Future perspectives in melanoma research: meeting report from the "Melanoma Bridge", Napoli, December 5th-8th 2013 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-10-28

AUTHORS

Paolo A Ascierto, Antonio M Grimaldi, Ana Carrizosa Anderson, Carlo Bifulco, Alistair Cochran, Claus Garbe, Alexander M Eggermont, Mark Faries, Soldano Ferrone, Jeffrey E Gershenwald, Thomas F Gajewski, Ruth Halaban, F Stephen Hodi, Richard Kefford, John M Kirkwood, James Larkin, Sancy Leachman, Michele Maio, Richard Marais, Giuseppe Masucci, Ignacio Melero, Giuseppe Palmieri, Igor Puzanov, Antoni Ribas, Yvonne Saenger, Bastian Schilling, Barbara Seliger, David Stroncek, Ryan Sullivan, Alessandro Testori, Ena Wang, Gennaro Ciliberto, Nicola Mozzillo, Francesco M Marincola, Magdalena Thurin

ABSTRACT

The fourth "Melanoma Bridge Meeting" took place in Naples, December 5 to 8th, 2013. The four topics discussed at this meeting were: Diagnosis and New Procedures, Molecular Advances and Combination Therapies, News in Immunotherapy, and Tumor Microenvironment and Biomarkers.Until recently systemic therapy for metastatic melanoma patients was ineffective, but recent research in tumor biology and immunology has led to the development of new targeted and immunotherapeutic agents that prolong progression-free survival (PFS) and overall survival (OS). New therapies, such as mitogen-activated protein kinase (MAPK) pathway inhibitors, like BRAF and MEK inhibitors, as well as other signaling pathways inhibitors, are being tested in metastatic melanoma either as monotherapy or in combination, and have yielded promising results.Improved survival rates have also been observed with immune therapy for patients with metastatic melanoma. Immune-modulating antibodies came to the forefront with anti-CTLA-4, programmed cell death-1 (PD-1) and PD-1 ligand 1 (PD-L1) pathway blocking antibodies that result in durable responses in a subset of melanoma patients. Agents targeting other immune inhibitory (e.g., Tim-3) or immune stimulating (e.g., CD137) receptors and other approaches such as adoptive cell transfer demonstrate clinical benefit in melanoma as well.This meeting's specific focus was on advances in targeted therapy and immunotherapy. Both combination targeted therapy approaches and different immunotherapies were discussed. Similarly to the previous meetings, the importance of biomarkers for clinical application as markers for diagnosis, prognosis and prediction of treatment response was an integral part of the meeting. Significant consideration was given to issues surrounding the development of novel therapeutic targets as further study of patterns of resistance to both immunologic and targeted drugs are paramount to future drug development to guide existing and future therapies. The overall emphasis on biomarkers supports novel concepts toward integrating biomarkers into contemporary clinical management of patients with melanoma across the entire spectrum of disease stage. Translation of the knowledge gained from the biology of tumor microenvironment across different tumors represents a bridge to impact on prognosis and response to therapy in melanoma. More... »

PAGES

277

References to SciGraph publications

  • 2014-02-15. Age as a Predictor of Sentinel Node Metastasis among Patients with Localized Melanoma: An Inverse Correlation of Melanoma Mortality and Incidence of Sentinel Node Metastasis Among Young and Old Patients in ANNALS OF SURGICAL ONCOLOGY
  • 2014-04-16. Effects of AKT inhibitor therapy in response and resistance to BRAF inhibition in melanoma in MOLECULAR CANCER
  • 2005-11-06. BRAF mutation predicts sensitivity to MEK inhibition in NATURE
  • 2012-07-29. Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma in NATURE GENETICS
  • 2002-06-09. Mutations of the BRAF gene in human cancer in NATURE
  • 2011-04-20. Novel targeted therapeutics: inhibitors of MDM2, ALK and PARP in JOURNAL OF HEMATOLOGY & ONCOLOGY
  • 2013-07-10. Age as a Prognostic Factor in Patients with Localized Melanoma and Regional Metastases in ANNALS OF SURGICAL ONCOLOGY
  • 2008-03. Digital mRNA profiling in NATURE BIOTECHNOLOGY
  • 2010-03-19. 2010 TNM Staging System for Cutaneous Melanoma…and Beyond in ANNALS OF SURGICAL ONCOLOGY
  • 2014-02-18. Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8+ T cells directly within the tumor microenvironment in JOURNAL FOR IMMUNOTHERAPY OF CANCER
  • 2013-09-18. Innate and adaptive immune cells in the tumor microenvironment in NATURE IMMUNOLOGY
  • 2011-09-18. A human memory T cell subset with stem cell–like properties in NATURE MEDICINE
  • 2007-08-07. Stage-IV Melanoma and Pulmonary Metastases: Factors Predictive of Survival in ANNALS OF SURGICAL ONCOLOGY
  • 2012-07-10. Serum markers lactate dehydrogenase and S100B predict independently disease outcome in melanoma patients with distant metastasis in BRITISH JOURNAL OF CANCER
  • 2013-04-02. Treating B-cell cancer with T cells expressing anti-CD19 chimeric antigen receptors in NATURE REVIEWS CLINICAL ONCOLOGY
  • 2010-11-24. Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation in NATURE
  • 2000-04. Does endogenous immune response determine the outcome of surgical therapy for metastatic melanoma? in ANNALS OF SURGICAL ONCOLOGY
  • 2008-01-15. Prognosis and Determinants of Outcome Following Locoregional or Distant Recurrence in Patients with Cutaneous Melanoma in ANNALS OF SURGICAL ONCOLOGY
  • 2012-08-21. IRF5 gene polymorphisms in melanoma in JOURNAL OF TRANSLATIONAL MEDICINE
  • 2013-03-03. The additional facet of immunoscore: immunoprofiling as a possible predictive tool for cancer treatment in JOURNAL OF TRANSLATIONAL MEDICINE
  • 2006-04-16. A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus in NATURE GENETICS
  • 2009-10-15. A multi-center phase II evaluation of the small molecule survivin suppressor YM155 in patients with unresectable stage III or IV melanoma in INVESTIGATIONAL NEW DRUGS
  • 2009-03-06. Molecular classification of melanomas and nevi using gene expression microarray signatures and formalin-fixed and paraffin-embedded tissue in MODERN PATHOLOGY
  • 2013-12-01. Long-lasting response to electrochemotherapy in melanoma patients with cutaneous metastasis in BMC CANCER
  • 2014-05-06. Phase Ib/II, open-label, dose-escalation study of LGX818, an oral selective BRAF inhibitor, in combination with MEK162, an oral MEK1/2 inhibitor, in patients with BRAF V600-dependent advanced solid tumors: preliminary results in JOURNAL OF TRANSLATIONAL MEDICINE
  • 2013-01-09. Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance in NATURE
  • 2006-02-09. Tumor progression despite massive influx of activated CD8+ T cells in a patient with malignant melanoma ascites in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • Journal

