Let-7a inhibits migration, invasion and epithelial-mesenchymal transition by targeting HMGA2 in nasopharyngeal carcinoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Aibing Wu, Kunpeng Wu, Jinmei Li, Yanli Mo, Yanming Lin, Yuzhou Wang, Xiang Shen, Shujun Li, Lixia Li, Zhixiong Yang

ABSTRACT

BACKGROUND: Let-7a has been shown to play important roles in nasopharyngeal carcinoma (NPC) cell proliferation and apoptosis, but little is known about the function and mechanism of let-7a in nasopharyngeal carcinoma metastasis. We aimed to investigate the function and mechanism of let-7a in nasopharyngeal carcinoma metastasis and clarified the regulation of high mobility group A2 (HMGA2) by let-7a. METHODS: The expression levels of let-7a and HMGA2 were examined in NPC clinical specimens using quantitative reverse transcription-PCR (RT-qPCR). HMGA2 was confirmed as a target of let-7a through luciferase reporter assays, RT-qPCR, and Western blotting. Furthermore, the roles of let-7a and HMGA2 in regulating NPC cells biological properties including proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) process were analyzed with let-7a mimics and si-HMGA2 transfected cells. RESULTS: Our study demonstrated that let-7a was downregulated and inversely associated with the clinical stage, T classification and N classification, and HMGA2 was upregulated and directly associated with the clinical stage and N classification in patients with NPC. Moreover, there was an inverse correlation between let-7a expression and HMGA2 expression in NPC patient. In addition, HMGA2 was negatively regulated at the posttranscriptional level by let-7a via a binding site of HMGA2-3'UTR. In addition, synthetic let-7a mimics suppressed NPC cells migration, invasion and EMT process and knockdown of HMGA2 was consistent with the effects of let-7a in NPC cells. CONCLUSION: Let-7a directly downregulates HMGA2 protein expression, which suppress NPC cell migration, invasion and EMT process. Let-7a could serve as a potential diagnostic marker and therapeutic target for NPC. More... »

PAGES

105

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12967-015-0462-8

DOI

http://dx.doi.org/10.1186/s12967-015-0462-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026693276

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25884389


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "3' Untranslated Regions", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Movement", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Down-Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epithelial-Mesenchymal Transition", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Feedback, Physiological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Knockdown Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HMGA2 Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "MicroRNAs", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nasopharyngeal Carcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nasopharyngeal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Invasiveness", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Binding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Up-Regulation", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Affiliated Hospital of Guangdong Medical College Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413372.0", 
          "name": [
            "Oncology Center, Affiliated Hospital of Guangdong Medical College, No.57 Peoples Avenue South, 524002, Zhanjiang, Guangdong, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wu", 
        "givenName": "Aibing", 
        "id": "sg:person.0654374541.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654374541.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Affiliated Hospital of Guangdong Medical College Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413372.0", 
          "name": [
            "Oncology Center, Affiliated Hospital of Guangdong Medical College, No.57 Peoples Avenue South, 524002, Zhanjiang, Guangdong, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wu", 
        "givenName": "Kunpeng", 
        "id": "sg:person.0722507741.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722507741.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Affiliated Hospital of Guangdong Medical College Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413372.0", 
          "name": [
            "Oncology Center, Affiliated Hospital of Guangdong Medical College, No.57 Peoples Avenue South, 524002, Zhanjiang, Guangdong, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Jinmei", 
        "id": "sg:person.01221300141.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221300141.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Affiliated Hospital of Guangdong Medical College Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413372.0", 
          "name": [
            "Oncology Center, Affiliated Hospital of Guangdong Medical College, No.57 Peoples Avenue South, 524002, Zhanjiang, Guangdong, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mo", 
        "givenName": "Yanli", 
        "id": "sg:person.0706566365.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706566365.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Affiliated Hospital of Guangdong Medical College Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413372.0", 
          "name": [
            "Oncology Center, Affiliated Hospital of Guangdong Medical College, No.57 Peoples Avenue South, 524002, Zhanjiang, Guangdong, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lin", 
        "givenName": "Yanming", 
        "id": "sg:person.01226754400.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226754400.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Affiliated Hospital of Guangdong Medical College Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413372.0", 
          "name": [
            "Oncology Center, Affiliated Hospital of Guangdong Medical College, No.57 Peoples Avenue South, 524002, Zhanjiang, Guangdong, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Yuzhou", 
        "id": "sg:person.01046003552.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046003552.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Affiliated Hospital of Guangdong Medical College Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413372.0", 
          "name": [
            "Oncology Center, Affiliated Hospital of Guangdong Medical College, No.57 Peoples Avenue South, 524002, Zhanjiang, Guangdong, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shen", 
        "givenName": "Xiang", 
