Ontology type: schema:ScholarlyArticle Open Access: True
2018-12
AUTHORSAlexander T. Cohen, Anthony Maraveyas, Jan Beyer-Westendorf, Agnes Y. Y. Lee, Lorenzo G. Mantovani, Miriam Bach, on behalf of the COSIMO Investigators
ABSTRACTBackground: Around 20% of venous thromboembolism (VTE) cases occur in patients with cancer. Current guidelines recommend low molecular weight heparin (LMWH) as the preferred anticoagulant for VTE treatment. However, some guidelines state that vitamin K antagonists (VKAs) and direct oral anticoagulants (DOACs) are acceptable alternatives for long-term therapy in some patients if LMWHs are not available. LMWHs and VKAs have a number of drawbacks that can increase the burden on patients. DOACs, such as rivaroxaban, can ameliorate some burdens and may offer an opportunity to increase patient satisfaction and health-related quality of life (HRQoL). The Cancer-associated thrOmboSIs - patient-reported outcoMes with rivarOxaban (COSIMO) study is designed to provide real-world information on treatment satisfaction in patients with active cancer who switch from LMWH or VKA to rivaroxaban for the treatment of acute VTE or to prevent recurrent VTE. Methods: COSIMO is a prospective, non-interventional, single-arm cohort study that aims to recruit 500 patients in Europe, Canada and Australia. Adults with active cancer who are switching to rivaroxaban having received LMWH/VKA for the treatment and secondary prevention of recurrent VTE for at least the previous 4 weeks are eligible. Patients will be followed for 6 months. The primary outcome is treatment satisfaction assessed as change in the Anti-Clot Treatment Scale (ACTS) Burdens score at week 4 after enrolment compared with baseline. Secondary outcomes include treatment preferences, measured using a discrete choice experiment, change in ACTS Burdens score at months 3 and 6, and change in HRQoL (assessed using the Functional Assessment of Chronic Illness Therapy - Fatigue questionnaire). COSIMO will collect data on patients' medical history, patterns of anticoagulant use and incidence of bleeding and thromboembolic events. Study recruitment started in autumn 2016. Conclusions: COSIMO will provide information on outcomes associated with switching from LMWH or VKA therapy to rivaroxaban for the treatment or secondary prevention of cancer-associated thrombosis in a real-life setting. The key goal is to assess whether there is a change in patient-reported treatment satisfaction. In addition, COSIMO will facilitate the evaluation of the safety and effectiveness of rivaroxaban in preventing recurrent VTE in this patient population. Trial registration: NCT02742623. Registered 19 April 2016. More... »
PAGES21
http://scigraph.springernature.com/pub.10.1186/s12959-018-0176-2
DOIhttp://dx.doi.org/10.1186/s12959-018-0176-2
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1105230256
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30186045
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Public Health and Health Services",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "King's College London",
"id": "https://www.grid.ac/institutes/grid.13097.3c",
"name": [
"Department of Haematological Medicine, Guys and St Thomas\u2019 NHS Foundation Trust, King\u2019s College London, Westminster Bridge Road, London, UK"
],
"type": "Organization"
},
"familyName": "Cohen",
"givenName": "Alexander T.",
"id": "sg:person.0621256066.77",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621256066.77"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hull York Medical School",
"id": "https://www.grid.ac/institutes/grid.413631.2",
"name": [
"Joint Centre for Cancer Studies, Hull York Medical School, QCOH, Castle Hill Hospital, Hull, UK"
],
"type": "Organization"
},
"familyName": "Maraveyas",
"givenName": "Anthony",
"id": "sg:person.01276160442.39",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276160442.39"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "King's College London",
"id": "https://www.grid.ac/institutes/grid.13097.3c",
"name": [
"Thrombosis Research Unit, Department of Medicine I, Division Hematology, University Hospital \u201cCarl Gustav Carus\u201d Dresden, Dresden, Germany",
"Kings Thrombosis Service, Department of Haematology, Kings College London, London, UK"
],
"type": "Organization"
},
"familyName": "Beyer-Westendorf",
"givenName": "Jan",
"id": "sg:person.01315313403.41",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315313403.41"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of British Columbia",
"id": "https://www.grid.ac/institutes/grid.17091.3e",
"name": [
"Division of Hematology, University of British Columbia, British Columbia Cancer Agency, Vancouver, BC, Canada"
],
"type": "Organization"
},
"familyName": "Lee",
"givenName": "Agnes Y. Y.",
"type": "Person"
},
{
"affiliation": {
"name": [
"CESP-Center for Public Health Research, University of Milan Bicocca, Monza, Italy"
],
"type": "Organization"
},
"familyName": "Mantovani",
"givenName": "Lorenzo G.",
"id": "sg:person.07442362324.37",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07442362324.37"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Bayer (Germany)",
"id": "https://www.grid.ac/institutes/grid.420044.6",
"name": [
"Bayer AG, Berlin, Germany"
],
"type": "Organization"
},
"familyName": "Bach",
"givenName": "Miriam",
"id": "sg:person.014133470223.09",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014133470223.09"
],
"type": "Person"
},
{
"familyName": "on behalf of the COSIMO Investigators",
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1186/1471-2407-13-284",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000589576",
"https://doi.org/10.1186/1471-2407-13-284"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2147/ppa.s79373",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000870957"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.thromres.2014.11.008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003217169"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s12955-015-0257-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008620087",
"https://doi.org/10.1186/s12955-015-0257-x"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s12955-015-0257-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008620087",
"https://doi.org/10.1186/s12955-015-0257-x"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2014.59.7351",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013097753"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/jth.12923",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013107051"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3389/fcvm.2016.00024",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014381602"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1477-7525-2-22",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014914147",
"https://doi.org/10.1186/1477-7525-2-22"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1470-2045(16)30369-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017453559"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s2352-3026(14)70018-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017522628"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1538-7836.2007.02374.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017990984"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2002-01-0108",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019785571"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/eurheartj/ehw210",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020125462"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/eurheartj/ehw210",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020125462"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11239-015-1263-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021177818",
