Cost-effectiveness of the recommended medical intervention for the treatment of dysmenorrhea and endometriosis in Japan View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-04-10

AUTHORS

Ichiro Arakawa, Mikio Momoeda, Yutaka Osuga, Ikuko Ota, Kaori Koga

ABSTRACT

Background and objective: This study aims to assess the cost-effectiveness of early physician consultation and guideline-based intervention to prevent endometriosis and/or disease progression using oral contraceptive (OC) and progestin compared to follow-up of self-care for dysmenorrhea in Japan. Methods: A yearly-transmitted Markov model of five major health states with four sub-medical states was constructed. Transition probabilities among health and medical states were derived from Japanese epidemiological patient surveys and converted to appropriate parameters for inputting into the model. The dysmenorrhea and endometriosis-associated direct costs included inpatient, outpatient visit, surgery, and medication (OC agents, over-the-counter drugs), etc. The utility measure for patients with phase I-IV endometriosis comprised a visual analogue scale. We estimated the cost per quality-adjusted life year (QALY) at a time horizon of 23 years. An annual discount rate at 3% for both cost and outcome was considered. Results: The base case outcomes indicated that the intervention would be more cost-effective than self-care, as the incremental cost-effectiveness ratio (ICER) yielded 115,000 JPY per QALY gained from the healthcare payers' perspective and the societal monetary value (SMV) was approximately positive 3,130,000 JPY, favoring the intervention in the cost-benefit estimate. A tornado diagram depicting the stochastic sensitivity analysis of the ICER and SMV from both the healthcare payers' and societal perspectives confirmed the robustness of the base case. A probabilistic analysis resulting from 10,000-time Monte Carlo simulations demonstrated efficiency at willingness-to-pay thresholds in more than 90% of the iterations. Conclusions: The present analysis demonstrated that early physician consultation and guideline-based intervention would be more cost-effective than self-care in preventing endometriosis and/or disease progression for patients with dysmenorrhea in Japan. More... »

PAGES

12

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12962-018-0097-8

DOI

http://dx.doi.org/10.1186/s12962-018-0097-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1103148786

