Selective deletion of hepatocyte platelet-derived growth factor receptor α and development of liver fibrosis in mice View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Beom Jin Lim, Woon-Kyu Lee, Hyun Woong Lee, Kwan Sik Lee, Ja Kyung Kim, Hye Young Chang, Jung Il Lee

ABSTRACT

BACKGROUND: Platelet-derived growth factor receptor α (PDGFRα) expression is increased in activated hepatic stellate cells (HSCs) in cirrhotic liver, while normal hepatocytes express PDGFRα at a negligible level. However, cancerous hepatocytes may show upregulation of PDGFRα, and hepatocellular carcinoma is preceded by chronic liver injury. The role of PDGFRα in non-cancerous hepatocytes and liver fibrosis is unclear. We hypothesized that upon liver injury, PDGFRα in insulted hepatocytes contributes to liver fibrosis by facilitating intercellular crosstalk between hepatocytes and HSCs. METHODS: Hepatocytes were isolated from normal and thioacetamide (TAA)-induced cirrhotic livers for assessment of PDGFRα expression. Conditional knock-out (KO) C57BL/6 mice, in which PDGFRα was selectively deleted in hepatocytes, were generated. Liver fibrosis was induced by injecting TAA for 8 weeks. Hep3B cells were transfected with a small interfering RNA (siRNA) (PDGFRα or control) and co-cultured with LX2 cells. RESULTS: PDGFRα expression was increased in hepatocytes from fibrotic livers compared to normal livers. Conditional PDGFRα KO mice had attenuated TAA-induced liver fibrosis with decreased HSC activation and proliferation. Immunoblot analyses revealed decreased expression of phospho-p44/42 MAPK in TAA-treated KO mice; these mice also showed almost complete suppression of the upregulation of mouse double minute 2. Although KO mice exhibited increased expression of transforming growth factor (TGF)-β and Smad2/3, this was compensated for by increased expression of inhibitory Smad7. LX2 cells co-cultured with PDGFRα siRNA-infected Hep3B cells showed decreased PDGFRα, α smooth muscle actin, collagen α1(I), TGFβ, and Smad2/3 expression. LX2/PDGFRα-deleted hepatocyte co-culture medium showed decreased PDGF-BB and PDGF-CC levels. CONCLUSIONS: Deletion of PDGFRα in hepatocytes attenuated the upregulation of PDGFRα in HSCs after TAA treatment, resulting in decreased liver fibrosis and HSC activation. This suggests that in the event of chronic liver injury, PDGFRα in hepatocytes plays an important role in liver fibrosis by affecting PDGFRα expression in HSCs. More... »

PAGES

93

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12964-018-0306-2

DOI

http://dx.doi.org/10.1186/s12964-018-0306-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1110351805

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30509307


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Yonsei University", 
          "id": "https://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Pathology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lim", 
        "givenName": "Beom Jin", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Inha University", 
          "id": "https://www.grid.ac/institutes/grid.202119.9", 
          "name": [
            "Laboratory of Developmental Genetics, Department of Biomedical Sciences, Inha University College of Medicine, Incheon, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Woon-Kyu", 
        "id": "sg:person.0721571574.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721571574.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yonsei University", 
          "id": "https://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Hyun Woong", 
        "id": "sg:person.0604617375.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604617375.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yonsei University", 
          "id": "https://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Kwan Sik", 
        "id": "sg:person.010640450027.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010640450027.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yonsei University", 
          "id": "https://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Ja Kyung", 
        "id": "sg:person.0634505520.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634505520.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gangnam Severance Hospital", 
          "id": "https://www.grid.ac/institutes/grid.459553.b", 
          "name": [
            "Medical Research Center, Gangnam Severance Hospital, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chang", 
        "givenName": "Hye Young", 
        "id": "sg:person.01063175623.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063175623.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yonsei University", 
          "id": "https://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Jung Il", 
        "id": "sg:person.01143757535.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143757535.18"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00441-011-1246-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000661086", 
          "https://doi.org/10.1007/s00441-011-1246-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00441-011-1246-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000661086", 
          "https://doi.org/10.1007/s00441-011-1246-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2008.03.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001724122"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1432-0436.2007.00235.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002248502"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1210121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002388118", 
