The magnitude of nephron number reduction mediates intrauterine growth-restriction-induced long term chronic renal disease in the rat. A comparative study ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Farid Boubred, Laurent Daniel, Christophe Buffat, Michel Tsimaratos, Charles Oliver, Martine Lelièvre-Pégorier, Umberto Simeoni

ABSTRACT

BACKGROUND: Intrauterine growth restriction (IUGR) is a risk factor for hypertension (HT) and chronic renal disease (CRD). A reduction in the nephron number is proposed to be the underlying mechanism; however, the mechanism is debated. The aim of this study was to demonstrate that IUGR-induced HT and CRD are linked to the magnitude of nephron number reduction, independently on its cause. METHODS: Systolic blood pressure (SBP), glomerular filtration rate (GFR), proteinuria, nephron number, and glomerular sclerosis were compared between IUGR offspring prenatally exposed to a maternal low-protein diet (9% casein; LPD offspring) or maternal administration of betamethasone (from E17 to E19; BET offspring) and offspring with a normal birth weight (NBW offspring). RESULTS: Both prenatal interventions led to IUGR and a similar reduction in birth weight. In comparison to NBW offspring, BET offspring had a severe nephron deficit (-50% in males and -40% in females, p < 0.01), an impaired GFR (-33%, p < 0.05), and HT (SBP+ 17 mmHg, p < 0.05). Glomerular sclerosis was more than twofold higher in BET offspring than in NBW offspring (p < 0.05). Long-term SBP, GFR, and glomerular sclerosis were unchanged in LPD offspring while the nephron number was moderately reduced only in males (-28% vs. NBW offspring, p < 0.05). CONCLUSION: In this study, the magnitude of nephron number reduction influences long term renal disease in IUGR offspring: a moderate nephron number is an insufficient factor. Extremely long-term follow-up of adults prenatally exposed to glucocorticoids are required. More... »

PAGES

331

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12967-016-1086-3

DOI

http://dx.doi.org/10.1186/s12967-016-1086-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006243073