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29643744


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/14", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Economics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1402", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Applied Economics", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Faculty of Pharmaceutical Sciences, Teikyo Heisei University, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.440938.2", 
          "name": [
            "Faculty of Pharmaceutical Sciences, Teikyo Heisei University, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arakawa", 
        "givenName": "Ichiro", 
        "id": "sg:person.0762752760.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762752760.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Japan Enlightenment Committee in Endometriosis (JECIE), Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Obstetrics and Genecology, St. Luke International Hospital, Tokyo, Japan", 
            "Japan Enlightenment Committee in Endometriosis (JECIE), Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Momoeda", 
        "givenName": "Mikio", 
        "id": "sg:person.0727023244.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727023244.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Japan Enlightenment Committee in Endometriosis (JECIE), Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Obstetrics and Genecology, The University of Tokyo, Tokyo, Japan", 
            "Japan Enlightenment Committee in Endometriosis (JECIE), Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Osuga", 
        "givenName": "Yutaka", 
        "id": "sg:person.01055223566.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055223566.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Japan Enlightenment Committee in Endometriosis (JECIE), Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Genecology, Kurashiki Heisei Hospital, Kurashiki, Japan", 
            "Japan Enlightenment Committee in Endometriosis (JECIE), Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ota", 
        "givenName": "Ikuko", 
        "id": "sg:person.01167264043.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167264043.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Japan Enlightenment Committee in Endometriosis (JECIE), Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Obstetrics and Genecology, The University of Tokyo, Tokyo, Japan", 
            "Japan Enlightenment Committee in Endometriosis (JECIE), Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Koga", 
        "givenName": "Kaori", 
        "id": "sg:person.01171452166.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171452166.57"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "2018-04-10", 
    "datePublishedReg": "2018-04-10", 
    "description": "Background and objective: This study aims to assess the cost-effectiveness of early physician consultation and guideline-based intervention to prevent endometriosis and/or disease progression using oral contraceptive (OC) and progestin compared to follow-up of self-care for dysmenorrhea in Japan.\nMethods: A yearly-transmitted Markov model of five major health states with four sub-medical states was constructed. Transition probabilities among health and medical states were derived from Japanese epidemiological patient surveys and converted to appropriate parameters for inputting into the model. The dysmenorrhea and endometriosis-associated direct costs included inpatient, outpatient visit,\u00a0surgery, and medication (OC agents, over-the-counter drugs), etc. The utility measure for patients with phase I-IV endometriosis comprised a visual analogue scale. We estimated the cost per quality-adjusted life year (QALY) at a time horizon of 23\u00a0years. An annual discount rate at 3% for both cost and outcome was considered.\nResults: The base case outcomes indicated that the intervention would be more cost-effective than self-care, as the incremental cost-effectiveness ratio (ICER) yielded 115,000 JPY per QALY gained from the healthcare payers' perspective and the societal monetary value (SMV) was approximately positive 3,130,000 JPY, favoring the intervention in the cost-benefit estimate. A tornado diagram depicting the stochastic sensitivity analysis of the ICER and SMV from both the healthcare payers' and societal perspectives confirmed the robustness of the base case. A probabilistic analysis resulting from 10,000-time Monte Carlo simulations demonstrated efficiency at willingness-to-pay thresholds in more than 90% of the iterations.\nConclusions: The present analysis demonstrated that early physician consultation and guideline-based intervention would be more cost-effective than self-care in preventing endometriosis and/or disease progression for patients with dysmenorrhea in Japan.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s12962-018-0097-8", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1032048", 
        "issn": [
          "1478-7547"
        ], 
        "name": "Cost Effectiveness and Resource Allocation", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "16"
      }
    ], 
    "keywords": [
      "incremental cost-effectiveness ratio", 
      "quality-adjusted life years", 
      "guideline-based intervention", 
      "oral contraceptives", 
      "physician consultation", 
      "disease progression", 
      "visual analog scale", 
      "treatment of dysmenorrhea", 
      "healthcare payer perspective", 
      "cost-effectiveness ratio", 
      "annual discount rate", 
      "outpatient visits", 
      "analog scale", 
      "patient survey", 
      "payer perspective", 
      "dysmenorrhea", 
      "endometriosis", 
      "life years", 
      "healthcare payers", 
      "medical interventions", 
      "medical state", 
      "societal perspective", 
      "phase I", 
      "direct costs", 
      "intervention", 
      "patients", 
      "health states", 
      "progression", 
      "base case outcomes", 
      "outcomes", 
      "cost-benefit estimates", 
      "consultation", 
      "utility measures", 
      "medications", 
      "surgery", 
      "contraceptives", 
      "progestins", 
      "inpatients", 
      "years", 
      "visits", 
      "treatment", 
      "payers", 
      "health", 
      "case outcomes", 
      "tornado diagrams", 
      "present analysis", 
      "Japan", 
      "cases", 
      "study", 
      "analysis", 
      "sensitivity analysis", 
      "background", 
      "measures", 
      "rate", 
      "survey", 
      "JPY", 
      "base case", 
      "objective", 
      "threshold", 
      "time horizon", 
      "willingness", 
      "ratio", 
      "scale", 
      "perspective", 
      "model", 
      "cost", 
      "state", 
      "time Monte Carlo simulations", 
      "Markov model", 
      "values", 
      "discount rate", 
      "estimates", 
      "parameters", 
      "monetary value", 
      "appropriate parameters", 
      "transition", 
      "stochastic sensitivity analysis", 
      "probabilistic analysis", 
      "horizon", 
      "efficiency", 
      "Monte Carlo simulations", 
      "Carlo simulations", 
      "robustness", 
      "iteration", 
      "diagram", 
      "simulations", 
      "early physician consultation", 
      "major health states", 
      "sub-medical states", 
      "Japanese epidemiological patient surveys", 
      "epidemiological patient surveys", 
      "endometriosis-associated direct costs", 
      "SMV"
    ], 
    "name": "Cost-effectiveness of the recommended medical intervention for the treatment of dysmenorrhea and endometriosis in Japan", 
    "pagination": "12", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1103148786"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s12962-018-0097-8"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29643744"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s12962-018-0097-8", 
      "https://app.dimensions.ai/details/publication/pub.1103148786"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:41", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_767.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s12962-018-0097-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12962-018-0097-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12962-018-0097-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12962-018-0097-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12962-018-0097-8'


 

This table displays all metadata directly associated to this object as RDF triples.