        "id": "sg:person.01105051541.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105051541.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Affiliated Hospital of Guangdong Medical College Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413372.0", 
          "name": [
            "Oncology Center, Affiliated Hospital of Guangdong Medical College, No.57 Peoples Avenue South, 524002, Zhanjiang, Guangdong, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Shujun", 
        "id": "sg:person.01137243365.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137243365.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Affiliated Hospital of Guangdong Medical College Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413372.0", 
          "name": [
            "Oncology Center, Affiliated Hospital of Guangdong Medical College, No.57 Peoples Avenue South, 524002, Zhanjiang, Guangdong, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Lixia", 
        "id": "sg:person.01167375517.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167375517.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Affiliated Hospital of Guangdong Medical College Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413372.0", 
          "name": [
            "Oncology Center, Affiliated Hospital of Guangdong Medical College, No.57 Peoples Avenue South, 524002, Zhanjiang, Guangdong, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Zhixiong", 
        "id": "sg:person.01267413341.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267413341.92"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1158/0008-5472.can-06-0479", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000561623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2271", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001411797", 
          "https://doi.org/10.1038/nrc2271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg1379", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001799892", 
          "https://doi.org/10.1038/nrg1379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg1379", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001799892", 
          "https://doi.org/10.1038/nrg1379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1540407", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002090828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(05)66698-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003322195"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(05)66698-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003322195"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/his.12176", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003910472"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/his.12401", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006662352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/his.12401", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006662352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-10-2388", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007738821"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3322/caac.20107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009055747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ydbio.2006.08.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009298891"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.26311", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010428350"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200512110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010456121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6604948", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018517435", 
          "https://doi.org/10.1038/sj.bjc.6604948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/moo.0b013e32835e1d6e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018671460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/moo.0b013e32835e1d6e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018671460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.2138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023764750"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-10-2132", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024212626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2407-14-274", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025456783", 
          "https://doi.org/10.1186/1471-2407-14-274"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2407-14-274", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025456783", 
          "https://doi.org/10.1186/1471-2407-14-274"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-12-3848", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025642336"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci39104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026879393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci39104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026879393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2012.573", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030198930", 
          "https://doi.org/10.1038/onc.2012.573"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1840", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030226923", 
          "https://doi.org/10.1038/nrc1840"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1840", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030226923", 
          "https://doi.org/10.1038/nrc1840"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00432-010-0898-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031178398", 
          "https://doi.org/10.1007/s00432-010-0898-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00432-010-0898-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031178398", 
          "https://doi.org/10.1007/s00432-010-0898-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(04)00045-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031254572"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tcb.2006.12.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032185534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m802016200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035802234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-11-1322", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036895247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.febslet.2004.08.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039282750"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2008.202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039969896", 