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27899104


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1114", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Paediatrics and Reproductive Medicine", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals, Newborn", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Betamethasone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Birth Weight", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Pressure", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fetal Growth Retardation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney Function Tests", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nephrons", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Sprague-Dawley", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Renal Insufficiency, Chronic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Systole", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "H\u00f4pital de la Conception", 
          "id": "https://www.grid.ac/institutes/grid.411535.7", 
          "name": [
            "NORT, Aix-Marseille Universit\u00e9, INRA, INSERM, 13005, Marseille, France", 
            "Department of Neonatology, H\u00f4pital la Conception, AP-HM, 147 Boulevard Baille, 13385, Marseille Cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boubred", 
        "givenName": "Farid", 
        "id": "sg:person.01261350754.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261350754.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Aix-Marseille University", 
          "id": "https://www.grid.ac/institutes/grid.5399.6", 
          "name": [
            "UPRES EA3281, Aix-Marseille Universit\u00e9, 13005, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Daniel", 
        "givenName": "Laurent", 
        "id": "sg:person.01313332604.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313332604.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Marseille Public University Hospital System", 
          "id": "https://www.grid.ac/institutes/grid.414336.7", 
          "name": [
            "Laboratoire de Biologie m\u00e9dicale, AP-HM, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Buffat", 
        "givenName": "Christophe", 
        "id": "sg:person.0625442376.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625442376.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital de la Timone", 
          "id": "https://www.grid.ac/institutes/grid.411266.6", 
          "name": [
            "P\u00e9diatrie Multidisciplinaire-H\u00f4pital de la Timone, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tsimaratos", 
        "givenName": "Michel", 
        "id": "sg:person.01125060332.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125060332.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Aix-Marseille University", 
          "id": "https://www.grid.ac/institutes/grid.5399.6", 
          "name": [
            "NORT, Aix-Marseille Universit\u00e9, INRA, INSERM, 13005, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oliver", 
        "givenName": "Charles", 
        "id": "sg:person.07672656262.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07672656262.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre de Recherche des Cordeliers", 
          "id": "https://www.grid.ac/institutes/grid.417925.c", 
          "name": [
            "INSERM U652, Institut Biom\u00e9dical des Cordeliers, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leli\u00e8vre-P\u00e9gorier", 
        "givenName": "Martine", 
        "id": "sg:person.0700040327.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700040327.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Orthop\u00e9dique de la Suisse Romande", 
          "id": "https://www.grid.ac/institutes/grid.414250.6", 
          "name": [
            "DOHaD Laboratory, CHUV University Hospital and UNIL, Lausanne, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Simeoni", 
        "givenName": "Umberto", 
        "id": "sg:person.0673555576.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673555576.49"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0140-6736(05)66617-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000393337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(05)66617-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000393337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1677/joe-07-0327", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001742137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpregu.00455.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001989541"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.2003.550004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003354951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1440-1681.2003.03787.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004730025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/adc.2007.128470", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006548458"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.0000049763.51269.51", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007810307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.0000049763.51269.51", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007810307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.298.6673.564", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008085604"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9378(00)70513-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011215493"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajprenal.90704.2008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013168668"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrendo.2014.73", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013520703", 
          "https://doi.org/10.1038/nrendo.2014.73"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.semperi.2010.02.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013744302"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0272-6386(12)80967-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013900390"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpregu.00481.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016352026"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00428-011-1100-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017784310", 
          "https://doi.org/10.1007/s00428-011-1100-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa071453", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018088529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.298.17.2038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022327258"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpregu.00037.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022751964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpregu.00848.2009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023231664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-006-0175-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023489894", 
          "https://doi.org/10.1007/s00125-006-0175-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-006-0175-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023489894", 
          "https://doi.org/10.1007/s00125-006-0175-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-006-0175-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023489894", 
          "https://doi.org/10.1007/s00125-006-0175-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(13)60311-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025953860"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.2009.170407", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026647056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/14651858.cd004454.pub2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029511630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physiolgenomics.00167.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029707952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncpendmet0515", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030987637", 
          "https://doi.org/10.1038/ncpendmet0515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra0708473", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033629081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajprenal.00141.2007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036851474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hypertensionaha.109.136580", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039925773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hypertensionaha.109.136580", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039925773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajog.2008.05.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042237472"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajprenal.00049.2010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042443512"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1681/asn.2005030300", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045871060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1681/asn.2005030300", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045871060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2013/346067", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047346062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpregu.00079.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050748550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajprenal.00156.2007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051325985"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpregu.00741.2007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052180543"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1071-5576(03)00151-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054679140"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/ajh.2010.177", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056440937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajh/1.4.335", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059381524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2007-0765", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064248799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jcem.86.11.8036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064324001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jn/137.4.1066", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077388610"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-12", 
    "datePublishedReg": "2016-12-01", 
    "description": "BACKGROUND: Intrauterine growth restriction (IUGR) is a risk factor for hypertension (HT) and chronic renal disease (CRD). A reduction in the nephron number is proposed to be the underlying mechanism; however, the mechanism is debated. The aim of this study was to demonstrate that IUGR-induced HT and CRD are linked to the magnitude of nephron number reduction, independently on its cause.\nMETHODS: Systolic blood pressure (SBP), glomerular filtration rate (GFR), proteinuria, nephron number, and glomerular sclerosis were compared between IUGR offspring prenatally exposed to a maternal low-protein diet (9% casein; LPD offspring) or maternal administration of betamethasone (from E17 to E19; BET offspring) and offspring with a normal birth weight (NBW offspring).\nRESULTS: Both prenatal interventions led to IUGR and a similar reduction in birth weight. In comparison to NBW offspring, BET offspring had a severe nephron deficit (-50% in males and -40% in females, p\u00a0<\u00a00.01), an impaired GFR (-33%, p\u00a0<\u00a00.05), and HT (SBP+\u00a017\u00a0mmHg, p\u00a0<\u00a00.05). Glomerular sclerosis was more than twofold higher in BET offspring than in NBW offspring (p\u00a0<\u00a00.05). Long-term SBP, GFR, and glomerular sclerosis were unchanged in LPD offspring while the nephron number was moderately reduced only in males (-28% vs. NBW offspring, p\u00a0<\u00a00.05).\nCONCLUSION: In this study, the magnitude of nephron number reduction influences long term renal disease in IUGR offspring: a moderate nephron number is an insufficient factor. Extremely long-term follow-up of adults prenatally exposed to glucocorticoids are required.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12967-016-1086-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1032886", 
        "issn": [
          "1479-5876"
        ], 
        "name": "Journal of Translational Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "14"
      }
    ], 
    "name": "The magnitude of nephron number reduction mediates intrauterine growth-restriction-induced long term chronic renal disease in the rat. A comparative study in two experimental models", 
    "pagination": "331", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "1dbd024d1dd1a51fa014b91221d686e1019445f6aa3630045b2e02dfb448d73b"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27899104"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101190741"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12967-016-1086-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1006243073"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12967-016-1086-3", 
      "https://app.dimensions.ai/details/publication/pub.1006243073"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:42", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000363_0000000363/records_70058_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs12967-016-1086-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12967-016-1086-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12967-016-1086-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12967-016-1086-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12967-016-1086-3'


 

This table displays all metadata directly associated to this object as RDF triples.