    TITLE

    Journal of Translational Medicine

    ISSUE

    1

    VOLUME

    12

    Author Affiliations

  • Istituto Nazionale Tumori, Fondazione "G.Pascale", Napoli, Italy
  • Center for Neurologic Diseases, Harvard Medical School, Boston, MA, USA
  • Translational Molecular Pathology, Earle A. Chiles Research Institute, Providence Cancer Center, Portland, OR, USA
  • Departments of Pathology and Laboratory Medicine and Surgery, David Geffen School of Medicine at University of California Los Angeles (UCLA), John Wayne Cancer Institute, Santa Monica, CA, USA
  • Center for Dermato Oncology, Department of Dermatology, University of Tübingen, Tübingen, Germany
  • Cancer Institute Gustave Roussy, Villejuif/Paris-Sud, Villejuif, France
  • Donald L. Morton Melanoma Research Program, John Wayne Cancer Institute, Santa Monica, CA, USA
  • Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
  • Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
  • Departments of Medicine and of Pathology, Immunology and Cancer Program, The University of Chicago Medicine, Chicago, IL, USA
  • Department of Dermatology, Yale University School of Medicine, New Haven, CT, USA
  • Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
  • Westmead Institute for Cancer Research, Westmead Millennium Institute and Melanoma Institute Australia, University of Sydney, Sydney, NSW, Australia
  • Division of Hematology/Oncology, Departments of Medicine, Dermatology, and Translational Science, University of Pittsburgh School of Medicine and Melanoma Program of the Pittsburgh Cancer Institute, Pittsburgh, PA, USA
  • Royal Marsden NHS Foundation Trust, London, UK
  • Department of Dermatology, Oregon Health Sciences University, Portland, OR, USA
  • Medical Oncology and Immunotherapy, Department of Oncology, University Hospital of Siena, Istituto Toscano Tumori, Siena, Italy
  • Molecular Oncology Group, The Paterson Institute for Cancer Research, Wilmslow Road, M20 4BX, Manchester, UK
  • Department of Oncology-Pathology, The Karolinska Hospital, Stockholm, Sweden
  • Centro de Investigación Médica Aplicada, Clinica Universidad de Navarra, Pamplona, Navarra, Spain
  • Unit of Cancer Genetics, Institute of Biomolecular Chemistry, National Research Council, Sassari, Italy
  • Vanderbilt University Medical Center, Nashville, TN, USA
  • Tumor Immunology Program, Jonsson Comprehensive Cancer Center (JCCC), David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA, USA
  • Division of Hematology and Oncology, Tisch Cancer Institute, Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
  • German Cancer Consortium (DKTK), Heidelberg, Germany
  • Martin Luther University Halle-Wittenberg, Institute of Medical Immunology, Halle, Germany
  • Cell Processing Section, Department of Transfusion Medicine, Clinical Center, NIH, Bethesda, MD, USA
  • Center for Melanoma, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA
  • Istituto Europeo di Oncologia, Milan, Italy
  • Division Chief of Translational Medicine, Sidra Medical and Research Centre, Doha, Qatar
  • Sidra Medical and Research Centre, Doha, Qatar
  • Cancer Diagnosis Program, National Cancer Institute, NIH, Bethesda, MD, USA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s12967-014-0277-z

    DOI

    http://dx.doi.org/10.1186/s12967-014-0277-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1053630747

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25348889


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