188 TRIPLES      21 PREDICATES      119 URIs      111 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s12962-018-0097-8 schema:about anzsrc-for:14
2 anzsrc-for:1402
3 schema:author N6430c2ad12f64a21b3ca5b756cefea67
4 schema:datePublished 2018-04-10
5 schema:datePublishedReg 2018-04-10
6 schema:description Background and objective: This study aims to assess the cost-effectiveness of early physician consultation and guideline-based intervention to prevent endometriosis and/or disease progression using oral contraceptive (OC) and progestin compared to follow-up of self-care for dysmenorrhea in Japan. Methods: A yearly-transmitted Markov model of five major health states with four sub-medical states was constructed. Transition probabilities among health and medical states were derived from Japanese epidemiological patient surveys and converted to appropriate parameters for inputting into the model. The dysmenorrhea and endometriosis-associated direct costs included inpatient, outpatient visit, surgery, and medication (OC agents, over-the-counter drugs), etc. The utility measure for patients with phase I-IV endometriosis comprised a visual analogue scale. We estimated the cost per quality-adjusted life year (QALY) at a time horizon of 23 years. An annual discount rate at 3% for both cost and outcome was considered. Results: The base case outcomes indicated that the intervention would be more cost-effective than self-care, as the incremental cost-effectiveness ratio (ICER) yielded 115,000 JPY per QALY gained from the healthcare payers' perspective and the societal monetary value (SMV) was approximately positive 3,130,000 JPY, favoring the intervention in the cost-benefit estimate. A tornado diagram depicting the stochastic sensitivity analysis of the ICER and SMV from both the healthcare payers' and societal perspectives confirmed the robustness of the base case. A probabilistic analysis resulting from 10,000-time Monte Carlo simulations demonstrated efficiency at willingness-to-pay thresholds in more than 90% of the iterations. Conclusions: The present analysis demonstrated that early physician consultation and guideline-based intervention would be more cost-effective than self-care in preventing endometriosis and/or disease progression for patients with dysmenorrhea in Japan.
7 schema:genre article
8 schema:inLanguage en
9 schema:isAccessibleForFree true
10 schema:isPartOf N29840a27b23d4f839ae6f7e8d5ebebcc
11 Na5248b70cdbb4aedaca01e713abb808b
12 sg:journal.1032048
13 schema:keywords Carlo simulations
14 JPY
15 Japan
16 Japanese epidemiological patient surveys
17 Markov model
18 Monte Carlo simulations
19 SMV
20 analog scale
21 analysis
22 annual discount rate
23 appropriate parameters
24 background
25 base case
26 base case outcomes
27 case outcomes
28 cases
29 consultation
30 contraceptives
31 cost
32 cost-benefit estimates
33 cost-effectiveness ratio
34 diagram
35 direct costs
36 discount rate
37 disease progression
38 dysmenorrhea
39 early physician consultation
40 efficiency
41 endometriosis
42 endometriosis-associated direct costs
43 epidemiological patient surveys
44 estimates
45 guideline-based intervention
46 health
47 health states
48 healthcare payer perspective
49 healthcare payers
50 horizon
51 incremental cost-effectiveness ratio
52 inpatients
53 intervention
54 iteration
55 life years
56 major health states
57 measures
58 medical interventions
59 medical state
60 medications
61 model
62 monetary value
63 objective
64 oral contraceptives
65 outcomes
66 outpatient visits
67 parameters
68 patient survey
69 patients
70 payer perspective
71 payers
72 perspective
73 phase I
74 physician consultation
75 present analysis
76 probabilistic analysis
77 progestins
78 progression
79 quality-adjusted life years
80 rate
81 ratio
82 robustness
83 scale
84 sensitivity analysis
85 simulations
86 societal perspective
87 state
88 stochastic sensitivity analysis
89 study
90 sub-medical states
91 surgery
92 survey
93 threshold
94 time Monte Carlo simulations
95 time horizon
96 tornado diagrams
97 transition
98 treatment
99 treatment of dysmenorrhea
100 utility measures
101 values
102 visits
103 visual analog scale
104 willingness
105 years