310 TRIPLES      21 PREDICATES      84 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12967-016-1086-3 schema:about N06cd9bde9f4142d8975edc92fc6ef7c5
2 N0d78c385035d40eea36ad3ec8aaf36db
3 N5ff9c535e4ef497cb6353ca8dcd64a7d
4 N6c51c3688f6c44de9b4e3a80e432a4b5
5 N8246ff31479745b89c5e79e74cdfb64e
6 N84ac2f29d15647fdb9e256321cb1b030
7 N8a0733c2dd2e478e836e3343849b40ea
8 Nb8596856330b49a49aac4b0fc996345c
9 Ncae20a1ec4d84a99b9f91b64744ad603
10 Nd8069b5ef251436487453f4fe2dc7a73
11 Ndf7f7738d2c04c3890d6fa276b7b8d74
12 Ne3647b16d4ed4f90a9043e197a6ece94
13 Ne91d92cc2a174847855bd33dde39fa5e
14 Nf38768dcd6f24f36a0a8e3af10e176ba
15 anzsrc-for:11
16 anzsrc-for:1114
17 schema:author N894345b81bef4698aeeaff061caafe58
18 schema:citation sg:pub.10.1007/s00125-006-0175-x
19 sg:pub.10.1007/s00428-011-1100-3
20 sg:pub.10.1038/ncpendmet0515
21 sg:pub.10.1038/nrendo.2014.73
22 https://doi.org/10.1001/jama.298.17.2038
23 https://doi.org/10.1002/14651858.cd004454.pub2
24 https://doi.org/10.1016/j.ajog.2008.05.018
25 https://doi.org/10.1016/s0002-9378(00)70513-8
26 https://doi.org/10.1016/s0140-6736(05)66617-2
27 https://doi.org/10.1016/s0140-6736(13)60311-6
28 https://doi.org/10.1016/s0272-6386(12)80967-x
29 https://doi.org/10.1016/s1071-5576(03)00151-5
30 https://doi.org/10.1038/ajh.2010.177
31 https://doi.org/10.1046/j.1440-1681.2003.03787.x
32 https://doi.org/10.1053/j.semperi.2010.02.002
33 https://doi.org/10.1056/nejmoa071453
34 https://doi.org/10.1056/nejmra0708473
35 https://doi.org/10.1093/ajh/1.4.335
36 https://doi.org/10.1093/jn/137.4.1066
37 https://doi.org/10.1113/jphysiol.2003.550004
38 https://doi.org/10.1113/jphysiol.2009.170407
39 https://doi.org/10.1136/adc.2007.128470
40 https://doi.org/10.1136/bmj.298.6673.564
41 https://doi.org/10.1152/ajpregu.00037.2003
42 https://doi.org/10.1152/ajpregu.00079.2006
43 https://doi.org/10.1152/ajpregu.00455.2004
44 https://doi.org/10.1152/ajpregu.00481.2006
45 https://doi.org/10.1152/ajpregu.00741.2007
46 https://doi.org/10.1152/ajpregu.00848.2009
47 https://doi.org/10.1152/ajprenal.00049.2010
48 https://doi.org/10.1152/ajprenal.00141.2007
49 https://doi.org/10.1152/ajprenal.00156.2007
50 https://doi.org/10.1152/ajprenal.90704.2008
51 https://doi.org/10.1152/physiolgenomics.00167.2004
52 https://doi.org/10.1155/2013/346067
53 https://doi.org/10.1161/01.hyp.0000049763.51269.51
54 https://doi.org/10.1161/hypertensionaha.109.136580
55 https://doi.org/10.1210/en.2007-0765
56 https://doi.org/10.1210/jcem.86.11.8036
57 https://doi.org/10.1677/joe-07-0327
58 https://doi.org/10.1681/asn.2005030300
59 schema:datePublished 2016-12
60 schema:datePublishedReg 2016-12-01
61 schema:description BACKGROUND: Intrauterine growth restriction (IUGR) is a risk factor for hypertension (HT) and chronic renal disease (CRD). A reduction in the nephron number is proposed to be the underlying mechanism; however, the mechanism is debated. The aim of this study was to demonstrate that IUGR-induced HT and CRD are linked to the magnitude of nephron number reduction, independently on its cause. METHODS: Systolic blood pressure (SBP), glomerular filtration rate (GFR), proteinuria, nephron number, and glomerular sclerosis were compared between IUGR offspring prenatally exposed to a maternal low-protein diet (9% casein; LPD offspring) or maternal administration of betamethasone (from E17 to E19; BET offspring) and offspring with a normal birth weight (NBW offspring). RESULTS: Both prenatal interventions led to IUGR and a similar reduction in birth weight. In comparison to NBW offspring, BET offspring had a severe nephron deficit (-50% in males and -40% in females, p < 0.01), an impaired GFR (-33%, p < 0.05), and HT (SBP+ 17 mmHg, p < 0.05). Glomerular sclerosis was more than twofold higher in BET offspring than in NBW offspring (p < 0.05). Long-term SBP, GFR, and glomerular sclerosis were unchanged in LPD offspring while the nephron number was moderately reduced only in males (-28% vs. NBW offspring, p < 0.05). CONCLUSION: In this study, the magnitude of nephron number reduction influences long term renal disease in IUGR offspring: a moderate nephron number is an insufficient factor. Extremely long-term follow-up of adults prenatally exposed to glucocorticoids are required.
62 schema:genre research_article
63 schema:inLanguage en
64 schema:isAccessibleForFree true
65 schema:isPartOf N671c3af8f535486dbe580aa4258fb11f
66 Nbeec4b509d624819b2f68f54b5a36ed2
67 sg:journal.1032886
68 schema:name The magnitude of nephron number reduction mediates intrauterine growth-restriction-induced long term chronic renal disease in the rat. A comparative study in two experimental models