          "https://doi.org/10.1038/modpathol.2008.202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2011.629", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040172028", 
          "https://doi.org/10.1038/onc.2011.629"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2011.629", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040172028", 
          "https://doi.org/10.1038/onc.2011.629"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/emboj.2008.294", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042185525"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(03)00428-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042988434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02871", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043341870", 
          "https://doi.org/10.1038/nature02871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02871", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043341870", 
          "https://doi.org/10.1038/nature02871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.humpath.2009.08.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045242059"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-09-1298", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046367769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2011.131", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047174148", 
          "https://doi.org/10.1038/onc.2011.131"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11010-011-0862-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050099380", 
          "https://doi.org/10.1007/s11010-011-0862-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molmed.2008.07.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051149608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-10-1850", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052371669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(12)70102-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052497203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(12)70102-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052497203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/cbr.2012.1307", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059243300"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1111444", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062452139"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1137999", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062455163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci20530", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063416449"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/or.2011.1360", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071531473"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/or.2012.1709", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071531766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/or.2012.2027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071532057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/or.2012.2027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071532057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078312833", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-12", 
    "datePublishedReg": "2015-12-01", 
    "description": "BACKGROUND: Let-7a has been shown to play important roles in nasopharyngeal carcinoma (NPC) cell proliferation and apoptosis, but little is known about the function and mechanism of let-7a in nasopharyngeal carcinoma metastasis. We aimed to investigate the function and mechanism of let-7a in nasopharyngeal carcinoma metastasis and clarified the regulation of high mobility group A2 (HMGA2) by let-7a.\nMETHODS: The expression levels of let-7a and HMGA2 were examined in NPC clinical specimens using quantitative reverse transcription-PCR (RT-qPCR). HMGA2 was confirmed as a target of let-7a through luciferase reporter assays, RT-qPCR, and Western blotting. Furthermore, the roles of let-7a and HMGA2 in regulating NPC cells biological properties including proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) process were analyzed with let-7a mimics and si-HMGA2 transfected cells.\nRESULTS: Our study demonstrated that let-7a was downregulated and inversely associated with the clinical stage, T classification and N classification, and HMGA2 was upregulated and directly associated with the clinical stage and N classification in patients with NPC. Moreover, there was an inverse correlation between let-7a expression and HMGA2 expression in NPC patient. In addition, HMGA2 was negatively regulated at the posttranscriptional level by let-7a via a binding site of HMGA2-3'UTR. In addition, synthetic let-7a mimics suppressed NPC cells migration, invasion and EMT process and knockdown of HMGA2 was consistent with the effects of let-7a in NPC cells.\nCONCLUSION: Let-7a directly downregulates HMGA2 protein expression, which suppress NPC cell migration, invasion and EMT process. Let-7a could serve as a potential diagnostic marker and therapeutic target for NPC.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12967-015-0462-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6997457", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1032886", 
        "issn": [
          "1479-5876"
        ], 
        "name": "Journal of Translational Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "13"
      }
    ], 
    "name": "Let-7a inhibits migration, invasion and epithelial-mesenchymal transition by targeting HMGA2 in nasopharyngeal carcinoma", 
    "pagination": "105", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "7f2a3a7112c9d9788fe56834e92c3422c1e1a378fa5bd1c40bef231970ce4f53"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25884389"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101190741"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12967-015-0462-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1026693276"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12967-015-0462-8", 
      "https://app.dimensions.ai/details/publication/pub.1026693276"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:11", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000367_0000000367/records_88255_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2Fs12967-015-0462-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12967-015-0462-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12967-015-0462-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12967-015-0462-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12967-015-0462-8'


 

This table displays all metadata directly associated to this object as RDF triples.

