Surgical site infection after laparoscopic resection of colorectal cancer is associated with compromised long-term oncological outcome View Full Text


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Article Info

DATE

2022-04-07

AUTHORS

Nana Sugamata, Takashi Okuyama, Emiko Takeshita, Haruka Oi, Yuhei Hakozaki, Shunya Miyazaki, Musashi Takada, Takashi Mitsui, Takuji Noro, Hideyuki Yoshitomi, Masatoshi Oya

ABSTRACT

BackgroundWe evaluated the influence of infectious complications, particularly surgical site infection (SSI), on long-term oncological results after elective laparoscopic resection of colorectal cancer.MethodsA total of 199 patients who underwent laparoscopic elective resection with negative resection margins for stage I–III colorectal cancer were retrospectively examined. The postoperative course was recorded based on hospital records, and cancer relapse was diagnosed based on radiological or pathological findings under a standardized follow-up program. The severity of complications was graded using Clavien-Dindo (CD) classification.ResultsSSI was found in 25 patients (12.6%), with 12 (6.0%) showing anastomotic leak. The postoperative relapse-free survival (RFS) rate was significantly lower in patients with SSI (49.2%) than in patients without SSI (87.2%, P<0.001). Differences in RFS were found after both colectomy and rectal resection (P<0.001 and P<0.001, respectively). RFS did not differ between patients who had major SSI CD (grade III) and those who had minor SSI CD (grades I or II). Multivariate Cox regression analysis identified the occurrence of SSI and pathological stage as independent co-factors for RFS (P<0.001 and P=0.003).ConclusionThese results suggest that postoperative SSI compromises long-term oncological results after laparoscopic colorectal resection. Further improvements in surgical technique and refinements in perioperative care may improve long-term oncological results. More... »

PAGES

111

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  • Identifiers

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    http://scigraph.springernature.com/pub.10.1186/s12957-022-02578-2

    DOI

    http://dx.doi.org/10.1186/s12957-022-02578-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1146920478

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/35387666


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