Amelioration of autoimmune arthritis by adoptive transfer of Foxp3-expressing regulatory B cells is associated with the Treg/Th17 cell balance View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Mi Kyung Park, Young Ok Jung, Seon-Yeong Lee, Seung Hoon Lee, Yu Jung Heo, Eun Kyung Kim, Hye Jwa Oh, Young Mee Moon, Hye-Jin Son, Min Jung Park, Sung Hwan Park, Ho Youn Kim, Mi La Cho, Jun Ki Min

ABSTRACT

BACKGROUND: Foxp3 is a key regulator of the development and function of regulatory T cells (Tregs), and its expression is thought to be T cell-restricted. We found that B cells in mice can express Foxp3 and B cells expressing Foxp3 may play a role in preventing the development of collagen-induced arthritis (CIA) in DBA/1J mice. METHODS: Foxp3 expression was modulated in CD19(+) B cells by transfection with shRNA or using an over-expression construct. In addition, Foxp3-transfected B cells were adoptively transferred to CIA mice. We found that LPS or anti-IgM stimulation induced Foxp3 expression in B cells. Foxp3-expressing B cells were found in the spleens of mice. RESULTS: Over-expression of Foxp3 conferred a contact-dependent suppressive ability on proliferation of responder T cells. Down-regulation of Foxp3 by shRNA caused a profound induction in proliferation of responder T cells. Adoptive transfer of Foxp3(+)CD19(+) B cells attenuated the clinical symptoms of CIA significantly with concomitant suppression of IL-17 production and enhancement of Foxp3 expression in CD4(+) T cells from splenocytes. CONCLUSION: Our data indicate that Foxp3 expression is not restricted to T cells. The expression of Foxp3 in B cells is critical for the immunoregulation of T cells and limits autoimmunity in a mouse model. More... »

PAGES

191

References to SciGraph publications

  • 2001-01. X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy in NATURE GENETICS
  • 2001-04. Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide in NATURE IMMUNOLOGY
  • 2001-01. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3 in NATURE GENETICS
  • 2000-12. Reciprocal regulation of polarized cytokine production by effector B and T cells in NATURE IMMUNOLOGY
  • 2008-05. Not always the bad guys: B cells as regulators of autoimmune pathology in NATURE REVIEWS IMMUNOLOGY
  • 2009-05. A novel regulatory B-cell population in sheep Peyer's patches spontaneously secretes IL-10 and downregulates TLR9-induced IFNα responses in MUCOSAL IMMUNOLOGY
  • 2003-04. An essential role for Scurfin in CD4+CD25+ T regulatory cells in NATURE IMMUNOLOGY
  • 2014-02. Reduced numbers of regulatory B cells are negatively correlated with disease activity in patients with new-onset rheumatoid arthritis in CLINICAL RHEUMATOLOGY
  • 2003-04. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells in NATURE IMMUNOLOGY
  • 2002-06. CD4+CD25+ suppressor T cells: more questions than answers in NATURE REVIEWS IMMUNOLOGY
  • 2001-01. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse in NATURE GENETICS
  • 2005-09. Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis in NATURE MEDICINE
  • 2002-10. B cells regulate autoimmunity by provision of IL-10 in NATURE IMMUNOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12967-016-0940-7

    DOI

    http://dx.doi.org/10.1186/s12967-016-0940-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1039829232

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27350539


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