381 TRIPLES      21 PREDICATES      100 URIs      45 LITERALS      33 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12967-015-0462-8 schema:about N0c1378286198416bae7b70865e1de007
2 N0d324929162e4603832d8a8a65bdf7f5
3 N15821c72355b469c91f0c790592e9715
4 N266fea81520f41d6a671db15c27f23ac
5 N2de68d1fbc784b2a8e4ae5faa3e645a2
6 N33710936fe334099916ea384593e8590
7 N38408e6c75b942b3b718842d4eccca7a
8 N3b45706cbf4c416c98f5025cf6e1bb0b
9 N43c232e594314c5b8ca0c7aeab5dd69d
10 N50133a012422413e8f98fa16cb11bdd0
11 N60c1f02781cc4eb08d773d366772748e
12 N711aea1fd12e456cb3d8b90229175734
13 N76fb34ac373843a58f420f8f32b2a14a
14 Na2665491c3d24801a23d01012f5981fd
15 Na2eabc0c28eb411b9accf1785218957c
16 Naadabff6fc95461bb50a198a0c7fed60
17 Nb0ddecd0ac5443eba2f2ecb59e449aa0
18 Nb2675e49d0da466d85e96bcbb59a24a8
19 Nba7046d5ad18456a89222cba6b5adecb
20 Nc723a7a4ffff44c6b971a66ea8ae3587
21 Nde0a111fb42645ce9c202ec8e25c0be0
22 Ndea3fd42fc974f3aa735fb63ff6dd561
23 Nf19450370aa942a6b697cfe9aa6bd951
24 Nf4aaabe4139044d08e0ec41732434b3d
25 anzsrc-for:11
26 anzsrc-for:1103
27 schema:author Nee86438d1e2148e6ad381a492ac28e8d
28 schema:citation sg:pub.10.1007/s00432-010-0898-4
29 sg:pub.10.1007/s11010-011-0862-x
30 sg:pub.10.1038/modpathol.2008.202
31 sg:pub.10.1038/nature02871
32 sg:pub.10.1038/nrc1840
33 sg:pub.10.1038/nrc2271
34 sg:pub.10.1038/nrg1379
35 sg:pub.10.1038/onc.2011.131
36 sg:pub.10.1038/onc.2011.629
37 sg:pub.10.1038/onc.2012.573
38 sg:pub.10.1038/sj.bjc.6604948
39 sg:pub.10.1186/1471-2407-14-274
40 https://app.dimensions.ai/details/publication/pub.1078312833
41 https://doi.org/10.1002/ijc.26311
42 https://doi.org/10.1002/path.2138
43 https://doi.org/10.1016/j.febslet.2004.08.013
44 https://doi.org/10.1016/j.humpath.2009.08.022
45 https://doi.org/10.1016/j.molmed.2008.07.001
46 https://doi.org/10.1016/j.tcb.2006.12.001
47 https://doi.org/10.1016/j.ydbio.2006.08.028
48 https://doi.org/10.1016/s0092-8674(03)00428-8
49 https://doi.org/10.1016/s0092-8674(04)00045-5
50 https://doi.org/10.1016/s0140-6736(05)66698-6
51 https://doi.org/10.1016/s1470-2045(12)70102-x
52 https://doi.org/10.1038/emboj.2008.294
53 https://doi.org/10.1074/jbc.m802016200
54 https://doi.org/10.1083/jcb.200512110
55 https://doi.org/10.1089/cbr.2012.1307
56 https://doi.org/10.1097/moo.0b013e32835e1d6e
57 https://doi.org/10.1101/gad.1540407
58 https://doi.org/10.1111/his.12176
59 https://doi.org/10.1111/his.12401
60 https://doi.org/10.1126/science.1111444
61 https://doi.org/10.1126/science.1137999
62 https://doi.org/10.1158/0008-5472.can-06-0479
63 https://doi.org/10.1158/0008-5472.can-09-1298
64 https://doi.org/10.1158/0008-5472.can-10-1850
65 https://doi.org/10.1158/0008-5472.can-10-2388
66 https://doi.org/10.1158/0008-5472.can-11-1322
67 https://doi.org/10.1158/0008-5472.can-12-3848
68 https://doi.org/10.1158/1078-0432.ccr-10-2132
69 https://doi.org/10.1172/jci20530
70 https://doi.org/10.1172/jci39104
71 https://doi.org/10.3322/caac.20107
72 https://doi.org/10.3892/or.2011.1360
73 https://doi.org/10.3892/or.2012.1709
74 https://doi.org/10.3892/or.2012.2027
75 schema:datePublished 2015-12
76 schema:datePublishedReg 2015-12-01
77 schema:description BACKGROUND: Let-7a has been shown to play important roles in nasopharyngeal carcinoma (NPC) cell proliferation and apoptosis, but little is known about the function and mechanism of let-7a in nasopharyngeal carcinoma metastasis. We aimed to investigate the function and mechanism of let-7a in nasopharyngeal carcinoma metastasis and clarified the regulation of high mobility group A2 (HMGA2) by let-7a. METHODS: The expression levels of let-7a and HMGA2 were examined in NPC clinical specimens using quantitative reverse transcription-PCR (RT-qPCR). HMGA2 was confirmed as a target of let-7a through luciferase reporter assays, RT-qPCR, and Western blotting. Furthermore, the roles of let-7a and HMGA2 in regulating NPC cells biological properties including proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) process were analyzed with let-7a mimics and si-HMGA2 transfected cells. RESULTS: Our study demonstrated that let-7a was downregulated and inversely associated with the clinical stage, T classification and N classification, and HMGA2 was upregulated and directly associated with the clinical stage and N classification in patients with NPC. Moreover, there was an inverse correlation between let-7a expression and HMGA2 expression in NPC patient. In addition, HMGA2 was negatively regulated at the posttranscriptional level by let-7a via a binding site of HMGA2-3'UTR. In addition, synthetic let-7a mimics suppressed NPC cells migration, invasion and EMT process and knockdown of HMGA2 was consistent with the effects of let-7a in NPC cells. CONCLUSION: Let-7a directly downregulates HMGA2 protein expression, which suppress NPC cell migration, invasion and EMT process. Let-7a could serve as a potential diagnostic marker and therapeutic target for NPC.