          "https://doi.org/10.1038/sj.onc.1210121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1210121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002388118", 
          "https://doi.org/10.1038/sj.onc.1210121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.27332", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002461993"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajpath.2013.01.047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005054488"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci24282", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006469641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-4644(19970301)64:3<343::aid-jcb1>3.0.co;2-v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006704928"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1517/14728220902719233", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008612953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cytogfr.2015.10.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008883763"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj2870255", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011542214"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj2870255", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011542214"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cyto.2005.06.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011614949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/aps.2010.142", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011931912", 
          "https://doi.org/10.1038/aps.2010.142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/aps.2010.142", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011931912", 
          "https://doi.org/10.1038/aps.2010.142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/labinvest.2008.71", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012417721", 
          "https://doi.org/10.1038/labinvest.2008.71"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0092925", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012740713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.92.7.2572", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017787606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.1840220344", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017956939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0091-679x(08)61797-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018711343"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00535-016-1190-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019098275", 
          "https://doi.org/10.1007/s00535-016-1190-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.2011.208", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019333810", 
          "https://doi.org/10.1038/ki.2011.208"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1309/d7au-eyw7-4b6c-k08y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020997143"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.030338", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023243478"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1755-1536-5-s1-s26", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023542107", 
          "https://doi.org/10.1186/1755-1536-5-s1-s26"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1755-1536-5-s1-s26", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023542107", 
          "https://doi.org/10.1186/1755-1536-5-s1-s26"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.gene.2008.05.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024361018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.10898", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027090776"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cld.2008.07.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027189632"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2006.04.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027421879"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/meth.2001.1262", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027621591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/meth.2001.1262", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027621591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/375691a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031186310", 
          "https://doi.org/10.1038/375691a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0409722102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032390334"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1478-811x-11-97", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034089550", 
          "https://doi.org/10.1186/1478-811x-11-97"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci117497", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035067718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cld.2008.07.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037307807"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cld.2008.07.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038084213"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2015.01.036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038438609"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11926-012-0304-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038622229", 
