200/jco.2014.55.4634 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052235891
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1515/raon-2016-0006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019774909
299 rdf:type schema:CreativeWork
300 https://doi.org/10.2340/00015555-1134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070751252
301 rdf:type schema:CreativeWork
302 https://doi.org/10.2340/00015555-1361 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070751470
303 rdf:type schema:CreativeWork
304 https://doi.org/10.2478/raon-2013-0002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024693803
305 rdf:type schema:CreativeWork
306 https://doi.org/10.4103/0378-6323.136989 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046232906
307 rdf:type schema:CreativeWork
308 https://www.grid.ac/institutes/grid.412917.8 schema:alternateName Christie Hospital NHS Foundation Trust
309 schema:name Christie NHS Foundation Trust, M20 4BX, Manchester, UK
310 Department of Surgery, Oncology and Gastroenterology (DISCOG), University of Padova, Padua, Italy
311 rdf:type schema:Organization
312 https://www.grid.ac/institutes/grid.419546.b schema:alternateName Istituto Oncologico Veneto
313 schema:name Radiotherapy Unit, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy
314 rdf:type schema:Organization
315 https://www.grid.ac/institutes/grid.5608.b schema:alternateName University of Padua
316 schema:name Department of Surgery, Oncology and Gastroenterology (DISCOG), University of Padova, Padua, Italy
317 Dermatology Unit, University of Padova, Padua, Italy
318 Surgical Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata, 64, 35128, Padua, Italy
319 University of Padova School of Medicine, Padua, Italy
320 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...