78 schema:genre research_article
79 schema:inLanguage en
80 schema:isAccessibleForFree true
81 schema:isPartOf N85cfeb59f3ee4e72bbd4c43cadc1cdac
82 Ne5bf4e161f554269a1be64ad10ace7dd
83 sg:journal.1032886
84 schema:name Let-7a inhibits migration, invasion and epithelial-mesenchymal transition by targeting HMGA2 in nasopharyngeal carcinoma
85 schema:pagination 105
86 schema:productId N6cf8a16c2b684b87b9ef718d5f7dd617
87 N9d41e181d11d4afc801f060ac79ab8a9
88 N9f37dad1477c423d9696ba071988bfe2
89 Nbf2ad0d4f2834a7487af6190142d7b98
90 Nc6710a2ffe9f48748fa8f3df53640f11
91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026693276
92 https://doi.org/10.1186/s12967-015-0462-8
93 schema:sdDatePublished 2019-04-11T13:11
94 schema:sdLicense https://scigraph.springernature.com/explorer/license/
95 schema:sdPublisher Nb47bc9a1f37d4ae795b4d71750130024
96 schema:url http://link.springer.com/10.1186%2Fs12967-015-0462-8
97 sgo:license sg:explorer/license/
98 sgo:sdDataset articles
99 rdf:type schema:ScholarlyArticle
100 N0c1378286198416bae7b70865e1de007 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Down-Regulation
102 rdf:type schema:DefinedTerm
103 N0d324929162e4603832d8a8a65bdf7f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Up-Regulation
105 rdf:type schema:DefinedTerm
106 N15821c72355b469c91f0c790592e9715 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Nasopharyngeal Neoplasms
108 rdf:type schema:DefinedTerm
109 N266fea81520f41d6a671db15c27f23ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Molecular Sequence Data
111 rdf:type schema:DefinedTerm
112 N2c0805fdb5b94e0694cada822d20872b rdf:first sg:person.0722507741.33
113 rdf:rest Nf703a194bbee4128bdfe4a2df8cba58f
114 N2de68d1fbc784b2a8e4ae5faa3e645a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name HMGA2 Protein
116 rdf:type schema:DefinedTerm
117 N33710936fe334099916ea384593e8590 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name MicroRNAs
119 rdf:type schema:DefinedTerm
120 N38408e6c75b942b3b718842d4eccca7a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Female
122 rdf:type schema:DefinedTerm
123 N3b45706cbf4c416c98f5025cf6e1bb0b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Gene Knockdown Techniques
125 rdf:type schema:DefinedTerm
126 N43c232e594314c5b8ca0c7aeab5dd69d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Protein Binding
128 rdf:type schema:DefinedTerm
129 N50133a012422413e8f98fa16cb11bdd0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Cell Movement
131 rdf:type schema:DefinedTerm
132 N60c1f02781cc4eb08d773d366772748e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Male
134 rdf:type schema:DefinedTerm
135 N6cf8a16c2b684b87b9ef718d5f7dd617 schema:name doi
136 schema:value 10.1186/s12967-015-0462-8
137 rdf:type schema:PropertyValue
138 N711aea1fd12e456cb3d8b90229175734 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Carcinoma
140 rdf:type schema:DefinedTerm
141 N76fb34ac373843a58f420f8f32b2a14a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Base Sequence
143 rdf:type schema:DefinedTerm
144 N80c52204ca0a4e68b66197f9982b6c25 rdf:first sg:person.0706566365.07
145 rdf:rest Nf61e988ec13b41e6bfd38313c3c25edd
146 N85cfeb59f3ee4e72bbd4c43cadc1cdac schema:volumeNumber 13
147 rdf:type schema:PublicationVolume
148 N8c821c3ff6134b36a23de5078c992214 rdf:first sg:person.01167375517.98
149 rdf:rest Nc8f55ca4e1ec4cc0b251ef21f1d33ca5
150 N9d41e181d11d4afc801f060ac79ab8a9 schema:name dimensions_id
151 schema:value pub.1026693276
152 rdf:type schema:PropertyValue
153 N9f37dad1477c423d9696ba071988bfe2 schema:name pubmed_id
154 schema:value 25884389
155 rdf:type schema:PropertyValue