69 schema:pagination 331
70 schema:productId N3f7b706539e14b0aa617b941dc4fc7c7
71 N4b5a5f85db01495c9c75a487cdcd443c
72 N77636033416c4c2594e116065cb00053
73 Nb1ac817030b04805ac70735a8989a1ae
74 Nd74d43cd0c374b2ca1fda73bf44afd83
75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006243073
76 https://doi.org/10.1186/s12967-016-1086-3
77 schema:sdDatePublished 2019-04-11T12:42
78 schema:sdLicense https://scigraph.springernature.com/explorer/license/
79 schema:sdPublisher N17314feb6096471198bb0c0fd5128fbb
80 schema:url https://link.springer.com/10.1186%2Fs12967-016-1086-3
81 sgo:license sg:explorer/license/
82 sgo:sdDataset articles
83 rdf:type schema:ScholarlyArticle
84 N06cd9bde9f4142d8975edc92fc6ef7c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Kidney
86 rdf:type schema:DefinedTerm
87 N0d78c385035d40eea36ad3ec8aaf36db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Fetal Growth Retardation
89 rdf:type schema:DefinedTerm
90 N17314feb6096471198bb0c0fd5128fbb schema:name Springer Nature - SN SciGraph project
91 rdf:type schema:Organization
92 N3f7b706539e14b0aa617b941dc4fc7c7 schema:name doi
93 schema:value 10.1186/s12967-016-1086-3
94 rdf:type schema:PropertyValue
95 N4879efcbc229434cba771a77bad4c3a4 rdf:first sg:person.0625442376.48
96 rdf:rest Nc97d97a0f2294a8dbc7b0d449408746a
97 N4b5a5f85db01495c9c75a487cdcd443c schema:name pubmed_id
98 schema:value 27899104
99 rdf:type schema:PropertyValue
100 N5ff9c535e4ef497cb6353ca8dcd64a7d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Animals, Newborn
102 rdf:type schema:DefinedTerm
103 N671c3af8f535486dbe580aa4258fb11f schema:issueNumber 1
104 rdf:type schema:PublicationIssue
105 N6c51c3688f6c44de9b4e3a80e432a4b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Systole
107 rdf:type schema:DefinedTerm
108 N762da4da3f7a4f9cb514dfdda9e65c52 rdf:first sg:person.0673555576.49
109 rdf:rest rdf:nil
110 N77636033416c4c2594e116065cb00053 schema:name readcube_id
111 schema:value 1dbd024d1dd1a51fa014b91221d686e1019445f6aa3630045b2e02dfb448d73b
112 rdf:type schema:PropertyValue
113 N8246ff31479745b89c5e79e74cdfb64e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Male
115 rdf:type schema:DefinedTerm
116 N84ac2f29d15647fdb9e256321cb1b030 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Renal Insufficiency, Chronic
118 rdf:type schema:DefinedTerm
119 N894345b81bef4698aeeaff061caafe58 rdf:first sg:person.01261350754.95
120 rdf:rest Nf19db3b4233d41a19b85d4ff8b5c8802
121 N8a0733c2dd2e478e836e3343849b40ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Rats, Sprague-Dawley
123 rdf:type schema:DefinedTerm
124 N9cd98c128be8422ea35203543787455a rdf:first sg:person.0700040327.97
125 rdf:rest N762da4da3f7a4f9cb514dfdda9e65c52
126 Nb1ac817030b04805ac70735a8989a1ae schema:name dimensions_id
127 schema:value pub.1006243073
128 rdf:type schema:PropertyValue
129 Nb8596856330b49a49aac4b0fc996345c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Nephrons
131 rdf:type schema:DefinedTerm
132 Nbeec4b509d624819b2f68f54b5a36ed2 schema:volumeNumber 14
133 rdf:type schema:PublicationVolume
134 Nc97d97a0f2294a8dbc7b0d449408746a rdf:first sg:person.01125060332.86
135 rdf:rest Ne4e78187b5384b58bfe2060d328a9cb0
136 Ncae20a1ec4d84a99b9f91b64744ad603 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Betamethasone
138 rdf:type schema:DefinedTerm
139 Nd74d43cd0c374b2ca1fda73bf44afd83 schema:name nlm_unique_id
140 schema:value 101190741
141 rdf:type schema:PropertyValue
142 Nd8069b5ef251436487453f4fe2dc7a73 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Animals
144 rdf:type schema:DefinedTerm
145 Ndf7f7738d2c04c3890d6fa276b7b8d74 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Blood Pressure
147 rdf:type schema:DefinedTerm
148 Ne3647b16d4ed4f90a9043e197a6ece94 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Female
150 rdf:type schema:DefinedTerm
151 Ne4e78187b5384b58bfe2060d328a9cb0 rdf:first sg:person.07672656262.16
152 rdf:rest N9cd98c128be8422ea35203543787455a
153 Ne91d92cc2a174847855bd33dde39fa5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Birth Weight
155 rdf:type schema:DefinedTerm
156 Nf19db3b4233d41a19b85d4ff8b5c8802 rdf:first sg:person.01313332604.26
157 rdf:rest N4879efcbc229434cba771a77bad4c3a4
158 Nf38768dcd6f24f36a0a8e3af10e176ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Kidney Function Tests
160 rdf:type schema:DefinedTerm
161 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
162 schema:name Medical and Health Sciences
163 rdf:type schema:DefinedTerm
164 anzsrc-for:1114 schema:inDefinedTermSet anzsrc-for:
