Comparative study of environmental pollutants bisphenol A and bisphenol S on sexual differentiation of anteroventral periventricular nucleus and spermatogenesis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-07-10

AUTHORS

Naham John, Humaira Rehman, Suhail Razak, Mehwish David, Waheed Ullah, Tayyaba Afsar, Ali Almajwal, Iftikhar Alam, Sarwat Jahan

ABSTRACT

BackgroundBisphenol A is well known endocrine-disrupting chemical while Bisphenol S was considered a safe alternative. The present study aims to examine the comparative effects of xenobiotic bisphenol-A (BPA) and its substitute bisphenol-S (BPS) on spermatogenesis and development of sexually dimorphic nucleus population of dopaminergic neurons in the anteroventral periventricular nucleus (AVPV) of the hypothalamus in male pups.MethodsSprague Dawley rat’s pups were administered subcutaneously at the neonatal stage from postnatal day PND1 to PND 27. Thirty animals were divided into six experimental groups (6 animals/group). The first group served as control and was provided with normal olive oil. The four groups were treated with 2 μg/kg and 200 μg/kg of BPA and BPS, respectively. The sixth group was given with 50 μg/kg of estradiol dissolved in olive oil as a standard to find the development of dopaminergic tyrosine hydroxylase neurons in AVPV regions. Histological analysis for testicular tissues and immunohistochemistry for brain tissues was performed.ResultsThe results revealed adverse histopathological changes in testis after administration of different doses of BPA and BPS. These degenerative changes were marked by highly significant (p < 0.001) decrease in tubular and luminal diameters of seminiferous tubule and epithelial height among bisphenols treated groups as compared to control. Furthermore, significantly increased (p < 0.001) TH-ir cell bodies in the AVPV region of the brain with 200 μg/kg dose of BPA and BPS was evident.ConclusionIt is concluded that exposure of BPA and BPS during a critical developmental period can structural impairments in testes and affects sexual differentiation of a dimorphic dopaminergic population of AVPV region of hypothalamus in the male brain. More... »

PAGES

53

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s12958-019-0491-x

DOI

http://dx.doi.org/10.1186/s12958-019-0491-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1117918820

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31292004


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91 luminal diameter
92 male brain
93 male pups
94 neonatal stage
95 neurons
96 nuclei population
97 nucleus
98 oil
99 olive oil
100 period
101 periventricular nucleus
102 pollutants
103 population
104 present study
105 pups
106 rat pups
107 region
108 results
109 safe alternative
110 seminiferous tubules
111 sexual differentiation
112 sixth group
113 spermatogenesis
114 stage
115 standards
116 structural impairment
117 study
118 testicular tissue
119 testis
120 tissue
121 tubules
122 tyrosine hydroxylase neurons
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