156 Na2665491c3d24801a23d01012f5981fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Neoplasm Invasiveness
158 rdf:type schema:DefinedTerm
159 Na2eabc0c28eb411b9accf1785218957c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Humans
161 rdf:type schema:DefinedTerm
162 Na8f4e5aec04d4280ac49dfe2263425b1 rdf:first sg:person.01137243365.54
163 rdf:rest N8c821c3ff6134b36a23de5078c992214
164 Naadabff6fc95461bb50a198a0c7fed60 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Gene Expression Regulation, Neoplastic
166 rdf:type schema:DefinedTerm
167 Nb0ddecd0ac5443eba2f2ecb59e449aa0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Cell Line, Tumor
169 rdf:type schema:DefinedTerm
170 Nb2675e49d0da466d85e96bcbb59a24a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Feedback, Physiological
172 rdf:type schema:DefinedTerm
173 Nb47bc9a1f37d4ae795b4d71750130024 schema:name Springer Nature - SN SciGraph project
174 rdf:type schema:Organization
175 Nba7046d5ad18456a89222cba6b5adecb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name 3' Untranslated Regions
177 rdf:type schema:DefinedTerm
178 Nbf2ad0d4f2834a7487af6190142d7b98 schema:name nlm_unique_id
179 schema:value 101190741
180 rdf:type schema:PropertyValue
181 Nc107d2862d994bc7b932d816deb22bc2 rdf:first sg:person.01105051541.28
182 rdf:rest Na8f4e5aec04d4280ac49dfe2263425b1
183 Nc6710a2ffe9f48748fa8f3df53640f11 schema:name readcube_id
184 schema:value 7f2a3a7112c9d9788fe56834e92c3422c1e1a378fa5bd1c40bef231970ce4f53
185 rdf:type schema:PropertyValue
186 Nc723a7a4ffff44c6b971a66ea8ae3587 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Epithelial-Mesenchymal Transition
188 rdf:type schema:DefinedTerm
189 Nc8f55ca4e1ec4cc0b251ef21f1d33ca5 rdf:first sg:person.01267413341.92
190 rdf:rest rdf:nil
191 Nde0a111fb42645ce9c202ec8e25c0be0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Middle Aged
193 rdf:type schema:DefinedTerm
194 Ndea3fd42fc974f3aa735fb63ff6dd561 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Nasopharyngeal Carcinoma
196 rdf:type schema:DefinedTerm
197 Ne5bf4e161f554269a1be64ad10ace7dd schema:issueNumber 1
198 rdf:type schema:PublicationIssue
199 Nee86438d1e2148e6ad381a492ac28e8d rdf:first sg:person.0654374541.17
200 rdf:rest N2c0805fdb5b94e0694cada822d20872b
201 Nf1233a9787d3477f987c6579dbbcce02 rdf:first sg:person.01046003552.37
202 rdf:rest Nc107d2862d994bc7b932d816deb22bc2
203 Nf19450370aa942a6b697cfe9aa6bd951 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
204 schema:name Cell Proliferation
205 rdf:type schema:DefinedTerm
206 Nf4aaabe4139044d08e0ec41732434b3d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
207 schema:name Aged
208 rdf:type schema:DefinedTerm
209 Nf61e988ec13b41e6bfd38313c3c25edd rdf:first sg:person.01226754400.72
210 rdf:rest Nf1233a9787d3477f987c6579dbbcce02
211 Nf703a194bbee4128bdfe4a2df8cba58f rdf:first sg:person.01221300141.17
212 rdf:rest N80c52204ca0a4e68b66197f9982b6c25
213 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
214 schema:name Medical and Health Sciences
215 rdf:type schema:DefinedTerm
216 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
217 schema:name Clinical Sciences
218 rdf:type schema:DefinedTerm
219 sg:grant.6997457 http://pending.schema.org/fundedItem sg:pub.10.1186/s12967-015-0462-8
220 rdf:type schema:MonetaryGrant
221 sg:journal.1032886 schema:issn 1479-5876
222 schema:name Journal of Translational Medicine
223 rdf:type schema:Periodical
224 sg:person.01046003552.37 schema:affiliation https://www.grid.ac/institutes/grid.413372.0
225 schema:familyName Wang
226 schema:givenName Yuzhou
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046003552.37
228 rdf:type schema:Person
229 sg:person.01105051541.28 schema:affiliation https://www.grid.ac/institutes/grid.413372.0
230 schema:familyName Shen
231 schema:givenName Xiang
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105051541.28
233 rdf:type schema:Person
234 sg:person.01137243365.54 schema:affiliation https://www.grid.ac/institutes/grid.413372.0
235 schema:familyName Li
236 schema:givenName Shujun
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137243365.54
238 rdf:type schema:Person
239 sg:person.01167375517.98 schema:affiliation https://www.grid.ac/institutes/grid.413372.0
240 schema:familyName Li
241 schema:givenName Lixia
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167375517.98
