Autoinflammatory diseases: a possible cause of thrombosis? View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Micaela La Regina, Francesco Orlandini, Raffaele Manna

ABSTRACT

Autoinflammatory diseases are a group of disorders due to acquired or hereditary disfunction of innate immune system and characterized by systemic or localized manifestations. The prototype is Familial Mediterranean Fever, a monogenic hereditary disorder, whose causing gene (MeFV gene) was identified in 1997 and opened the way to a new fascinanting chapter of rheumatology. A growing body of monogenic and poligenic autoinflammatory disorders has been described since then. Arterial and venous thrombosis is a common medical problem, with significant morbidity and mortality. Strong evidences from basic research and clinical epidemiological studies support the theory that inflammation and thrombosis can be associated. Because of their recurrent/chronic inflammatory nature, autoinflammatory diseases are a putative cause of thrombotic manifestations. In the present work, we reviewed the available evidences about monogenic autoinflammatory disorders, complicated by thrombotic manifestations. More... »

PAGES

19

References to SciGraph publications

Journal

TITLE

Thrombosis Journal

ISSUE

1

VOLUME

13

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12959-015-0049-x

DOI

http://dx.doi.org/10.1186/s12959-015-0049-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043489154

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25969671


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