165 schema:name Paediatrics and Reproductive Medicine
166 rdf:type schema:DefinedTerm
167 sg:journal.1032886 schema:issn 1479-5876
168 schema:name Journal of Translational Medicine
169 rdf:type schema:Periodical
170 sg:person.01125060332.86 schema:affiliation https://www.grid.ac/institutes/grid.411266.6
171 schema:familyName Tsimaratos
172 schema:givenName Michel
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125060332.86
174 rdf:type schema:Person
175 sg:person.01261350754.95 schema:affiliation https://www.grid.ac/institutes/grid.411535.7
176 schema:familyName Boubred
177 schema:givenName Farid
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261350754.95
179 rdf:type schema:Person
180 sg:person.01313332604.26 schema:affiliation https://www.grid.ac/institutes/grid.5399.6
181 schema:familyName Daniel
182 schema:givenName Laurent
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313332604.26
184 rdf:type schema:Person
185 sg:person.0625442376.48 schema:affiliation https://www.grid.ac/institutes/grid.414336.7
186 schema:familyName Buffat
187 schema:givenName Christophe
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625442376.48
189 rdf:type schema:Person
190 sg:person.0673555576.49 schema:affiliation https://www.grid.ac/institutes/grid.414250.6
191 schema:familyName Simeoni
192 schema:givenName Umberto
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673555576.49
194 rdf:type schema:Person
195 sg:person.0700040327.97 schema:affiliation https://www.grid.ac/institutes/grid.417925.c
196 schema:familyName Lelièvre-Pégorier
197 schema:givenName Martine
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700040327.97
199 rdf:type schema:Person
200 sg:person.07672656262.16 schema:affiliation https://www.grid.ac/institutes/grid.5399.6
201 schema:familyName Oliver
202 schema:givenName Charles
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07672656262.16
204 rdf:type schema:Person
205 sg:pub.10.1007/s00125-006-0175-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023489894
206 https://doi.org/10.1007/s00125-006-0175-x
207 rdf:type schema:CreativeWork
208 sg:pub.10.1007/s00428-011-1100-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017784310
209 https://doi.org/10.1007/s00428-011-1100-3
210 rdf:type schema:CreativeWork
211 sg:pub.10.1038/ncpendmet0515 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030987637
212 https://doi.org/10.1038/ncpendmet0515
213 rdf:type schema:CreativeWork
214 sg:pub.10.1038/nrendo.2014.73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013520703
215 https://doi.org/10.1038/nrendo.2014.73
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1001/jama.298.17.2038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022327258
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1002/14651858.cd004454.pub2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029511630
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/j.ajog.2008.05.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042237472
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/s0002-9378(00)70513-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011215493
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/s0140-6736(05)66617-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000393337
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/s0140-6736(13)60311-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025953860
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/s0272-6386(12)80967-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013900390
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/s1071-5576(03)00151-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054679140
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1038/ajh.2010.177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056440937
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1046/j.1440-1681.2003.03787.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004730025
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1053/j.semperi.2010.02.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013744302
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1056/nejmoa071453 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018088529
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1056/nejmra0708473 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033629081
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1093/ajh/1.4.335 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059381524
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1093/jn/137.4.1066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077388610