243 rdf:type schema:Person
244 sg:person.01221300141.17 schema:affiliation https://www.grid.ac/institutes/grid.413372.0
245 schema:familyName Li
246 schema:givenName Jinmei
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221300141.17
248 rdf:type schema:Person
249 sg:person.01226754400.72 schema:affiliation https://www.grid.ac/institutes/grid.413372.0
250 schema:familyName Lin
251 schema:givenName Yanming
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226754400.72
253 rdf:type schema:Person
254 sg:person.01267413341.92 schema:affiliation https://www.grid.ac/institutes/grid.413372.0
255 schema:familyName Yang
256 schema:givenName Zhixiong
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267413341.92
258 rdf:type schema:Person
259 sg:person.0654374541.17 schema:affiliation https://www.grid.ac/institutes/grid.413372.0
260 schema:familyName Wu
261 schema:givenName Aibing
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654374541.17
263 rdf:type schema:Person
264 sg:person.0706566365.07 schema:affiliation https://www.grid.ac/institutes/grid.413372.0
265 schema:familyName Mo
266 schema:givenName Yanli
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706566365.07
268 rdf:type schema:Person
269 sg:person.0722507741.33 schema:affiliation https://www.grid.ac/institutes/grid.413372.0
270 schema:familyName Wu
271 schema:givenName Kunpeng
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722507741.33
273 rdf:type schema:Person
274 sg:pub.10.1007/s00432-010-0898-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031178398
275 https://doi.org/10.1007/s00432-010-0898-4
276 rdf:type schema:CreativeWork
277 sg:pub.10.1007/s11010-011-0862-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050099380
278 https://doi.org/10.1007/s11010-011-0862-x
279 rdf:type schema:CreativeWork
280 sg:pub.10.1038/modpathol.2008.202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039969896
281 https://doi.org/10.1038/modpathol.2008.202
282 rdf:type schema:CreativeWork
283 sg:pub.10.1038/nature02871 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043341870
284 https://doi.org/10.1038/nature02871
285 rdf:type schema:CreativeWork
286 sg:pub.10.1038/nrc1840 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030226923
287 https://doi.org/10.1038/nrc1840
288 rdf:type schema:CreativeWork
289 sg:pub.10.1038/nrc2271 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001411797
290 https://doi.org/10.1038/nrc2271
291 rdf:type schema:CreativeWork
292 sg:pub.10.1038/nrg1379 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001799892
293 https://doi.org/10.1038/nrg1379
294 rdf:type schema:CreativeWork
295 sg:pub.10.1038/onc.2011.131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047174148
296 https://doi.org/10.1038/onc.2011.131
297 rdf:type schema:CreativeWork
298 sg:pub.10.1038/onc.2011.629 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040172028
299 https://doi.org/10.1038/onc.2011.629
300 rdf:type schema:CreativeWork
301 sg:pub.10.1038/onc.2012.573 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030198930
302 https://doi.org/10.1038/onc.2012.573
303 rdf:type schema:CreativeWork
304 sg:pub.10.1038/sj.bjc.6604948 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018517435
305 https://doi.org/10.1038/sj.bjc.6604948
306 rdf:type schema:CreativeWork
307 sg:pub.10.1186/1471-2407-14-274 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025456783
308 https://doi.org/10.1186/1471-2407-14-274
309 rdf:type schema:CreativeWork
310 https://app.dimensions.ai/details/publication/pub.1078312833 schema:CreativeWork
311 https://doi.org/10.1002/ijc.26311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010428350
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1002/path.2138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023764750
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1016/j.febslet.2004.08.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039282750
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1016/j.humpath.2009.08.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045242059
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1016/j.molmed.2008.07.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051149608
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1016/j.tcb.2006.12.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032185534