"https://doi.org/10.1007/s11239-015-1263-x"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3324/haematol.2015.127126",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021533844"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2013.49.1118",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022692210"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/eurheartj/ehu283",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024127988"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa025313",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024707641"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pmed.1001275",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025561823"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.thromres.2015.02.001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027178314"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4103/2278-330x.149942",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031173618"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/jama.293.6.715",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031368268"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1538-7836.2011.04197.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032048791"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/jama.2015.9243",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032108796"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.thromres.2016.07.013",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032564135"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/bmj.328.7436.360",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036985070"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jval.2012.08.2223",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037115565"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa1007903",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044711794"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11739-012-0844-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045085835",
"https://doi.org/10.1007/s11739-012-0844-3"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/eurheartj/ehu243",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046257046"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11239-016-1429-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047090941",
"https://doi.org/10.1007/s11239-016-1429-1"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11239-016-1429-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047090941",
"https://doi.org/10.1007/s11239-016-1429-1"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1477-7525-1-79",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047768593",
"https://doi.org/10.1186/1477-7525-1-79"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/annonc/mdr392",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048198947"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.amjmed.2015.12.025",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051112496"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.chest.2015.11.026",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051826247"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1477-7525-10-120",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052009198",
"https://doi.org/10.1186/1477-7525-10-120"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.blre.2013.11.001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053066608"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1055/s-0041-101770",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1057371441"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1160/th13-03-0243",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1063293370"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1160/th15-08-0686",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1063294144"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1160/th16-06-0486",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1063294359"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1160/th16-08-0615",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1063294387"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074253670",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1160/th16-10-0793",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1084819431"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1055/s-0037-1603924",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1090284255"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1160/th17-03-0193",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1091330941"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa1711948",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1099653207"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2018.78.8034",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1103934927"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2018.78.8034",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1103934927"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1160/th17-03-0193",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1106393181"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2017.35.15_suppl.e18268",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1106849035"
],
"type": "CreativeWork"
}
],
"datePublished": "2018-12",
"datePublishedReg": "2018-12-01",
"description": "Background: Around 20% of venous thromboembolism (VTE) cases occur in patients with cancer. Current guidelines recommend low molecular weight heparin (LMWH) as the preferred anticoagulant for VTE treatment. However, some guidelines state that vitamin K antagonists (VKAs) and direct oral anticoagulants (DOACs) are acceptable alternatives for long-term therapy in some patients if LMWHs are not available. LMWHs and VKAs have a number of drawbacks that can increase the burden on patients. DOACs, such as rivaroxaban, can ameliorate some burdens and may offer an opportunity to increase patient satisfaction and health-related quality of life (HRQoL). The Cancer-associated thrOmboSIs - patient-reported outcoMes with rivarOxaban (COSIMO) study is designed to provide real-world information on treatment satisfaction in patients with active cancer who switch from LMWH or VKA to rivaroxaban for the treatment of acute VTE or to prevent recurrent VTE.\nMethods: COSIMO is a prospective, non-interventional, single-arm cohort study that aims to recruit 500 patients in Europe, Canada and Australia. Adults with active cancer who are switching to rivaroxaban having received LMWH/VKA for the treatment and secondary prevention of recurrent VTE for at least the previous 4 weeks are eligible. Patients will be followed for 6 months. The primary outcome is treatment satisfaction assessed as change in the Anti-Clot Treatment Scale (ACTS) Burdens score at week 4 after enrolment compared with baseline. Secondary outcomes include treatment preferences, measured using a discrete choice experiment, change in ACTS Burdens score at months 3 and 6, and change in HRQoL (assessed using the Functional Assessment of Chronic Illness Therapy - Fatigue questionnaire). COSIMO will collect data on patients' medical history, patterns of anticoagulant use and incidence of bleeding and thromboembolic events. Study recruitment started in autumn 2016.\nConclusions: COSIMO will provide information on outcomes associated with switching from LMWH or VKA therapy to rivaroxaban for the treatment or secondary prevention of cancer-associated thrombosis in a real-life setting. The key goal is to assess whether there is a change in patient-reported treatment satisfaction. In addition, COSIMO will facilitate the evaluation of the safety and effectiveness of rivaroxaban in preventing recurrent VTE in this patient population.\nTrial registration: NCT02742623. Registered 19 April 2016.",
"genre": "research_article",
"id": "sg:pub.10.1186/s12959-018-0176-2",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1032055",
"issn": [
"1477-9560"
],
"name": "Thrombosis Journal",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "16"
}
],
"name": "COSIMO \u2013 patients with active cancer changing to rivaroxaban for the treatment and prevention of recurrent venous thromboembolism: a non-interventional study",
"pagination": "21",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"7f4888e41483ff2856f38e439d7e7bc4d77e3f3c3d477b16c4b54285d916fa3f"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30186045"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"101170542"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1186/s12959-018-0176-2"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1105230256"
]
}
],
"sameAs": [
"https://doi.org/10.1186/s12959-018-0176-2",
"https://app.dimensions.ai/details/publication/pub.1105230256"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T18:29",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8675_00000571.jsonl",
"type": "ScholarlyArticle",
"url": "https://link.springer.com/10.1186%2Fs12959-018-0176-2"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s12959-018-0176-2'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s12959-018-0176-2'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s12959-018-0176-2'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s12959-018-0176-2'
This table displays all metadata directly associated to this object as RDF triples.
274 TRIPLES
21 PREDICATES
78 URIs
21 LITERALS
9 BLANK NODES