          "https://doi.org/10.1007/s11926-012-0304-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2014.07.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039371323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1535-7163.mct-06-0720", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042094155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev-pathol-011110-130246", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042822909"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(93)90509-o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043118200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20041393", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045080455"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.1840150211", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045846728"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cr.2008.308", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047502630", 
          "https://doi.org/10.1038/cr.2008.308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.2005.088690", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048087432"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jacc.2006.07.060", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048098482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.preteyeres.2013.12.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048254157"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1440-1746.2006.04658.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049274214"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209083", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053248481", 
          "https://doi.org/10.1038/sj.onc.1209083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209083", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053248481", 
          "https://doi.org/10.1038/sj.onc.1209083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.01321-10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053727503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-0032-1330422", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057277381"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpcell.00423.2014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063191988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpgi.1999.276.4.g1059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074356240"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpgi.2000.279.5.g845", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074719137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074980667", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.gene.2017.03.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084076796"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.17134", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084880940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajpath.2017.06.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090833560"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "BACKGROUND: Platelet-derived growth factor receptor \u03b1 (PDGFR\u03b1) expression is increased in activated hepatic stellate cells (HSCs) in cirrhotic liver, while normal hepatocytes express PDGFR\u03b1 at a negligible level. However, cancerous hepatocytes may show upregulation of PDGFR\u03b1, and hepatocellular carcinoma is preceded by chronic liver injury. The role of PDGFR\u03b1 in non-cancerous hepatocytes and liver fibrosis is unclear. We hypothesized that upon liver injury, PDGFR\u03b1 in insulted hepatocytes contributes to liver fibrosis by facilitating intercellular crosstalk between hepatocytes and HSCs.\nMETHODS: Hepatocytes were isolated from normal and thioacetamide (TAA)-induced cirrhotic livers for assessment of PDGFR\u03b1 expression. Conditional knock-out (KO) C57BL/6 mice, in which PDGFR\u03b1 was selectively deleted in hepatocytes, were generated. Liver fibrosis was induced by injecting TAA for 8\u2009weeks. Hep3B cells were transfected with a small interfering RNA (siRNA) (PDGFR\u03b1 or control) and co-cultured with LX2 cells.\nRESULTS: PDGFR\u03b1 expression was increased in hepatocytes from fibrotic livers compared to normal livers. Conditional PDGFR\u03b1 KO mice had attenuated TAA-induced liver fibrosis with decreased HSC activation and proliferation. Immunoblot analyses revealed decreased expression of phospho-p44/42 MAPK in TAA-treated KO mice; these mice also showed almost complete suppression of the upregulation of mouse double minute 2. Although KO mice exhibited increased expression of transforming growth factor (TGF)-\u03b2 and Smad2/3, this was compensated for by increased expression of inhibitory Smad7. LX2 cells co-cultured with PDGFR\u03b1 siRNA-infected Hep3B cells showed decreased PDGFR\u03b1, \u03b1 smooth muscle actin, collagen \u03b11(I), TGF\u03b2, and Smad2/3 expression. LX2/PDGFR\u03b1-deleted hepatocyte co-culture medium showed decreased PDGF-BB and PDGF-CC levels.\nCONCLUSIONS: Deletion of PDGFR\u03b1 in hepatocytes attenuated the upregulation of PDGFR\u03b1 in HSCs after TAA treatment, resulting in decreased liver fibrosis and HSC activation. This suggests that in the event of chronic liver injury, PDGFR\u03b1 in hepatocytes plays an important role in liver fibrosis by affecting PDGFR\u03b1 expression in HSCs.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s12964-018-0306-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1032046", 
        "issn": [
          "1478-811X"
        ], 
        "name": "Cell Communication and Signaling", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "16"
      }
    ], 
    "name": "Selective deletion of hepatocyte platelet-derived growth factor receptor \u03b1 and development of liver fibrosis in mice", 
    "pagination": "93", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "34f944c776759c055e10c6cb940e4aae67b59ac816d6f2597ef404dcb20591c1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30509307"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101170464"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12964-018-0306-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1110351805"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12964-018-0306-2", 