106 schema:name Cost-effectiveness of the recommended medical intervention for the treatment of dysmenorrhea and endometriosis in Japan
107 schema:pagination 12
108 schema:productId N2655e3d7759a42979540d38ffa3a9b35
109 N90df7895f62241f6a2e6e16116fecc23
110 Ndaed08aa2e0c44518da5e997fa6ed452
111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103148786
112 https://doi.org/10.1186/s12962-018-0097-8
113 schema:sdDatePublished 2021-12-01T19:41
114 schema:sdLicense https://scigraph.springernature.com/explorer/license/
115 schema:sdPublisher N7bfe6af4827541f58b600e6dca93a573
116 schema:url https://doi.org/10.1186/s12962-018-0097-8
117 sgo:license sg:explorer/license/
118 sgo:sdDataset articles
119 rdf:type schema:ScholarlyArticle
120 N200da615abac4d68917b74bd7c6052ec rdf:first sg:person.01055223566.15
121 rdf:rest Nc6f9a7c89e344531b9a10fd14de70d85
122 N20686cc5eba342d0831daaa7ec7d8bdb rdf:first sg:person.0727023244.74
123 rdf:rest N200da615abac4d68917b74bd7c6052ec
124 N2655e3d7759a42979540d38ffa3a9b35 schema:name doi
125 schema:value 10.1186/s12962-018-0097-8
126 rdf:type schema:PropertyValue
127 N29840a27b23d4f839ae6f7e8d5ebebcc schema:volumeNumber 16
128 rdf:type schema:PublicationVolume
129 N6430c2ad12f64a21b3ca5b756cefea67 rdf:first sg:person.0762752760.28
130 rdf:rest N20686cc5eba342d0831daaa7ec7d8bdb
131 N764474e1f5ad44f0b2ecbf494b73ad85 rdf:first sg:person.01171452166.57
132 rdf:rest rdf:nil
133 N7bfe6af4827541f58b600e6dca93a573 schema:name Springer Nature - SN SciGraph project
134 rdf:type schema:Organization
135 N90df7895f62241f6a2e6e16116fecc23 schema:name pubmed_id
136 schema:value 29643744
137 rdf:type schema:PropertyValue
138 Na5248b70cdbb4aedaca01e713abb808b schema:issueNumber 1
139 rdf:type schema:PublicationIssue
140 Nc6f9a7c89e344531b9a10fd14de70d85 rdf:first sg:person.01167264043.53
141 rdf:rest N764474e1f5ad44f0b2ecbf494b73ad85
142 Ndaed08aa2e0c44518da5e997fa6ed452 schema:name dimensions_id
143 schema:value pub.1103148786
144 rdf:type schema:PropertyValue
145 anzsrc-for:14 schema:inDefinedTermSet anzsrc-for:
146 schema:name Economics
147 rdf:type schema:DefinedTerm
148 anzsrc-for:1402 schema:inDefinedTermSet anzsrc-for:
149 schema:name Applied Economics
150 rdf:type schema:DefinedTerm
151 sg:journal.1032048 schema:issn 1478-7547
152 schema:name Cost Effectiveness and Resource Allocation
153 schema:publisher Springer Nature
154 rdf:type schema:Periodical
155 sg:person.01055223566.15 schema:affiliation grid-institutes:None
156 schema:familyName Osuga
157 schema:givenName Yutaka
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055223566.15
159 rdf:type schema:Person
160 sg:person.01167264043.53 schema:affiliation grid-institutes:None
161 schema:familyName Ota
162 schema:givenName Ikuko
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167264043.53
164 rdf:type schema:Person
165 sg:person.01171452166.57 schema:affiliation grid-institutes:None
166 schema:familyName Koga
167 schema:givenName Kaori
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171452166.57
169 rdf:type schema:Person
170 sg:person.0727023244.74 schema:affiliation grid-institutes:None
171 schema:familyName Momoeda
172 schema:givenName Mikio
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727023244.74
174 rdf:type schema:Person
175 sg:person.0762752760.28 schema:affiliation grid-institutes:grid.440938.2
176 schema:familyName Arakawa
177 schema:givenName Ichiro
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762752760.28
179 rdf:type schema:Person
180 grid-institutes:None schema:alternateName Japan Enlightenment Committee in Endometriosis (JECIE), Tokyo, Japan
181 schema:name Department of Genecology, Kurashiki Heisei Hospital, Kurashiki, Japan
182 Department of Obstetrics and Genecology, St. Luke International Hospital, Tokyo, Japan
183 Department of Obstetrics and Genecology, The University of Tokyo, Tokyo, Japan
184 Japan Enlightenment Committee in Endometriosis (JECIE), Tokyo, Japan
185 rdf:type schema:Organization
186 grid-institutes:grid.440938.2 schema:alternateName Faculty of Pharmaceutical Sciences, Teikyo Heisei University, Tokyo, Japan
187 schema:name Faculty of Pharmaceutical Sciences, Teikyo Heisei University, Tokyo, Japan
188 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...