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1113/jphysiol.2003.550004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003354951
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1113/jphysiol.2009.170407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026647056
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1136/adc.2007.128470 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006548458
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1136/bmj.298.6673.564 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008085604
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1152/ajpregu.00037.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022751964
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1152/ajpregu.00079.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050748550
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1152/ajpregu.00455.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001989541
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1152/ajpregu.00481.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016352026
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1152/ajpregu.00741.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052180543
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1152/ajpregu.00848.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023231664
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1152/ajprenal.00049.2010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042443512
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1152/ajprenal.00141.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036851474
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1152/ajprenal.00156.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051325985
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1152/ajprenal.90704.2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013168668
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1152/physiolgenomics.00167.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029707952
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1155/2013/346067 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047346062
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1161/01.hyp.0000049763.51269.51 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007810307
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1161/hypertensionaha.109.136580 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039925773
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1210/en.2007-0765 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064248799
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1210/jcem.86.11.8036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064324001
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1677/joe-07-0327 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001742137
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1681/asn.2005030300 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045871060
290 rdf:type schema:CreativeWork
291 https://www.grid.ac/institutes/grid.411266.6 schema:alternateName Hôpital de la Timone
292 schema:name Pédiatrie Multidisciplinaire-Hôpital de la Timone, Marseille, France
293 rdf:type schema:Organization
294 https://www.grid.ac/institutes/grid.411535.7 schema:alternateName Hôpital de la Conception
295 schema:name Department of Neonatology, Hôpital la Conception, AP-HM, 147 Boulevard Baille, 13385, Marseille Cedex, France
296 NORT, Aix-Marseille Université, INRA, INSERM, 13005, Marseille, France
297 rdf:type schema:Organization
298 https://www.grid.ac/institutes/grid.414250.6 schema:alternateName Hôpital Orthopédique de la Suisse Romande
299 schema:name DOHaD Laboratory, CHUV University Hospital and UNIL, Lausanne, Switzerland
300 rdf:type schema:Organization
301 https://www.grid.ac/institutes/grid.414336.7 schema:alternateName Marseille Public University Hospital System
302 schema:name Laboratoire de Biologie médicale, AP-HM, Marseille, France
303 rdf:type schema:Organization
304 https://www.grid.ac/institutes/grid.417925.c schema:alternateName Centre de Recherche des Cordeliers
305 schema:name INSERM U652, Institut Biomédical des Cordeliers, Paris, France
306 rdf:type schema:Organization
307 https://www.grid.ac/institutes/grid.5399.6 schema:alternateName Aix-Marseille University
308 schema:name NORT, Aix-Marseille Université, INRA, INSERM, 13005, Marseille, France
309 UPRES EA3281, Aix-Marseille Université, 13005, Marseille, France
310 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...