      "https://app.dimensions.ai/details/publication/pub.1110351805"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T08:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000282_0000000282/records_78263_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs12964-018-0306-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12964-018-0306-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12964-018-0306-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12964-018-0306-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12964-018-0306-2'


 

This table displays all metadata directly associated to this object as RDF triples.

298 TRIPLES      21 PREDICATES      86 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12964-018-0306-2 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author N12db77f3289b469792931e7a5fbd00c3
4 schema:citation sg:pub.10.1007/s00441-011-1246-y
5 sg:pub.10.1007/s00535-016-1190-4
6 sg:pub.10.1007/s11926-012-0304-0
7 sg:pub.10.1038/375691a0
8 sg:pub.10.1038/aps.2010.142
9 sg:pub.10.1038/cr.2008.308
10 sg:pub.10.1038/ki.2011.208
11 sg:pub.10.1038/labinvest.2008.71
12 sg:pub.10.1038/sj.onc.1209083
13 sg:pub.10.1038/sj.onc.1210121
14 sg:pub.10.1186/1478-811x-11-97
15 sg:pub.10.1186/1755-1536-5-s1-s26
16 https://app.dimensions.ai/details/publication/pub.1074980667
17 https://doi.org/10.1002/(sici)1097-4644(19970301)64:3<343::aid-jcb1>3.0.co;2-v
18 https://doi.org/10.1002/cncr.10898
19 https://doi.org/10.1002/hep.1840150211
20 https://doi.org/10.1002/hep.1840220344
21 https://doi.org/10.1002/hep.27332
22 https://doi.org/10.1006/meth.2001.1262
23 https://doi.org/10.1016/0092-8674(93)90509-o
24 https://doi.org/10.1016/j.ajpath.2013.01.047
25 https://doi.org/10.1016/j.ajpath.2017.06.009
26 https://doi.org/10.1016/j.cld.2008.07.006
27 https://doi.org/10.1016/j.cld.2008.07.007
28 https://doi.org/10.1016/j.cld.2008.07.008
29 https://doi.org/10.1016/j.cyto.2005.06.005
30 https://doi.org/10.1016/j.cytogfr.2015.10.002
31 https://doi.org/10.1016/j.gene.2008.05.022
32 https://doi.org/10.1016/j.gene.2017.03.003
33 https://doi.org/10.1016/j.jacc.2006.07.060
34 https://doi.org/10.1016/j.jhep.2006.04.010
35 https://doi.org/10.1016/j.jhep.2015.01.036
36 https://doi.org/10.1016/j.preteyeres.2013.12.006
37 https://doi.org/10.1016/s0091-679x(08)61797-5
38 https://doi.org/10.1042/bj2870255
39 https://doi.org/10.1053/j.gastro.2008.03.003
40 https://doi.org/10.1053/j.gastro.2014.07.018
41 https://doi.org/10.1055/s-0032-1330422
42 https://doi.org/10.1073/pnas.0409722102
43 https://doi.org/10.1073/pnas.92.7.2572
44 https://doi.org/10.1084/jem.20041393
45 https://doi.org/10.1111/j.1432-0436.2007.00235.x
46 https://doi.org/10.1111/j.1440-1746.2006.04658.x
47 https://doi.org/10.1128/mcb.01321-10
48 https://doi.org/10.1136/gut.2005.088690
49 https://doi.org/10.1146/annurev-pathol-011110-130246
50 https://doi.org/10.1152/ajpcell.00423.2014
51 https://doi.org/10.1152/ajpgi.1999.276.4.g1059
52 https://doi.org/10.1152/ajpgi.2000.279.5.g845
53 https://doi.org/10.1158/1535-7163.mct-06-0720
54 https://doi.org/10.1172/jci117497
55 https://doi.org/10.1172/jci24282
56 https://doi.org/10.1242/dev.030338
57 https://doi.org/10.1309/d7au-eyw7-4b6c-k08y
58 https://doi.org/10.1371/journal.pone.0092925
59 https://doi.org/10.1517/14728220902719233
60 https://doi.org/10.18632/oncotarget.17134
61 schema:datePublished 2018-12
62 schema:datePublishedReg 2018-12-01
63 schema:description BACKGROUND: Platelet-derived growth factor receptor α (PDGFRα) expression is increased in activated hepatic stellate cells (HSCs) in cirrhotic liver, while normal hepatocytes express PDGFRα at a negligible level. However, cancerous hepatocytes may show upregulation of PDGFRα, and hepatocellular carcinoma is preceded by chronic liver injury. The role of PDGFRα in non-cancerous hepatocytes and liver fibrosis is unclear. We hypothesized that upon liver injury, PDGFRα in insulted hepatocytes contributes to liver fibrosis by facilitating intercellular crosstalk between hepatocytes and HSCs. METHODS: Hepatocytes were isolated from normal and thioacetamide (TAA)-induced cirrhotic livers for assessment of PDGFRα expression. Conditional knock-out (KO) C57BL/6 mice, in which PDGFRα was selectively deleted in hepatocytes, were generated. Liver fibrosis was induced by injecting TAA for 8 weeks. Hep3B cells were transfected with a small interfering RNA (siRNA) (PDGFRα or control) and co-cultured with LX2 cells. RESULTS: PDGFRα expression was increased in hepatocytes from fibrotic livers compared to normal livers. Conditional PDGFRα KO mice had attenuated TAA-induced liver fibrosis with decreased HSC activation and proliferation. Immunoblot analyses revealed decreased expression of phospho-p44/42 MAPK in TAA-treated KO mice; these mice also showed almost complete suppression of the upregulation of mouse double minute 2. Although KO mice exhibited increased expression of transforming growth factor (TGF)-β and Smad2/3, this was compensated for by increased expression of inhibitory Smad7. LX2 cells co-cultured with PDGFRα siRNA-infected Hep3B cells showed decreased PDGFRα, α smooth muscle actin, collagen α1(I), TGFβ, and Smad2/3 expression. LX2/PDGFRα-deleted hepatocyte co-culture medium showed decreased PDGF-BB and PDGF-CC levels. CONCLUSIONS: Deletion of PDGFRα in hepatocytes attenuated the upregulation of PDGFRα in HSCs after TAA treatment, resulting in decreased liver fibrosis and HSC activation. This suggests that in the event of chronic liver injury, PDGFRα in hepatocytes plays an important role in liver fibrosis by affecting PDGFRα expression in HSCs.
