Experimental detection of short regulatory motifs in eukaryotic proteins: tips for good practice as well as for bad View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-11-18

AUTHORS

Toby J. Gibson, Holger Dinkel, Kim Van Roey, Francesca Diella

ABSTRACT

It has become clear in outline though not yet in detail how cellular regulatory and signalling systems are constructed. The essential machines are protein complexes that effect regulatory decisions by undergoing internal changes of state. Subcomponents of these cellular complexes are assembled into molecular switches. Many of these switches employ one or more short peptide motifs as toggles that can move between one or more sites within the switch system, the simplest being on-off switches. Paradoxically, these motif modules (termed short linear motifs or SLiMs) are both hugely abundant but difficult to research. So despite the many successes in identifying short regulatory protein motifs, it is thought that only the “tip of the iceberg” has been exposed. Experimental and bioinformatic motif discovery remain challenging and error prone. The advice presented in this article is aimed at helping researchers to uncover genuine protein motifs, whilst avoiding the pitfalls that lead to reports of false discovery. More... »

PAGES

42

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12964-015-0121-y

DOI

http://dx.doi.org/10.1186/s12964-015-0121-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015281242

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26581338


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