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1016/j.ydbio.2006.08.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009298891
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1016/s0092-8674(03)00428-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042988434
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1016/s0092-8674(04)00045-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031254572
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1016/s0140-6736(05)66698-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003322195
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1016/s1470-2045(12)70102-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052497203
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1038/emboj.2008.294 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042185525
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1074/jbc.m802016200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035802234
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1083/jcb.200512110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010456121
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1089/cbr.2012.1307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059243300
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1097/moo.0b013e32835e1d6e schema:sameAs https://app.dimensions.ai/details/publication/pub.1018671460
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1101/gad.1540407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002090828
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1111/his.12176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003910472
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1111/his.12401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006662352
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1126/science.1111444 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062452139
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1126/science.1137999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062455163
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1158/0008-5472.can-06-0479 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000561623
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1158/0008-5472.can-09-1298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046367769
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1158/0008-5472.can-10-1850 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052371669
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1158/0008-5472.can-10-2388 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007738821
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1158/0008-5472.can-11-1322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036895247
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1158/0008-5472.can-12-3848 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025642336
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1158/1078-0432.ccr-10-2132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024212626
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1172/jci20530 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063416449
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1172/jci39104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026879393
370 rdf:type schema:CreativeWork
371 https://doi.org/10.3322/caac.20107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009055747
372 rdf:type schema:CreativeWork
373 https://doi.org/10.3892/or.2011.1360 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071531473
374 rdf:type schema:CreativeWork
375 https://doi.org/10.3892/or.2012.1709 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071531766
376 rdf:type schema:CreativeWork
377 https://doi.org/10.3892/or.2012.2027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071532057
378 rdf:type schema:CreativeWork
379 https://www.grid.ac/institutes/grid.413372.0 schema:alternateName Affiliated Hospital of Guangdong Medical College Hospital
380 schema:name Oncology Center, Affiliated Hospital of Guangdong Medical College, No.57 Peoples Avenue South, 524002, Zhanjiang, Guangdong, People’s Republic of China
381 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...