64 schema:genre research_article
65 schema:inLanguage en
66 schema:isAccessibleForFree true
67 schema:isPartOf N11e4ae21222c481d95d05e63640a032f
68 N92a17ff06e8c49679f3b374c12d4fc78
69 sg:journal.1032046
70 schema:name Selective deletion of hepatocyte platelet-derived growth factor receptor α and development of liver fibrosis in mice
71 schema:pagination 93
72 schema:productId N0e63d5af816a42458ecd05da938e6310
73 N6681bee5a0d846eeb9a1a041f7202eca
74 N9c9ec7188f7a4170b68047ed3f28874e
75 Nabcfb1eb568b4e0eb86863aedd4792a7
76 Nd2c90a0ad19c4ab4ae7f60f6f196b979
77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110351805
78 https://doi.org/10.1186/s12964-018-0306-2
79 schema:sdDatePublished 2019-04-11T08:19
80 schema:sdLicense https://scigraph.springernature.com/explorer/license/
81 schema:sdPublisher Nf3f8fb09da184fa69a869cddea87a4c8
82 schema:url https://link.springer.com/10.1186%2Fs12964-018-0306-2
83 sgo:license sg:explorer/license/
84 sgo:sdDataset articles
85 rdf:type schema:ScholarlyArticle
86 N062db98942044a44a661330a1c983302 rdf:first sg:person.01063175623.27
87 rdf:rest N335832cc7bfb4b168183c8f143bc9adf
88 N0e63d5af816a42458ecd05da938e6310 schema:name nlm_unique_id
89 schema:value 101170464
90 rdf:type schema:PropertyValue
91 N11e4ae21222c481d95d05e63640a032f schema:issueNumber 1
92 rdf:type schema:PublicationIssue
93 N12db77f3289b469792931e7a5fbd00c3 rdf:first Na38be92b4082418aa108fc1e097bffea
94 rdf:rest Ne19016a9b35f492fb3cc2fcafae307ee
95 N335832cc7bfb4b168183c8f143bc9adf rdf:first sg:person.01143757535.18
96 rdf:rest rdf:nil
97 N5b12649cb7e64f28a2c6a76250d5ad48 rdf:first sg:person.0634505520.15
98 rdf:rest N062db98942044a44a661330a1c983302
99 N6681bee5a0d846eeb9a1a041f7202eca schema:name dimensions_id
100 schema:value pub.1110351805
101 rdf:type schema:PropertyValue
102 N92a17ff06e8c49679f3b374c12d4fc78 schema:volumeNumber 16
103 rdf:type schema:PublicationVolume
104 N9c9ec7188f7a4170b68047ed3f28874e schema:name pubmed_id
105 schema:value 30509307
106 rdf:type schema:PropertyValue
107 Na1022a6a39a945308ff53ed4a7f87dc1 rdf:first sg:person.0604617375.89
108 rdf:rest Nf7c68f8c69b74ead8477dcc7c2829a6c
109 Na38be92b4082418aa108fc1e097bffea schema:affiliation https://www.grid.ac/institutes/grid.15444.30
110 schema:familyName Lim
111 schema:givenName Beom Jin
112 rdf:type schema:Person
113 Nabcfb1eb568b4e0eb86863aedd4792a7 schema:name doi
114 schema:value 10.1186/s12964-018-0306-2
115 rdf:type schema:PropertyValue
116 Nd2c90a0ad19c4ab4ae7f60f6f196b979 schema:name readcube_id
117 schema:value 34f944c776759c055e10c6cb940e4aae67b59ac816d6f2597ef404dcb20591c1
118 rdf:type schema:PropertyValue
119 Ne19016a9b35f492fb3cc2fcafae307ee rdf:first sg:person.0721571574.52
120 rdf:rest Na1022a6a39a945308ff53ed4a7f87dc1
121 Nf3f8fb09da184fa69a869cddea87a4c8 schema:name Springer Nature - SN SciGraph project
122 rdf:type schema:Organization
123 Nf7c68f8c69b74ead8477dcc7c2829a6c rdf:first sg:person.010640450027.34
124 rdf:rest N5b12649cb7e64f28a2c6a76250d5ad48
125 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
126 schema:name Medical and Health Sciences
127 rdf:type schema:DefinedTerm
128 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
129 schema:name Clinical Sciences
130 rdf:type schema:DefinedTerm
131 sg:journal.1032046 schema:issn 1478-811X
132 schema:name Cell Communication and Signaling
133 rdf:type schema:Periodical
134 sg:person.01063175623.27 schema:affiliation https://www.grid.ac/institutes/grid.459553.b
135 schema:familyName Chang
136 schema:givenName Hye Young
137 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063175623.27
138 rdf:type schema:Person
139 sg:person.010640450027.34 schema:affiliation https://www.grid.ac/institutes/grid.15444.30
140 schema:familyName Lee
141 schema:givenName Kwan Sik
142 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010640450027.34
143 rdf:type schema:Person
144 sg:person.01143757535.18 schema:affiliation https://www.grid.ac/institutes/grid.15444.30
145 schema:familyName Lee
146 schema:givenName Jung Il
147 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143757535.18
148 rdf:type schema:Person
149 sg:person.0604617375.89 schema:affiliation https://www.grid.ac/institutes/grid.15444.30
150 schema:familyName Lee
151 schema:givenName Hyun Woong
152 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604617375.89
153 rdf:type schema:Person
154 sg:person.0634505520.15 schema:affiliation https://www.grid.ac/institutes/grid.15444.30
155 schema:familyName Kim
156 schema:givenName Ja Kyung
157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634505520.15
158 rdf:type schema:Person
159 sg:person.0721571574.52 schema:affiliation https://www.grid.ac/institutes/grid.202119.9
160 schema:familyName Lee
161 schema:givenName Woon-Kyu
162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721571574.52
163 rdf:type schema:Person
164 sg:pub.10.1007/s00441-011-1246-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1000661086
165 https://doi.org/10.1007/s00441-011-1246-y
166 rdf:type schema:CreativeWork
167 sg:pub.10.1007/s00535-016-1190-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019098275
168 https://doi.org/10.1007/s00535-016-1190-4
169 rdf:type schema:CreativeWork
170 sg:pub.10.1007/s11926-012-0304-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038622229
171 https://doi.org/10.1007/s11926-012-0304-0
172 rdf:type schema:CreativeWork
173 sg:pub.10.1038/375691a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031186310
174 https://doi.org/10.1038/375691a0
175 rdf:type schema:CreativeWork
176 sg:pub.10.1038/aps.2010.142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011931912
177 https://doi.org/10.1038/aps.2010.142
178 rdf:type schema:CreativeWork
179 sg:pub.10.1038/cr.2008.308 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047502630
180 https://doi.org/10.1038/cr.2008.308
181 rdf:type schema:CreativeWork
182 sg:pub.10.1038/ki.2011.208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019333810
183 https://doi.org/10.1038/ki.2011.208
184 rdf:type schema:CreativeWork
185 sg:pub.10.1038/labinvest.2008.71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012417721
186 https://doi.org/10.1038/labinvest.2008.71
187 rdf:type schema:CreativeWork
188 sg:pub.10.1038/sj.onc.1209083 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053248481
189 https://doi.org/10.1038/sj.onc.1209083
190 rdf:type schema:CreativeWork
191 sg:pub.10.1038/sj.onc.1210121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002388118
192 https://doi.org/10.1038/sj.onc.1210121
193 rdf:type schema:CreativeWork
194 sg:pub.10.1186/1478-811x-11-97 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034089550
195 https://doi.org/10.1186/1478-811x-11-97
196 rdf:type schema:CreativeWork
197 sg:pub.10.1186/1755-1536-5-s1-s26 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023542107
198 https://doi.org/10.1186/1755-1536-5-s1-s26
199 rdf:type schema:CreativeWork
200 https://app.dimensions.ai/details/publication/pub.1074980667 schema:CreativeWork
201 https://doi.org/10.1002/(sici)1097-4644(19970301)64:3<343::aid-jcb1>3.0.co;2-v schema:sameAs https://app.dimensions.ai/details/publication/pub.1006704928
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1002/cncr.10898 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027090776
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1002/hep.1840150211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045846728
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1002/hep.1840220344 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017956939
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1002/hep.27332 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002461993
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1006/meth.2001.1262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027621591
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/0092-8674(93)90509-o schema:sameAs https://app.dimensions.ai/details/publication/pub.1043118200
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/j.ajpath.2013.01.047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005054488
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/j.ajpath.2017.06.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090833560
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/j.cld.2008.07.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027189632
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/j.cld.2008.07.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037307807
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/j.cld.2008.07.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038084213
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/j.cyto.2005.06.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011614949
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/j.cytogfr.2015.10.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008883763
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/j.gene.2008.05.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024361018
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/j.gene.2017.03.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084076796
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/j.jacc.2006.07.060 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048098482
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1016/j.jhep.2006.04.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027421879
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/j.jhep.2015.01.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038438609
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/j.preteyeres.2013.12.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048254157
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1016/s0091-679x(08)61797-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018711343
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1042/bj2870255 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011542214
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1053/j.gastro.2008.03.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001724122
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1053/j.gastro.2014.07.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039371323
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1055/s-0032-1330422 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057277381
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1073/pnas.0409722102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032390334
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1073/pnas.92.7.2572 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017787606
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1084/jem.20041393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045080455
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1111/j.1432-0436.2007.00235.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002248502
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1111/j.1440-1746.2006.04658.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049274214
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1128/mcb.01321-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053727503
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1136/gut.2005.088690 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048087432
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1146/annurev-pathol-011110-130246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042822909
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1152/ajpcell.00423.2014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063191988
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1152/ajpgi.1999.276.4.g1059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074356240
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1152/ajpgi.2000.279.5.g845 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074719137
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1158/1535-7163.mct-06-0720 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042094155
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1172/jci117497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035067718
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1172/jci24282 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006469641
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1242/dev.030338 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023243478
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1309/d7au-eyw7-4b6c-k08y schema:sameAs https://app.dimensions.ai/details/publication/pub.1020997143
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1371/journal.pone.0092925 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012740713
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1517/14728220902719233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008612953
286 rdf:type schema:CreativeWork
287 https://doi.org/10.18632/oncotarget.17134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084880940
288 rdf:type schema:CreativeWork
289 https://www.grid.ac/institutes/grid.15444.30 schema:alternateName Yonsei University
290 schema:name Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea
291 Department of Pathology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea
292 rdf:type schema:Organization
293 https://www.grid.ac/institutes/grid.202119.9 schema:alternateName Inha University
294 schema:name Laboratory of Developmental Genetics, Department of Biomedical Sciences, Inha University College of Medicine, Incheon, Republic of Korea
295 rdf:type schema:Organization
296 https://www.grid.ac/institutes/grid.459553.b schema:alternateName Gangnam Severance Hospital
297 schema:name Medical Research Center, Gangnam Severance Hospital, Seoul, South Korea
298 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...